CRISPR: A Gene-Editing Superpower
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- Опубликовано: 26 сен 2024
- Any molecular biologist will tell you that genetic engineering is tricky. But up until recently we might be witnessing a new age in human development.
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Fuck ethics, I want my super powers.
Aaaaaaand the world's first super villain was created ...
Nigga is just keepin it real
They're more likely to use it for ethnic cleansing
+Eric B- a Moor especially if you can edit an embryo.
SuperSalazar94 like my little bro?
Kurzgesagt's video about this is also very informative.
Yep, their videos are really good :D
+EstherTheNicey Yes and this is good additive.
Could you send the link?
Kurzgesagt. Does investigate it more thoroughly than scishow
+William Lag Kurzgesagt just adresses more the ethical issue. Science show is more historical and technical here
CRISPR is simultaneously the coolest and most frightening thing I've ever heard of.
Coolest yes, but not as frightening as VR porn. That will be the fall of mankind.
+The Saitama it could help with the overpopulation
Much like my sex life.
I feel like when people heard about the atomic power for the first time. Biology is really what physics was to 20th century.
the problem is that it is too easy to get.
can CRISPR remove the hair on my butt
probably, but a razor or hot wax would do just fine.
>implying anyone would want to have their ass waxed
but it will regrow
This should be a mandatory gene edit by the 22nd century.
implying that im comfortable with having a razor near my ass.
I had a teacher who was obsessed with CRISPR cas9. He'd make us recite Clustered Regularly Interspaced Short Palindromic Repeat ("Just rolls off the tongue") every day and tell us to tell it to our parents at he dinner table. He wouldn't tell us what it did or how. Really appreciate the insight in the video!
As someone who's planning to become a biochemist, I find this extremely interesting and exciting.
You a biochemist now?
18th century : industrial revolution
19th century : electrical revolution
20th century : medical and computing revolution
21st century : TBD
21rst?
21st: Intelligence/Transhumanist Revolution
Science fiction is science pending.
At the rate of innovation across multiple different fields, I foresee multiple revolutions within the 21th century.
+Jus10Ed You knew what he/her meant.
I loved this video! I actually work in a genetics laboratory and I am currently studying how to make CRISPR-Cas 9 more accurate!
How did it go?
Now we have the technology . Now we just need better understanding of cells and the genome
Then you are out too buddy.
Just a few years and one tiny tiptoe for humankind to be thrust into a world that once was only science fiction.
Also, the threat of the Zika virus and other such diseases could be eliminated, entirely! How freaking awesome is that?!
Josiah Klein It is funny because if you think about it right now we live in a sci-fi world compared to the sixties for example. The Internet, cell phones, cloning possible, gene editing, robots and AI...
+EstherTheNicey Indeed, friend. Indeed. One particularly evident example is the laser. It was originally thought up in a science fiction book. Another is almost anything recovered from DaVinci's journal.
Wow, wearing a sweatshirt with your own name on it = baller
***** Could not have said it better myself
Whoosh
Sweatshirt?
Oh no
No
Not again...
BABY YOU CAN WEAR MYYYYY SWEATSHIIIIIIRRRTTTTT
hey! don't bring that filth in here, i just cleaned.
Not just a name. A statement... with punctuation,...in bright color,...20cm long - in two directions - down both sides of a front zipper,... but keeping it humble with the lower case first letter... sort of.
Nice one Mr Aranda.
If you want to understand this better I recommend watching In A Nutshells video on it. It's very well animated as well, they are a great channel!
You mean Kurzgesagt?
+William Maduno they made the brand name change a few months ago
They still go by Kurzgesagt, they just also go by In A Nutshell. Mainly because a lot of people were having trouble pronouncing Kurzgesagt.
Human gene editing in an egalitarian society: fucking dope shit that would make the world a much better place.
Human gene editing in a capitalistic society: the stuff dystopias are made of.
Good example: batman beyond
egalitarian and capitalist are not opposites.
+commander frostwolf
Jeez I remember that show. Oh the nostalgia.
+Lucian Willi problem?
Paris Osuch, Yes
Does this mean I'll finally get my *Bioshock* Plasmids?
unfortunately and thankfully no
But be honest, shooting psychic attack bees out of your hands would be sick.
I just hope my conduit gene awakens so I can become Infamou... I mean a hero!
+ZewdPlays That is so true.
+ZewdPlays that's why it's unfortunate
CRISPR must be THE hottest trend on biology right now since so many science channels are talking about it
CRISPR... So hot right now!
+EstherTheNicey I see what you did there ;)
CRISPR-CAS9 is a really, really big deal in the genetics world (where I work).
It's probably not going to cure aging, or cancer, like some of these channels have suggested but it's still revolutionary in research. It's full potential is not yet known, so there is a lot of speculation.
Yes, this is a VERY big thing in the biotech world. There is a patent battle happening in the U.S. regarding who actually invented this breakthrough; scientists at UC Berkeley (Jennifer is one of them, but she's left Berkeley to found her own company using this technology) vs. scientists at The Broad Institute in Massachusetts.
well, it's always nice to have advancements in science, no matter in what field 😊
Vitamin C is made internally by most mammals except humans, most likely having been shut off by fluke in the evolutionary process. Could CRISPR re-activate our Vitamin C making gene and those like it? Because that would be super human.
Take that Scurvy!
But we have citrus and broccoli. And cancer.
I'm pretty sure our innate vitamin c creating process became defunct because as a species we were eating a lot of fruit and vegetables as meat was relatively scarce in comparison to fresh produce. It became unnecessary and the resources the body used to create vitamin c can then be used more efficiently.
Just eat an orange and you have more than 100%
Bostonzo B would have to be a pretty big orange. A medium sized on has under 3/4 of your rdi
Man it's so cool that last semester I did a report on CRISPR in my genomics class and now I'm hearing about this everywhere. Cool to learn about things that are so relevant
Quantum Computers are going to allow us to Simulate the results of Gene editing. That is when Pandora's Box will be opened.
I can't wait.
OPEN IT NOWWW. I WANNA SEE WHAT WE CAN DO WHEN WE CAN MODIFY LIFE AS WE PLEASE. WE WILL BE GODS!
basically the guys who do it will be gods all you will be destroyer like an insignificant frog :)
Yay i will have to compete with super kids in what ever job i get!!!
WOO HOO science!
Dear Santa,
I want 1 crispr, 1 watsn, 1 self repicating printor, and a Dwave the new one with games
also star wars
i was a good boy all yeer
I'm studying Biomolecular Engineering in college and this video just explained CRISPR-CAS9 infinitely better than any one of my professors or textbooks.
Man everyone's making CRISPR videos this month. Wink wink...
That´s because finally this technique can solve a lot of problems in maybe our life time. Scientist says it can defeat cancer, malaria, HIV and many diseases forever in a decade or two. That´s really exciting
Oh yeah I agree. I'm working on a video about it myself :P
let me know when you upload your video :)
Oh, hey, it's you! :D I'm looking forward to your CRISPR sick beat.
acapellascience harmonium guide
That was actually a pretty simple/good description of CRISPR. Makes me trust the scientific accuracy of this channel more =D
Whoo future and stuff! Yeah! Science. Lets make some glow in the dark kittens.
there already are
glow in the dark kittens already exist
Ok glow in the dark humans than.
Don't tell me we already there
+The deathless face of the unborn mind. humans are bioluminescent and glow brightest at 2:00 PM
Literally, I used this channel to study all semester for Microbiology. The content got me through a whole half a test worth of information I didn't realize was going to be on it. I had just happened to watch the evolution of life videos XD
Is Michael Aranda seriously wearing a zip-up hoodie that says "Michael" on the left side and "Aranda" on the right side?
That's right, cat.
+Naiadryade :) I understood that reference. /captainamerica
+Peter Rabitt +
It says Michael on the right side and Aranda on the left, you genius.
I wear a hoodie with Michael on the left and Aranda on the right; I must go to war with him!
Outstanding. I love genetics. Crazy cool and useful.
"Hey doc can I have a baby with blue eyes and strawberry blond hair?"
"Sure, that'll be just four payments of 19.99"
The future
I've heard of CRSIPR before but this was a more accessible way to present it for me, so thank you. Interested in seeing how it changes cancer research. On that note, you guys should totally do an episode on cancer and nutrition. =D
"Regardless of natural selection" my new favorites words, people worship gods without realizing that with this kind of "power" men can be gods themselves.
Yeah I don't think you could convince people of that who belive the Earth is 6000 years old.
We already ARE gods.
Don't trust me, I'm crazy Nah gods don't exist but we do.
EstherTheNicey Reread my comment again.
Don't trust me, I'm crazy Yeah, I did, I am probably dumb but I still don't get it. What I meant was we cannot become gods, because by definition they don't exist. We can't become vampires or gods, they just don't exist.
This is awesome, been keeping my eyes out for info on CRISPR, funny to think that this is the stuff that just 15yrs ago was little more than science fiction.
Only genetically modify embryos? From what I heard, any organism could be genetically modified with CRISPR.
any species of organism. You still have to do the CRISPR injection at the 1-cell embryo
Sorry but you're too late to the party. No genetic modification therapy for us
We could still become cyborgs.
Holy crap. That mosquito extermination idea sounds like a real pandora's box.
@Briar Nixon You Don't know? than you better know no one cares. :)
I talk about CRISPR a lot, it is amazingly important. A huge pivotal point for humanity.
Can you do one on cerebral aneurysms? I had one rupture at 19 and would love to learn more!
1:58 Finally they mention some of the genetic work into aids resistance! Now if only they would do an episode specifically about the anti-adhesion gene therapy. Also, one step closer to real life anthro!
IMO:
Our technological advancement is a two-sided thing. Curiosity to research is really great, but the advancement we have gives us as a humanity more responsibility that we can handle.
Went to deep mode to write this thing. I think I'm coming back slowly.
This is how the Duck billed platypus was created .
can CRISPR finally make cat-girls a reality?
A lot of the stuff described in this video (Like what CRISPR-CAS9 is) sounds like it would be some advanced technology, but instead, it's living and so small you can't see it. The cell is an awesome thing
Biological immortality, here I come!
7:55 : Quip about zombie apocalypse gave me a momentary vision of a petri dish filled with modified cells. The scientist walks away, and the scene zooms in on the dish from which we hear a tiny squeaky voice saying: "Braaaaaiiin cells!"
I sense a new kind of warfare.
Just learned about this in Virology as a bacteria's adaptive immune response to DNA phages. It is, needless to say, pretty cool.
Genetically modified bees on the pronto! We lose them, we lose a lot more than just nuts and berries.
It's about time you guys made a video about this, this info has been out a long time~
My fridge has a crisper!
Well, when were you going to tell us?! We need that thing to cure cancer!
TheFishCostume Its been holding my celery
5oClock OcO Can the celery cure cancer at least?
TheFishCostume Only one way to find out. Bring me a cancer patient and ill stab them in the tumor with the celery
r/nocontext
CRISPR-CAS9 is essentially the "Find & Replace" in Genetic engineering
So....I can finally grow a beard?!
Nah you are too late m8, you could get your kid be engineered so he could grow one.
You could grow a modified clone with a beard and harvest the facial hair. Throw the rest away when you're done.
Bruce Dunn At this point it would be easier to just buy a fake beard.
EstherTheNicey
What are you, anti science? Besides it's not like we still throw clone husks in landfills, they can be recycled.
Bruce Dunn Why recycle them when you can turn them into Soylent Green.
I thought the title of this video was CRISPER: A Gene-Eating Superpower My brain was overloaded with weird food and clothing thoughts
This should be available to everybody except creationists and climate change deniers
And Flat earthers
And anti-vaxxers.
And spiders. Im sorry.
Anyone who denies evidence based thinking.
+Bob Hope oh but ghosts n shit and crystal healing
so THATS what being a moron feels like.
Kinda like math where if you can multiply, you can do anything.
In CRISPR case, cut is like that multiply.
wow im early, better make a joke.
saying you're first.
dude. the discovery of Crispr is akin to that of a hammer. You can smash the skulls of your enemies. You can also use it to build houses. For your enemies.
That was a great explanation. Much respect for your very informative video +SciShow
I want glowing vampire eyes.
I want nightvision.
+Stray Pay No you dont
Then that'd make you hard to go out in the day, since your brain will boost light sensitivity in order to see where there's not much light. Side effect is, if there's light, there'll be even more light, and that'll hurt your eyes or brain.
CorruptHumanoid What if I only change one eye to be nightvision and wear an eyepatch.
At night I'd take that eyepatch off.
Not necessarily. Even ignoring the fact that the brain is adaptable, there are proteins that can be turned on and off with light levels; so you could incorporate those to inhibit the extra photoreceptors when the light level is high enough, and viola, night vision AND day vision without a problem :)
Can crispr be used on adult humans? Or only embryos? Answer me dammit
Yes
Interestingly enough, I get an ad for "CRISPR/Cas9 Full Service" for "Mouse Models" and "Rat Models" in the sidebar.
Also surely people will engineer supersoldiers.
Capt America FTW.
USA USA USA USA USA USA USA
(eagle screams)
ypsawbones 364 When Captain America throws his mighty shield...
China is already working on it
>Engineering something that takes a long while to be "built".
>Is intended for combat.
Meanwhile in the real world a 20 quadrillion dollar supersoldier that took 16+ years to be useful catches a 55 cent .30 round with their face and dies.
Do we need to teach you the lesson taught in WW1 that machines are just plain out flat out better, AGAIN?
Do we need to teach you the lesson taught in WW2 that whoever can build more faster is plain out flat out better, AGAIN?
CRISPR is the first step in chimera research.
now we just need a Dr. Andonuts.
the next 20 years should be pretty exciting!
Or a nightmare
My suggested first use for in-vivo human CRISPR/Cas9 therapy: myostatin knockouts. Myostatin is a gene that makes a protein which inhibits muscle growth. Animals (and humans) who have dysfunctional or missing myostatin genes have more muscle mass and are stronger than average, with virtually no negative effects.
So if we did this, we'd be engineering superhuman strength, as well as potentially curing muscle degeneration from many diseases and old age. With no additional drawbacks. Plus, the public media hype from "scientists create superhuman strength serum" would be sure to fund more research into other uses. I SAY WE START HERE.
(Also, to those who don't know, one of the most recent advances in CRISPR/Cas9 technology is that we've finally gotten it small enough to enter the nucleus of a cell unaided, which makes it suitable for in vivo use--in other words, it can finally be used to edit a living organism's genes without needing special lab equipment to force it into the nucleus.)
but then that creates the debate of those that don't have the money to go to a hospital, or those that don't have the money to receive the augmentation, and segregation based on your genes occurs.
also that would drastically affect things like sports and other competitions, and rules would have to be rewritten in a multi trillion dollar industry (just look at the olympics alone), because they clearly have an artificial advantage over competitors that don't have this augmentation, but they can't be denied due to enhancement, not only because it's in thier genes, but because they didn't have a choice as to whether they wanted to implement this augmentation or not. all of these ethical decisions will probably halt the industry, (for multiple years, if the speed at which augmenting humans gained traction was anything to go bye,) screwing up economies everywhere.
perhaps an alternative would be to inject a switch into the child, which, once old enough, can be flipped? I don't know if that's really possible yet the way I've described it, but I'm pretty sure it is
Hemlock
"but then that creates the debate of those that don't have the money to go to a hospital, or those that don't have the money to receive the augmentation, and segregation based on your genes occurs."
Which is why I'm also a proponent of socialized medicine :)
"also that would drastically affect things like sports and other competitions, and rules would have to be rewritten in a multi trillion dollar industry (just look at the olympics alone), because they clearly have an artificial advantage over competitors that don't have this augmentation, but they can't be denied due to enhancement, not only because it's in thier genes, but because they didn't have a choice as to whether they wanted to implement this augmentation or not. all of these ethical decisions will probably halt the industry, (for multiple years, if the speed at which augmenting humans gained traction was anything to go bye,) screwing up economies everywhere."
The sports industry has dealt just fine with the introduction of anabolic steroids; they'll be fine with this as well. There are currently humans who naturally have double-myostatin knockouts (in other words, they're born with two faulty copies of the myostatin gene due to natural mutations). If they want to play sports, the same way they're handled now would be the way they'd be handled with artificial myostatin mutants.
"perhaps an alternative would be to inject a switch into the child, which, once old enough, can be flipped? I don't know if that's really possible yet the way I've described it, but I'm pretty sure it is"
They'd need constant "switch" injections for as long as you want to keep it active, but that doesn't really help anything, and only serves to complicate matters more.
Wow. Can you edit Harambe's genes?
he be dead, m8
+Slithereenn dicks out for harambe
We could still clone him though.
Prinny
No thanks, i prefer bitches with less hair and more tits.
Slithereenn Don't get so butthurt it was just a joke, sorry for the typo.
We hold life to be sacred, but we also know the foundation of life consists in a stream of codes not so different from the successive frames of a watchvid. Why then cannot we cut one code short here, and start another there? Is life so fragile that it can withstand no tampering? Does the sacred brook no improvement?
--Chairman Sheng-ji Yang, "Dynamics of Mind"
Eve been doing it for thosands of years, there are no wild poodles afterall.
But if we kill all the mosquitoes how are robots scientists of the future going to build Anthropocene Park?
The age of genetics is finally coming.Understanding the possibilities of such technology makes me both very excited and scared at the same time.
NO MORE MOSQUITOES!!!!!
Is there a way to run simulations on what would happen if a species just got rekt completely?
+TabascoMan1 bats will die small birds will increase fruit decrease ants decrease pretty much everything decrease
+TheChosenSquirrel 438,000 deaths caused per year by malaria alone. this does not include the other diseases spread by mosquitos. I'm perfectly ok with destroying the little fuckers.
Malaria has killed more humans than anything else in the history of humanity. That doesn't include other diseases like yellow fever. Mosquitoes do not pollinate, they are not key in any ecosystem and cause millions of deaths.
There is nothing wrong with exterminating them bar having one less species of insect, which isn't morally wrong in any case.
Kyrator I don't know man,
they're probably the one who control the population incase It when out of control.
also some species will be pretty much starve without them
I am so excited about this new tool! I so disrupting, scaring and mesmerizing.
Couldn't editing human embryos be a good thing? Like, couldn't we get rid of harmful genetic mutations before babies are born?
but if you detect it when the embryo has over 10million cells then...
One word: Gattaca
I really hope that SciShow crew will follow CRISPR development very closely.
what a gene-ious idea
Nafisul Haque nonobononkmk
Michael Aranda is such a boss that he wears a hoodie that says "Michael Aranda" on it.
Come on people, get over the squick about editing embryos, I want a cat girl damnit!
Would that be a Human with cat DNA or cat with Human DNA?
I'd rather have a horse girl, personally. Horse's have ugly faces and ugly personalities and, well, aren't intelligence. A shame considering how perfect their rears are. However, if we could get horse genitals, both male and female, on humans... Bam. Humans would be the best animal in the animal kingdom. Hung like a horse? Check. Human brains and looks? Check. Extremely obvious physical displays of arousal in females? Check.
fuckin furry
afruitlesshippo I'm pretty sure he, as I am, is joking.
cortster12
Fooled me.
Mosquitos with DNA to exterminate Malaria are actually already created and alive in labs. With the length of this video, 5 people have died from malaria already. The reason that these mosquitos have yet to be released is due to ethical dilemmas...where we don't know if there are unintended consequences
#StopGeneticalMosquitoGenocideNow #MosquitoLivesMatter
I'm going to create a teleporting spider that breaths fire and has Ebola as it's venom. Who's with me?
Is it just me, or whenever he talks there is a bit of static?
yeah, i hear that too.
ave ave I thought It was just my headphones fucking up lol. I even checked other videos to see if it happened.
Probably not just you, since there is probably some small noise removal that can't take out noise with his voices frequency.
Sounds like some added reverb gone wrong.
Just passed college biology. Now I have to relearn microbiology. GREAT!
i will use crispr and give my kid white color so he doesn't get killed by cops
you should make him look Asian then everyone will assume he's smart as well.
No, make him actually smart, unless he actually is, in which case, congratulations!
+EstherTheNicey then he'll suck at driving
BeBeVe now that's a sterotype I haven't heard before.
+EstherTheNicey ikr
"name sounds like some ad for VEGETABLES.....changing the entire FIELD of biology"
TAT PUN THO
Think we know who's going to live forever then
why not zoidberg?
Our children will
And orcs.
Angreh Kittunz Well, in Tolkien's writings the orcs are the descendants of corrupted elves.
+EstherTheNicey how and why do you even know that? 😂😂😂😂😂
4:50 Cancer is a bad example though, isn't it? Cancers evolve through natural selection: the better a mutated gene is at making the cell replicate itself as quickly as possible, the more it will be represented in the tumor. That's why cancer in the later stages is so hard to beat: it has already had enough time to become resilient against all kinds of things.
So a random mutation through CRISPR gene editing in an already evolved cancer isn't actually very likely to make the cancer more dangerous at that point.
house hippo's confirmed. pre-order now
This one of those cases when I needed exactly this for my exam in molecular evolution tomorrow.
I cannot tell you how happy I am to hear that scientists are considering not doing the embryo editing. That sounds terrible.
Well for me it's not good I'm an carrier for nf1 and being able to have the gene removed if I was to have kids would mean I can't have any
I believe it should be used for some cases like yours but I think it is wrong to modify your embryo and have so called "designer babies"
It's not wrong if you have a family with hereditary diseases. Just have them edit whatever gene gives rise to the disease, and presto, a healthy baby.
+Armendicus Yeah I was just talking about modifying the looks unnecessarily.
Why is it "wrong"?
Dope animation/visualization with the robots.
Ethical questions? Religious freaks shouldn't have a say. If we can improve ourselves we should go for it.
It's not just religious people. Leftwingers and rightwingers both have serious ethical concerns for gene-editing although for different reasons.
I mean ppl could use it for ethnic cleansing.
> Medical procedure is made super expensive by governments around the world
> Only rich people are able to get a genetic modification
> Middle class and lower class people are vastly inferior to the 1%
Another example:
> Half the population is genetically modified
> The other half refuses to modify their DNA or breed with anyone who has modified their DNA
> Because of the DNA modifications essentially causing a rift in society, tensions escalate and war breaks out
and
> People start going crazy with gene modification, messing with things that shouldn't necessarily be messed with
> Turns out that we accidentally shortened our lifespan by 90%, significantly increased the chances of getting a severe, crippling disorder such as MS or DS, and weakened our immune system.
+William Maduno I will modify strength that's it :)
You be dumb and disregard ethics despite the fact they aren't tied to humans. As a result, (sarcasm incoming) I reason you must be both Atheist and Unethical, but only together, never apart!
Really though, the two aren't tied. Religion doesn't control ethics, ethics don't need religions.
That sounds really cool! specifically the mosquito part!
We can rebuild Harambe, we have the technology
Good news everyone! I have a brilliant idea! What if we made all the mosquitos much larger? Then they would be easier to catch!
I've been waiting for you to do a video on this
I knew it was awexome, but didn't fully understand it. Many thanks!
This is very cool i actually read a magazine about this topic and also about the Gene Drive
You had me at 'kill all the mosquitoes'!
Before people ask - yes, this can genetically modify adult humans, it'll just take longer. The benefit of doing it to an embryo is that all cells are made from the embryo. In adult humans, it might take years for the modification to spread to all cells. All cells die and are replaced - you just modify the gene for those cells where they're made.
Physician in the near future, "Would you like your baby CRISPY or EXTRA CRISPY?"
CRISPR the friendly gene editor
Mitochondria is the powerhouse of the cell
SciShow: You're late. Kurzgesagt made a video about this, 3 weeks ago.
This is how Divergent starts... (actually the backstory, but you get what I'm saying)
A son of mine was given HGH when he was 11 for what was diagnosed as a growth deficiency. When he turned 25 he lost alot of weight, was very weak, yet refused to see a Dr. He finally agreed to see a Dr.and was diagnosed with Type 1 diabetes. This disease doesn't run in either my or my exes family at all. The HGH DNA I believe is responsible for the mutation in his DNA. Hopefully Crispr can correct the mutation. It's promising.
An idea I had is: alter the genetics of the mosquito population so they don't suck blood. Plenty of other insects can reproduce without it, so just turn them into that.
Great video, but I'm curious. If a gene regulating fertility were introduced as a control of mosquito populations wouldn't that mean that the individual's fitness is decreased, consequently resulting in reduced fecundity which would decrease the likelihood of that gene being passed on after the first or second progeny? When advantageous mutations arise they are generally only passed on if they increase an individual's fitness (i.e. its ability to survive and successfully reproduce). Thus, mutations that decrease an individual's fitness are unlikely to be passed on (at least in natural environments anyway). Maybe I'm missing the point?