if compare this with computer programming, this looks like a function, here you have a start point ( loop anchors ) and a body with the code ( loop domain ), where when called ( loop domain streched out ) and that function does a job ( the genetic information being read and produce proteins... etc...). maybe i'm totally wrong, and that comparison isn't even close to be considered plausible. but would be awesome if that works this way.
It's probably (my limited understanding) a correct analogy but an analogy nevertheless, because DNA is much more physical and 3-dimensional than computer code. It's like coding very complex programs with quipus (the ancient Andean way of "writing" with strings and knots).
“maybe I’m totally wrong, and that comparison isn’t even close to be considered plausible” The comparison is a comparison, there is no “plausibility” unless of likeness. And what you’re watching is a simulation, parts of which control the dna with loops galore. So I’m afraid it is the dna which came before the program as you describe it. Any likeness then should reveal the proximity we are to fully simulating the dna action. Here we replace environmental influences with stochastics, despite how crucial we know the environment to be to the foldings and unfoldings of the strands.
Interesting to explain domain segregation but each domain still has plenty of contacts with its neighbours... so how does this explain the functional separation of domains? Also, may I ask the timescale of the simulation?
Awesome video. The animations did a really good job helping me understand the concept.
That was maybe a bit too brief but awesomely interesting, thank you. Guess I'll read the paper now to get a more nuanced understanding, good job!
if compare this with computer programming, this looks like a function, here you have a start point ( loop anchors ) and a body with the code ( loop domain ), where when called ( loop domain streched out ) and that function does a job ( the genetic information being read and produce proteins... etc...).
maybe i'm totally wrong, and that comparison isn't even close to be considered plausible. but would be awesome if that works this way.
It's probably (my limited understanding) a correct analogy but an analogy nevertheless, because DNA is much more physical and 3-dimensional than computer code. It's like coding very complex programs with quipus (the ancient Andean way of "writing" with strings and knots).
“maybe I’m totally wrong, and that comparison isn’t even close to be considered plausible”
The comparison is a comparison, there is no “plausibility” unless of likeness. And what you’re watching is a simulation, parts of which control the dna with loops galore. So I’m afraid it is the dna which came before the program as you describe it. Any likeness then should reveal the proximity we are to fully simulating the dna action. Here we replace environmental influences with stochastics, despite how crucial we know the environment to be to the foldings and unfoldings of the strands.
Wow awesome video! Thanks for the great explanation. Cool Paper!
I hope this model wins a nobel prize
Spatially segregated domains at 1:37? All I see is a bunch of spaghetti. Doesn't look separated at all.
Keep watching, it turns into a red clump and a blue clump.
Beautiful video! Thanks for sharing.
kinda like when I untangle my headphones
Thank you so much sir😁🙏
Is it the same process for eukaryotes and procaryotes?
No bc loop extrusion is only necessary for the DNA of eukaryotes, bc their DNA needs to fit into the nucleus of the eukaryotic cell.
Interesting to explain domain segregation but each domain still has plenty of contacts with its neighbours... so how does this explain the functional separation of domains? Also, may I ask the timescale of the simulation?
Only from the video, my impresion was that loop = unfolded domain, i.e. there's a code that marks the beginning and the end of the loop/domain.
transcription factor promotor incompatibilities perhaps?
Excellent
god have mercy on my poor soul.
2:48 mini voice crack
❤
Im looking for healing dna
Cutting the strings makes it unstable
OMG
Is this still a theory or already proven?
There's a paper linked to in the description.
XD!