What is Click Chemistry? | DW News
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- Опубликовано: 4 окт 2022
- Americans Carolyn R. Bertozzi and Morten Meldal, and Denmark's K. Barry Sharpless have won this year's Nobel Prize for chemistry for their work in developing "click chemistry and bioorthogonal chemistry," Sweden's Karolinska Institute announced on Wednesday.
The award marks the second Nobel for 81-year-old Sharpless, who won the chemistry Nobel in 2001.
Co-winner Bertozzi hopes the prize will be energizing for the field.
"The interface between chemistry and biology is such a rich interface with great technology development and fundamental science discovery. But it’s now time to reflect on how fortunate I’ve been with them and share the celebrations," she told journalists in an interview on Wednesday.
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#nobelprize #chemistry #clickchemistry
you know you a productive guy when you get not one but two Nobel prizes.
You're
Around 2003, I heard about research being done that resembles the 'click chemistry' mentioned here. In order to target cancer cells for radiation therapy, they experimented with ways to attach gold to proteins that had an affinity to bind to specific cancer cells. The idea was that an injection of these 'golden proteins' would circulate in the blood and bind only to the cancer cells. The gold greatly enhanced the heating and effects of radiation at sites where cancer existed.
reminds me of the south park episode when they injected cash money to cure HIV
Two Nobel prizes won by just one guy, I would say he is doing his part for science and humanity!
Even Einstein only has one! Curie had two.
@@tomatochemist and what does the count of prizes say about the scientist or the work it self? Now Einstein is second rate? The only reason the Nobel prize has prestige is because they were initially associated with Einstein
@@davyroger3773 Not at all, only pointing out the rarity of two prizes going to one person
@@tomatochemist Fair enough, please excuse my outburst lol
@sigmaxon_yt Yes I know that
Great scientific research and progress should always be commended.
DE-FUNDED
(4:05) "How [masters are going] to make more robust new [slave] materials, which is of course, um yeah, kind of needed in these times of climate change [of emotional affiliation]." :D :D :) Well, when the glue of the distractive faith has been consumed and lost all its credibility completely, the pillars of the world are going to bend drastically...
The Bible Leviticus 20 : 27 "Moreover, a man or a woman who has a ritual spirit [show-knowledge] or a familiar spirit [independent entertainer] is certainly to die. They are to be stoned to death with boulders. They will continue to bear responsibility for their guilt." - The swindler fear nothing more than truth and competition.
'Click chemistry'...is a new branch of chemistry which is gaining prominence for past two decades...it is mainly useful in the radiation therapy for Curing Cancer... Heartely congratulations to the Nobel winners...👍👍🙏
Thank you so much for sharing!
their discovery really CLICKED with the committee!
AAAAARG! :-) My late aunt would have loved that one.
Wow! A new era for chemistry ?
It's a new era for the whole world.
Let's hope we can somehow use this for better/cheap water desalination. I love the international cooperation too, see what we can do together!
How is this different from ionic, hydrogen and covalent bonds?
It is not a new type of bond, but rather a new type of reaction. The products formed in the reaction are still held together by very standard covalent bonds, but the ease of synthesis and great selectivity are what make this particular reaction so useful compared to many others. So many reactions that achieve similar things require really high temperatures, dangerous solvents, sometimes in completely dry and air-free atmosphere, etc. On the other hand, Click chemistry allows to 'click' molecules together at low temperatures, in water, and only requires a copper catalyst, which makes things much easier. Bertozzi's contribution also eliminates the need to use copper (which is toxic to cells), and that allows us to do these reactions even in a living cell.
They call it bioorthogonal because click reactions are easy and fast in biological buffers such as salty phosphate (PBS). Also the reacting groups (azides, tetrazine, cyclooctynes) are not common in nature so side products are very rare in biological systems. Finally, there are no leaving groups (acids or bases or salts) during the reaction so you don't change the characteristics of the environment during the reaction. Super fun.
@@hi-us6do 🥲how do you stop a nosebleed?
@@benzenering2183 thank ye kind sir
more information on this please, It needs more than just 5 minutes.
thank you.
This lady explained the subject so well
How does this compare to crispr?
Awesome!!!! 😮
Amazing. I'm in aw how intelligent some people are.
I bet sharpless lives near SF.
Apparently there’s the most winners around that area
Beautiful
Wow. This is cool.
These fields that are attached to medical science will always have the greatest funding and biggest research...that can lead to great breakthroughs BUT also a lack of funding into fields that aren't attached to medical application.
I want a segment for the physics nobel prize. I don't understand that one at all. I just know it's about quantum mechanics and apparently the results from the experiments concluded that the universe doesn't exist locally, which completely goes over my head.
Nobody understands that well enough to explain. The scientists themselves say so.
What I do not understand, is why the 2nd year in a row the research around Messenger RNA has been ignored, despite its global relevance and application against the deadly pandemics and in cancer treatment! Does the Nobel committee paying attention to current events?
They will be awarded in coming years, there are simply too many researches to acknowledge
I'm not a scientist, but my understanding is that mRNA is nothing new, only it was applied for making a vaccine this time. Besides, the efficacy of mRNA is yet to be tested, especially for its lasting effect. To early for Nobel.
Oh thats cool
Can this work with two of the same type of atoms ?
That lady is so pleasant, always with a smile. Of course, her answers are so lucid. What an asset to have!
Could they be describing cybernetics in the molecular level?!
How will the big pharma reacts to this? Since it's a new era for medicine field
GRATTIS TILL NOBELPRISET 🙏🇸🇪🙏🇸🇪🙏
BRAVO BRAVO BRAVO
Polyatomic ions have been known for a long time - so what is new here? Are these lego like molecules much larger and utilize other bonding than ionic?
Read the papers
This discovery has nothing to do with ionic bonds, really. Click chemistry is a class of reactions that makes strong covalent bonds between two usually large and complex molecules. One molecule has to have a particular group known as an alkyne, while the other has to have a group known as the azide. The alkyne and the azide groups essentially act as 'buckles' that the lady in the video was describing and they react together to form one much larger molecule. Click chemistry has found so many applications, because it requires very mild conditions (low temperatures, no need for harsh solvents, carried out in water), highly specific (molecules react exactly the way we want them to), has great yields, uses cheap reagents, can be used to make complex structures.
@@benzenering2183 Thanks for the nice explanation. I think amino acids are always touted as the "building blocks of life". Ok, so this is a very specific context of chemistry especially for the pharma sector.
@@DJ1573 Yes indeed. One paper said it was developed in the 1950s - I love chemistry so I will dive in.
@@williamm8069 Happy to hear that I've made it clear! Yes, indeed. These click reactions have found many uses in material science, drug discovery, and also in the development of biosensors - specific analytic tools that allow us to detect various cellular processes.
Lol a molecule animation amator with 200 dollars and 2 hours could make a fantastic explanation video, worth 20 minutes of this.
👏🏻👏🏻👏🏻
Like a tiny magnetic pole.
👍👍👍🙏
i think zeilingers nobel price would have been worth a report too!! very selective reporting there!
Yes, because as we all know when you pick a topic to report on you MUST drill down all the way to the utmost depths and be totally inclusive. Go find a report on Zeilinger's prize and get over yourself. I'm fairly certain you can probably find tens of them.
Click chemistry
This guy did not understand this at all: "Can this make me a new kidney?" Like WTF? This isn't organ regeneration. This is a way chemists can build molecule's easier, rather than being stuck with all these steps to synthesize a reaction
i don't think he's aware of the structure/scale difference between molecules and entire organs
He's a news presenter...
does this mean we can make cheaper LSD?
okay guess not. didn't get to the part where the buckle was explained.
I like how awareness around psychedelics are increasing. But still there are ediots who stereotype psychedelic users.
Sounds a lot like Legos.
I'm a simple man, lincoln logs > legos
Pretty sure we have terms for this already... Catalysts, enzymes, Ionic/ covalent bonds, this video seems more like CLICKbait.
You will need a 3D printer from Amazon for your kidney.
NYU just fired a renowned chemistry professor because students complained his class was too difficult. We are reaching the end of knowledge, but only because people don’t want to do difficult things anymore
Anti-Matter and Alchemy incoming..
playing god before end, be fast.
Terrible explanation
I thought they always knew this..(self taught scientist).. you guys are way behind if barely discovering this..
You read the paper?
@@DJ1573 don't need too hehe already know what they are doing..
@@DJ1573 alot of these "nobel" prize winners compete in a competition invented by oil mercenaries aka "wall street "( during or starting then ww1)they then use the nobel to attack the world.. with companies etc.. inventions such as nuclear missles.. and Japan received nobel data for mass production etc..
You notice that she slipped the climate change garbage statement into her answer. It's required for scientist's to show their loyalty in the climate change religion...
Maybe we should trust scientists and not someone who can't even spell the word
Remember when President Trump was invited to and visited NK and China? NPP
Sorry to say but this is ridiculous!! You want a REAL Nobel prize? Release the Cure for all Cancer, now that will be a real contribution to humanity!!
This click chemesty can be the cure for cancer or at least a rocket launch toward it.
Instead of running 20 miles and say hello to your neighbor you can now just call him before you run there.
@@tiddybearkush Really? How come she never mentioned it? Sorry to say but there is too much money involved and Big Pharma will not allow any cure of any kind!
(4:05) "How [masters are going] to make more robust new [slave] materials, which is of course, um yeah, kind of needed in these times of climate change [of emotional affiliation]." :D :D :) Well, when the glue of the distractive faith has been consumed and lost all its credibility completely, the pillars of the world are going to bend drastically...
The Bible Leviticus 20 : 27 "Moreover, a man or a woman who has a ritual spirit [show-knowledge] or a familiar spirit [independent entertainer] is certainly to die. They are to be stoned to death with boulders. They will continue to bear responsibility for their guilt." - The swindler fear nothing more than truth and competition.