Understanding the Virus that Causes COVID-19, Animation
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- Опубликовано: 26 мар 2020
- Overview of coronavirus family, origin of SARS-CoV-2, viral structure and life cycle, pathophysiology.
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Voice by: Ashley Fleming
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Coronaviruses are a large family of enveloped, RNA viruses. There are 4 groups of coronaviruses: alpha and beta, originated from bats and rodents; and gamma and delta, originated from avian species. Coronaviruses are responsible for a wide range of diseases in many animals, including livestock and pets. In humans, they were thought to cause mild, self-limiting respiratory infections until 2002, when a beta-coronavirus crossed species barriers from bats to a mammalian host, before jumping to humans, causing the Severe Acute Respiratory Syndrome, SARS, epidemic. More recently, another beta-coronavirus is responsible for the serious Middle East Respiratory Syndrome, MERS, started in 2012. The novel coronavirus responsible for the Coronavirus Disease 2019 pandemic, COVID-19, is also a beta-coronavirus. The genome of the virus is fully sequenced and appears to be most similar to a strain in bats, suggesting that it also originated from bats. The virus is also very similar to the SARS-coronavirus and is therefore named SARS-coronavirus 2, SARS-CoV 2. At the moment, it’s not yet clear if the virus jumped directly from bats to humans, or if there is a mammalian intermediate host.
Coronavirus genome is a large, single-stranded, positive-sense RNA molecule that contains all information necessary for the making of viral components. The RNA is coated with structural proteins, forming a complex known as nucleocapsid. The nucleocapsid is enclosed in an envelope, which is basically a LIPID membrane with embedded proteins. From the envelope, club-like spikes emanate, giving the appearance of a crown. This is where the “corona” name came from.
The integrity of the envelope is essential for viral infection, and is the Achilles’ heel of the virus, because the lipid membrane can easily be destroyed by lipid solvents such as detergents, alcohol and some disinfectants. In fact, enveloped viruses are the easiest to inactivate when they are outside a host.
In order to infect a host cell, the spikes of the virus must BIND to a molecule on the cell surface, called a receptor. The specificity of this binding explains why viruses are usually species specific - they have receptors in certain species, and not others. Host jumping is usually triggered by mutations in spike proteins which change them in a way that they now can bind to a receptor in a new species.
The novel coronavirus appears to use the same receptor as SARS-coronavirus for entry to human cells, and that receptor is the angiotensin-converting enzyme 2, ACE2. Infection usually starts with cells of the respiratory mucosa, then spreads to epithelial cells of alveoli in the lungs.
Receptor binding is followed by fusion of the viral membrane with host cell membrane, and the release of nucleocapsid into the cell. The virus then uses the host machinery to replicate, producing viral RNAs and proteins. These are then assembled into new viral particles, called virions, by budding into intracellular membranes. The new virions are released and the host cell dies.
Uncontrolled growth of the virus destroys respiratory tissues, producing symptoms. Infection triggers the body’s inflammatory response, which brings immune cells to the site to fight the virus. While inflammation is an important defense mechanism, it may become excessive and cause damage to the body’s own tissues, contributing to the severity of the disease. In an otherwise healthy person, there is a good chance that the virus is eventually eliminated and the patient recovers, although some may require supportive treatments. On the other hand, people with weakened immune system or underlying chronic diseases may progress to severe pneumonia or acute respiratory distress syndrome, which can be fatal.
Praying for the Physicians, Nurse practitioners, physician assistants, nurses, first responders, police force and those not mentioned. God bless them, protect them and empower them. Thank you for your courage.
My moms a nurse and dads a cop they gotta work during quarantine im scared
solo may God be with them. My husband is police. Stabbing call yesterday had him in ER😷... thanks people who cant control anger.
Pharmacists too
Pharmcist also a part of health department. But nobody mentioned us in any media and al. Plz consider us. We are doing our part well in this pandamic condition.pharmacist serve as an essential part of the health care team.
they did not mention it might have come from a lab...
In order to spread happiness and hope, we recorded another balcony concert here:ruclips.net/video/Ava3MkuITS4/видео.html
I never thought my bio class would be important but my goodness
Thank you for sharing.You made me understand concepts that i never able to learn during dental college.I expected this video from you
PLEASE GOD❤HELP US
WE NEED YOU NOW MORE THAN EVER
Amen
God created this
@Matteo yes I stay home and I don't go outside
@@kdkjlfk id be more likely to believe that covid is a man made virus.
God didn’t create corona all he does is watch us suffer but he might help us..
Thank you for providing information about it.
We need to learn how to coexist or nature will find extreme ways to reclaim her space.
Oooooorrrr maybe we just need to stop eating uncooked bats.
Or, maybe we shouldn't eat bats at all
*Matthew Noneya* mhm also snakes
Humans created this virus, idiot 🤦♀️
Sincere thanks to all scientists and medical reporters
The first time it jumped to a human from a pangolin, shut down the wet markets in China
Been saying this since Sars. In 2002!!!!! Insanely stupid people. Insanely evil CCP.
Actually, it was already shutdown BUT based on the news, they make another strategy to sell it. "ONLINE" 😤
Yep and shut down all wildlife trade. Traditional Chinese medicine can find alternatives.
It’s those poor animals taking revenge for human cruelty.
Krysty Cavallo HIV , Ebola, covid2 all came from wet market food/bush meat
If any entity were to design a biological weapon, this would be the one. 1. Highly contagious, 2. long infection - symptom period, 3. Lack of news about initial infections, 4. No known immunization, or cure.
The way this spreads, the entity’s own population would soon be grappling with it so unless they’re on a suicide path it’s a dumb idea.
@@lacountess they can put it into ramen noodles and ship it any where they want
Any old virus would hav 3 and 4 though.
@@Fummy007 What if an immunization and cure was known only to the people who developed it, and what if those people considered a few thousand of their own collateral damage?
Devils Angel's are here
Thank you for excellent declaration.,🌺
I live in Northern Virginia 25min from Washington D.C My whole family got infected and it was due to doctor telling my brother to stay home. With no test he was super sick ! With a fever and because they told him not to get tested he spread it to our whole family and myself. When I got it I went to my primary care as directed to us from the health department I had to argue with the doctor to get tested! And we waited a whole week to get the results. The clinic was horrible to us. Only cared about getting paid. When I said my brother is terribly sick they only asked for his insurance and when I told them he was uninsured they just quoted how much everything would cost. Over 150 just to be seen and for a flu test first. He couldn’t afford it. We are now being monitored by phone calls from the health Department and dont get the luxury to test the rest of the family, stay in a hospital or get retested to help us know. We are being told if something gets worse call the on call nurse or call 911. They are going to tell us if we don’t have anymore symptoms to wait 3 days after that before we can leave the house for groceries. We get 3 phone calls.Me and my two brothers have survived the virus with a few symptoms no fever anymore but my parents have been sick for over a week and the cough and fever just won’t go away...
I am praying God heals your parents.
Thank you very much for your itellegant information
So the Corona Lipid membrane is easy to inactivate when outside a host but what about INSIDE?
Im having the virus for about 10 days now, its almost gone, but i will tell you that itns not fun at all
@THE DOC Its getting better with de days, my doc said that in 4 days it must be over, so im good! Thanks :)
Haven't we as humans exterminated enough on this planet? When does it ever cease?
What were your symptoms? You okay now?
@@randel9658 I think he died
@@minxgore Well that's unfortunate.
So in other words, extermination of bats. Got it.
Come on Joker, stop fooling around...
I think they should
But peta wanna die,yet they havent said anything about Tiger King,
Dumb.
TheIceLurker yep
PedroAk jr were not joking it’s true face it it caused Ebola as well
Anyone feel like me that having some kind of pain & worried it could be corona 🦠? 🤣😛
Omg! Last night. I couldnt sleep, i had horrible anxiety and nightmare! Since i was suffering from runny nose and fatigue but when i woke up with completely Healthy condition😂 n it was just a physcological tricks played in mind.
So calm down. Dont panick!
Tenzin choden 😂👍🏽
Like me😂
Week ago scared shitless then quick recovery so was allergies but worse three days of my life . Not fearing my own health I'm ok with a end if it is my time idea I can hurt or infected God Forbid even been responsible for a casualty is what has my Xanax script out ten days early. My fears are releastic to reality of people will live in our new future aware they may have infected personally own family own parents or children with truly never being aware they are sick. The reality of this I believe is another huge issue we as a human race must try to learn to live with and not sure how we as a whole will.
Trey Dyer true ❤️
Primary symptoms of COVID-19 are :
- Cough
- Fever
- Shortness of breath
Dry cough to be exact
And an urge to travel the world.
Funny how with how crazy shit is going, there are so many people that dont know this.
Do i need to have all of these symptoms at the same time or even a single one. ?
My wife has a slight of Shortness of breath.
Should i be worried. ?
@@dantemaria206 I have cough with little bit cold ,but got confused
Excellent class. Thank you.
It's great and intetive information..... thanks
So I got it -
1. The SARS CoV-2 enters the cell through endocytosis through the ACE2 receptor.
2. There, it uses the host cell's RNA to replicate the entered virus into copies of new viruses.
3. The new viruses then release its own exotoxins that infect the host cell and the host cell apoptosizes (dies off), and the new viruses are released to attack new host cells, and then replicate once more, and then kills off more good host cells, and then the replication and more host cell apoptoses happen again - a vicious cycle.
4. ARDS - This is when a severe localized pulmonary cytokine storm caused by overinflammation of the immune system affects the lobes, bronchial tubes, and more often, the air sacs of the lungs, by pulmonary-infiltrate-filled fluid. This blocks severely the exchange of oxygen and carbon dioxide in the respiratory system It can worsen with time to respiratory failure, and then sepsis and then septic shock where blood pressure goes dangerously down to severe hypotension, and can lead to TSS (multi-organ failure, including heart failure), which can cause the person to die.
What makes bats to develop the #Antibodies against #corona #virus or #COVID19 it may give the idea or solution to develop the #Vaccine !!
Since it's RNA virus also can use the RNA silencing techniques to controle the virus
Bats have evolved over time to not have the same inflammatory response to viruses. In humans the anti-inflammatory response to the virus goes to far and causes pneumonia and eventually death.
@@twowayyo11 RNA silencing??
Well thought out video!
Have any stats been kept on HIV+ patients on antiviral drugs who have contracted Covid 19?
Antiviral drugs are not as broad-spectrum as something like an anti-biotic, the main reason for this is that bacteria are actually alive and thus can be poisoned etc. Viruses are not so you have to be a lot more specific in developing drugs against them a toxin that would kill infected cells would kill healthy cells too as they are both human cells. Mostly anti-virals are targetted to bind to and disrupt specific viral proteins but these will generally be unique to a single virus or it's close relatives. HIV and SARS-CoV-2 are not even in the same family (Retroviridae for HIV, Coronaviridae for SARS-CoV-2) so it's unlikely there is any crossover there even if there was you can't really compare HIV patients with healthy patients easily as you would have no way to account for the lower average white cell count of the HIV group. If there was any reason to think the HIV anti-virals could be effective you would either need to compare with a group of patients that had HIV and Coronavirus coinfection that have refused anti-viral treatment or easier to achieve run a clinical trial testing their effectiveness on patients infected with Coronavirus only which is certainly doable the potential subject pool is rising at an alarming rate and there are certainly research funding bodies that are prioritizing funding proposals that could help tackle the current pandemic so the resources are there if the science is there to support it being a viable lead to pursue.
@@seraphina985 I appreciate your response. I'm not a medically or scientific trained person. Purely asking if people taking existing antivirals for other conditions might avoid catching it.
Thank you 🙏🏼
Good job guys 👍
Can u do video on antigen in detail
Can u pls explain abt pathogenesis in human body as animation.......
Thank you for sharing 🤟🏻 and stay safe 🙏🏻
Amazing explanation
Thank you. It seems that this age is a time for prayer... "Ordain Thou for me what becometh the heaven of Thy generosity, and the ocean of Thy bounty. Thou art, verily, the Almighty, the Most Powerful." ~ Baha'i Prayer
I've been reading n hearing that pangolins, a delicacy in China, is a possible source.
Everything mentioned above is a delicacy in China .....I swear to God these people just 😤😤😤😤😤.
Most likely the cause , pangolins for exAmple and a snake or bat shouldn’t be in contact, different parts of the world and should stay that way, haven’t we learned this over the years , between bursts of predators in unitive land red/grey squirrel for example frogs in Australia or disease within trees being transplanted where they want , cmon guys get with the program , leave Mother Nature alone or shit like this happens
@@ellismcconnell7672 I second that.
Very well explained.
I caught covid19 from this video and i died(writing this from heaven).
Please take care😔
brownpunk rip
Her voice is so soothing omgg
AI effect
Praying and hoping for world healing. 🙏🏼 😭
Its been 2days now..all of sudden, i started getting fatigue but fever is absent and mild sore throat and runny nose! I m kinda freaking out rn..
Tenzin choden just Be positive whether you have it or not... Because science proved that when you become positive your immune system become stronger..
@@kmailangkiiakai9164 hey thank you for your worthy comfort! N now i m totally in stable condition. I just had a common cold!💓
Your welcome tenzin.. All the best for future tenzin..
☺️
Are you alive?
@@senethys yeah
been sneezing lately and came here to learn about covid lol. interesting info, especially the fact that there are multiple coronaviruses that we never really knew about . seriously tho i’ve been social distancing and i just hope we all be safe and make it through this. god bless! and remember, say no to drugz 🤘🏻😝
i want to translate this video to arabic, how can i connect with you?
You can add Arabic subtitles to our video. Here is how : ruclips.net/video/_3MMKHqoZrs/видео.html
@@Alilamedicalmedia
I need to talk with u directly for somthing else, please
You can find our contact information in the "About" tab of our channel.
You have a nice voice. I could listen to you describe my death.
good explaination
“Sometimes I want to ask God why He allows poverty, famine, and injustice when He could do something about it, but I’m afraid he might just ask me the same question.” ~ Abdu’l-Baha, Baha'i Faith
@@michellewilcox7175 True enough. Mankind has many lessons to learn.
@@michellewilcox7175 “Tribulations will continue to assail humanity as the old structures around us show themselves increasingly unable to find answers to our problems” ~ Baha'i Faith
@@michellewilcox7175 Best Wishes & Blessings to you & yours.
Thank you for the great video.
Thank you so much, it's now published.
Waiting for this video, you have best way to understand covid19
We all need to get down on our knees and ask our God for forgiveness.
Wright!!may Allah protect us
God doesn’t do bad things he didn’t do this . That would be the work of evil
Allahuakbar
There is no God, but allah is only! Allah know best❤
? Should we take [Cold Medicine] to help fight and prevent, Coronavirus. ? is it true you can self heal in 2 weeks
If you really need the symptom relief cold medicines can provide it but they do not actually help with the virus itself and instead target symptoms including those which are in fact caused by your own immune system fighting the virus such as fever and inflammation especially in combination cold and flu products (Paracetamol/Tylenol is used for this purpose) usually. If the symptoms are something you can deal with might be better off dealing with it than taking symptom relief which may take the edge off at the cost of slightly prolonging recovery. Taking a separate decongestant (If you develop blocked nose) or cough medicine (If you develop a productive cough ie one that has phlem) in the latter case make sure it's the one for chesty coughs not a dry cough as the latter is a cough suppressant and you want to help the body eliminate mucus since this is one way the body is getting rid of the virus.
@@seraphina985 Thanks you should paste that I bought a lot cold medicine thanks for the tips
Much needed information.
So the other theory I had. Was I think COVID to actually treat it? Woulbabe a rabie shot? I think it's a might be a mutated version of Rabies. So it mutated past the point of having to bite another thing to just airborne out this. Is still out there still doing without the mouth as a transfer device, but it's switched it up. Cause biding and stuff wasn't working..
I had a fever for about 5 days a small one and then 2 days later I felt fine and then just yesterday I felt like
I had a hard time breathing and today I’m starting to feel bad back pain can someone help me I’m just 18 and I’m scared :(!!! Any suggestions???!
Call your doctor or health department.
0:59 What if it was a Alpha Corona Virus? Would it be worse or no?
Is that how it all began?
Useful
Video Was needed !
But is less animated 🤗 .
My wife can't smell or taste I'm super scared at this moment
Has she had any large doses of zinc? For example immune boosters that contain high levels of zinc can cause that symptom.
Get off RUclips and take her to a dr.
@@barelyfree9427 thank you.. interesting
What did you do to her?
@stiizzy jizzy stop panicking people. Sick people with mild symptoms also experience loss of smell and taste. People just need to follow the instructions provided by a professional in their respective countries. And us, as Internet users, need to be more careful to avoid the spread of false information.
Easy Explanation.
You can get this awful covid just by smelling someone's anal gas release. Yes, virus from farts. I've got my butt plug in just in case. Same as with rain.
Yes
well done
मोदी सरकार, लोकल डॉक्टर्स को ये अधिकार दे, कि जो भी मरीज डॉक्टर के पास आए, वो उनकी कोरोना जाच कर सके, और संदेश होने पर, उन मरीज को आगे रेफर कर सके, इससे कोरॉन्ना मरीज जल्द ही पकड़ में आ सकते है। जो कि छिपे बैठे है अपने घरों में।
इससे सरकार का काम आसान हो जाएगा।
और ये बीमारी जल्द ही समाप्त हो जाएगी।
No te entendi ni vergas
I dont understand the "...jumped directly from bats to humans, or if there was a mammal intermediate" thing - bats are mammals.
Another mammal as intermediate.
Great video!! We have also been putting out a lot of COVID-19 content, WhiteBoard style! It is great so many channels are taking this on and working to keep everyone informed!
What to do in quarantine? I know! And you?
Well I be damned I got a weak immune system and possibly got COVID
heard that loud and clear doesn't really affect healthy others but it will affect the forbidden
Good msg
Try looking into medicine for malaria to battle the Coronavirus👍
shout out to James Ludden for extra credit
Les diré mi tesis completa en mi futuro canal.
praying for the nurses doing synchronized tiktok dance videos. stay safe, everyone!
Stephanie Patpig Cordy 1983
Su eficacia en la tres fases de estudio en entendimiento y ciencia es 100%, es decir todos se sanan al 100%. De cualquier sepa, mutación.
It has genetic materials RNA, how it is replicate in human cells , great wonder
There are in the air already for long years, since the existence of the 1st dinosaur on Earth.
The question is when it becomes a real problem for us animals. And the answer is also very ancient: since the 1st time homo sapiens discovered the the fire. Since then, he still hangs on to it, as it can be very addictive (tabagism, the use of stoves, heating systems, car industry)
may be they should see the people that first got the virus see what pets that they have or what animals the peted or huged or some thing or thuched or for got to whash thier hand and ate something if thay are alive
Vegetarianism might be a good idea to prevent virus infection! .... chicken and beef probable risks .....
The same virus is killing in india a purely vegeterian community.
Bats are mammals too.
Man, that's a good point that the video brought up the originating from rats.And it's been transferred ond other animals.So, if it's Rabies related, that should clear up that and then it will also clear up.Probably a bird flu and h one n one and yeah.
If you wanna survive stay home if u want to go outside be prepared co
ivid 19
Ye animals sa hota he to animals ki medical use kar ke deko ba because this virus was first in animal make a mix match of animals and humans test that and make that vaccine
The movie contagion was telling us that covid 19 was coming 💯
All are explaining Coronavirus but no one getting the vaccine video
PROFESSOR.
Inhibit the receptor = cure.
If covid19 is known to be originated from bats then their antidote must be formed within bats body
Harsha Lohani what?
@@Alienazor3 ya bats are immune to the virus, it means their bodies produces antibodies against it... If it originated within them then covids antidote can be made
Like this
COVID-19 Issue: Why we keep on touching our face unconciously?
@
Because the face has bacteria and we really wanna itch that spot.
I'm might be dead wrong here, but I have a feeling that the coronavirus is due to these tiny little white bugs that I keep seeing flying around.
Where did you see the bugs at
God knows everything just keep praying for the nation
103.
good information
I am legend
A bat is a mammalian species.
Covid 19 is not sars.Different genome.Pangolin genome.
Pangolins genome covid19.
İnternational information
Coronavirus is not a joke don’t make it a meme it’s serious
science will win
Right allwas fresh,but why fresh please right tok
We have been around animals for thousands of years, no excuses, world depopulation, them playing God. Judgement is coming , it's just time
all this death better not be because katie and co have smack habits ..