Focussing Containment - Episode 09 - CIP or WIP?

Is CIP the only way to clean highly active ingredients in production machines? Or is WIP or even manual cleaning acceptable for a good cleaning result. What must be considered in CIP processes?
A discussion with Armin Scheuermann, Editor in Chief of CHEMIE TECHNIK and Pharma + Food.
containment.glatt.com/videoblog/