Fc gamma receptor activation during viral infections: a double-edged sword

Presented By: Raymond A. Alvarez, PhD
Speaker Biography: Dr. Alvarez is an Assistant Professor, in the division of Infectious Diseases at the Ichan School of Medicine at Mount Sinai, where his work focuses on the antibody-mediated mechanisms that correlate with HIV-1 suppression in HIV-1 controller patients. Dr. Alvarez has over 20 years experience conducting translational research in the infectious disease space.
Webinar: Fc gamma receptor activation during viral infections: a double-edged sword
Webinar Abstract: Over the last several decades, antibodies (Abs) have become a valuable weapon in the fight against viral infections, with several studies demonstrating the importance of both neutralizing and non-neutralizing Ab responses in preventing or controlling viral infections in-vivo. Fc receptor mediated non-neutralizing effector functions such as, Ab-dependent Cellular Cytotoxicity (ADCC), phagocytosis and cytokine expression, have all been shown to contribute to effective immune responses in-vivo. However, in the case of some viral infections, such as dengue, Ab/Fc receptor mediated interactions enhance the severity of dengue hemorrhagic fever via Antibody Dependent Enhancement (ADE), which is hypothesized to primarily occur via Fc gamma receptor (FcγR) interactions.
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