Macrophages also eat up dead blood cells. Ceruloplasmin-bound copper is required to convert the ferrous iron to ferric iron so that transferrin can transport the iron back to the bones so it can be recycled. What happens when ceruloplasmin-bound copper is depleted? Iron builds up in the lysosomes of the macrophages. So, imagine a macrophage depicted in this video with loads of toxic iron it just waiting to oxidize whatever it comes into contact with. In addition, a macrophage loaded with toxic iron almost certainly will not function optimally.
Interesting shit ngl. I've been increasing my ATP => In returns increases Mitochondrial. If there an increased of K+ extracellular due to the breakdown of ATP. That's when you've fucked up. => Intaking alcohol does not allow ATP to mitochondrial to bind at the same rate. Given that low potassium and other food intake. I could see how would've triggered NLRP3 Inflammasome activation. Basically stopped intaking Tomatoes during the week that had FA ( ferulic acid ) to inhibit NLRP3 Inflammasome activation for 3 days while still have low food intake with low electrolytes except magnesium. => Fixed Low Potassium yesterday by drinking 660ml of coconut water. Which had 1.6g of Potassium => Fixed Low Sodium increased low blood pressure w/ caffeine to normal blood pressure, roughly of 2g of Sodium, 1g of Potassium with 250mg of Magnesium => Excess intake of Ferulic Acid Today around 100mg+ derived from foods and skincare itself. Inflammation stopped. The worse thing about it, that Tylenol and anti-histamine doesn't work and other people around are not sick. So it confuses the heck out of you. Only at FA 100mg per kg it gets interesting because it mimics the NSAID of Diclofenac. Which I have in my draws ofc. => What symptoms you do get: - low blood pressure => Which causes: Low brain thinking capacity obv. => fluctuating oral temperature either hypothermia to fever but never in middle. no no! => excessive mucus build up. that will only go away, if you take mucinex or raise blood pressure. ... what happens if you can't raise blood pressure via caffeine? just take more sodium throughout the day. The surprising thing is that you won't be thristy but very indeed salty. => sore throat for no reason but using throat coat. It sure helps prior to sleep. // backstory: almost gotten parkinson meds, still have the option but it's manageable to a point; just not when you're getting transferred between specialist 8 ). => increases ATP via Coq10 w/ Thiamine binding sure helps imo. but introducing alcohol and inflammatory foods ie chips, fries. Basically anything that has a very high GI index will kind of cause it. If you had it within back to back to back plus an allergic reaction on top. You're fucked. // not a medical student yet, maybe in 10 years but I may get this wrong. COQ10 binds with Vitamin B1 to support ATP production to make more Mitochondria availability in the brain, digestion and muscles. It's suppose to suppress KATP, which is basically the inflammation of nerves/neurons due to binding extracellular Potassium => Creates KATP. If this ticks up and let's say it's 90% KATP and 10% ATP in a hypothetical world. Only ATP is produces the byproduct of adenosine unlike it's sister of KATP and caffeine only binds with adenosine to block it to prevent sleepiness while keeping you awake. However that sleep debt will keep on building up, ie if ATP keeps building up => there will be new receptors created to trigger sleepiness => no amount of caffeine will override that. => If you intaked alcohol during the weekends. Granted you didn't intake electrolytes to prevent dehydration => Ate inflammatory foods to get electrolytes. => You have rapid ATP breakdown to get electrolytes ie Potassium. => KATP is produced. => Malfunctions ie NLP3 Inflammasome is activated. => You've fucked up. That was Day #1 ( Sunday, August 20th ) => Sleep Debt was insane less than 4 hours a day of sleep but awake for more than 20 hours a day. => 200mg of Caffeine does not block the excessive amount of Adenosine from accumulation that's available. => More inflammatory foods, adding fuel to the fire. => By end of the day. Couldn't speak and had sore throat. => Intaked 1.6g Potassium derived from coconut water to stop dehydration from Electrolytes because I was pissing what I just drank. That was Day #2 ( Monday, August 21st ) => Had a 7 hour Sleep => 30mg of Caffeine worked, anything above was meh. => Reflect how I felt sluggish during the past week while i was grinding. What was derived in those tomatos. Oh, you have Vitamin B's that sure helped ATP. Wait what's FA? Ferulic Acid. It's the precursor of inhibiting NLRP3 Inflammasome activation. => How? Can I get more FA? Shoved tomatos in my mouth. Oh wow, it worked mimic as if I took mucinex to mucus then stopped working after I ate more inflammatory foods. => Ate Bran Flakes with Kefir + Asian Instant Oatmeal. Anti-Inflammatory + Partial. Felt great until I drank the Asian Instant Oatmeal at Hot Temperatures. Heat = Inflammation lol? => Took a hot shower, we got inflammation => Applied 3% FA Skincare Serum - Oil Based. at 3ml, it's 90mg. Which is basically like eating 200g of Bran Flakes. All of the inflammation symptoms GONE. Throat? Sore? Gone. Dry? Somewhat. Chapped Lips? Gone. Brain Fog? Gone. => That's how you know that FA worked => stopped NLRP3 Inflammasome in it's tracks. Took Diclofenac for Cotton Mouth from Modafinil due to low water intake but my brain is operating at 100%. However at such a low ratio. You wouldn't feel the effects as a person even if you took 370-400mg of caffeine. It wouldn't work because there's not enough adenosine to bind with => in return you're going to pee it out. Usually, my tolerance would be 30-40mg but when I took 300mg. I wasn't even jittery, just tired and sleepy. The only reason that ATP would break down is when KATP starts up ticking due to Low Intracellular Potassium levels => KATP will bind with extracellular potassium levels => Will trigger a host of inflammatory responses of trying to protect the cells from cell death.
Where is the proof that NLRP3 is activated AFTER the plaque has formed? Where is the proof that a person with a high cholesterol diet and no systemic inflammation (adequate magnesium in the cell, adequate bio-copper in the cells, no toxic iron overload in the tissues) develops these plaques? Where does calcium fit into this given that it is actually what is searched for to find these plaques? And since magnesium regulates every step of calcium metabolism, why isn't magnesium on nutrition labels. My understanding is that it is oxidized LDL cholesterol that is bad, not other types of cholesterol. Do you know differently? What are your research result sources?
I have a question. Around 4:56 ask of the soul? Then says so called asks mech I'm not sure if my phone spelled things wrong and it has another name or spelling. Does anyone have any info on ask of the soul. I believe I understand this and what is happening. Please help thank you for this knowledge
it sounded good until you said block don't block them find out what is causing the inflamation and deal with that otherwise we just have another drug and not real cure
Ottima Lezione sull'Inflamosoma NLRP3, coinvolto nell'arteriosclerosi.
Really wonderful explanation! Watch twice!
Well done! Thank you so much for this excellent video!
The narrative is amazing 👌
Incredible explanation! thank you
Great content and presentation skill is also good
Wonderful explaination madam
Macrophages also eat up dead blood cells. Ceruloplasmin-bound copper is required to convert the ferrous iron to ferric iron so that transferrin can transport the iron back to the bones so it can be recycled. What happens when ceruloplasmin-bound copper is depleted? Iron builds up in the lysosomes of the macrophages. So, imagine a macrophage depicted in this video with loads of toxic iron it just waiting to oxidize whatever it comes into contact with. In addition, a macrophage loaded with toxic iron almost certainly will not function optimally.
wowwww. great explanation.....
Great explanation. Thanks
GOOD PRESENTATION
Thanks for the lesson it really helped
My project really on this protein nlrp3 inflammasom
How you doing with your project so far?
So good!
Interesting shit ngl.
I've been increasing my ATP => In returns increases Mitochondrial.
If there an increased of K+ extracellular due to the breakdown of ATP. That's when you've fucked up.
=> Intaking alcohol does not allow ATP to mitochondrial to bind at the same rate. Given that low potassium and other food intake. I could see how would've triggered NLRP3 Inflammasome activation.
Basically stopped intaking Tomatoes during the week that had FA ( ferulic acid ) to inhibit NLRP3 Inflammasome activation for 3 days while still have low food intake with low electrolytes except magnesium.
=> Fixed Low Potassium yesterday by drinking 660ml of coconut water. Which had 1.6g of Potassium
=> Fixed Low Sodium increased low blood pressure w/ caffeine to normal blood pressure, roughly of 2g of Sodium, 1g of Potassium with 250mg of Magnesium
=> Excess intake of Ferulic Acid Today around 100mg+ derived from foods and skincare itself. Inflammation stopped. The worse thing about it, that Tylenol and anti-histamine doesn't work and other people around are not sick. So it confuses the heck out of you.
Only at FA 100mg per kg it gets interesting because it mimics the NSAID of Diclofenac. Which I have in my draws ofc.
=> What symptoms you do get:
- low blood pressure
=> Which causes: Low brain thinking capacity obv.
=> fluctuating oral temperature either hypothermia to fever but never in middle. no no!
=> excessive mucus build up. that will only go away, if you take mucinex or raise blood pressure.
... what happens if you can't raise blood pressure via caffeine? just take more sodium throughout the day. The surprising thing is that you won't be thristy but very indeed salty.
=> sore throat for no reason but using throat coat. It sure helps prior to sleep.
// backstory: almost gotten parkinson meds, still have the option but it's manageable to a point; just not when you're getting transferred between specialist 8 ).
=> increases ATP via Coq10 w/ Thiamine binding sure helps imo.
but introducing alcohol and inflammatory foods ie chips, fries. Basically anything that has a very high GI index will kind of cause it. If you had it within back to back to back plus an allergic reaction on top. You're fucked.
// not a medical student yet, maybe in 10 years but I may get this wrong.
COQ10 binds with Vitamin B1 to support ATP production to make more Mitochondria availability in the brain, digestion and muscles. It's suppose to suppress KATP, which is basically the inflammation of nerves/neurons due to binding extracellular Potassium => Creates KATP.
If this ticks up and let's say it's 90% KATP and 10% ATP in a hypothetical world. Only ATP is produces the byproduct of adenosine unlike it's sister of KATP and caffeine only binds with adenosine to block it to prevent sleepiness while keeping you awake. However that sleep debt will keep on building up, ie if ATP keeps building up => there will be new receptors created to trigger sleepiness => no amount of caffeine will override that.
=> If you intaked alcohol during the weekends. Granted you didn't intake electrolytes to prevent dehydration
=> Ate inflammatory foods to get electrolytes.
=> You have rapid ATP breakdown to get electrolytes ie Potassium.
=> KATP is produced.
=> Malfunctions ie NLP3 Inflammasome is activated.
=> You've fucked up.
That was Day #1 ( Sunday, August 20th )
=> Sleep Debt was insane less than 4 hours a day of sleep but awake for more than 20 hours a day.
=> 200mg of Caffeine does not block the excessive amount of Adenosine from accumulation that's available.
=> More inflammatory foods, adding fuel to the fire.
=> By end of the day. Couldn't speak and had sore throat.
=> Intaked 1.6g Potassium derived from coconut water to stop dehydration from Electrolytes because I was pissing what I just drank.
That was Day #2 ( Monday, August 21st )
=> Had a 7 hour Sleep
=> 30mg of Caffeine worked, anything above was meh.
=> Reflect how I felt sluggish during the past week while i was grinding. What was derived in those tomatos. Oh, you have Vitamin B's that sure helped ATP. Wait what's FA? Ferulic Acid. It's the precursor of inhibiting NLRP3 Inflammasome activation.
=> How? Can I get more FA? Shoved tomatos in my mouth. Oh wow, it worked mimic as if I took mucinex to mucus then stopped working after I ate more inflammatory foods.
=> Ate Bran Flakes with Kefir + Asian Instant Oatmeal. Anti-Inflammatory + Partial. Felt great until I drank the Asian Instant Oatmeal at Hot Temperatures. Heat = Inflammation lol?
=> Took a hot shower, we got inflammation
=> Applied 3% FA Skincare Serum - Oil Based. at 3ml, it's 90mg. Which is basically like eating 200g of Bran Flakes. All of the inflammation symptoms GONE.
Throat? Sore? Gone. Dry? Somewhat. Chapped Lips? Gone. Brain Fog? Gone.
=> That's how you know that FA worked => stopped NLRP3 Inflammasome in it's tracks.
Took Diclofenac for Cotton Mouth from Modafinil due to low water intake but my brain is operating at 100%.
However at such a low ratio. You wouldn't feel the effects as a person even if you took 370-400mg of caffeine. It wouldn't work because there's not enough adenosine to bind with => in return you're going to pee it out. Usually, my tolerance would be 30-40mg but when I took 300mg. I wasn't even jittery, just tired and sleepy.
The only reason that ATP would break down is when KATP starts up ticking due to Low Intracellular Potassium levels
=> KATP will bind with extracellular potassium levels
=> Will trigger a host of inflammatory responses of trying to protect the cells from cell death.
Amazing
What is the role of NLRP3 signaling
Good
Where is the proof that NLRP3 is activated AFTER the plaque has formed?
Where is the proof that a person with a high cholesterol diet and no systemic inflammation (adequate magnesium in the cell, adequate bio-copper in the cells, no toxic iron overload in the tissues) develops these plaques?
Where does calcium fit into this given that it is actually what is searched for to find these plaques? And since magnesium regulates every step of calcium metabolism, why isn't magnesium on nutrition labels.
My understanding is that it is oxidized LDL cholesterol that is bad, not other types of cholesterol. Do you know differently? What are your research result sources?
I have a question. Around 4:56 ask of the soul? Then says so called asks mech I'm not sure if my phone spelled things wrong and it has another name or spelling. Does anyone have any info on ask of the soul. I believe I understand this and what is happening. Please help thank you for this knowledge
... the entire ASC of the cell comes together within a single location within the cell the so called ASC SPECK...
it sounded good until you said block don't block them find out what is causing the inflamation and deal with that otherwise we just have another drug and not real cure