That is a great question. In reality that proton transfer does occur (which would be it's own mini-equilibrium "side-road"); however, you can think of it as a dead end pathway. The equilibrium that provides the pathway forward involves forming the iminium ion (where the nitrogen is protonated). That creates a group that can be kicked off as a urea biproduct. That pathway drives the overall reaction pathway forward. I hope that helps!
@@JeffreyEngle sir I take one side valline and another phenylamine. After making dipeptide of it it show very. Close two spots.. Acco to me recimisation problem.
Racemization of amino acids can occur, but typically the interconversion is relatively slow under most conditions. The study of this interconversion (amino acid dating) is outside of my area of expertise. @@ashishreshamiya6428
Great video 👍🏿
I am glad I found your videos. These are GOLD
Fantastic video. I’ve been obsessed with chemistry ever since I took organic. This is a huge help for some questions I had
Good
Great 💯💯
Could I know the name of application you used ?
I use Microsoft OneNote for my lectures.
During the proton transfer step after the amine coupled to the ester why would the proton not want to transfer to the negatively charge oxygen?
That is a great question. In reality that proton transfer does occur (which would be it's own mini-equilibrium "side-road"); however, you can think of it as a dead end pathway. The equilibrium that provides the pathway forward involves forming the iminium ion (where the nitrogen is protonated). That creates a group that can be kicked off as a urea biproduct. That pathway drives the overall reaction pathway forward. I hope that helps!
even if already know that iam not gonna do this on the exam igot the point tnx
Hlo sir.
Sir please tell how can I stop recimisation problem.
I am not sure what you mean. Formation of a peptide bond does not result in a stereocenter.
@@JeffreyEngle sir I take one side valline and another phenylamine.
After making dipeptide of it it show very. Close two spots..
Acco to me recimisation problem.
Racemization of amino acids can occur, but typically the interconversion is relatively slow under most conditions. The study of this interconversion (amino acid dating) is outside of my area of expertise. @@ashishreshamiya6428