Antimalarial Drugs (Part-05) Chloroquine Mechanism of Action | Chloroquine | Chloroquine MOA

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Malaria is a life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes.
Malaria is caused by single-celled microorganisms of the Plasmodium group. The disease is most commonly spread by an infected female Anopheles mosquito. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver where they mature and reproduce. Five species of Plasmodium can infect and be spread by humans. Most deaths are caused by P. falciparum because P. vivax, P. ovale, and P. malariae generally cause a milder form of malaria.
The signs and symptoms of malaria typically begin 8-25 days following infection, but may occur later in those who have taken antimalarial medications as prevention. Initial manifestations of the disease-common to all malaria species-are similar to flu-like symptoms, and can resemble other conditions such as sepsis, gastroenteritis, and viral diseases. The presentation may include headache, fever, shivering, joint pain, vomiting, hemolytic anaemia, jaundice, haemoglobin in the urine, retinal damage, and convulsions. In the life cycle of Plasmodium, a female Anopheles mosquito (the definitive host) transmits a motile infective form (called the sporozoite) to a vertebrate host such as a human (the secondary host), thus acting as a transmission vector. A sporozoite travels through the blood vessels to liver cells (hepatocytes), where it reproduces asexually (tissue schizogony), producing thousands of merozoites. These infect new red blood cells and initiate a series of asexual multiplication cycles (blood schizogony) that produce 8 to 24 new infective merozoites, at which point the cells burst and the infective cycle begins.
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[@54manojsomvanshi37]

Finally chloroquine aa hi gaya.....Most waited.......Chloroquine aisa shaks hei jaane sari duniya ko bharat ki pharmacy ki takat dikha di........Salute you chloroquine,.........😄😅😊

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Ha ha ha

[@ranjitbhullar2750]

YOUR EFFORTS ARE TRULY WORTHY

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Thank you

[@prajaktakulkarni9814]

Enzyme participate in conversation of heme to hemazoin is heme polymerase & Chloroquine may block this enzyme....MOA -heme polymerase inhibitors.....Nice lecture sir ....My score 9/10 ....

[@solutionpharmacy]

Good score

[@vraj_3005_]

Sir Thank you 🙇🏻‍♂️🙏🏻

[@vrijendra_maurya100]

Thank you so much sir❤❤❤❤

[@rajivdas8185]

Good

[@cricketanalysisbyankit5170]

8/10 thanks sir for your support

[@solutionpharmacy]

Good. But can be improve

[@loveyrai3245]

Thank u sir...and I scored 10/10

[@solutionpharmacy]

Very nice

[@shubhamSharma-cq8en]

Nice

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Thank you

[@irfankhan0072]

Thanks sir app ko dil se

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Thank you

[@ashuhooda1012]

Thanku u so much sir

[@chandrashekharkarhale2422]

Thanks

[@solutionpharmacy]

My pleasure

[@neelamyadav5052]

Thanks sir Today's score is 10/10 Helpful lecture

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Good going.

[@pratibharajpurohit4406]

10 out of 10

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Pratibha Rajpurohit v good

[@vibhapatel7918]

Thank you sir

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Vibha Patel welcome

[@arshisiddiqui7657]

Thank u so so much sir...👏✌️😊

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My pleasure.

[@zulfaabdulnasir]

Wikipedia is jealous to bit_because I take your words😎... thank you for awesome 👌 informative session... Scored10/10🥳✌️

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Thank you so much.

[@mr.predator8302]

Thanku sir , aapka ye video kafi sarlta se smaj me aa gya...

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Thank you

[@JavedKhan-xp6wl]

Helpful

[@Tradewithgoodmorning]

My score is 7/10

[@desizooster1994]

Thank you so much sir, I hope I will selected in pharmacist exam. By the help of this vedios. Thank you so much sir.

[@solutionpharmacy]

Sure. All the best

[@shaguftakhanam1273]

Scored 10/10.....😊 Thank you sir the way u teach is really awesome
Sir last one week I was searching any pharmacology online classes lucky I found your channel on my u tube list I saw your one two lecture n became a new student now I'm going to subscribe you sir can u please help me out from where I started your videos because list is too long..........now I'm continue with antimalarial drug till part 5

[@solutionpharmacy]

Shagufta Khanam Thank you. We have upload topics of b pharmacy 4 to 6 sem. So videos list is long. In which sem you are. There is seprate playlist too. You can to to specific playlist

[@shubhamkumarmishra7493]

Now i got 10/10 .....🥰🤩
First time... 🤩.

[@solutionpharmacy]

Great

[@rajuryadav7972]

Score 9/10 thank u sir

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Good one

[@rahultamang8324]

I got 9/10

[@solutionpharmacy]

Good one

[@himanshuukey540]

Thank u sir for amazing and easily understandable.lecture 🤩❣❣❣

[@solutionpharmacy]

HIMANSHU UKEY thank you

[@smitpatkar6553]

amazing teaching sir
animation is very useful for mechanism of action

[@solutionpharmacy]

Thanj you so much

[@shabbirroyal1359]

Thank you so much sir 10/10🙂🙏

[@prachisinghkashyap8471]

10/10 sir it is also contraindicated in patient with psoriasis and porphyria as can provoke the attack also sir prolong qt interval will be seen on administration of chloroquine

[@solutionpharmacy]

Right

[@uvsagu7]

Thanks sir ji 🙏🙏

[@deepanshupandey5594]

10 on 10 😍

[@solutionpharmacy]

V nice

[@anushrikudatarkar1527]

Scored 10/10 Thank you sir 🙌

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Good

[@roopalsoni2955]

let in participation due to not having the mobile phone ... but score is 10/10..thankyou sir

[@solutionpharmacy]

Its very nice to see your passion. Late does not matter if score is like this. Great

[@roopalsoni2955]

@@solutionpharmacy this is all because of you sir... thank u so much....

[@payalhumane3674]

10/10 😃

[@solutionpharmacy]

Good

[@shaileshmaurya9381]

Today, also we got 10/10.
Sir, if possible then gives all questions in this topic in a pdf form.
Thank you sir.

[@solutionpharmacy]

shailesh maurya. Many people many demamd and inam 01. When inwas giving pdf students ask about immediate online and now offline pdf. Please apply some effort and note down the questions and make pdf. Atleast this much home work is expexted by students. Sorry to say like this but take it in positive way

[@shaileshmaurya9381]

@@solutionpharmacy no problem sir, I'll write in my notebook.

[@poojabadve7777]

Thank you so much sir.....🙏

[@solutionpharmacy]

Most welcome

[@devakibhadi1999]

Thank you so much sir
10/10

[@solutionpharmacy]

V good

[@gauravpandey2558]

You are amazing sir, you always cover each and every imp point and explain it in simpler way and now this quiz thing is amazing.
Thank you so much sir.
Happy Teacher's Day and may god always bless you

[@solutionpharmacy]

Thank you so much

[@VikasGupta-uk1ft]

My score10/10, lot of thanks sir

[@solutionpharmacy]

V good.

[@Tradewithgoodmorning]

Hi good morning sir

[@archanakumbhar2060]

Thanks sir ☺☺☺☺ my score is 10/10

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My pleasure

[@harry6489]

10/10 score 🤗

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Ajay pal Singh good

[@k.kbishnoi5607]

Sir aapne hb se hematin me convert konsa enzyme krta h uska naam aapne proteolytic btaya h or likha aapne proteolysis h sir shi konsa h plz tell me

[@nishachouhan8709]

Tq sir 10/10

[@solutionpharmacy]

Very good score.

[@pharmacologists..5848]

Sir unfortunately 8/10😃

[@solutionpharmacy]

No problem

[@vibhapatel7918]

My score 9

[@solutionpharmacy]

Vibha Patel good one

[@sandeepgl3666]

Bro can u please help me in acral lentignios melanoma mechanism of action

[@aryanmaurya3902]

Sir I suffer for malaria vivex 6 year I take many time primaquine but hypnozoit stage not clear please suggest sir

[@kartiktaneja7868]

U r gajab

[@solutionpharmacy]

Thank you

[@priyankatandon69]

❤️❤️🙏

[@yaduvenderyadav3912]

Sir please upload STD topic

[@galib_ka_chutiyap]

largest volume of distribution chloroquine ka hi hota hai na sir?

[@solutionpharmacy]

I think yes

[@pharmacistaltamashansari6668]

10/10, nice lecture sir,sir option 1 kya hai last number ka

[@solutionpharmacy]

Altamash Ansari Good. That was default and blank question. Kabhi kabhi jan bukh kar galat karna padta hai aise taki students ke alertnes ko samjha ja sake. 03 ne bus report kia aapko mila kar ke.

[@anayatali8966]

Jaise study IQ walung k clear sun pata hai..

[@solutionpharmacy]

Sorry sabke pass ek jaisi facility nahi hote.

[@bien1839]

sir can you add captions so i can easily understand please Thank you sir

[@solutionpharmacy]

Really sorry but adding caption will also not help you, it will be like reading a book. Soon i will start english channel

[@bien1839]

@@solutionpharmacy thank you sir

[@alfajkhan175]

Sir can’t understand the correct option for chloroquine answer ..plz clear it

[@solutionpharmacy]

Whats wrong in it

[@suntuzuki5753]

Sorry sir I obtained only 8 Mark's

[@solutionpharmacy]

No issue. You will do better

[@suntuzuki5753]

Thanks sir

[@vibhapatel7918]

Sir score 9/11 hai but last question show nahi kar raha

[@solutionpharmacy]

Vibha Patel corrected. That was blank

[@vibhapatel7918]

Sir last question me bs option 1 likha hai samjh nahi aa raha

[@solutionpharmacy]

Vibha Patel ha wo correct ho gaya.

[@anayatali8966]

Aaap ke sound clear nhi sun pa rha ha
Eco type ata h
Plzzz sir improve 🙏

[@solutionpharmacy]

ANAYAT ALI sorry for this. Please use headphone and reduce the volume. I am trying to manage it

[@anshumanchaudhary3636]

Thanks

[@adwaitvaidya8036]

Thank you sir🙏..

[@solutionpharmacy]

Welcome

[@neerajrao9217]

Thank you so much sir 🙏🏻

[@solutionpharmacy]

Most welcome

[@Shivamnarayanpandey8061]

Thank you sir ji 🙏🙏

[@solutionpharmacy]

Ganeshprasad welcome