Acid Chloride + Ammonia = Amide (Mechanism)
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- Опубликовано: 17 окт 2024
- The nitrogen of ammonia attack the carbonyl carbon (C=O) of the acid chloride. The Cl leaves, as a chloride ion, which goes on to remove one of the H's from what was the ammonia molecule. This leaves -NH2 attached the carbonyl group, which makes the product an amide.
This works for NH3, primary amines and secondary amines. It does NOT work for tertiary amines because they don't have an H to be removed by the Cl.
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