I am now in my eighties, and will not go to University for many reasons. This is mindblowing and very exiting, I feel priviliged and invigorated to be able to have this type of education available in the comfort of my own home. Thank you, thank you, thank you.
I am so excited to take this course again! Vincent is the best! Thankyou sooooooo much to every single one of you who donates to keep the Incubator Studio space thriving!!!!!
Agreed Dr Racaniello is a fantastic lecturer and his passion for and deep knowledge of viruses really shines through in his talks. A great source of information on a very pertinent subject
My doctorate is in the social sciences, not the biological sciences and, while some things he presents are beyond me, I LOVE this guy. I always learn something worthwhile. Thank you Vincent Racaniello!
When I started learning from Vincent's courses 3 years ago, I had to stop the video, look up a term in Google, which usually sent me on a Wikipedia, down-the-rabbit hole of one term leading to another and another. But, it all started making sense. Some of his one hour lectures would take me 6 hours to get through. I still get stumped though, and it's off to Wikipedia again. You'll learn all about viruses and biology, microbiology, genetics, and immunology.
I am sooooooper excited that you have RESTARTED the course. Thank you!! I bought your book, too. I will be doing this with 'religious' zeal! Thanks a lot!!!
Took this course as a MOOC several years ago since then have been an avid TWIV/Q&A with A&V listener and am very excited to run through the course again. Thank you Vincent for the extraordinary effort you put into these programs and making them accessible.
Thanks for letting us freeloaders listen in on your class professor! I have few uninformed opinions and/or questions: 1) I think viruses are not alive even within a cell during the reproduction phase: the RNA/DNA message is taken apart, copied and reassembled by the host cell; nobody is holding a gun to it ;) 2) what is the original purpose of the sequence for a cell to capture a protein structure, such as a virus, from the outside, replicate it, then reassemble it? fixing other cells? 3) do viruses pathogenic to humans or other animals have an original beneficial purpose in some distant original host? 4) what exactly kills the host cell during viral capture? resource exhaustion, or not enough room to hold newly created virions {membrane bursts}? 5) is it the case that viruses not resulting in infection symptoms simply either do not match the intake signals for a host cell, or not replicable with the host's resources?
"I think viruses are not alive even within a cell during the reproduction phase" Vincent Racaniello agrees with you. He said the [viral particle + cell] is alive not that the virus is alive when it is in the cell. "what is the original purpose of the sequence" Purpose? Vincent Racaniello warned you not to anthropomorphise because it will eventually cloud your thinking. "what exactly kills the host cell during viral capture?" Stay tuned. I'm sure this will be covered in the lecture series. Same for your other questions.
I've told too many people that Vincent is the best teacher ever! I never thought I'd be interested in viruses. It takes a fantastic, gifted teacher to inspire thought and interest❤.
I'm really enjoying watching the class, and I'll definitely keep watching all the videos on the channel. Thank you so much for making content full of teaching and fundamental knowledge available free of charge!
I'm not even in college, and I love classes like these, thank you for making my day so interesting Mr. Racaniello, you've earned a sub and a person interested in viruses.
Good to come back to his course again to refresh my memory after the Covid-19 pandemic! It is so true that virology encompasses other sciences and even all of medical science, and is of course especially relevant for the human sciences.
Excellent lecture Vincent. I have been looking forward to this since hearing on TWIV that you planned to put your virology course on youtube. Thanks very much!
I thought this would help me fall asleep...I couldn't have been more wrong. I never thought viruses were interesting until watching this lecture . Vincent is such a magnificent teacher! ❤️ On to the next Virology lecture !
Jaw drop! As a layperson this was fascinating though I doubt I will remember much of the retails. But a big thank you. I wish all journalists covering the pandemic had done your courses before writing about Covid.
I have learned everything i wanted to know about viruses by catching covid a dozen times. Essentially what we know about viruses is so simplistic its wrong.. I had to learn all this to understand what the virus was doing to my body... just know i was more blissful when i was ignorant. It hurts me how ignorant the general public is about viruses
Have followed these classes many years - well before COVID came along. Could you recommend a similar class which will provide some of the missing information on DNA/RNA replication processes at the molecular/structural level? These details are (necessarily) left out of many of these lectures. Thanks!
There should exist viruses with very large genomes that can translate rna on their own and have very slow metabolism. I reckon they would appear as obligate parasite bacteria.
Aerosols from toilets: during SARS1 outbreak a whole tower block was infected by the flushing of one toilet! Yet there are still scientists who deny aerosol transmission (John M Conly).
I'm pretty sure all viruses have capsids (which encloses the genetic material). The envelope/membrane/coat - which encloses the capsid - is optional (ie not all viruses have them).
I heard about Lady Montague in a RUclips vid about a painting about her rejecting some famous writer/poets who confessed his love for her when he had met her as a married woman from the get go. And she wasn't the ambassador, she was his wife, unfortunately they weren't that progressive and certainly not when sending ambassadors to patriarchal countries
It would be better if you gave the phage length as well as its mass, as you compare its weight with elephants (assuming a million of? Hope there are that many left...), but give no length dimension to build to those light years.
If viruses were nothing but exosomes from our own cells, they would not generate an immune response -- but they do. This is because the nucleic acid of the virus encodes for proteins that are not part of the human organism, and are recognized as foreign by our immune system. Exosomes are not transmissible and there are mountains of studies doing contact tracing and transmission routes.
@@gribbler1695 Good response… I have studied immunology and separately virology, but I not recall reading origins. Yes, first discovered dates are cited, but not the origin. I believe, that trees and fungi use exosomes to communicate. I have not studied in this area. - With regard to exosomes appearing as native to host… I wonder. I wonder about the purpose of exosomes. Is it just a mechanism/process of ridding the body of damaged nuclear material? I intend to finish the video. Thanks for your reply.
I am 18 minutes in, and this is painful to listen to. The prof appears to understand taxonomy of virus, lacks the ability to y the hunk critically. More specifically, he refers to the number of Covid dead - matter of factory, but does not speak to the lack of any influenza deaths. Relatedly, how would a PCR Test identify a disease state. Anyone reading this should look up Kary Mullis or read his papers or book. Somewhat relatedly, the reference to HIV and AIDS. No mention is made Luc Montangier change of mind. - The problem is institutional education.
This is a course not just a single lecture. Take a look at a previous year playlist and you can see what is covered here. This is Virology 101 and he is teaching mostly the principles of how viruses work and how the host protects itself. Although he and Dr. Griffin has answered the question with their speculations, you can ask it again during a livestream "Office Hours" episode or send an email to Dr. Griffin or Prof Vincent.
Here is the playlist for a previous older version of the course. ruclips.net/p/PLGhmZX2NKiNm0vqVhoYB_xZP6E6tGT6rU Lecture #23 covers HIV and AIDS. The lectures are in that order to make sure the student has the background. Sars2 PCR tests work by detecting parts of the Spike RNA and part of the N(nucleocapsid) RNA. To make it work, that RNA is converted to DNA and then the DNA is duplicated. That DNA is made florescent and until it is bright enough or it does not glow within a certain number of doublings.
@@gribbler1695 I believe the video said… CDC deaths. Nothing was said about hospital or physician reported deaths. It is well established that hospitals inflated their reports… for the money. The data shows that there were no influenza deaths while the Covid narrative played out. Look at Denis Rancourt’s paper. - It was appointing to listen to institutionalized science miss the point. For this reason, universities will be down sized.
I am now in my eighties, and will not go to University for many reasons. This is mindblowing and very exiting, I feel priviliged and invigorated to be able to have this type of education available in the comfort of my own home. Thank you, thank you, thank you.
I am so excited to take this course again! Vincent is the best! Thankyou sooooooo much to every single one of you who donates to keep the Incubator Studio space thriving!!!!!
We are lucky to have him. He’s a great man. Doing this for the love of teaching.
Agreed Dr Racaniello is a fantastic lecturer and his passion for and deep knowledge of viruses really shines through in his talks. A great source of information on a very pertinent subject
My doctorate is in the social sciences, not the biological sciences and, while some things he presents are beyond me, I LOVE this guy. I always learn something worthwhile. Thank you Vincent Racaniello!
When I started learning from Vincent's courses 3 years ago, I had to stop the video, look up a term in Google, which usually sent me on a Wikipedia, down-the-rabbit hole of one term leading to another and another. But, it all started making sense. Some of his one hour lectures would take me 6 hours to get through. I still get stumped though, and it's off to Wikipedia again. You'll learn all about viruses and biology, microbiology, genetics, and immunology.
Thank you for publishing this on RUclips.
I appreciate it.
Thank you for providing this lecture to the public on the principles of virology. Lis
Vincent, your course lectures get better and better every year. Fantastic.
Wonderful class. Thanks so much.
Yes! So happy this is starting up.
Thank you so much. Excellent class.
I am sooooooper excited that you have RESTARTED the course. Thank you!! I bought your book, too. I will be doing this with 'religious' zeal! Thanks a lot!!!
OMG. I am enjoying this lecture. This is so interesting to me from a food and gardening perspective. I was not expecting that.
Oh this is going to be awesome!
Oh yeah. It's time for another year!
Thanks for sharing Vincent
Especially exciting time to study virus, from someone who studied with Baltimore. Wow, free. Thanks much.
Guess you missed that interview with Baltimore about HIV? (House of Numbers).
That is the most enlightening explanation I've heard on whether viruses are alive.
Thank you. This is a wonderful gift.
Racaniellos enthusiasm is infectious, you could say
Took this course as a MOOC several years ago since then have been an avid TWIV/Q&A with A&V listener and am very excited to run through the course again. Thank you Vincent for the extraordinary effort you put into these programs and making them accessible.
Thanks for letting us freeloaders listen in on your class professor!
I have few uninformed opinions and/or questions:
1) I think viruses are not alive even within a cell during the reproduction phase: the RNA/DNA message is taken apart, copied and reassembled by the host cell; nobody is holding a gun to it ;)
2) what is the original purpose of the sequence for a cell to capture a protein structure, such as a virus, from the outside, replicate it, then reassemble it? fixing other cells?
3) do viruses pathogenic to humans or other animals have an original beneficial purpose in some distant original host?
4) what exactly kills the host cell during viral capture? resource exhaustion, or not enough room to hold newly created virions {membrane bursts}?
5) is it the case that viruses not resulting in infection symptoms simply either do not match the intake signals for a host cell, or not replicable with the host's resources?
"I think viruses are not alive even within a cell during the reproduction phase"
Vincent Racaniello agrees with you. He said the [viral particle + cell] is alive not that the virus is alive when it is in the cell.
"what is the original purpose of the sequence"
Purpose? Vincent Racaniello warned you not to anthropomorphise because it will eventually cloud your thinking.
"what exactly kills the host cell during viral capture?"
Stay tuned. I'm sure this will be covered in the lecture series. Same for your other questions.
Thank you for making this available to us! Appreciate you!
I've told too many people that Vincent is the best teacher ever! I never thought I'd be interested in viruses. It takes a fantastic, gifted teacher to inspire thought and interest❤.
Oh, awesome. I caught you on lecture 1.
I'm really enjoying watching the class, and I'll definitely keep watching all the videos on the channel. Thank you so much for making content full of teaching and fundamental knowledge available free of charge!
I'm not even in college, and I love classes like these, thank you for making my day so interesting Mr. Racaniello, you've earned a sub and a person interested in viruses.
Good to come back to his course again to refresh my memory after the Covid-19 pandemic! It is so true that virology encompasses other sciences and even all of medical science, and is of course especially relevant for the human sciences.
Vira play an integral role in human physiology and cellular biology. And yes they are incredibly fascinating.
Excellent lecture Vincent. I have been looking forward to this since hearing on TWIV that you planned to put your virology course on youtube. Thanks very much!
His past lectures are still available on his RUclips channel. But, each year he updates them. They really should get uploaded to the Internet Archive.
Thank you for sharing
That was a great overview and hints of what’s to come over the next few weeks! Thanks a bunch for all you do Vincent!
I LOOVE VIRUSES TOO!!
Thank you for posting this lecture series Dr. Racaniello, a very pertinent and important subject for sure.
Awesome
I thought this would help me fall asleep...I couldn't have been more wrong. I never thought viruses were interesting until watching this lecture . Vincent is such a magnificent teacher! ❤️ On to the next Virology lecture !
So glad you are here to teach us!
Jaw drop! As a layperson this was fascinating though I doubt I will remember much of the retails. But a big thank you.
I wish all journalists covering the pandemic had done your courses before writing about Covid.
Thank you very much for sharing this course!
This is amazing 😍
I feel like the virus particle is like a seed. Once the seed is buried into the ground “the cell”, it grows and is “alive” which produces more seeds.
Muchas gracias por hacer tan amena esta clase
So excited for this
Thanku so much sir ☺️😇👏👏
Weird, the lack of angry conspiracy theorists making comments here. I guess this is not where they get their information from.....
Either that, or YT is heavily on the case and the comments aren't shown.
As a microbiology student, thank you for uploading!
So very interesting! Thenk you!
Oh yay
Thanks for the course
Absolutely we live in universe of micro forms of cellular interactions
thank you so much
I have learned everything i wanted to know about viruses by catching covid a dozen times.
Essentially what we know about viruses is so simplistic its wrong..
I had to learn all this to understand what the virus was doing to my body... just know i was more blissful when i was ignorant.
It hurts me how ignorant the general public is about viruses
I enjoy my VR, and I enjoy my micro since the only way I am alive
Hello Vincent, I can use your class for tralsate in spanish?
What a treasure, honestly
Thank you! Amazing
1.5x speed...trust me....such a wonderful course... thank you
This is awesome 👌
Have followed these classes many years - well before COVID came along. Could you recommend a similar class which will provide some of the missing information on DNA/RNA replication processes at the molecular/structural level? These details are (necessarily) left out of many of these lectures. Thanks!
Bacteriophages 😍
There should exist viruses with very large genomes that can translate rna on their own and have very slow metabolism. I reckon they would appear as obligate parasite bacteria.
What role does the mammalian end cannabinol system and viruses play and maintaining tissue and integrity in the human body?
Aerosols from toilets: during SARS1 outbreak a whole tower block was infected by the flushing of one toilet! Yet there are still scientists who deny aerosol transmission (John M Conly).
Appreciate the concern about ‘unnecessary’(!) deaths but really John you should interview a pulmonary intensifiât that works in A&E/ ICUs..
We must redefined the term in fact
Is there a name for the RNA/DNA plus envelope, if any? i.e. is there a name for the thing excluding the capsid?
I'm pretty sure all viruses have capsids (which encloses the genetic material). The envelope/membrane/coat - which encloses the capsid - is optional (ie not all viruses have them).
There are bacteria that have to use the host cells machinery to replicate. They may be the largest viruses
Thank you very much.
I know that discord is used to get data or information, but can anyone do it?
Professor, Could I get the lecture contents like PPT for the email~? cuz I really want to take some note on the lecture
I heard about Lady Montague in a RUclips vid about a painting about her rejecting some famous writer/poets who confessed his love for her when he had met her as a married woman from the get go.
And she wasn't the ambassador, she was his wife, unfortunately they weren't that progressive and certainly not when sending ambassadors to patriarchal countries
Finally!!!
💕💕💕💕🥰
Can we define what the role of a virus is?
Without Vai, life would not exist
It would be better if you gave the phage length as well as its mass, as you compare its weight with elephants (assuming a million of? Hope there are that many left...), but give no length dimension to build to those light years.
"it's like Ailen, it eats it's way out of the catapillar, not the movie"
Haha, only me who reacted to this strange statement?
Is this going to be on Spotify, too? 😻😻😻😻😻😻😻💛
I hope there is a distinction made in this video - between virus and exosomes.
If viruses were nothing but exosomes from our own cells, they would not generate an immune response -- but they do. This is because the nucleic acid of the virus encodes for proteins that are not part of the human organism, and are recognized as foreign by our immune system.
Exosomes are not transmissible and there are mountains of studies doing contact tracing and transmission routes.
@@gribbler1695
Good response… I have studied immunology and separately virology, but I not recall reading origins. Yes, first discovered dates are cited, but not the origin.
I believe, that trees and fungi use exosomes to communicate. I have not studied in this area.
-
With regard to exosomes appearing as native to host… I wonder. I wonder about the purpose of exosomes. Is it just a mechanism/process of ridding the body of damaged nuclear material?
I intend to finish the video.
Thanks for your reply.
Why viruses cannot have both DNA and RNA at same time
hi my teacher how are you i am from ethiopia, i want to be scientist help me
Thank you for giving me a new and scientific reason not to like the ocean hahahahaha
No, we knew this in the 80s
Planet earth feels over rated sometimes?! Lol yes its like earth when back to 1996 😮🎉
I am 18 minutes in, and this is painful to listen to. The prof appears to understand taxonomy of virus, lacks the ability to y the hunk critically. More specifically, he refers to the number of Covid dead - matter of factory, but does not speak to the lack of any influenza deaths. Relatedly, how would a PCR Test identify a disease state.
Anyone reading this should look up Kary Mullis or read his papers or book. Somewhat relatedly, the reference to HIV and AIDS. No mention is made Luc Montangier change of mind.
-
The problem is institutional education.
This is a course not just a single lecture. Take a look at a previous year playlist and you can see what is covered here. This is Virology 101 and he is teaching mostly the principles of how viruses work and how the host protects itself. Although he and Dr. Griffin has answered the question with their speculations, you can ask it again during a livestream "Office Hours" episode or send an email to Dr. Griffin or Prof Vincent.
Here is the playlist for a previous older version of the course.
ruclips.net/p/PLGhmZX2NKiNm0vqVhoYB_xZP6E6tGT6rU
Lecture #23 covers HIV and AIDS. The lectures are in that order to make sure the student has the background.
Sars2 PCR tests work by detecting parts of the Spike RNA and part of the N(nucleocapsid) RNA. To make it work, that RNA is converted to DNA and then the DNA is duplicated. That DNA is made florescent and until it is bright enough or it does not glow within a certain number of doublings.
A diagnosis of COVID-19 is made by a physician using test results, the pre-test probability of having an infection, and the patient's history.
@@gribbler1695
I believe the video said… CDC deaths. Nothing was said about hospital or physician reported deaths.
It is well established that hospitals inflated their reports… for the money.
The data shows that there were no influenza deaths while the Covid narrative played out. Look at Denis Rancourt’s paper.
-
It was appointing to listen to institutionalized science miss the point. For this reason, universities will be down sized.
@@lesfaby8997
Thanks… I will look. I am interested in what this chap has to say about the ongoing origins of ‘virus’ and separately, about exosomes.
Virus isolation is absolutely ridiculous