The State of the Pandemic, Therapeutics, and Emerging Data on Variants
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- Опубликовано: 24 мар 2021
- This week’s UCSF Department of Medicine Covid-19 Grand Rounds features three segments. First, George Rutherford will review the state of the pandemic, including the implications of hot spots in the United States and Europe. Annie Luetkemeyer then gives us an update on outpatient treatments for Covid, including monoclonal antibodies and a large group of oral agents (such as ivermectin, vitamin D, fluoxetine, colchicine, and hydroxychloroquine) that have been touted as beneficial despite uncertain evidence. Finally, Adam Lauring of the University of Michigan will describe emerging data on Covid variants, including the current uptick in cases in Michigan. The session is moderated by UCSF Department of Medicine Chair Bob Wachter.
Program
Bob Wachter: Introduction
00:04:29-00:16:47 - The State of the Pandemic with George Rutherford (UCSF Professor, Dept. of Epidemiology & Biostatistics; Director of the Prevention and Public Health Group)
00:16:47-00:24:04 - Q&A
00:24:05-00:41:43 - Therapeutics with Annie Luetkemeyer (UCSF Professor of Medicine, Division of HIV, ID and Global Medicine at ZSFG)
00:41:43-00:49:21 - Q&A
00:49:22-01:03:54 - Variants with Adam Lauring (Associate Professor, Depts. of Internal Medicine, Microbiology and Immunology, and Ecology and Evolutionary Biology, University of Michigan)
01:03:54-01:16:24 - Q&A
Bob Wachter: Closing
See previous Covid-19 Medical Grand Rounds:
• March 11: Covid at One Year: Looking Back and Looking Ahead • Covid at One Year: Loo...
• February 18: The 23rd Annual Reza Gandjei Memorial Lecture: A Conversation with Atul Gawande • The 23rd Annual Reza G...
• February 11: The New Vaccines, Attitudes Toward Vaccination, and the Biden Covid-19 Task Force • The New Vaccines, Atti...
• January 28: Covid-19: Vaccine Roll-out, the State of the Pandemic, and Variants - in the U.S. and U.K. • Covid-19: Vaccine Roll...
See all UCSF Covid-19 grand rounds, which have been viewed over 1.68M times, here: medicine.ucsf.edu/covid-19-ne...
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I'm glad you're having a discussion but also we need to consider what other countries are using as far as Therapeutics and some of them have had incredible results worth a thought
The poorly designed ivermectin study in JAMA failed to give statistically valid results because it was underpowered. Even the JAMA editors are now concerned about that study. Can't believe this was even brought up. There have also been many good studies, not to mention the entire country of Peru, demonstrating that ivermectin is very safe and effective. Why didn't you cite Dr. Tess Lawrie's meta-analysis? Dreadfully biased review.
Apparently, the Columbian RCT participants were informed that their trial consisted of a certain "molecule" (or placebo). Chances were good that sick patients availed themselves of OTC Ivermectin. Both arms were doing remarkably well. Goalposts had to be changed.
There is more to be interested in than rna dependent rna polymerase.
The world needs Ivermectin while we wait for Merck and Pfizer to undergo trials.
@Kicapu I switched from thinking the virus came from a wet market. Flexible thinking is not a negative, dogmatism is.
@Kicapu What's funny is they are right now pushing the wet market theory again. Is the wet market theory one of those stubborn facts you're referring to?
SYDH some more if you like.
the govt shills are SO AFRAID people will discover the truth about IVERMECTIN and how fast and efficient it is at Stopping Replication of the virus ; it's truly horrifying to them to LOSE control of the Fake Narrative .
@Kicapu read it and Weep ! LOL
I am so impressed with the knowledge I am getting about the pandemic from this group of professionals. I've been following the UCSF School of Medicine for some time and I'm grateful that I have. Thanks to all of you. Greetings from Canada.
Amen. They've been great during this pandemic. Love their updates.
1918 - Over 50 million dead out of 1.8 Billion was a pandemic
covid-19 - About 2.7 million out of 7.8 billion is not worth fucking the world over.
You morons have fallen for the scare the shit out of you sensationalism of the language you are familiar with.
@@yourefuked8542 So, approaching 600,000 US deaths is nothing?
Not sure where to ask this but the numbers become very confusing in how we responded as a country when it’s obvious there have been political influence on testing and data collection. The CDC grouped cv19 with flu and pneumonia in July 2020, labs clearly over reported false positives, PCR testing has been hinted at not being designed for this and WHO changed testing protocol the day after an inauguration. So, it’s hard to trust the numbers, as well as the response to the numbers. None of this includes the many many deaths that occurred in people with major co morbidity. How does your studies account for these issues? Is there a procedure for acknowledging these major issues ?
@Kicapu Is that why my life long best friend who was given three years to live before colon cancer took him in 2010 that survived covid in January 2020 and passed in January 2021 has covid as a "comorbidity" of his death certificate?
His wife and kids want to know why as do I and my family.
Thank you for continuing efforts to keep us informed. One strong recommendation: most of these slides are far too busy to appreciate their content and presenters should design their content to clearly communicate information (not to densely pack-in information). This has been a challenge to this series of talks over the past year. Presenters need to consider what the audience sees and not what they see on their own computer monitors. Also, the moderator could make better use of the screen space: I don’t need to see the presenter when they are discussing their slides; I need to see the content of their slides. Thank you for considering and for your continuing efforts.
In the UK the outbreak of the B.1.1.7 variant was not controlled by vaccines, but by lockdown. The peak in cases was 9th Jan 2021. Vaccinations did not start until 14th Dec. Requiring at least 2 weeks (and 3 weeks for the elderly, who were the first to be vaccinated). The impact of vaccines in controlling the outbreak was miniscule.
The immunity resulting from the vaccines, has slowly made an increasing contribution in maintaining the reduction in cases. The cases are now rising, the underlying trends have been upwards for weeks.
The third wave in Europe is now underway.
For the US it is just starting. The trip point seems to be about 10% prevalence.
These all vaccines are all mistakes.. why are people so freaking cowards.. go out on sun, and fight off the virus.. which we always do for tens of thousands of years.... always relying on drugs by western countries is killing the whole mankind faster now.. 500 years.. the human race will be wiped out from this earth.
The UK is not “doing great”, it’s the hardest hit country in Europe.
Check again after the third wave in EU.
@@tomjohnson4747
You mean the wave that the UK just had? And the wave they are getting over because they cheated their way into getting more vaccines? Ask Boris, he knows.
@@Shelmerdine745 You mean the vaccine EU didn't get because they are being cheap on ordering the vaccine (19:20)? Yeah, not able to secure a vaccine is a part of the failure of the EU. No use to blame anyone else for it.
This was great, please continue this series. Thank you!
Wow Annie is fantastic, best objective presentation on D3/covid so far! Thank You!!! This is the best summary/update available.
Please share the data that clearly shows that vaccines are responsible for affecting the statistics, versus lower infection rates due to prior exposure and reduced testing. I feel it is presumptive to say it is solely driven by vaccinations.
Can you please turn the volume up.
The most basic question on variants unanswered. What are the biological differences of these variants biologically in people? To throw terms like more transmissible without clinical studies makes these pronouncements useless. Do make science and not guesses as you do when you mention statistics and not biology or clinical studies. It's hard to do science but people need science not hypotheses. If one need guesses there is more than enough from CNN MS etc, they're not so good so don't join them. I know science standards under Covid plummeted but the opposite is what we need.
Thank you for your comments.. that's exactly my points too.. Thanks.
The most important human phase
of CV-19 vaccine trials just begun.
Very helpful info. Thank you.
Sturgis could be a big event isn't that deja vu?
Annie, love the info, but please get a better mic. I'm struggling to hear you. Perhaps the stream manager could boost your gain next time?
Immune escape or vaccines resistant mutations likely to occur?
BGates did warn us about the next virus, with his trademark charming smirk on.
The man is brilliant!
Have you seen any studies on Humavir? Or Cell Armour?
"Strain is basically a garbage term these days" 😂
I'm thinking of Professor Vincent Racaniello at Columbia University, who is very adamant about defining "strain" as having distinct biological feature(s) in comparison to the WT.
Thanks for the presentations!!! Especially loved hearing about therapeutics!
@tee vee Why would there be a need for truth and treatments if there wasn't a cause for fear? I get the sense that we're only paying this much attention to covid research because of how harmful the pandemic has been?
@tee vee Close your eyes, ears and most importantly mouth.
@@stellam5872 2.7 million lost to covid out of 7.8 billion is not "harmful" or a pandemic.
50 million PLUS out of 1.7 billion in 1918 was a pandemic and harmful.
Biggest fact of life is death. Get over it and yourself. Live for today, you can die at any time.
@@yourefuked8542 Do you think deaths from wars are harmful?
@@stellam5872 What does the have to do with this tragedy?
But no, it is not "harmful". It is a sad fact of man's inhumanity to man and the repercussion of said inhumanity.
Did you understand what my statement reveals?
It’s the variant.
George, for all my respect for you, I think you are already clearly outdated. We have a clear indication of the fourth wave in the US which is not only Northeast and Midwest but wider as well, rising in some Southern states as well. Of course B.1.1.7 will dominate, it does this in Europe, we can see it. But there is enough data from Brazil to give us a great pause about P.1. Not only that it is faster than B.1.1.7, at least in Brazil, it seems to be as lethal as well. So in the long run when it takes hold we shall see P.1 as our biggest problem, in my view. To deny that these variants are more dangerous is truly foolish, we have enough of data to know that this is the case. I am really getting tired of virologists pretending to know more about Epidemiology than Epidemiologists. For one thing, Epidemiologists know some math and I am yet to find a single virologist to show the most basic math knowledge. Isn't math a requirement in US universities to study Biology? If it is then why do these people think that this is something to be proud of - not knowing any mathematics? Racaniello and his clique seem to be totally incapable of calculating simple ratios and yet they seem to be always ready to comment on models and probabilities. With a consequence of making utterly foolish predictions on almost every turn. How can anybody call himself a scientist without even a modicum of math knowledge is a complete mystery to me.
Why did you not discuss ivermectin??
She did and of course rubbished it. Obviously under instruction to do so. Quoting unsubstantiated claims again. There is not one person who has been harmed by Ivermectin. Four billion doses over 40 years for various parasitic diseases such as river blindness is proof positive of the safety. They talk about people overdosing on veterinarian Ivermectin without a shred of evidence. If it were true they would obviously give the details. They don't. Try yourself to find it online. It does not exist. No names or anything. Repurposed drugs are a no no for these people. Pharma can not make money on repurposed drugs so they and their cronies rubbish them. It's an absolute disgrace and people are dying as a result.
IVERMECTIN WORKS ; DON'T LISTEN TO THE LIARS RUNNING THE COVID PLANDEMIC ; THEY DON'T WANT TO SAVE LIVES ; THEY WANT TO SELL VACCINES AND DESTROY LIVES ;
@Kicapu wrong! Visit flccc and you will be enlightened. Please don't pass along falsehoods without doing your own research.
@Kicapu I am unimpressed. It seems you know nothing about the molecule ivermectin, or you are purposefully attempting to derail it.
Interesting either way. But not helpful to human survival and health at a time of crisis.
She's part of the system. Not acknowledging all the evidence related to Ivermectin efficacy. No Big Pharma money in Ivermectin.
Excellent as usual. Very exciting to think of rapid outpatient treatments becoming available. Especially interesting is Fluoxetine. Cheap(ish) and available. If you work in healthcare, you know this is far from over.
B.I.R.D. UK
19:20 Is saving lives more important or money more important? EU had an answer.
Here in the USA we are giving the drug companies tax dollars to make them richer.
We have given "relief money" to anybody with a hand out.
Me, my fellow tax payers and the next ten generations will be paying for the few with the most to get more of what little the rest of us have.
You just don't get it.
They do, but they like it up the backside.
I had an allergic reaction 7 minutes post jab. Pfizer. first dose. Flushing, disorientation and diarrhea. Please start talking about these reactions.
small: hopefully you were observed as the CDC recommends, and they responded to you effectively. Your reactions, and similar reactions, are what clinicians in facilities doing vaccination are expecting and prepared to address. Speak with your PCP regarding your second dose.
I was well taken care of at the vaccination site and at the er. PCP had no idea what to say other than hi so an allergist.
@tee vee It does not have to to be 100X, even 2000 deaths is already too much and it's already freaking hideously Genocides.... people need to be brought to justice here soon. Not even deaths, even the disabled cases are already adequate enough to lock them all these bastards for life.
@tee vee I have lost lot of old friends due to covid.. not becuase they died due to covid, but because of how MSM and govts brainwashed them and they are afraid to hear my arguments against those narratives. And they are lazy to research themselves the facts, instead simply being gullible to believe MSM media and govts.
@@smallhitchfarm9090 According to their narratives, your flushing, disorientation and diarrhea are not due to covid vaccine. Do you still believe this fucking narrative? They are ruining the human race... For lot of people , it's like Living today, Living tomorrow.. they are going to kill all of us soon.. at this rate...
Why no ivermectin
I agree. Anyone wanting to learn more about it, visit flccc website. They have videos and videos of its efficacy.
The folks in charge wouldn't be able to get their vaccine pushed under EUA with this info out in the public sphere. Be careful and do your research; connect the dots; put the puzzle pieces together. No need for the fear and panic.
Because it works
Eastern Europe didn’t really have a first wave, so it’s a comparatively naive population.
This is true. Also Germany was relatively lightly hit during the first wave. But both France and Italy were badly hit by the first wave and are once again hit badly.
Why?
@@christopherrobinson7541
Well, it actually looks more like the UK just got through their third wave and that it now hits the EU.
Why? Because people constantly stop following the guidelines.
@@christopherrobinson7541 "are once again hit badly.
Why?"
Because social/news media are using scare the shit out of you sensationalism.
2.7 million lost to covid out of 7.8 billion is not "harmful" or a pandemic.
50 million PLUS out of 1.7 billion in 1918 was a pandemic and harmful.
Biggest fact of life is death. Get over it and yourself. Live for today, you can die at any time.
The 3rd wave in Europe is being driven by the B.1.1.7 variant becoming dominant. When the prevalence of the variant reached 10% in the UK the cases accelerated rapidly, the doubling rate was down to 10 days. In one month the deads doubled and we lost 50,000 additional lives (the equivalent of 250,000 in the US).
Despite having achieved over 50% immunity (by natural infection and vaccination) and being in strict lockdown since 26th Dec, the cases in UK are beginning to rise.
As now they are in the US.
The prevalence of the B.1.1.7 variant in the US is still relatively low, just under 10% in the states with the mosts cases (Florida, Michigan , etc). I think that the US could suffer a 3rd wave similar to that in the UK and some other European countries (Spain, Ireland and Portugal) last year, and now most of the other countries in Europe.
@@christopherrobinson7541
It’s being driven by stupid people and by opening up too soon, just like in the UK. There is no proof that any variant is causing anything like that.
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The Colombia-originated JAMA paper on ivm quoted at about 32:20 is really funny, and not in a good way.
Check out jamaletter dor com.
I thought this was common knowledge. Ask your pharma rep, doctor, again.