So we-the Pastafarians-now have new evidence for our Lord and Saviour, the Flying Spaghetti Monster?! Huzzah! Now go and spread the word! Tell everyone how He can save us from our sins, lest we be boiled in the fiery lake of sauce for eternity! May He hold you tight in His noodly appendages... R’Amen.
Our pasta, who art in a colander, draining be your noodles. Thy noodle come, Thy sauce be yum, on top some grated Parmesan. Give us this day, our garlic bread, …and forgive us our trespasses, as we forgive those who trample on our lawns. And lead us not into vegetarianism, but deliver us some pizza, for thine is the meatball, the noodle, and the sauce, forever and ever. R’amen.
J.C. Hitosis Agreed! This is complete brainwash! And people believe everything that comes out of the mouth of this dude! Just look at the likes & comments!
Not everything we know in science is necessarily accurate or true. Just like back then, some of the knowledge they knew was wrong. The only difference this time is that we have better technology.
Thanks for this video. I'm a geneticist but took early retirement 9 years ago - so I too haven't seen this model of the 3D spatial organisation of interphase chromosomes in the nucleus. It's fascinating! You've made my day!
I love your videos! They are packed full of information. I do wish your background music was more in the background. . . quieter. It is hard to concentrate on the "meaty" information with how "loud" the music is. But, keep doing more videos. I love being able to understand this stuff better.
I just want to find out how they physically manoeuvred the DNA in order to take samples and to change the DNA. What do i search to find out that? Usually it's just animations
It’s been awhile but i just want to say i think your best bet if you haven’t found out yet is to probably read some science journals that scientists have written and they should explain how they maneuvered it.
So the animations of chromatin are not necessarily right, but the input data is from DNA-DNA interactions. How this is done is through a technique Chromatin Conformation Capture (Hi-C), this is done by "freezing" the DNA, then "chopping" DNA using enzymes, and gluing everything back by ligation. Then you can get 2D maps of DNA contacts. You can visualize these maps here: higlass.io/
Glowing Pterosauria I don't have a scienst teacher because I'm in elementary school but if I got to middle school on going to tell my science teacher he or she is lying
I don't get it... What's incorrect about the common double helix depiction of DNA? Or are you just saying that that's not the full story, because it doesn't show the several levels of coiling?
I think they're assuming people think that's how dna exists in a cell. Anyone who took biology would know about the coiling, but i assume they thought most people didn't know about it.
Ivar Kråbøl IMO, the worst part about the simple double helix is that it doesn't show the protein globs. Those proteins play an essential role in stabilizing the DNA. DNA does not release from those proteins for very much time. Just long enough to make an RNA molecule. DNA is also quite charged. Without the protein, the DNA might make moving through the nucleus impossible due to the excessive charges.
Double helix is good, he is just using the new data to make a video, in fact there is not need to despise common DNA image. Same with the commonly know atom image(solar system-like) nowadays scientist know atom look different but the common image works really well to make scientist stuff because the real atom image is not well know yet and is useless.
Ivar Kråbøl Don't worry... it's the same as saying that a wire, string or wool isn't a single straight strand because it isn't wound into a reel or ball... we know what string looks like whether it's balled-up or not. He even showed his headphone cable... headphone cable is a cable, not a balled-up jumble of knots! The double helix (ie a 'strand' of DNA) is still a very real picture. To me, this vid is pretty pedantic on that score... shoulda been called something else.
It was really cool looking at the 3D rendering of what DNA actually looks like. Gives me a better perspective on things that we can’t see. Also I really think that shirt is cool
all dr Franklin did was x ray DNA, she had x ray machines available. The two doctors that were credited with the discovery of DNA didn't have access to x ray machines. So basically she had a special camera that most docs didn't have. So the two men doctors are much more worthy of the award for discovering DNA.
+Ellis Lyon So all she had was the equipment to make the observation, the skill to use that equipment properly, and the knowledge to recognize what it was she had seen. But hey, testicles.
She didn't just perform the X-ray diffraction on the crystallised DNA. She was the one who crystallised DNA (produced crystallised DNA) in the first place. What would those fancy instruments diffract if she hadn't crystallised it?
"DNA Doesn't Look Like What You Think!", "Biology textbooks are full of drawings of DNA, but none of those show what DNA actually looks like." Taken from the title and their own comment. Well they don't show DNA the way that you did because what you are talking about is chromatin, not DNA. Sure it includes it, but you can't use the two terms interchangeably. That's why you will never see chromatin as DNA in biology textbooks. So what I leave you guys with is AMERIKA EXBLAINE!
love your stuff, keep up the good work. a little sidenote, the music by the end is a little too loud for your narrating tone and it became kind of difficult to follow you. your edit is usually flawless but i thought i should mention that
Fascinating video, but please check the sound mix. When listening at low volumes I couldn't hear you over the music very well. Music is often mixed too high on RUclips, it's a very common mistake.
A re-posting a 'no music video' for those of us who want to hear the words, rather than reading the subscripts and trying to view the video at the same time would be nice. Just a thought.
Actually that whole "bad DNA" thing is not true. It is true that most DNA is found in a right handed spiral, but left handed spirals also exist. There are three biologically acitve forms of DNA (A-DNA, B-DNA, and Z-DNA). Both A and B variaties are right handed spirals, but Z-DNA is a left handed spiral. And it actually plays a role in RNA editing by interacting with certain enzymes.
Yeah, you’re right but you have to consider that Z-DNA isn’t as “regular” as B-DNA. I mean, when u search for picture of DNA (like the image he shows us in the end) what u will look at is B-DNA’ s pictures, so it is incorrect to draw DNA with left-handed helix.
It's because of the blue light. Animals are hardwired to be awake and alert when blue light hits their eye. That's an evolutionary trait animals gained to regulate their sleep. That's how our body knows when to sleep. When we get close to night blue light decreases and the sky will go dark. Then our body will start to produce a hormone called melatonin that makes you sleepy. Blue light however messes with your biological clock and prevents melatonin to form. That's exactly why working with a smartphone before bed is a bad idea because it also emits blue light and disturbs your biological clock.
Awesome video! Always wondered how so much DNA could remain unwound but not get tangled inside that tiny nucleus! Computer modeling will help push knowledge of biology forward, can't wait for the future!
nice! this is a great video with great content. great marketing strategies too 😉 it's mind blowing how much dna fits inside a tiny nucleus and shapes perfectly. this is why i love science. the music was a little loud in the video, almost drowns out your message :)
DNA encodes life and soon it already allows us to store information in huge amounts in almost no volume. How can you not love it? =D Thanks for the great video
RainAngel111 exactly my thoughts! Some know-it-all video just wants to debunk something ended up telling a whole new story which is unrelated. Geez At the end of the day, he just kept talking mumbo jumbo abt organisation of DNA clusters (chromosomes) in cells and didn't get to the main point a single bit. Thumbs down
But... when you tried to clarify the spiral direction at the end, you got the two images backwards (when you talked about left hand spiral, you showed the right hand spiral. And vise versa.). So you actually confused matters even more. Other than that, great video!
Mads Andreasen A more accurate for RNA, might be a flash drive, since it not only stores genetic information, but can transfer it as well. This is, of course, my rudimentary understanding of it.
FrennisDaemon Close, but RNA is also processed. It's quite simple processing, but it's there. It's like transferring a program onto a Raspberry Pi from your desktop.
Cool video! But in the end you left with a very vague conclusion: mirrored DNA is a bad DNA. So questions! How bad is a bad DNA? Is it bad because it doesn't occur in nature? If so, why? Or it's bad because it will cause cell to malfunction? If so, how? Do you have examples? If I understand correctly a mirrored version of some molecule has different chemical/biological properties. Is it the case for DNA? Or just its physical arrangement preventing mRNA to correctly copy the data? Thanks
1) Left-handed B-DNA doesn't exist in nature 2) Left-handed B-DNA can't be read by the cell's machinery 3) Left-handed B-DNA can't be made by the cell's machinery
+It's Okay To Be Smart B-ZNA is right-handed. A right-handed spiral is not left-handed. so that there is no left-handed B-DNA is as obvious as it's trivial. But why do you tell people who can't know better, that there would be no left-handed DNA ? That's rubbish and every bsaic textbook of melecular biology tells you that. Ever heard of Z-DNA ? You should, 1st semester biochemistry. Does it have biological relevance ? Can biological molecules bind to it ? Sure they can: Herbert, Alfken, Kim, Mian, Nishikura, Rich (1997). "A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase.". Proc Natl Acad Sci USA. 94 (16): 8421-6 Herbert, Schade, Lowenhaupt, Alfken, Schwartz, Shlyakhtenko, Lyubchenko, Rich (1998). "The Zalpha domain from human ADAR1 binds to the Z-DNA conformer of many different sequences". Nucleic Acids Res. 26 (15): 2669-72 Why are you people telling such crap ? Given, B-DNA is the by far most common conformation, but there is a difference between telling "there is none, never ever, it's only right-handed, everything else is wrong and a lie" and "it's mostly right-handed".
Nice video!! I wonder how evolution happened at this level while interacting chromosomes, cells, inner organs, reflected on living beings... it's okay to ask a question :)
"Not an image of DNA" "Well this isn't a picture, it's just a recording of the photons that bounced off something" Getting really tired of this clickbait. I like learning about DNA, but dear god, don't just lie to us.
Z-DNA? If bacteria's DNA is organized differently then how is it organised? You are the one that opened the question. Thanks for the interesting video.
Hi, I’m a Genomic Biotechnologist I just want to tell you that the DNA that goes in the same direction as the fingers of your left hand isn’t wrong, DNA has different configurations, if I recall correctly is called Z-DNA, greetings!
Stupid people don't REALLY realize they're stupid. Living a stupid life but being useless but not realizing you are useless is far better than living a clever life whilst still somehow being useless and realizing it. Yea?
I comment for no other reason than wasting your 3 seconds of your useless life reading my username What you’re describing sounds like the Dunning-Kruger Effect. I recommend you check it out :)
"ignorance is bliss". the reason why its better to be stupid sometimes is because sometimes, your curiosity leads you to info you really didnt want to know and would rather forget
This is all very interesting, the structure and organization of DNA, but this is not what DNA looks like. DNA looks like a white ball of goo (when precipitated).
Our whole universe was in a hot, dense state Then nearly fourteen billion years ago expansion started, wait The earth began to cool, the autotrophs began to drool Neanderthals developed tools We built a wall (we built the pyramids) Math, science, history, unraveling the mysteries That all started with the big bang! Hey! Since the dawn of man is really not that long As every galaxy was formed in less time than it takes to sing this song A fraction of a second and the elements were made The bipeds stood up straight, the dinosaurs all met their fate They tried to leap but they were late And they all died (they froze their asses off) The oceans and Pangea, see ya wouldn't wanna be ya Set in motion by the same big bang! It all started with the big bang! It's expanding ever outward but one day It will cause the stars to go the other way Collapsing ever inward, we won't be here, it won't be hurt Our best and brightest figure that it'll make an even bigger bang! Australopithecus would really have been sick of us Debating how we're here, they're catching deer (we're catching viruses) Religion or astronomy (Descartes or Deuteronomy) It all started with the big bang! Music and mythology, Einstein and astrology It all started with the big bang! It all started with the big bang! Sorry I got bored
haha 3000 people die a year because god was too stupid to put the eating and breathing holes in different spots haha xd ;) If there is design it sure as hell isn't intelligent.
I was thinking something similar Brandon. It seems odd that every time we look closer at life, it gets more and more complicated. And yet some people believe that these insanely complex system that build more insanely complex system, that build even more insanely complex systems, can all be created and function purely by accident. And not just one accident, but millions of accidents stacked upon millions of accidents. It's like believing that if you roll a 20 sided die 20 million times it will come up a 20 every single time. And then saying that it's no big deal and probably happens all the time. Maybe it's just me, but if I found a nanobot that was microscopic, could self replicate, and build a fully functional robot trillions of times it's size, I would think there was something more involved than just random chance.
Is this a reference to the concept of gender as a social construct? Because gender _is_ a social construct. When someone says they were born male but identify as female, that does not mean they believe that their DNA is an illusion or that their DNA is subjective. There's no denying what your chromosomes are. However, there's plenty of room for disagreement on what those chromosomes should mean about your station in life.
And generally, it's kind of a dick move to turn this discussion into something it wasn't. Imagine a transgender person who is interested in biology watching this video because they found the title interesting, just as anyone else would. Then they see your comment. Why did they need to see that? Why, just from watching this video, should they be reminded about the struggles they face as a transgender person?
DNA Doesn’t Look Like You Think! but... i never think about how DNA looks like... who sits around and think what a DNA looks like... why is that even a thing?...
I highly doubt anyone outside the field of biology thinks about the wonders of DNA on a daily basis. But, his point still stands. When we do think of DNA we would have thought of the double helix, which he falsified.
Some do. And there is a good reason to think about how it looks. Without trying to figure this out then we would not have figured out the basic coding mechanism of DNA. It would still be bits of mysterious strings to us. By getting a clear and clear picture we and understand how DNA code for things which in turn lets us find new cures and use bio engineering to solve our problems. Personally, I see this just as atomic models. There several. Some more accurate than others. Sometimes a less accurate model might be actually more useful as it helps you build an understanding of the fundamentals before you dive deeper. So even if the Bohr model of atoms is less correct then atomic orbital model it still has it uses.
Fire your Sound Mixer. He/She is useless and had the voiceover volume lower than the background music. Amateur. I'll happily take over... skill guaranteed. I have *EARS*
GamesGirlsMovies I thought of that, too. Like HOW does someone believe that NOTHING created all of this? Like...POOF this stuff happened on their own through a process only, without anything setting it into motion.
It's not even sufficient proof that any god is _possible._ Whatever flavor of whichever religion you follow, you are just as incorrect as everyone else is about their religion. Every religion is a childish coping mechanism for people unable to face reality. I hope you find the strength to examine how it is you came to believe what you do, why anyone believes in any religion. If you need emotional support along the way, I'm here.
It does not work on regional version of RUclips, seems you need to have English version to have it to work. Also I think you forgot to properly format the joke in *bold* if you know what I mean. *Read more*
Since watching this the first time, I have learned that DNA is much more interesting than we thought. Right handed DNA can form a left-handed helix and often does.
Hei this was great. Thanks a lot. But i did not get the last part. Why do you say the helix spirals in one direction? If you turn the part you are looking at upside down, the direction it curls would be the opposite. So how do you fix which direction to look at? Not convinced..
Speaking of common misleading visualisations, at 0:51 the light wave is drawn as if it oscillates spatially. In fact it's a straight line (neglecting spacetime curvature) in space, with oscillating electromagnetic field strength.
I'm a biologist, and this has bothered me for years. I hope life's most interesting molecule just got a lot more interesting for you!
Your channel is one of my favourites
How did you post this comment 51 minutes
quantum mechanics more pls
It's Okay To Be Smart wow my mind just got blown!!! I never expected the DNA to be that way.
That's physics territory, not bio.
So basically, what you're trying to say is that life is programmed in spaghetti code
So we-the Pastafarians-now have new evidence for our Lord and Saviour, the Flying Spaghetti Monster?! Huzzah! Now go and spread the word! Tell everyone how He can save us from our sins, lest we be boiled in the fiery lake of sauce for eternity! May He hold you tight in His noodly appendages... R’Amen.
Yes, created by our almighty flying spaghetti monster.
Adam Soli just because you can program something doesnt mean life is programmed this is why scientific accidents will destroy life on earth
Ramen code, actually
Our pasta, who art in a colander, draining be your noodles. Thy noodle come, Thy sauce be yum, on top some grated Parmesan. Give us this day, our garlic bread, …and forgive us our trespasses, as we forgive those who trample on our lawns. And lead us not into vegetarianism, but deliver us some pizza, for thine is the meatball, the noodle, and the sauce, forever and ever. R’amen.
I got, I got, I got, I got loyalty, got royalty inside my DNA.
Technicality cocaine quarter piece, got war and piece inside my D.N.A
I got power,poison,and joy inside my DNA
I got hustle though, ambition flow inside my DNA
Technicality I was born like this, since 1 like this, immaculate conception
I transform like this, perform like this
Was Yeshua new weapon
With videos like this, slowly, my life becomes more of a lie
No... with videos like this, slowly, your life becomes LESS of a lie. That's why knowledge matters.
J.C. Hitosis
Agreed! This is complete brainwash!
And people believe everything that comes out of the mouth of this dude!
Just look at the likes & comments!
Santa isn't real
No this is Patrick Noooooooooooo!
Not everything we know in science is necessarily accurate or true. Just like back then, some of the knowledge they knew was wrong. The only difference this time is that we have better technology.
Physicists have the right hand rule for vectors, Biologists have the right hand rule for DNA :^)
I need to stop doing the right-hand rule with my left hand
😂
and organic chemists have it for "R" and "S" sequences of stereocenters in chiral compounds ;)
Perverts have their right hand rule for stroking.
its not coincidence that each sciencefields have the same right hand rule, its all just about vector spaces, nothing else.
But you still didn't tell us how DNA really looks like .
HAL 9000 He answered what he meant by it. What he was saying, is how it is stored... He didn’t actually mean like one unit of DNA.
No picture of DNA so far..
The cambridge uni graphic is as close as they've got. It's ramen noodles...
Right totally confused lol not even one sorta drawing
Vic Wawa you telling me it’s not red and blue and looks like an awesome rollercoaster? 🎢
Thanks for this video. I'm a geneticist but took early retirement 9 years ago - so I too haven't seen this model of the 3D spatial organisation of interphase chromosomes in the nucleus. It's fascinating! You've made my day!
I love your videos! They are packed full of information. I do wish your background music was more in the background. . . quieter. It is hard to concentrate on the "meaty" information with how "loud" the music is. But, keep doing more videos. I love being able to understand this stuff better.
True. Music is too loud. I noticed that. I had to put the subtitles on.
I just want to find out how they physically manoeuvred the DNA in order to take samples and to change the DNA. What do i search to find out that? Usually it's just animations
It’s been awhile but i just want to say i think your best bet if you haven’t found out yet is to probably read some science journals that scientists have written and they should explain how they maneuvered it.
So the animations of chromatin are not necessarily right, but the input data is from DNA-DNA interactions. How this is done is through a technique Chromatin Conformation Capture (Hi-C), this is done by "freezing" the DNA, then "chopping" DNA using enzymes, and gluing everything back by ligation. Then you can get 2D maps of DNA contacts. You can visualize these maps here: higlass.io/
I knew my science teacher was lying!
Angry Azhdarchid he wasnt lying, he just didnt explain everything
Angry Azhdarchid I know you...
Without intent to deceive, your teacher wasn't lying.
Glowing Pterosauria I don't have a scienst teacher because I'm in elementary school but if I got to middle school on going to tell my science teacher he or she is lying
xD
I need that "I did a science" shirt 😂😂
Hey, it's Mimi! The link is in the description
It's Mimi He has the merch link at the end of the video...
peachesNcream 18 ok
Great, all you have to do is leave both your testes at the door and they give you one shirt for free!
I didnt a grammer
You should rename your video to "Chromosomes Don’t Look Like What You Think!"
14vimalk Yeah, the title is a bit clickbaity.
I agree!
Mhmm
I have Biology exam tomorrow.
Good luck with that! Hahaha!
Oh wait me too..
Shubhang Singh good luck, I am emo
already? my school hasn't even started yet
same lol
+king potato same
I don't get it... What's incorrect about the common double helix depiction of DNA? Or are you just saying that that's not the full story, because it doesn't show the several levels of coiling?
I think they're assuming people think that's how dna exists in a cell. Anyone who took biology would know about the coiling, but i assume they thought most people didn't know about it.
Ivar Kråbøl IMO, the worst part about the simple double helix is that it doesn't show the protein globs. Those proteins play an essential role in stabilizing the DNA. DNA does not release from those proteins for very much time. Just long enough to make an RNA molecule. DNA is also quite charged. Without the protein, the DNA might make moving through the nucleus impossible due to the excessive charges.
Double helix is good, he is just using the new data to make a video, in fact there is not need to despise common DNA image.
Same with the commonly know atom image(solar system-like) nowadays scientist know atom look different but the common image works really well to make scientist stuff because the real atom image is not well know yet and is useless.
Yup, kinda deceiving title
Ivar Kråbøl Don't worry... it's the same as saying that a wire, string or wool isn't a single straight strand because it isn't wound into a reel or ball... we know what string looks like whether it's balled-up or not. He even showed his headphone cable... headphone cable is a cable, not a balled-up jumble of knots! The double helix (ie a 'strand' of DNA) is still a very real picture. To me, this vid is pretty pedantic on that score... shoulda been called something else.
This is way better than class lecture!!!👏👏👏
Nx Ta Thai food is always better than class
Scotty Roxwell well I would love to include Chicago too XD
Neel Iyer yeah Asian food are delicious!!!😉
Neel Iyer She is Khmeriatic you fucking degenerate.
Scotty Roxwell Never thought that small English spelling word drive this guy mad!!!
It was really cool looking at the 3D rendering of what DNA actually looks like. Gives me a better perspective on things that we can’t see. Also I really think that shirt is cool
Thank you for giving Ms. Franklin credit
Colette Sheaff I think you mean Dr. Franklin! :)
all dr Franklin did was x ray DNA, she had x ray machines available. The two doctors that were credited with the discovery of DNA didn't have access to x ray machines. So basically she had a special camera that most docs didn't have. So the two men doctors are much more worthy of the award for discovering DNA.
+Ellis Lyon So all she had was the equipment to make the observation, the skill to use that equipment properly, and the knowledge to recognize what it was she had seen.
But hey, testicles.
She didn't just perform the X-ray diffraction on the crystallised DNA. She was the one who crystallised DNA (produced crystallised DNA) in the first place. What would those fancy instruments diffract if she hadn't crystallised it?
I thought everyone gave her credit.
music too loud :( This is why I think many small communities are important.
Music is too loud.
nah, thats just how ur ears were built based on ur DNA :>
And get off my lawn!
Indeed. I was struggling to hear his voice.
vsmash2 ok.
I concur!
Lost you at 1:19 but listened to the end anyhow; often information becomes more useful as I hear more. Anyhow, thank you for your video.
"DNA Doesn't Look Like What You Think!", "Biology textbooks are full of drawings of DNA, but none of those show what DNA actually looks like." Taken from the title and their own comment. Well they don't show DNA the way that you did because what you are talking about is chromatin, not DNA. Sure it includes it, but you can't use the two terms interchangeably. That's why you will never see chromatin as DNA in biology textbooks. So what I leave you guys with is AMERIKA EXBLAINE!
can bilgin some common sense!
Anterobius vermiculatis
This just blew my mind. I'll have to watch out like 5 times just to get it! Thank you so much.
So DNA actually looks the way I thought it looked? What's the point of this title?
Syra Madeily You thought that it looked like a ball? 3:21
Pedro SG No, I understand dna’s double-helical structure. I was merely commenting on another comment.
Pedro SG I see your point, however it might be that I took his point slightly different, and since it was intended as a joke.
love your stuff, keep up the good work. a little sidenote, the music by the end is a little too loud for your narrating tone and it became kind of difficult to follow you. your edit is usually flawless but i thought i should mention that
Fascinating video, but please check the sound mix. When listening at low volumes I couldn't hear you over the music very well. Music is often mixed too high on RUclips, it's a very common mistake.
Totally agree macronencer
A re-posting a 'no music video' for those of us who want to hear the words, rather than reading the subscripts and trying to view the video at the same time would be nice. Just a thought.
Why is the music so loud? I almost can't hear what you're saying and I don't wanna miss it because it's great
Actually that whole "bad DNA" thing is not true. It is true that most DNA is found in a right handed spiral, but left handed spirals also exist. There are three biologically acitve forms of DNA (A-DNA, B-DNA, and Z-DNA). Both A and B variaties are right handed spirals, but Z-DNA is a left handed spiral. And it actually plays a role in RNA editing by interacting with certain enzymes.
Gabriel Zaremba thank you... I was searching for this comment for a while now.
Yeah, you’re right but you have to consider that Z-DNA isn’t as “regular” as B-DNA. I mean, when u search for picture of DNA (like the image he shows us in the end) what u will look at is B-DNA’ s pictures, so it is incorrect to draw DNA with left-handed helix.
What little I could hear above the background music was awesome. Thank goodness for closed captioning.
You should make a video on what happens when you are jet lagged.
It's because of the blue light. Animals are hardwired to be awake and alert when blue light hits their eye. That's an evolutionary trait animals gained to regulate their sleep.
That's how our body knows when to sleep. When we get close to night blue light decreases and the sky will go dark. Then our body will start to produce a hormone called melatonin that makes you sleepy. Blue light however messes with your biological clock and prevents melatonin to form.
That's exactly why working with a smartphone before bed is a bad idea because it also emits blue light and disturbs your biological clock.
Awesome video! Always wondered how so much DNA could remain unwound but not get tangled inside that tiny nucleus! Computer modeling will help push knowledge of biology forward, can't wait for the future!
nice! this is a great video with great content. great marketing strategies too 😉 it's mind blowing how much dna fits inside a tiny nucleus and shapes perfectly. this is why i love science. the music was a little loud in the video, almost drowns out your message :)
I will be honest: I came here for the thumbnail, but the content was way better that I expected-
Love the video, but the music? Oiiiii! It was hard to hear you over it. How about just a bit at the beginning and the end?
Wow I've known what chirality is for years, but I only just now understood its connection to "handedness" thanks to this video.
DNA encodes life and soon it already allows us to store information in huge amounts in almost no volume. How can you not love it? =D Thanks for the great video
Learn something new every day. From what I Learned in 6th grade was completely trashed by this.
Why is the background music so loud, wtf
Commodore1236 It's the speech volume too low :p
I had trouble hearing his voice also.
Just when we're learning this at school! You're the best!
Kinda misleading. DNA zoomed in still looks like a double helix. The title should really be "chromosomes don't look the way you think".
RainAngel111 thank you!
I just made this same exact point!
RainAngel111 exactly my thoughts! Some know-it-all video just wants to debunk something ended up telling a whole new story which is unrelated. Geez
At the end of the day, he just kept talking mumbo jumbo abt organisation of DNA clusters (chromosomes) in cells and didn't get to the main point a single bit. Thumbs down
FINALLY!
But... when you tried to clarify the spiral direction at the end, you got the two images backwards (when you talked about left hand spiral, you showed the right hand spiral. And vise versa.). So you actually confused matters even more. Other than that, great video!
What about RNA? Now that's the real building block
Don't worry, I'll get to RNA some day. That's what I did my PhD on!
I think of mRNA as the ram of a computer. The DNA is the hard drive, and the enzyme that it makes is the output of the program
Mads Andreasen
A more accurate for RNA, might be a flash drive, since it not only stores genetic information, but can transfer it as well. This is, of course, my rudimentary understanding of it.
FrennisDaemon Close, but RNA is also processed. It's quite simple processing, but it's there. It's like transferring a program onto a Raspberry Pi from your desktop.
I know that answer I know I know!!! Minecraft RNA synthesis! watch?v=lKpZqsGoQT8
xD :D 8D
Years back same que. I ask to our biology teacher. And he make my laugh. Today I got my answer. Not satisfied but understand bit ☮️
That background xylophone is extremely irritating!
Life is intricately complex, impossible even.
Drs. Crick and Watson deserve to be honored as two of the greatest scientists of all time.
AND Rosalind Franklin 😉
Cool video! But in the end you left with a very vague conclusion: mirrored DNA is a bad DNA.
So questions! How bad is a bad DNA? Is it bad because it doesn't occur in nature? If so, why? Or it's bad because it will cause cell to malfunction? If so, how? Do you have examples? If I understand correctly a mirrored version of some molecule has different chemical/biological properties. Is it the case for DNA? Or just its physical arrangement preventing mRNA to correctly copy the data?
Thanks
1) Left-handed B-DNA doesn't exist in nature
2) Left-handed B-DNA can't be read by the cell's machinery
3) Left-handed B-DNA can't be made by the cell's machinery
It's Okay To Be Smart Thanks!
But I'm left handed. Ha! Explain that!
JK. Couldn't resist.
+It's Okay To Be Smart
B-ZNA is right-handed. A right-handed spiral is not left-handed. so that there is no left-handed B-DNA is as obvious as it's trivial.
But why do you tell people who can't know better, that there would be no left-handed DNA ? That's rubbish and every bsaic textbook of melecular biology tells you that. Ever heard of Z-DNA ? You should, 1st semester biochemistry. Does it have biological relevance ? Can biological molecules bind to it ? Sure they can:
Herbert, Alfken, Kim, Mian, Nishikura, Rich (1997). "A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase.". Proc Natl Acad Sci USA. 94 (16): 8421-6
Herbert, Schade, Lowenhaupt, Alfken, Schwartz, Shlyakhtenko, Lyubchenko, Rich (1998). "The Zalpha domain from human ADAR1 binds to the Z-DNA conformer of many different sequences". Nucleic Acids Res. 26 (15): 2669-72
Why are you people telling such crap ? Given, B-DNA is the by far most common conformation, but there is a difference between telling "there is none, never ever, it's only right-handed, everything else is wrong and a lie" and "it's mostly right-handed".
Frank Schneider
There are different kinds of DNA? :O
The video was very informative; however, that background noise track was almost as loud as the speech which made it hard to hear some parts.
Nice video!!
I wonder how evolution happened at this level while interacting chromosomes, cells, inner organs, reflected on living beings...
it's okay to ask a question :)
Suggestion - lower the backgrond muzak, and bump up the speaker's volume.
music too loud or you are too quiet, to consider...
I'm happy there was the little disclaimer at the end
I got some #badDNA in my gf's eye the other night. Bad for her, but good for me. Bah, who am I kidding... I have no gf.
You teach much better then they do in school on DNA. I learned about it a couple months ago in school.
I have Bangtan in my DNA
haha
congrats on making it to trending! love seeing my favorite channels make it.
skip to 3:10
Thank you
LOL, just got a whole lot more respect for my _High School_ Biology teacher who seems to be one of the few that actually explained this properly
I wish I could remove the background music... It makes me really annoyed when youtubers do that...
Not a biology major and this was one of the biggest question I had !?
I bet God smiles and chuckles every time we find and discover something new. Very cool!
Cooper Spaulding my idea of god in recent years has become that of the architect from the matrix ... lol the ultimate programmer
And when we realize how flawed alot of things are does god frown then??
I wonder what it'd do when all of us realize that it doesn't exist. :D
Cooper Spaulding God be like: i knew that before the universe existed. Lol
Yep, Quetzalcoatl is known to be very jovial and cheerful.
Good video, but I gotta complain about the background music; made it harder to hear his lecture.
Anyone else think so?
"Not an image of DNA"
"Well this isn't a picture, it's just a recording of the photons that bounced off something"
Getting really tired of this clickbait. I like learning about DNA, but dear god, don't just lie to us.
Fun Fact FWIW the "person standing next to the state of Rhode Island" is at Lone Tree Point in North Kingstown, Rhode Island.
Is it just me or does Joe look like the Green brothers
Manzie Pyrope yes !!!omg
Z-DNA? If bacteria's DNA is organized differently then how is it organised? You are the one that opened the question. Thanks for the interesting video.
BTS. BTS comes to my mind when I think of DNA.
K-pop boy band
if they cant see it, how do they even know its structure or even modify it or cut some part of dna? hope someone can answer my confussion
Youre gonna be waiting a longtime im afraid,because no one can. Childlike babble about cgi is best youre going to get. 😀👍
I love his shirt! :-D
Hi, I’m a Genomic Biotechnologist I just want to tell you that the DNA that goes in the same direction as the fingers of your left hand isn’t wrong, DNA has different configurations, if I recall correctly is called Z-DNA, greetings!
I know my DNA looks like Tom Cruise 😎
LolGuy But I'm sure you don't.
I'm confused... So it still does look like it? Just a bit different like at 5:05?
I don't get why being smart is bad. Would you rather be stupid?
Stupid people don't REALLY realize they're stupid. Living a stupid life but being useless but not realizing you are useless is far better than living a clever life whilst still somehow being useless and realizing it. Yea?
I comment for no other reason than wasting your 3 seconds of your useless life reading my username
What you’re describing sounds like the Dunning-Kruger Effect. I recommend you check it out :)
"ignorance is bliss". the reason why its better to be stupid sometimes is because sometimes, your curiosity leads you to info you really didnt want to know and would rather forget
NICE VIDEO.I had problem understanding how DNA was packed during my 2nd PUC...This video would have meant a lot to me back then..anyways good work!
Wow.
I always wondered how DND actually looked like, and in which way the they inside the cell. Great video
And how do virus ARN is organised in a 3D space?
Edit: I believe it's called RNA in English tho, so my bad
I don’t know why but I thought Joe Hanson (the host here) was the same guy as Hank Green (the host of Scishow)
This is all very interesting, the structure and organization of DNA, but this is not what DNA looks like. DNA looks like a white ball of goo (when precipitated).
🅱️ℹ️🆖🅾️ 🅱️🅾️🆖🅾️
shows intelligence exist like god
Who would give this a thumbs down? Wow. Great video
Our whole universe was in a hot, dense state
Then nearly fourteen billion years ago expansion started, wait
The earth began to cool, the autotrophs began to drool
Neanderthals developed tools
We built a wall (we built the pyramids)
Math, science, history, unraveling the mysteries
That all started with the big bang! Hey!
Since the dawn of man is really not that long
As every galaxy was formed in less time than it takes to sing this song
A fraction of a second and the elements were made
The bipeds stood up straight, the dinosaurs all met their fate
They tried to leap but they were late
And they all died (they froze their asses off)
The oceans and Pangea, see ya wouldn't wanna be ya
Set in motion by the same big bang!
It all started with the big bang!
It's expanding ever outward but one day
It will cause the stars to go the other way
Collapsing ever inward, we won't be here, it won't be hurt
Our best and brightest figure that it'll make an even bigger bang!
Australopithecus would really have been sick of us
Debating how we're here, they're catching deer (we're catching viruses)
Religion or astronomy (Descartes or Deuteronomy)
It all started with the big bang!
Music and mythology, Einstein and astrology
It all started with the big bang!
It all started with the big bang!
Sorry I got bored
Pretzel Punch u r seriously bored XD
hopefully I was not the only one who started to sing...
you make me want to die
Man if you are not a rapper you've chosen your profession wrong.
Neanderthals weren't the first to make tools.
Amazing info... Really didn't find anywhere
Oh god don't tell the creationists that life is even more complicated than they thought.
haha :) I was just think the opposite ;) What a beautiful example of intelligent design ;)
haha 3000 people die a year because god was too stupid to put the eating and breathing holes in different spots haha xd ;) If there is design it sure as hell isn't intelligent.
Dear hooligan bubsy,
I have a breathing spot on the back of my head, and only eat/drink with my mouth.
So...
James are you an anthropomorphic dolphin by any chance? Has science gone too far?
I was thinking something similar Brandon. It seems odd that every time we look closer at life, it gets more and more complicated. And yet some people believe that these insanely complex system that build more insanely complex system, that build even more insanely complex systems, can all be created and function purely by accident. And not just one accident, but millions of accidents stacked upon millions of accidents. It's like believing that if you roll a 20 sided die 20 million times it will come up a 20 every single time. And then saying that it's no big deal and probably happens all the time. Maybe it's just me, but if I found a nanobot that was microscopic, could self replicate, and build a fully functional robot trillions of times it's size, I would think there was something more involved than just random chance.
Well, I hate to tell you this, but DNA looks _EXACTLY_ how I thought it would look. I'm unfazed.
DNA is a social construct. smh. Yes it's come to that.
I self identify as royalty and demand to be treated as such.
jmchez I will never be royal, but I drive Cadillacs in my dreams
No, DNA is not a "social construct". And no, it hasn't "come to that".
Is this a reference to the concept of gender as a social construct? Because gender _is_ a social construct. When someone says they were born male but identify as female, that does not mean they believe that their DNA is an illusion or that their DNA is subjective. There's no denying what your chromosomes are. However, there's plenty of room for disagreement on what those chromosomes should mean about your station in life.
And generally, it's kind of a dick move to turn this discussion into something it wasn't. Imagine a transgender person who is interested in biology watching this video because they found the title interesting, just as anyone else would. Then they see your comment. Why did they need to see that? Why, just from watching this video, should they be reminded about the struggles they face as a transgender person?
This just makes me realize just how little we know about our existence. I mean, something/someone created this technology that we call DNA.
The work of God is wooooooow
whatever floats your confirmation bias boat....
@@justin_x_21I recommend this video, there is more evidence for God than you think.
ruclips.net/video/_H0yoBiBM5s/видео.html
I really like your videos Joe! Keep up the good work.
DNA Doesn’t Look Like You Think!
but... i never think about how DNA looks like...
who sits around and think what a DNA looks like... why is that even a thing?...
Tell Me This
So your basically saying it's only me
your comments are always the best 😁
I highly doubt anyone outside the field of biology thinks about the wonders of DNA on a daily basis. But, his point still stands. When we do think of DNA we would have thought of the double helix, which he falsified.
Well, me. I guess
Some do. And there is a good reason to think about how it looks. Without trying to figure this out then we would not have figured out the basic coding mechanism of DNA. It would still be bits of mysterious strings to us. By getting a clear and clear picture we and understand how DNA code for things which in turn lets us find new cures and use bio engineering to solve our problems.
Personally, I see this just as atomic models. There several. Some more accurate than others. Sometimes a less accurate model might be actually more useful as it helps you build an understanding of the fundamentals before you dive deeper. So even if the Bohr model of atoms is less correct then atomic orbital model it still has it uses.
I have biology tomorrow and I will definitely bring this up, very interesting 👍🏼
Fire your Sound Mixer. He/She is useless and had the voiceover volume lower than the background music.
Amateur.
I'll happily take over... skill guaranteed. I have *EARS*
onlyonewhyphy it was fine for me. Maybe you need better headphones
lolsquad
Maybe you need to listen to videos at a lower volume, as your going to ruin your hearing if it's fine to you.
That's actually sort of mindblowing... Thank you for making these videos!
this is all the proof anyone needs to know god is great :)
If the flying spaghetti monster doesn't exist, then why does our DNA look like pasta?
I'm sorry
and two million children who die slow painful deaths every year is all the proof anyone needs to know that god is far from great.
GamesGirlsMovies I thought of that, too. Like HOW does someone believe that NOTHING created all of this? Like...POOF this stuff happened on their own through a process only, without anything setting it into motion.
Two million? I thought eight million children die from starvation every year.
And even more from other causes.
And yes, I also don't believe in a god.
It's not even sufficient proof that any god is _possible._
Whatever flavor of whichever religion you follow, you are just as incorrect as everyone else is about their religion. Every religion is a childish coping mechanism for people unable to face reality. I hope you find the strength to examine how it is you came to believe what you do, why anyone believes in any religion. If you need emotional support along the way, I'm here.
How small is that needle that it could feel in between bumps of the DNA
I came early to make a joke:
Read more
It does not work on regional version of RUclips, seems you need to have English version to have it to work.
Also I think you forgot to properly format the joke in *bold* if you know what I mean.
*Read more*
Wear the silver condom and try coming second for a change.
I like how these videos are short and pack a lot of information, helps me with my ADHD to pay attention. :)
I really struggle to understand this. Hard concept to grasp for me. Thanks for the video.
Since watching this the first time, I have learned that DNA is much more interesting than we thought. Right handed DNA can form a left-handed helix and often does.
Thank you, This was my "learn something new everyday" moment.
The audio seemed a bit low in this video. But great content as always!
Hei this was great. Thanks a lot. But i did not get the last part. Why do you say the helix spirals in one direction? If you turn the part you are looking at upside down, the direction it curls would be the opposite. So how do you fix which direction to look at? Not convinced..
Speaking of common misleading visualisations, at 0:51 the light wave is drawn as if it oscillates spatially. In fact it's a straight line (neglecting spacetime curvature) in space, with oscillating electromagnetic field strength.