Hello everyone! I have enjoyed reading the comments and questions, and I appreciate the nice feedback. I will spend 2-3 hours each week responding to general scientific questions in the discussion. I probably won't be able to get to everything, but I encourage you to post your thoughts and ideas because I will read everything. Thanks! - Jarred Younger
THANK-YOU FOR YOUR RESEARCH AND CONTRIBUTIONS TO A FIELD THAT SO MANY OF US ARE DESPERATELY SEEKING ANSWERS TO. FOR MANY OF USEWE HAVE BEEN RESEARCHING ON OUR OWN TO FIND ANSWERS TO HELP US. WE NEED MORE PEOPLE LIKE YOU.
what drug did you say? Dextro... I think it would be ideal if you put some keynote form stuff you are going to go over in your video. It probably would help a lot of people or they may actually appreciate it like I would. I also like videos that give key information and don't lang on.. people with CFS, fibromyalgia etc aren't into listening to something long drawn out.. we want to get to the point of the matter.
okay listened to this 7 times to hear what the drug was.. and NOTHING. This is why it may be great to write out the keywords in your description box otherwise.. why tune in.. ya know..
Thank you for posting these updates, they're always so fascinating 🙂 It's also a lovely reminder that there are people out there that are working tirelessly to help us all 💖
🥳 good stuff! As a prototypical M.E. patient who is always far away from anything interesting, this is nice to hear. ..Someone needs to grab me for testing before I get some comorbid's 😆😝 ,my pure M.E. is going to waste.
Please use a ME/CFS patient that developed their illness after contracting a severe case of Epstein Barr virus. (The most common trigger for ME/CFS). Please!!!!!! 🙏
These have become my favorite videos to follow and give me hope about healing for better managing fibromyalgia and long covid symptoms. Love your work.
This is exciting news! I am really looking forward to this research because I have been diagnosed with moderately severe ME/CFS and experience a great deal of cognitive issues. Thank you for all of the work you do! Let us know when you will accept patients from out of state. I’d be interested in getting this scan.
Thanks! If the first scans suggest this is a promising line of research, we will obtain additional funding and expand the reach for participants. The out of state visits are a bit trickier with this PET scan than our MRI scans because the visit will need to be 3-4 days (where the MRI can be done in a single day), but it could be done. - Jarred Younger
Are you going to run the scans on people before and after exertion. To check how much the brain is inflamed from PEM. As it could be the case that we could look normal on the scan while we're not in a crash. I guess what I'm thinking is could you do the two-day cpat and do the scans to check what's happening as a consequence of the exertion.
Diagnosed in 2003 when ME/CFS was CFS. Also have Fibromyalgia,some viruses, infections,etc. Very grateful for your work and look forward to solutions for all of us!
Thank you so much for everything you're all doing. It's greatly appreciated. Thanks to people like you, we may find out what our bodies are doing and find treatments/cures to give us our lives back, although I'd settle for an improvement in quality of day to day life.
Great news! I just keep getting new prescriptions to try. Fibromyalgia, ME/CFS, PEM, etc. Only blood tests to see if any muscle is inflamed. Thank you for doing all of this!
Would love to see Dr. Alain Moreau run MicroRNAs on your patients to identify and stratify them- and then run the scans according to the group clusters. :) (ME/CFS has MicroRNAs, and so does MDD)
Dr Younger, this is so exciting - thank you for all you do! Question: Do I understand that an effective treatment for leukocyte infiltration "might" be available already? And that dextro-naltrexone, by contrast, would need to go through years and years of clinical trials?
Why would .5mg LDN cause its own unique persistent headahce in a chronic migraine patient with CFS? Shouldn't that itself provide some important clues? Thanks for your groundbreaking work. I'm looking forward to the Dextranaltrexone info.
Looking for the results . Please is there a way to be informed when you can officially communicate the results of imaging I’m a 1st year med student with chronic fatigue and treated sleep apnea and I’m very interested with your hypothesis on the role of peripheral immune cells in me cfs symptoms
I'm very interested in hearing about the results of your scan in the coming months hopefully. But I do have one thing that I thought of which is that if with ME/CFS (and other illness patients) are expected to have the leukocytes infiltrating the brain, and the way you're visualizing them is by making them radioactive, would doing this test potentially increase lifetime risk for brain cancer (due to the radioactive leukocytes going into and hanging out in the brain)? I know this is not the primary thing you're researching but I do think it'd be good to follow patients long-term to see whether having this test done (specifically in the patients where the radioactive leukocytes actually get into the brain) increases risk of brain cancer. I know it's pretty unlikely that this test will become a test seen in clinical practice any time within our lives (if ever), however it may be a very important research test not just in the ME/CFS & Fibro research spaces, but beyond. It's a very interesting and innovative test! So having this long-term follow-up on safety would be very good, just confirming that the lifetime brain cancer risk doesn't go up much due to having radioactive cells right there in the brain. And I'm sorry that this whole message is kind of a mess, I'm PEM'd currently and I'm struggling to get my thoughts out properly. I hope you understand what I'm trying to say, but if not please tell me and I'll try my best to explain better (perhaps when my brain's doing a bit better...)
That is a very good question. Yes, it is very important to make sure the total radioactive dosage is within safe limits. That is the main role for the FDA in asking for additional testing. We keep the total exposure below 25 millisieverts, which is the amount for a typical PET/CT scan used routinely in hospitals/clinics. This is considered a very safe level that is appropriate for medical imaging. There is quite a bit of good research looking at PET scans and increased risk of cancer. It would be contraindicated only in individuals who have other exposures (such as through work involving hazardous materials) where we just don't want to add more to an already high exposure. - Jarred Younger
Great to hear! Will you be inducing symptoms through excursion to increase the signal? Of course, the patient would have to agree to the PEM and to be scanned while In a crash.
For the first few participants, we will try to scan individuals during a PEM crash, but we won't be inducing it ourselves. After we have a good idea what the imaging generally looks like, we can try some experimental exacerbations. - Jarred Younger
@@youngerlab Great! Thanks for the response. To outsiders unfamiliar with these diseases it might sound "cruel" to induce PEM, but many knowledgable patients would love to have data while in crash since good days might look "normal" on tests.
@@youngerlab Very good. For me personally there's such a huge difference in neuro/cognitive/mood symptoms when in PEM. Definitely want to scan during PEM!
Wonderful! For those of us w lcov, mecfs, is we go outside our baseline, ust up too many "energy units"@youngerlab or "spoons",, crash is guaranteed, but some times can come a few days later, tu for all 💞💞
Thanks for your update. It’s pretty exciting ! It must be a bit nerve wracking for you Dr Younger (or is it Professor?), to get this first scan under way. Good luck and I really hope your hypothesis is correct.
Thanks! My favorite part is when we get to see the results. It feels like years of work being condensed into a few seconds. Yep, you are right about the title. For some reason, we don't use the Professor title very much in the U.S. as in the U.K., even when we obtain the rank. I visited Scotland a long time ago to talk to a Department Chair. I was an undergrad at the time. I asked for Dr. Morris, and I think the administration staff nearly threw me out of the building because I didn't say Professor Morris. :-D Now I know better. - Jarred Younger
Dr. Younger - thank you for this content. Fascinating project. One question - you had mentioned in a previous video that one potential cause of ongoing MECFS symptoms was chronically activated microglia. Could leukocytes in the brain cause the microglia to perpetually remain in an activated state?
Good question. Yes, an infiltrating leukocyte would almost certainly cause microglia to adopt a proinflammatory state. Also interesting is that it could work the other way as well. The microglia could be activated in a way that they open the blood-brain barrier and help the leukocytes to enter the brain. If we find leukocytes in the brain with this scan, we will have to figure out the order of events. - Jarred Younger
Thanks for your work! I'm really interested in understanding how you explain the delayed post-exercise impairment (PENE) in ME/CFS with the "stuck microglia" theory? Why do these reactions often occur after a time delay?
The results from animal models suggest that microglia penetrate the blood-brain barrier about 3 days following the inciting event. If the timeframe is the same for humans, that could explain the delay. - Jarred Younger
@@youngerlab Thank you for the answer, very interesting! I think it is one of the most important things to find out which mechanism causes the PENE, especially in relation to the delayed onset of the worsening of the symptoms and the potential cover-up of this worsening by adrenaline. I really hope the ICC or at least CCC will be used to determine the ME patients for your studies (no Fukuda or IOM). It would be such a waste of resources to have a group of patients with different diseases.
Yep! The default case criteria I use now is ME-ICC, but I assess the other definitions as well. We will likely run both people who show post-exertional malaise and those who do not so we can identify differences. - Jarred Younger
I would be happy to volunteer. Suffering from long covid & long vaxx - essentially spike protein toxicity. Cognitive problems, fatigue, tinnitis, and other neurological symptoms. Please reach out if you would conside including me in the trials!
I see you sort of answered that at 7:32! Please consider studying persons with MSA. Close to my heart as my father passed frm what used to be called Shy-Drager syndrome.
It is different. It has a key difference that I think will make it more effective than naltrexone/LDN, and a difference that will increase the percentage of responders. Stop by the channel this coming Monday and I'll have the video about it released! - Jarred Younger
My mother s severe ms started at grandmother's funeral i have cfs fybromyalgia both had have autism thats rhe cause un autism ADHD fir sure with food sleep
Hay doc are you aware of the effects on the body and mind from ultra processed foods everywhere in our society? Excessive carb/sugar and seed oils along with frequent meals are effecting us and that drugs may not be the answer. healing for the vast majority of people should start with diet and exercise, relaxation, sleep improvement it may not be sexy or ultra brain’y or payout big time for the medical industrial complex and big food industrial complex but it may reduce pain and suffering in the population. That would be a truly noble goal…
So tru Sarah myhill is a good doctor on this has it helped your pain it's highly comorbid with autism ADHD heds causation for cefs myself diagnosed late after loosing my son to severe ms now my sins diagnosed
Lost my mum to severe ms hut the cause is autism started at my grandmother s funeral stress in autism causes autoimmune ehat do you make rccx gene theory i have fybromyalgia or chronic bidy migraine
100% correct. You can treat pain and other symptoms that are caused by your spine being out of alignment with drugs. Drugs treat the symptoms and not the root. The "cure" is to go to a good chiropractor and get adjusted. I think we are out of whack and that we just need some sort of adjustment after which no drugs would be required.
This is so wonderful, w lc/me/cfs, a crash is not hard to come by, since we deal. In energy" units" often called "spoons", (mitochondrial dysfunction), I get mine within a few hrs, but some have occurrence , days later, it got all 🙏❤️
Why can't you do histology tests and chemical analysis on patients that have just died to find out of they have any traces of leukocytes? I would think that this would be the first step leading to the hypothesis rather than jumping in to full blow work on live patients. Also, is it rock solid that leukocytes cannot pass the BBR in all scenarios in a normal healthy patient? Maybe many diseases of the brain are related to some type of pathogen and under certain circumstances they can enter the brain to deal with it? The problem I see with my limited understanding of your hypothesis and method is that you may not find any evidence when, in fact, it is true. This is because you may simple get many false negatives in a row by sheer coincidence or specific circumstances leading you to think the hypothesis is false(you do mention this but you only will try "a few more patients"). Is there any postmortem evidence that backs up your hypothesis?
Good points. There are many relevant questions I think can be answered with postmortem analyses. My main concern with using postmortem samples for this particular question is that microglia would react quickly and severely to the sudden lack of oxygen perfusion at death. I suspect BBB leakage would occur far faster than someone would be able to sample the relevant tissue. The patient would have to be already in the hospital with the relevant medical personnel ready to go right at time of death, which would be atypical for an individual with ME/CFS unless they had significant comorbidities. Having said all that, there are a couple of groups that have incorporated postmortem analyses, and I can ask them what samples and analyses are in their protocol. You're right that there are some cases of leukocytes entering the healthy brain, at least transiently. They may be brought into the CNS quickly to survey the CNS to learn self-versus-other. And in diseased brains, leukocytes can be requested by microglia to enter the CNS and aid in severe damage or infection. And I agree the risk in this study is scanning the wrong people or scanning them at the wrong time. We will be scanning over 20 people in the first go, and select individuals who are most likely to show the effect due to their symptoms (e.g., acute exacerbation or symptom "flare"). It would be a huge shame to miss a true effect because of timing - e.g., running people when they are in some sort of remission and the leukocytes have left the brain. - Jarred Younger
@@youngerlab I hope you can find the smoking gun but as you obviously know that it is rarely that easy. But the more data/evidence will eventually reveal something. To be honest, the entire medical system needs to be reworked so that 1. It is not for profit. 2. Modern techniques are used that are far more optimal. I'd like to personally see a massive database of all data collected open to the public with the public also being able to fill in their own data such as their experiences/feelings, behaviors, non-prescribed drug use, anything they want at any time. The more data that is collected the more it will reveal problems(such as common external factors that are simply overlooked/ignored because people think they can't be causal when they are). E.g., maybe a certain type of toothpaste used + a certain blood type + a certain orange juice concentrate used when done regularly causes Crohn's disease in a certain class of people with certain genetic abnormalities. Our current medical system will never pick up such things but with enough data it would be easy to find such connections. We have the technology to do such a thing. E.g., I'd like to see an "app" where a person can at any time put in any info(no matter how seemingly irrelevant) with the goal for them to do daily entries(or even more) talking about how they feel, what they did, any changes in medications, etc. Any type of active monitoring like automatic glucose monitoring or blood pressure, etc are all added automatically in to their data set. Again, with enough data and basic probability analysis one will be able to find the high correlational. X + Y + ... + Z -> Q. [and if there is a negative result, no correlation for Q then that suggests internal or genetic issues but even these could potentially be found with enough data] If humanity would focus more on sane things rather than warring, profiteering, etc such a thing could exist and it would be a huge change in how medicine is actually done. After a few generations pretty much most of the health issues of humans can be dealt with because one would actually understand casual links and just how external factors drive disease. E.g., if one had a few hundred million profiles from childhood to old age of people putting in daily health related information along with medical data imagine what could be done! Also, the "app" could be retroactive like "Have you been eating lettuce X for the last 6 months without mentioning it? We have a potential link between it and diseases because there is a high correlation between other users with similar characteristic as yours except for lettuce X". [and obviously over time the software, techniques, and usage would become more refined making it even more powerful] Essentially it is taking what the medical system already does on some level to the extreme. [and it should be done outside government or capitalistic controls since it will be abused by them]
Well you're thinking along the same lines as my lab. :-) My graduate student Indonesia Jordan is doing her dissertation defense this semester on brain and peripheral blood glutamate and glutamine in the context of neuroinflammatory pain and fatigue. After her dissertation defense in a couple of months, I'll do a talk on the main points from that research. - Jarred Younger
@@youngerlab Great, thank you. I've deduced just from self analysis that I have a major glutamate sensitivity. A lot of my chronic fatigue symptoms came on at the same time as things vaguely associated with high glutamate (unnaturally fast reflexes, etc). I took an AMPA pam and crashed harder than ever. I respond particularly well to things that lower glutamate. I also just read a a CFS/Long covid study recently released that showed extremely high levels of glutamate
Hello everyone! I have enjoyed reading the comments and questions, and I appreciate the nice feedback. I will spend 2-3 hours each week responding to general scientific questions in the discussion. I probably won't be able to get to everything, but I encourage you to post your thoughts and ideas because I will read everything. Thanks! - Jarred Younger
THANK-YOU FOR YOUR RESEARCH AND CONTRIBUTIONS TO A FIELD THAT SO MANY OF US ARE DESPERATELY SEEKING ANSWERS TO. FOR MANY OF USEWE HAVE BEEN RESEARCHING ON OUR OWN TO FIND ANSWERS TO HELP US. WE NEED MORE PEOPLE LIKE YOU.
what drug did you say? Dextro...
I think it would be ideal if you put some keynote form stuff you are going to go over in your video.
It probably would help a lot of people or they may actually appreciate it like I would.
I also like videos that give key information and don't lang on..
people with CFS, fibromyalgia etc aren't into listening to something long drawn out.. we want to get to the point of the matter.
okay listened to this 7 times to hear what the drug was.. and NOTHING.
This is why it may be great to write out the keywords in your description box otherwise.. why tune in.. ya know..
@@SunshineGrove04 dextro-naltrexone
Thank you for posting these updates, they're always so fascinating 🙂 It's also a lovely reminder that there are people out there that are working tirelessly to help us all 💖
🥳 good stuff!
As a prototypical M.E. patient who is always far away from anything interesting, this is nice to hear. ..Someone needs to grab me for testing before I get some comorbid's 😆😝 ,my pure M.E. is going to waste.
As a biologist, I love seeing you push the boundaries. Not the same old stuff over and over. Really great to see you pressing forward!
Please use a ME/CFS patient that developed their illness after contracting a severe case of Epstein Barr virus. (The most common trigger for ME/CFS). Please!!!!!! 🙏
These have become my favorite videos to follow and give me hope about healing for better managing fibromyalgia and long covid symptoms. Love your work.
How exciting! It would be great to figure out why I have fibromyalgia. Good luck with this Dr. Younger!
This is exciting news! I am really looking forward to this research because I have been diagnosed with moderately severe ME/CFS and experience a great deal of cognitive issues. Thank you for all of the work you do! Let us know when you will accept patients from out of state. I’d be interested in getting this scan.
Thanks! If the first scans suggest this is a promising line of research, we will obtain additional funding and expand the reach for participants. The out of state visits are a bit trickier with this PET scan than our MRI scans because the visit will need to be 3-4 days (where the MRI can be done in a single day), but it could be done. - Jarred Younger
Are you going to run the scans on people before and after exertion. To check how much the brain is inflamed from PEM. As it could be the case that we could look normal on the scan while we're not in a crash. I guess what I'm thinking is could you do the two-day cpat and do the scans to check what's happening as a consequence of the exertion.
This is exciting news! I have had fibromyalgia syndrome for 45 years and this gives me hope that my pain can be treated.
Thanks Dr Younger! Good luck!
Can’t wait to hear the results - good luck!
Super interesting! You are definitely on the front line. Wish I could physically come and see your lab and it’s work. Would be very interesting to me😊
I am super excited by your work. I love your approach and humility. Once again Thank you to you and your team 💙🙏🏼💙
Very exciting!!
Diagnosed in 2003 when ME/CFS was CFS. Also have Fibromyalgia,some viruses, infections,etc. Very grateful for your work and look forward to solutions for all of us!
1997 neurosthenia CFS fybromyalgia 7 autism 43 heds are you hypermobile cause is the autism ADHD
Thank you so much for everything you're all doing. It's greatly appreciated. Thanks to people like you, we may find out what our bodies are doing and find treatments/cures to give us our lives back, although I'd settle for an improvement in quality of day to day life.
Good luck!!!
Love your work! So exciting.
Wish I lived closer to Alabama! Good luck!
You give me hope when I mostly feel like giving up...
Great news! I just keep getting new prescriptions to try. Fibromyalgia, ME/CFS, PEM, etc. Only blood tests to see if any muscle is inflamed. Thank you for doing all of this!
Do you have hypomobility
will you be doing the scans both without and during PEM on each patient as well?
🎉🎉🎉Looking forward to your Dextronaltrexone!🎉🎉🎉🙏🏻
Would love to see Dr. Alain Moreau run MicroRNAs on your patients to identify and stratify them- and then run the scans according to the group clusters. :) (ME/CFS has MicroRNAs, and so does MDD)
Congrats on the awesome news!!! 🎉
Very exciting! Keep up the good work
Whenever you say good news, I feel hope. Thanks for all the work you and your team do.
Dr Younger, this is so exciting - thank you for all you do! Question: Do I understand that an effective treatment for leukocyte infiltration "might" be available already? And that dextro-naltrexone, by contrast, would need to go through years and years of clinical trials?
What made you want to tackle things like ME/CFS, fibro, and LC? Thank you for all you’re doing!
Yay, good luck!
This is very exciting. So grateful for your work
Well done! 👍🏻
Great news! I really appreciate all your videos.
Why would .5mg LDN cause its own unique persistent headahce in a chronic migraine patient with CFS? Shouldn't that itself provide some important clues? Thanks for your groundbreaking work. I'm looking forward to the Dextranaltrexone info.
This is great news, biomarkers can't come soon enough. I wish you the best for this research.
Looking for the results . Please is there a way to be informed when you can officially communicate the results of imaging I’m a 1st year med student with chronic fatigue and treated sleep apnea and I’m very interested with your hypothesis on the role of peripheral immune cells in me cfs symptoms
In my mind I see you writing the last of 30 X-es on the wall of the lab and doing a little victory dance ;)
Ha! I have a bit of space on my wall -- so, next time! - Jarred Younger
I'm very interested in hearing about the results of your scan in the coming months hopefully. But I do have one thing that I thought of which is that if with ME/CFS (and other illness patients) are expected to have the leukocytes infiltrating the brain, and the way you're visualizing them is by making them radioactive, would doing this test potentially increase lifetime risk for brain cancer (due to the radioactive leukocytes going into and hanging out in the brain)?
I know this is not the primary thing you're researching but I do think it'd be good to follow patients long-term to see whether having this test done (specifically in the patients where the radioactive leukocytes actually get into the brain) increases risk of brain cancer.
I know it's pretty unlikely that this test will become a test seen in clinical practice any time within our lives (if ever), however it may be a very important research test not just in the ME/CFS & Fibro research spaces, but beyond. It's a very interesting and innovative test! So having this long-term follow-up on safety would be very good, just confirming that the lifetime brain cancer risk doesn't go up much due to having radioactive cells right there in the brain.
And I'm sorry that this whole message is kind of a mess, I'm PEM'd currently and I'm struggling to get my thoughts out properly. I hope you understand what I'm trying to say, but if not please tell me and I'll try my best to explain better (perhaps when my brain's doing a bit better...)
That is a very good question. Yes, it is very important to make sure the total radioactive dosage is within safe limits. That is the main role for the FDA in asking for additional testing. We keep the total exposure below 25 millisieverts, which is the amount for a typical PET/CT scan used routinely in hospitals/clinics. This is considered a very safe level that is appropriate for medical imaging. There is quite a bit of good research looking at PET scans and increased risk of cancer. It would be contraindicated only in individuals who have other exposures (such as through work involving hazardous materials) where we just don't want to add more to an already high exposure. - Jarred Younger
😢SO EXCITED
TO HEAR MORE ABOUT YOUR RESEARCH AND FINDINGS!!!!
Any updates on the timeline for this? Super excited to hear what you all find! Thank you for your work.
Yay! Good luck! Can't wait for the update 🎉
Dr. Younger, You are a rock star! Thank you
Great to hear! Will you be inducing symptoms through excursion to increase the signal? Of course, the patient would have to agree to the PEM and to be scanned while In a crash.
For the first few participants, we will try to scan individuals during a PEM crash, but we won't be inducing it ourselves. After we have a good idea what the imaging generally looks like, we can try some experimental exacerbations. - Jarred Younger
@@youngerlab Great! Thanks for the response. To outsiders unfamiliar with these diseases it might sound "cruel" to induce PEM, but many knowledgable patients would love to have data while in crash since good days might look "normal" on tests.
@@youngerlab Very good. For me personally there's such a huge difference in neuro/cognitive/mood symptoms when in PEM. Definitely want to scan during PEM!
Wonderful! For those of us w lcov, mecfs, is we go outside our baseline, ust up too many "energy units"@youngerlab or "spoons",, crash is guaranteed, but some times can come a few days later, tu for all 💞💞
Nicotine apparently can lower macrophage infiltration into the brain. Might it also help with leukocytes?
How is dextro naltrexone different from LDN? Will it still have the same effect on breakthrough depression? Will it be better for pain and fatigue?
dextro naltrexone doesnt interact with opioid receptors and might potentially be more powerful with less side effects.
Thanks for your update. It’s pretty exciting ! It must be a bit nerve wracking for you Dr Younger (or is it Professor?), to get this first scan under way. Good luck and I really hope your hypothesis is correct.
Thanks! My favorite part is when we get to see the results. It feels like years of work being condensed into a few seconds. Yep, you are right about the title. For some reason, we don't use the Professor title very much in the U.S. as in the U.K., even when we obtain the rank. I visited Scotland a long time ago to talk to a Department Chair. I was an undergrad at the time. I asked for Dr. Morris, and I think the administration staff nearly threw me out of the building because I didn't say Professor Morris. :-D Now I know better. - Jarred Younger
This is amazing.
Dr. Younger - thank you for this content. Fascinating project. One question - you had mentioned in a previous video that one potential cause of ongoing MECFS symptoms was chronically activated microglia. Could leukocytes in the brain cause the microglia to perpetually remain in an activated state?
Good question. Yes, an infiltrating leukocyte would almost certainly cause microglia to adopt a proinflammatory state. Also interesting is that it could work the other way as well. The microglia could be activated in a way that they open the blood-brain barrier and help the leukocytes to enter the brain. If we find leukocytes in the brain with this scan, we will have to figure out the order of events. - Jarred Younger
What about minocycline or low dose doxycycline for neuroinflammation? Thanks for all your great work.
very cool!
Thanks for your work! I'm really interested in understanding how you explain the delayed post-exercise impairment (PENE) in ME/CFS with the "stuck microglia" theory? Why do these reactions often occur after a time delay?
The results from animal models suggest that microglia penetrate the blood-brain barrier about 3 days following the inciting event. If the timeframe is the same for humans, that could explain the delay. - Jarred Younger
@@youngerlab Wow, fascinating!
@@youngerlab Thank you for the answer, very interesting! I think it is one of the most important things to find out which mechanism causes the PENE, especially in relation to the delayed onset of the worsening of the symptoms and the potential cover-up of this worsening by adrenaline.
I really hope the ICC or at least CCC will be used to determine the ME patients for your studies (no Fukuda or IOM). It would be such a waste of resources to have a group of patients with different diseases.
@@youngerlab What would I search to learn more about this mechanism in animals?
Please use MEICC to stratify research subjects so we are actually studying people w ME.
Yep! The default case criteria I use now is ME-ICC, but I assess the other definitions as well. We will likely run both people who show post-exertional malaise and those who do not so we can identify differences. - Jarred Younger
@@youngerlab Much gratitude. I can appreciate looking at differences in different categories of ME.
I would be happy to volunteer. Suffering from long covid & long vaxx - essentially spike protein toxicity. Cognitive problems, fatigue, tinnitis, and other neurological symptoms. Please reach out if you would conside including me in the trials!
“Neuroinflammation”..any connection at all to demyelinating brain disorders and the group of disorders under the umbrella of MSA?
I see you sort of answered that at 7:32! Please consider studying persons with MSA. Close to my heart as my father passed frm what used to be called Shy-Drager syndrome.
Lost my mum to severe ms last year I have fybromyalgia both have autism heds my father has CFS to but lit better 75 40.
Is Dextro-Naltrexone the same as Naltrexone, taken as Low Dose Naltrexone?
I was asking the same question on several different Web site and no one answer me
It is different. It has a key difference that I think will make it more effective than naltrexone/LDN, and a difference that will increase the percentage of responders. Stop by the channel this coming Monday and I'll have the video about it released! - Jarred Younger
@@youngerlabThanks for your response, I will stay tuned in
@@youngerlab Can't wait, thanks Dr. Younger!
🎉🎉🎉❤
IAM THE PERFECT PERFECT PATIENT
My mother s severe ms started at grandmother's funeral i have cfs fybromyalgia both had have autism thats rhe cause un autism ADHD fir sure with food sleep
Hay doc are you aware of the effects on the body and mind from ultra processed foods everywhere in our society? Excessive carb/sugar and seed oils along with frequent meals are effecting us and that drugs may not be the answer. healing for the vast majority of people should start with diet and exercise, relaxation, sleep improvement it may not be sexy or ultra brain’y or payout big time for the medical industrial complex and big food industrial complex but it may reduce pain and suffering in the population. That would be a truly noble goal…
So tru Sarah myhill is a good doctor on this has it helped your pain it's highly comorbid with autism ADHD heds causation for cefs myself diagnosed late after loosing my son to severe ms now my sins diagnosed
Also Dr schubiner says it's all stress in subconscious mind
Lost my mum to severe ms hut the cause is autism started at my grandmother s funeral stress in autism causes autoimmune ehat do you make rccx gene theory i have fybromyalgia or chronic bidy migraine
Great more pharma!! 😅. Maybe its time big pharma hit the road. Lets face truth
100% correct. You can treat pain and other symptoms that are caused by your spine being out of alignment with drugs. Drugs treat the symptoms and not the root. The "cure" is to go to a good chiropractor and get adjusted. I think we are out of whack and that we just need some sort of adjustment after which no drugs would be required.
This is so wonderful, w lc/me/cfs, a crash is not hard to come by, since we deal. In energy" units" often called "spoons", (mitochondrial dysfunction), I get mine within a few hrs, but some have occurrence , days later, it got all 🙏❤️
@@brendabrenner2891do you have much chronic muscle pain
Why can't you do histology tests and chemical analysis on patients that have just died to find out of they have any traces of leukocytes? I would think that this would be the first step leading to the hypothesis rather than jumping in to full blow work on live patients.
Also, is it rock solid that leukocytes cannot pass the BBR in all scenarios in a normal healthy patient? Maybe many diseases of the brain are related to some type of pathogen and under certain circumstances they can enter the brain to deal with it?
The problem I see with my limited understanding of your hypothesis and method is that you may not find any evidence when, in fact, it is true. This is because you may simple get many false negatives in a row by sheer coincidence or specific circumstances leading you to think the hypothesis is false(you do mention this but you only will try "a few more patients").
Is there any postmortem evidence that backs up your hypothesis?
Good points. There are many relevant questions I think can be answered with postmortem analyses. My main concern with using postmortem samples for this particular question is that microglia would react quickly and severely to the sudden lack of oxygen perfusion at death. I suspect BBB leakage would occur far faster than someone would be able to sample the relevant tissue. The patient would have to be already in the hospital with the relevant medical personnel ready to go right at time of death, which would be atypical for an individual with ME/CFS unless they had significant comorbidities. Having said all that, there are a couple of groups that have incorporated postmortem analyses, and I can ask them what samples and analyses are in their protocol.
You're right that there are some cases of leukocytes entering the healthy brain, at least transiently. They may be brought into the CNS quickly to survey the CNS to learn self-versus-other. And in diseased brains, leukocytes can be requested by microglia to enter the CNS and aid in severe damage or infection.
And I agree the risk in this study is scanning the wrong people or scanning them at the wrong time. We will be scanning over 20 people in the first go, and select individuals who are most likely to show the effect due to their symptoms (e.g., acute exacerbation or symptom "flare"). It would be a huge shame to miss a true effect because of timing - e.g., running people when they are in some sort of remission and the leukocytes have left the brain. - Jarred Younger
@@youngerlab
I hope you can find the smoking gun but as you obviously know that it is rarely that easy. But the more data/evidence will eventually reveal something.
To be honest, the entire medical system needs to be reworked so that 1. It is not for profit. 2. Modern techniques are used that are far more optimal.
I'd like to personally see a massive database of all data collected open to the public with the public also being able to fill in their own data such as their experiences/feelings, behaviors, non-prescribed drug use, anything they want at any time.
The more data that is collected the more it will reveal problems(such as common external factors that are simply overlooked/ignored because people think they can't be causal when they are). E.g., maybe a certain type of toothpaste used + a certain blood type + a certain orange juice concentrate used when done regularly causes Crohn's disease in a certain class of people with certain genetic abnormalities. Our current medical system will never pick up such things but with enough data it would be easy to find such connections. We have the technology to do such a thing.
E.g., I'd like to see an "app" where a person can at any time put in any info(no matter how seemingly irrelevant) with the goal for them to do daily entries(or even more) talking about how they feel, what they did, any changes in medications, etc. Any type of active monitoring like automatic glucose monitoring or blood pressure, etc are all added automatically in to their data set.
Again, with enough data and basic probability analysis one will be able to find the high correlational. X + Y + ... + Z -> Q. [and if there is a negative result, no correlation for Q then that suggests internal or genetic issues but even these could potentially be found with enough data]
If humanity would focus more on sane things rather than warring, profiteering, etc such a thing could exist and it would be a huge change in how medicine is actually done. After a few generations pretty much most of the health issues of humans can be dealt with because one would actually understand casual links and just how external factors drive disease.
E.g., if one had a few hundred million profiles from childhood to old age of people putting in daily health related information along with medical data imagine what could be done! Also, the "app" could be retroactive like "Have you been eating lettuce X for the last 6 months without mentioning it? We have a potential link between it and diseases because there is a high correlation between other users with similar characteristic as yours except for lettuce X". [and obviously over time the software, techniques, and usage would become more refined making it even more powerful]
Essentially it is taking what the medical system already does on some level to the extreme. [and it should be done outside government or capitalistic controls since it will be abused by them]
Could you ever do a video about glutamate in the context of neuroinflammation?
Well you're thinking along the same lines as my lab. :-) My graduate student Indonesia Jordan is doing her dissertation defense this semester on brain and peripheral blood glutamate and glutamine in the context of neuroinflammatory pain and fatigue. After her dissertation defense in a couple of months, I'll do a talk on the main points from that research. - Jarred Younger
@@youngerlab Great, thank you. I've deduced just from self analysis that I have a major glutamate sensitivity. A lot of my chronic fatigue symptoms came on at the same time as things vaguely associated with high glutamate (unnaturally fast reflexes, etc). I took an AMPA pam and crashed harder than ever. I respond particularly well to things that lower glutamate. I also just read a a CFS/Long covid study recently released that showed extremely high levels of glutamate
Much success!
Lyme disease, please!
YES!!!!