Thank you Brian for this clear and detailed explanation! It is not easy to find such a nice explanation of the H2 complex in mice. I just have one remaining question. I have been looking for the H2 gene structure of C57BL/6 mice. I could find that they have the haplotype b, so they are MHC-I = H-2Db, H-2Kb, H-2Lnull & MHC-II = H-2IAb, H-2IEnull. Do you know what does the null mean? Do they not have those loci? or do they have some mutations in them that make these H2 molecules not functional or unable to be expressed in the membrane? Hopefully you can help me!
Thank you for the amazing explanation. I have two questions please Q1. What is more polymorphic, MHC I or MHC II? Q2. MHC I is more polymorphic than MHC II yet only 6 different versions of MHC I and 12 different of MHC II, is there a possible explanation for this?
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Speaking as a physicist, this video is a masterpiece
Great work .
Genetics is one of the deepest subjects which got least explained on the net.
Thanks for your effort.
I am a liver transplant fellow, thank you for the amazing talk, is the best ever!
am i the only one here who is actualy focusing on his smile since the vd has started 💙
Thank you, I love your passion for the subject
Thank you for this Amazing explanation of a such hard topic, I'm a med student in Italy and I can say that is the best lecture I've ever heard
This was the best explanation i've encountered so far. Thank you!
a trick : watch movies at Kaldrostream. I've been using them for watching all kinds of movies during the lockdown.
@Leighton Alberto yea, been watching on kaldrostream for since december myself =)
This is great! Thanks!
Brilliant!
THANK YOU
Very beneficial! Thank you
Thankyou so much! 😃
Elaborate explanation, Thanks
Thank you Brian for this clear and detailed explanation! It is not easy to find such a nice explanation of the H2 complex in mice. I just have one remaining question. I have been looking for the H2 gene structure of C57BL/6 mice. I could find that they have the haplotype b, so they are MHC-I = H-2Db, H-2Kb, H-2Lnull & MHC-II = H-2IAb, H-2IEnull. Do you know what does the null mean? Do they not have those loci? or do they have some mutations in them that make these H2 molecules not functional or unable to be expressed in the membrane? Hopefully you can help me!
Thanks
Thank you for the amazing explanation. I have two questions please
Q1. What is more polymorphic, MHC I or MHC II?
Q2. MHC I is more polymorphic than MHC II yet only 6 different versions of MHC I and 12 different of MHC II, is there a possible explanation for this?
can you tell me which reference book you have used for this ?
Many of the diagrams are from Janeway's Immunology