Ergothioneine: A 'Longevity Vitamin' With Potential Benefits For Age-Related Outcomes?
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- Опубликовано: 28 июн 2024
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Papers referenced in the video:
Dietary Thiols: A Potential Supporting Strategy against Oxidative Stress in Heart Failure and Muscular Damage during Sports Activity:
www.ncbi.nlm.nih.gov/pmc/arti...
Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?
pubmed.ncbi.nlm.nih.gov/27444...
Is ergothioneine a ‘longevity vitamin’ limited in the American diet?
www.ncbi.nlm.nih.gov/pmc/arti...
Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility:
pubmed.ncbi.nlm.nih.gov/32295...
Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease:
pubmed.ncbi.nlm.nih.gov/31672...
Ergothioneine - a diet‐derived antioxidant with therapeutic potential:
febs.onlinelibrary.wiley.com/...
Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances:
www.nature.com/articles/s4139...
Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse:
microbiomejournal.biomedcentr... 
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You are quickly becoming my favorite RUclipsr. Relevant, important information. Asking the logical questions and walking us through the studies and data to answer them as best as we can. Real actions we can take on the new information. It's amazing this is all free. Thank you so much.
Thanks John!
strongly agree
Warning about L. reuteri - it increases oxytocin. Oxytocin is often touted as a panacea, the 'love hormone', but it can increase pain in women with chronic pain conditions and was found to increase anxiety-like behaviors in females in a rodent model. My own experience with an L reuteri probiotic (the Lifeway digestion shot) is that it caused labor pain-level menstrual cramps; I almost went to urgent care.
Recently i also experienced menstrual cramps ? So it may be my L reuteri suppliments?
@@amstvm Perhaps, you can try going off for a while and see if your cramping gets better. To know for sure you would have to go on and off again a few times, I think. It might be worth doing that if you had benefits from the supp. I'm not brave enough to try it again - the cramps were that bad.
Try the Seed brand probiotic to see if you will NOT deal with the negative side-effects of L reuteri
Thank you for another outstanding educational video. The world is a better place because of humble and kind people such as yourself! Please keep up your excellent work and may God richly bless you.
Thanks R.D.!
This is simply brilliant! Thank you very much and please bring us many more of these. Much appreciated...
Another terrific, understandable video. I am really learning a lot from you.
BTW, I was led to your channel by your excellent interview with Richard at Modern Healthspan (another channel that does a good job of summarizing the research in the health and longevity field).
Thank you!
Excellent information, thank you.
Am currently finishing up my dissertation on EGT, and you're spot on with this. This is a good primer for EGT!
Thanks Mark B. Have you seen my follow-up video on EGT?
ruclips.net/video/15OMr4EzeAY/видео.html
Excellent ! Thank you !
Porcini! One my favorites to buy dry and reconstitute.
That's what I use; I have a big container of porcini mushroom powder.
Good to hear
Another great Yt .. thank you
😊I can tell you love what you do! You present this research so effortlessly. Thanks for sharing 🍉🥑🍇New subscriber
great video. Thank you! You mention sulforaphane which the "found my fitness" doctor talked about, but few others have talked much about. Would be great to see a video on sulforaphane, because it seems to have a particularly good effect preventing prostate cancer. Good news for us men.
Thanks matthew. Rhonda covered a lot in her sulforaphane video, and I'm generally not one to popularize something that others have covered. Alternatively, I prefer telling the under-told stories in science, which potentially can become mainstream in the future.
@@conqueragingordietrying1797 That makes sense. However, I've not completely trusted / followed her as she often uncovers things that few else cover thereafter & so it leaves me feeling is this really worth it? Any of these lifestyle interventions require a real commitment to carry on doing them as part of our normal routines for, well... the rest of our lives! :). I wish someone else would talk more about things like sauna use and sulforaphane... just to give it some more credence.
But eating tempeh, mushrooms & kefir.. something i already do and can just step it up a bit, no problem.
@@conqueragingordietrying1797 Yeah but it would be nice to see a critical overview of the facts. The way she presents it, it looks like eveyone should have it in their stack. Do you? If not, why not?
@@conqueragingordietrying1797 the ‘problem’ is that frozen broccoli has no active sulfuraphane; though allegedly if you add mustard seed to it, the enzyme needed to potentate sulfuraphane is re-activated.
@@surfreadjumpsleep agreed. She seems like more of a popularizer than a scientist.
This channel is the best.
Thanks @GaiasFleas!
Love your videos, really really useful information
Thanks SbergPunkt!
Interesting. I do eat mushrooms but not kefir. Well, we’ll see what the next update shows. Thanks!
Excellent. It draws me to consume more Mushroom and Miso soup, luckily since that's a favourite of mine.
Great content
Thanks Ben B!
this channel is so unrated. amazing content, I am making my own kefir...
Ha, it won't be underrated for long, it's only a matter of time!
Nice work!
Are you using google presentation or another one?
I like how fast and well-presentated is the layout. easy and effective!
Thanks @francesco Silvestro! Nope, just PPT
I have been eating cooked button mushrooms (usually white) almost daily for a couple of years. With all of the diet and exercise interventions I do, I was hoping to feel like superman by now . It has not happened.
L Reuteri ATCC6475 has shown great anti-ageing effects in mice, but I've no idea if it releases ergothionine. There's a long thread about 6475 on Longecity forum. It cultures well in milk, yielding a pleasant tasting yoghurt.
I was thinking along similar lines myself and did a Google search on the terms "what probiotic produces l-ergothioneine" and found that, indeed, L. reuteri produces ergothioneine. I haven't looked to determine if that is limited to ATCC6475, or whether all strains produce it. I also haven't investigated how much ergothioneine is typically produced.
Let’s hope for RCT’s in the near future. An RCT was completed on Glynac and the results are impressive. Maybe this can be repeated and verified in future studies.
Michael I like you as much as PUBLISHED DATA and that says something
. . . first discovered in 1909 in Ergot fungus" -OUCH! but we ended up with a treatment for headaches(Ergotamine Tartrate), the 60s and uncle Tim, and now "a sulfur containing anti-oxidant" and wonder what else I left out. Had my eye on sulforaphane but never embraced but now I'm looking at a bag of Shitake powder in front of me. Sulfur based is a category I've been shy on and I do wonder if different anti-oxidant structures have discrete effects on certain tissues and not others?
. . or more important" cool now I don't have to do the grow Broccoli sprouts thing- sounds fun but I grow enough stuff already
Hey I was looking back over some of your older videos and came across this. One thing I learned from your and am applying to my approach to supplementation is to be careful not to downregulate production long term/desensitize. For example w/glutathione best to supplement with precursors or not at all. I am curious if supplementing alpha-lipoic acid could have similar affects? (less efficient naturally over time)
For glutathione, I think the best approach is to quantify it in blood 1st (both GSH and GSSG). Then, can diet changes optimize it (and the full panel of other biomarkers)? If not, then GlyNAC, supplementation in conjunction with regular testing to identify the dose that optimizes GSH while not messing up anything else.
🙏🏻
Is there any recommended supplements which contain L Reuteri strains JCM 1112 or JCM 5867s. Thank you.
Isn't shiitake mushroom supposed to be higher than all of them?
Good video, thank you!
Thanks Olya!
Are there any seen compound benefits from having the correct gut bacteria, AND having the appropriate spread of foods in the diet? Short of increased levels that is.
Also, for that matter, the humble mushroom is a lot cheaper commercially than kefir in most cases. If you were to say oysters and samphire for example, they're less staple foods to me at least.
Definitely out of my normal price range too.
So, to sum up, more brocolli sprouts, raw garlic and mycelium. That's no bad thing in anybody's book.
Yes, definitely. A big part of my approach is figuring out if some foods are better than others for overall systemic health, even on a whole-food based diet.
Hey, would this help my doggy? Been giving him little bits of Taurine.
❤️
So MCI patients didn’t show correlation between mushroom intake and Ergo levels? I think the data at 5:30 is quite confusing.
Going further than 5:30 in the video, it's possible that gut bacteria-produced ergothioneine may contribute to the effects on cognition. In support of that, the data at 5:30 shows that mushroom intake wasn't different between MCI and controls, so the ergothioneine has to come from somewhere...
Do any males out there do regular blood donation as part of your health regimen & if so have you noticed any impact on your biomarkers?
I do give blood every 6 weeks. Which biomarkers do you mean? My Levine phenotypical age is half my chronological age. Sort of doubt it's the blood donation though.
@@JohnSlack89 Any, really. Pheno age or its components, other blood biomarkers, methylation clock age, even something like HRV. It would be interesting to know if someone had been tracking biomarkers for a while and then started blood donation & observed a change - or not.
@@JohnSlack89 What do you think has had most impact on your pheno age?
Is Ergothioneine heat-sensitive? Can I cook the mushrooms and still get the full benefits?
I haven't looked into that, but if you do, please share!
Mike, any idea about whether ergothioneine is preserved in the cooked mushrooms? I'd much rather sautee than salad them ...
Hey Peter, a recent review on ergothioneine mentioned that no studies have looked at cooking on its purported health-related effects (see Section 3.3.3, www.sciencedirect.com/science/article/pii/S095528632030485X?via%3Dihub).
Uncooked mushrooms are highly carcinogenic. I also didn't even know people ate them raw, it's so bizarre to me.
@@RaynesX Got some published studies showing that uncooked mushrooms are carcinogenic?
@@conqueragingordietrying1797 "Warning on False or True Morels and Button
Mushrooms with Potential Toxicity Linked to
Hydrazinic Toxins: An Update" "To conclude, a safety measure is to avoid consuming any true morels or button mushrooms when
crude or poorly cooked, fresh or dried."
@@cloudstrife7349 Note that false morels aren't on the ergothionine list in the video, nor are they commonly consumed. Also, for the white button mushroom metabolite, the lifetime cancer risk was proposed as 1/100,000, which is very low.
Nonetheless, if mushroom intake adversely impacts health, we'd expect to see an increased all-cause mortality risk with increased consumption. However, the opposite is true:
pubmed.ncbi.nlm.nih.gov/33888143/
Do you think it can increase lifespan, or at least healthspan?
It could go either way, but I'd like to see that study!
Off topic here but didn't you mention elevated homocystine in older people so perhaps the low cysteine in cells is only in balance with low glutathione.....
This is why I hate trials with multiple supplements...
To many variables
Sorry low glycine not glutathione
What's an effective dose for general health?
That;s not clear, but getting some, rather than none, is the goal. The wild card in the ergothioneine is that it's degraded by gut bacteria, especially ones that increase during aging (E. coli). So without addressing that, an increased intake may not make a dent.
I want my blood ergothioneine levels measured.. is there a kit for it..
Not commercially, yet…
@@conqueragingordietrying1797 Thank you very much
I just learned that setting mushrooms in the sun increases the VitD content..
People should eat mushrooms instead of meat and junk food
😂😂 yes because meat is so bad, the food we've been eating for millions of years
How about Green Tea (ECCG)?
For a video?
@@conqueragingordietrying1797 yes, that would be terrific. I have been drinking ten cups (most of them decaf) daily, in addition to four cups (3 decaf) of coffee daily. I would love to see your analysis of Green Tea, Coffee, or both.
@@Avital4414 While we wait for that, here's a blog post from my website on green tea:
michaellustgarten.com/2019/09/15/drink-green-tea-reduce-and-all-cause-mortality-risk/
@@conqueragingordietrying1797 is white tea has same benefits as that of green tea ?
@@amstvm I haven't looked into studies comparing white vs green. If you have, please post them here!
I get all my ergothioneine and phytonutrients from grass fed beef.
Good thing I eat a lot of Oyster Mushrooms.
Useful information, but way too much stumbling. Consider editing it out.
There's a supplement on Amazon. Would it be better to supplement with ergotheionine or l ruteri?
The easiest, lowest risk approach is to include mushrooms in the diet. I almost always prefer whole foods over supplements as a primary approach.
Seems you don't know the difference of causality and relation
I definitely do understand the difference. At what point did I assume causality instead of correlation?