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In a word, yes. There is also a helper molecule called EF-Tu that makes sure that the wrong matches bounce away when they happen to come to the A site, and makes sure the right matches stay in and don't just bounce out. The principle behind this is thermodynamics: everything is happening randomly, but only one road leads to Rome.
WOAH It's ChrisFix! *Never* would have thought to see you here! That's quite awesome really. Thanks for being so helpful with car information by the way.
Interesting comment. Translated. I was always curious why the Bible story said ENOCH WAS TRANSLATED. also, God said Enoch was the " great artificer" who surprised God w his intellect. ( just talking about the book), It finally dawned on me that perhaps Enoch invented artificial intelligence way back when and that was what impressed God in this book and that was what he meant when he said he said Enoch was the great artificer. ai may be ancient, would explain simulations. Of Course we also have stories in the fifteen hundreds of Simon Magus who made an automobot. Or Android and Thomas Aquinas destroyed it. Your translated comment triggered this, lol
Right? Computer tape was already 50 years old in the early 2000s, when this video was produced. It *is* a decent analogy, but it doesn't really work if nobody in the audience understands the comparison. Then again, nobody really knows what a "powerhouse" is anymore and that hasn't stopped biology teachers keen on spreading the news about mitochondria.
This is really just good for sparking interest in genetics, I'm sure if this was truly 'advanced' I'd be leaving this video with a completely blown mind. I have no idea what these students are talking about below me, about the subunits and release factors, as the only videos that would probably explain those things are painfully dull 2 hour long lectures in 240p resolution.
It may spark an interest in genetics, but there would be no need to label the video as "advanced" if that is the intent. I'd bet it would be far better at grabbing the audience you describe if it had a title something like "basics" or "digging a little deeper" or something like that.
I thought “advanced” meant we would see all the factors in the same process. The factors functions aren’t complicated, most of them just provide energy to help the molecules move. Having them named helps me retain them better while studying but it’s not super complex stuff
Thank you. And indeed, this is as advanced as it gets (without getting into the molecular nitty-gritty)...worth noting is that the translation begins at the 5' side of the mRNA...just to be complete :)
Before clamping down, the ribosome scans the mRNA strand from the 5' end (the "front") toward the 3' end (the "back"). It looks for the start codon. This ensures translation begins at the correct location and not in the middle of the message.
Space Lizards: Wow signal just detected from Alpha Centauri Covid-19 is only a distraction for the PCR Tent Clowns *0.0004 is not a Pandemic it is Panning for gold*
@@marinarosabarbosa *Were* Until they got the bill for 400 page texts Where is the *B117* → That is the Russian Ducks invade Nederland's Minks are history already ~ this animation is slowed about 1 Million-x for humans ~ Badges? We ain't got no badges! We don't need no badges! I don't have to show you any stinking badges! Stores are packed, people are traveling all over the country coming to visit..... Downtown Nashville ! - 0.0004 ain't no Pandemic
This is actually a good visual representation of the whole thing to help you digest the topic. This is not to spoon feed you with everything. If you want detailed info, read a book.
The DNA learning center that this channel is representing is for middle and high school students. It's listed as advanced because it's geared towards the more advanced of the students that attend classes there, not in general.
This is a more basic version, definitely. The Large prokaryotic subunit is 50S (Svedberg Units, or sedimentation rate). It has 5SRNA (120 nucleotides) 23S RNA (2900 nucleotides) and 34 proteins. Small subunit is 30S with 16SRNA -1540 nucleotides and 21 proteins. 16S is the site of antibiotic action. Eurkaryotic is 60S and 40S. The steps are initiation, propagation and elongation, and wow I just realized that this video missed so much information.
I thought this was supposed to be advanced... No discussion on initiation or elongation factors, nothing about release factors, nothing about wobble, aninoacyl-trna synthetase, the polarity of the tRNA, 30s 50s ribosomes subunits...
I’m here because this was uploaded 10 years ago and today we in a pandemic COVID-19 Vaccine using this technology. Not sure what to think of about this.
@@microska2656 To speak for others there must be a Conspiracy Conspiracy Theories are often negative; - More than 1 in 3 Americans believe that the Chinese Bat Lady engineered the coronavirus as a weapon yet if I try to look into that Baseball Bats are the only bat that I am likely to find ~ As a painter you may be interested in Quantum chromodynamics
If the concern is about engaging with DNA, then don't be worried; It works without the such engagement. It simply does what the weakened virus versions would do, but without the infector as a whole, but with a part of it, responsible for creating virus spikes and/or triggering the immune system to create antibodies, without the immune system having to fight in a COVID-19. Don't take my word for it though, I'm not very qualified in this area. I just have read the topic a bit.
LOL "this technology", its anatomy, its the basic function of life. Ribosomes just makes things, they're little machines. Every virus ever uses them to make more viruses. The covid vaccine is just a small portion of the virial DNA, and only encodes for the proteins that coalesce and form the outer spike of the virus. Which then causes an immune system reaction and anti-bodies to generate. Its not rocket appliances
Holy kittens, I can't believe I have this going on in my cells basically all the time. It looks like a perfectly choreographed ballet. I've been searching for this because I want to be able to explain how the mRNA vaccines work to people who still don't understand why I'm so enthusiastic about this new development in the history of vaccines, but now I'm so fascinated that I need to dig deeper.
Most people don't know that, originally, RNA was the preferred form of genetic material. Evolution switched to DNA because it was less prone to base mutations and hydrolysis; RNA already existed as the "go-between" between DNA and polypeptides. The process is ridiculously unfathomable, but all the more wonderful for it :)
Strange, as RNA is very unstable and “temporary”. The turning on and off of DNA genes determines its production, which in turn determines the production of proteins/enzymes. Scientists weren’t there to observe what you described. It is just conjecture.
great video, but it would have been nice if you talked more about the P,A,E sites as well as the different enzymes used in translation. also Translation first starts on the P site when Trna transfers the metiyonin aminoacid over to the AUG codon located on the P site to start translation. overall Great video thank you
@@Kal-EL_Volta Yes, most of our bodies vital functions occur due to proteins, which make structures and molecular machines, or enzymes, which catalyze reactions. None of these parts really "know" what to do, but basically, the ribosome forms around a "start" sequence on the mRNA, and then waits for a tRNA molecule with the proper matching sequence on it to click into place. Whenever matching sets of RNA letters come together, A-U, and G-C, a small amount of energy is released and this energy drives forward the ribosome's action. Then another tRNA comes into place on the next available site, and the matching of 3 base pairs again provides enough energy to drive to the next step, which is fusing the two amino acids, after which the first tRNA is ejected. Basically, the video isn't showing all the wrong tRNA pieces coming in and going out, unable to provide the necessary energy, and only shows the correct pieces going in and driving the reaction
As someone who has done programming, I can say that the process shown here is quite similar to it. RNA = script ribosome = interpreter protein = output
This is a very basic animation over translation. It only simply mentions eukaryotic cells. It does not show how the Translation begins with EIF's which is attracted to the cap at the 5 prime end. This then attracts a methianine tRNA which will attract a 40s SSU ribosome bottom followed by the 60s LSU top of the ribosome. This is just the initiation of translation of eukaryotic cells.
Good video but not "advanced" enough. Didn't mention Elongation factors or proof reading CCA arm, editing site, active site etc. If the latter isn't a part of the translation itself, EF's are. The EF's that bring the tRNA to the ribosome for instance. Or am I wrong?
Initiation factors bind to the 5' cap of the mRNA and guide it into the small ribosomal subunit. And they hold it in place while the small subunit scans for the start 5'AUG3' codon. Then a tRNA carrying an elongation factor with an anti codon 3'UAC5' carrying a methionine comes and binds to the mRNA, the large subunit then joins the complex and begins the process
You're right. For eukaryotes, eEF1A brings charged tRNA to A/T site. If base pairing is successful, eEF1A would hydrolyze its GTP, dissociate, and leave the A/T tRNA in the A site. Then after peptide bond formation and 40S head rotation, eEF2 would come and help with translocation. The overall process is similar for prokaryotes, but instead of having eEF1A and eEF2 they use EF-TU and EF-G. On top of that there are initiation factors, most importantly eIF2, eIF3, eIF4E and eIF4G and release factors (eRF1 and eRF3), as well as other proteins that either promote ribosome re-initiation, recycling or hibernation.
It's not about being humble or not, it's a misleading title for a college student seeking extra info like me. I was expecting visual representation of say, EF mechanisms or IF1,2,3. So yeah, sorry but this should not be labelled as advanced.
@@JN-zr4ts Those are things that aren't usually answered, or even discussed. If there is any creator like God, then I believe he started the universe, or something where our universe is at, because such things as evolution, forming of complex stable structures is possible, and at studying that we probably are quite advanced and correct. Otherwise, it's hard to tell to a human that something can appear not as expected by our human comprehension.
im working now with 5S rRNA the small RNA in the Large subunit in Leishmania major :) I used this video to show te ribosome to my friends. So they can got and idea about my work :D.
No, they use reverse engineering of area 57 technology and shrink a submarine filled with biologists and a film crew and get injected Into the mRNA Vaccine jab site. Exit is usually by circumnavigation of the blood supply to be filtered into the kidneys where upon extraction - they are all reanimated with a reverse particle beam.
A request for a technical issue: use of occasional slow motion images. Too hectic activity is to pay attention to. It'd be very nice if those processes were shown at slower speed for a short while to have a clearer look at each elements. Anything else, perfect!
@@jungle1776 yeah. So programming is the process of creating code which creates an output, which is a computer program. The DNA acts like the code, with it defining the output: a protein. Software code is just a text. That text must be 'read' by something like an interpreter, that reads the text like a recipe and builds the software program. DNA follows the same process: the amenio acids are like words in the recipe, and the recipe is read to build a protein. The interpreter here is the ribosome. A wikipedia search on computer compilers might be nice further reading.
The “central dogma” mentioned at the end of this video is actually false. DNA does NOT contain all of the instructions necessary for life to develop. Building proteins is only a (very small) part of the story. Developmental pathways cause different cells to express different genes. Some of those gene regulatory networks reside in the DNA, but a lot of the control and signaling mechanisms do not. Simply building proteins does not include the necessary instructions that tell each individual cell which genes to turn on, which to turn off, as each cell differentiates and specializes (e.g., becomes nerve or neuron or muscle or bone cells). THAT information actually resides in information external to DNA. And there is other heritable information that does not reside in DNA at all. There are many sources of heritable information that are not found in the DNA, and scientists are just now beginning to learn about some of those (e.g., the “sugar code” on cell membranes that has been estimated as containing even more theoretical information storage capacity than DNA, or the heritable information contained in centrioles, etc.). While forming proteins is of course important, and different cell specializations require forming different proteins and in different amounts, the instructions for what type of proteins to make, in what quantities, and when, is actually not contained within the genome alone. And this video doesn’t even get into the information and complicated machinery required to perform post-transcriptional editing of the raw mRNA strand to edit out sections and splice unconnected stretches together into the final mRNA that contains the linear sequence of amino acids to form the final chosen protein. The level of information required for life to exist at all, let alone develop and diversify and specialize, etc. is actually much more complicated than simply building the right proteins.
@@metaphyziks7579 Great question! I would recommend checking out the Discovery Institute's Summer Seminars on Intelligent Design. Those seminars connect you with scientists working in the fields of biology, chemistry, cosmology, engineering, information theory, paleontology, etc. And the people who you attend with are often themselves scientists working in the field, whom you can connect with to stay current on the latest discoveries. I do read the literature myself as well, but it helps to have contacts working in the field to help provide context and help make sure I am interpreting the results correctly.
A great book that discusses all of the many challenges to all theories of abiogenesis is The Stairway To Life, by Robert Stadler and Change Tan. It is an excellent book that balances technical accuracy with readability by the general public who may not have advanced training in chemistry.
Even my Molecular Biology textbook by Lizabeth Alison doesn't say ''advanced'' when spending an entire chapter just for translation. In fact it goes and suggests further material to read at the end of the chapter to understand it in more detail. An advanced material would be something that would explain the process in detail so that you can read and understand journal articles about the process. SO PLEASE NAME THIS ... (BASIC - OVERVIEW). Many of us are university students
This is just amazing/mind-blowing/genius! aghh life is so complex... the biological processes that occur in living systems are highly complex and ordered. However these reactions are characterized on the basis of simple laws and principles. Whether divinely orchestrated, determined via evolution or both (which i believe)! there is no argument that this is genius.
The codons (on the template- such as AGCT) tell which anti-codon is required (anticodon is present on the tRNA, and is reverse of the codon- in this case it would be TCGA). As the template moves along in the RNA, different tRNA's enter into the ribososme through the A site, when the tRNA has the required anti-codon, it moves into the P site where the (protein is being made) and releases its amino acid to join the chain (that is the protein). After releasing the amino acid, the tRNA exits...
@LughGarrick The thing is that on such small scales like this we're talking about, molecules move relatively very fast. This animation being showed is slowed way down so you can see what is going on. In reality ribosomes can make hundreds of proteins a second.
Yes, all happened by chance. Hahahaha! If there is art, there is an artist; a building, there is a builder; a writing, there is a writer. Nothing “intelligent” happens by chance. The message for today is the key in mRNA is in the message being sent. When this can be manipulated by man, watch out!
Good logic. Scott in Texas doesn't feel right about anything complex arising over time on its own given enough time and space, so it mustn't be true. Humans are capable of better logic than this.
Amazing creation of our God Almighty! There is absolutely no way that such specific things in our body were made my accident/out of nowhere....Praise the Lord!
they forgot to mention precursor RNA is made first... which then changes to functional RNA by cutting out the intrones (RNA-splicing) anyway, this video is wicked :D
Base pairing in the ribosome isn't constrained by the structure of a DNA duplex or DNA polymerase, so it's a bit more relaxed. The nucleotide on the 5' position (usually the base most on the right) is free to "wobble". G can basepair with C like normal, or with U. U can base pair with A or G. Inosine, I is also incorporated. I can base pair with A,C,U. So, something like this mRNA CGU CGU tRNA GCA GCG This way, one tRNA can recognize multiple codons for the same amino acid so you don't need 1 tRNA for each codon. With wobble you only need 32. Make sense? It does in my head. I can send you a textbook screenshot. I think my book explains it well.
ChaseTheSunSet I put $20 In a box and you put $20 in a box. Then I sell the box( with the $40 in it) to you for $30....... who made profit and how much?
According to Francis Crick, "Biologists must constantly keep in mind that what they see was not designed, but rather evolved" You can see why he said that. If we once allow ourselves to be impartial, we would intuitively recognize the hallmark of design in the magnificent gene expression process. Humans use CAM (computer aided manufacturing) systems to turn information into real objects. The ribosome likewise, is the 3D print head that turns digital information into flesh and blood. Very well done indeed.
+reality programmer It's amazing that braindead fucks like christurds find it "amazing" that others might have different opinions from them about untestable unquantifiable imagaring things such as other realms.
@@freedomthrufaith agreed. Man can't even create a simple cell from scratch . What dose that tell us? The only real medicine is holistic natural medicine..
All of human literature, religion, politics, law, war, prisons, put together doesn't know how complex a single living cell is and has accomplished nothing to prove anything about them.
As far as I know, a total of 21 amino acids are used to synthesize protein in cells. Therefore, there may be several types of t-RNA, each of which can only deliver a particular amino acid. This may be because the anticodon of the t-RNA must match the corresponding codon of the RNA that is intended to encode that particular amino acid. At a given moment, a particular codon of RNA is located in the input chamber of the ribosome. Because only one t-RNA can fit into the ribosome at its site of entry, it is mandatory that the anticodon of the t-RNA match the current codon of the RNA. The synthesis of the protein requires that only the t-RNA whose aticodone matches the current codon of the RNA enter the ribosome. The question is, how do t-RNAs know when one can enter the ribosome? - so how do they know if their own anticodon matches the current codon of the RNA?
I have no training in this but my assumption would be simply random interactions. There are 21 different types of tRNA bouncing around in the cytoplasm at all times and protein synthesis cannot continue until the correct tRNA happens to collide with the A site. In the video it shows them hopping on one after the other but in reality it would be much messier and you’d have tons of collisions before the ribosome added an amino acid. I’m pretty sure this is how most cellular processes work.
@@berban Is it possible that a particular codon in RNA somehow attracts the complementary codon that can be linked to it (the so-called transport molecule of a particular amino acid)? And can this attraction be felt outside the ribosome?
@@LaszloToth55 Hm, I doubt it... what sort of force could you use for the attraction, magnetism or something? Cells can be attracted to sites in the body through complicated signaling mechanisms that involve both the cell itself and the blood vessels, but even that is only making the cells more likely to stop as they randomly pass by in the blood vessels. I don't think anything like that would be possible with these tiny molecules. but I really don't think it's necessary either... these things move so fast it's hard to comprehend
@@berban When atoms are connected to each other, there are electron donors and there are electron acceptors (sometimes both). An electrical interaction between electron donors and electron acceptors is established within a reasonable distance. It is conceivable that this phenomenon also plays a role in molecules: a codon (three base molecules) can be electrically attractive enough for a complementary codon. This may explain the rapid synthesis of proteins using ribosomes.
There are a few proofreading measures that the ribosome employs. First, a cognate match has to be made between the anticodon/codon pair on the tRNA and mRNA, respectively. Specifically the first two codons need to form precise Watson-Crick base pairs. This causes a conformation change on the small subunit of the ribosome which is then relayed and amplified to the large subunit. The tRNAs are carried to the ribosome via a small GTPase called EF-Tu (elongation factor). If a cognate pair is made between the first two codons of the mRNA and the second and third anticodons of the tRNA (they run antiparallel to each other), then the conformational change that this induces in the ribosomal small subunit is carried to the large subunit and allows for a domain on the large ribosome called the Sarcin-Ricin Loop to interact favorably with a histidine residue on the EF-Tu protein. This interaction then allows a water molecule to hydrolyze the GTP bound to active EF-Tu, and the free GDP dissociates. Once GTP is no longer bound, EF-Tu dissociates and the tRNA is effectively docked into the ribosome and locked into place, allowing for its movement to the P domain where the peptide bond is catalyzed.
Some of the "expert" commenting is amusing. The nerds of science may not understand that other professionals are just as interested in our health as they are in other areas that affect them. Like cooking! No one wants to eat half done collards or crunchy rice. So you learn the secrets of good food. Before learning how to cook you needed to know what to cook. In depth learning is always life changing...(BTW) Im a certified diesel mechanic and we remodel commercial and residential Real estate. But I don't want to take a vaccine that may not be safe. So I want better understanding so I don't think myself into an early grave or take the "mark" and end up in hell...🤦🏾♀️
This is not at all advanced! In-fact, this is a greatly simplified version. Please label the video appropriately. Using the true molecular structures is a nice touch though.
@DrStasso These are not simulations, these are animations, incorrect I may add. Both electron microscopy and X-ray crystallography allow one to see at least some of the events at a sufficient scale of details.
It's really difficult for me to look at all this cellular busyness and not believe that someone or something created it so. It would be like walking into a busy corporate building filled w working people and believing that its creation wasn't driven by intelligence. It's just not reasonable to me. What you do you folks out there have to say???
Stop making these pointless analogies, you are used to see lots of objects that have human creators around you. That doesn't mean that natural things must have a creator in the same way. Your failure to see the big picture comes from ignorance regarding evolution, I believe. Also I can't understand how you don't realize that your assumption raises more questions than answers. Just how can you jump to conclusions like that only by observing complex stuff? If you feel like this is awe inspiring (which it is) then why don't you try to study how this process came to be today instead of giving all the credits to something "bigger"?
***** Lol, "Evolution of the Gaps" fallacy, all "scientists" have to say about it is that it is "advantageous" and therefore must have been "selected". Absolutely no explanation of how it came to be. We don't know how it evolved, but it evolved for sure! Hahaha you evolutionist cultists are hilarious.
***** There is literally not a single biological structure for which the mutations required for its supposed evolution are demonstrated. Scientists will say "it evolved", but never will they say "how" it happened, because they would expose the absurdity of evolution.
Militant Anti-Leftist It seems to me like you are not familiar with the basics of the theory. Please explain briefly what you think evolution means. I will try to clear any confusion.
And why do we need cheap, man made fairy tales, spiritualism and other's form of bullshit when all these processes are million times more magical than any spiritual crap?
When clicking this I was worried that I am only undertaking an MD and not a PhD and this would be a bit over my head... I feel worried for humanity now.
And simple minded people continue to say we “evolved”? Seriously? This micro level complexity is greater than anything man can “create”. The God of Abraham, Isaac and Jacob is real. More proof Genesis 1:27 is not a fairytale. Isn’t it time you took a moment to look at the alternate world view of Creation? The puzzle pieces all begin to fit perfectly. 🎚
Other way around champion... no way a god could create such complexity. Even said it yourself: "complexity is greater than anything man can create". Funny how we have evolved such complex brains but people continue to be blinded and clouded by fake ideals and stories that were written thousands of years ago.
Is every component in a cell or body created through this process? Im just now beginning to understand what DNA really is. I had know it was "the genetci code" but until I saw transcription and translation I didnt understand how it was used. So now my question is does this process make everything? For example mitochondria, golgi apparatus etc - do all the parts needed to make those components need to be "3d printed" with this translation process?
lol i love how 90% of the comments are people that didn't comprehend anything in the video and are exclusively here to whine about vaccines because mRNA is in the title. i swear if they'd arbitrarily chosen to be upset about the water content of vaccines they'd be on videos about where municipal tap water comes from and whining about that instead
@@atomwaffel but it's not advanced tho. This is a basic summary to be honest. I get that they have to keep it simple for those who are not well versed in the many factors that go into this natural process, but @Baiju Sharda is right. This is not advanced. Why are you concerned that we are saying that this is not advanced? Wouldn't you want your scientists of the future to consider as many factors as they can when they conduct their studies for the sake of accuracy? Or would you rather scientists who keep things simple for the sake of those who hate "nerds"?
In this vid they neglect ALOT of factors that are very important in the completion of this natural process in DNA transcription, so this is a relatively basic summary my guy. Keep up tho. As you learn more, you will agree with us who say this vid be quite basic. ;)
Where did this information come from. Did evolution make trillions of stumbing mistakes to create life. As you know evolution can't think. It has to be random mutation. So evolution made trillions of random mutation mistakes and had to create woman too. Which came first man or woman. Imagine all knowledge had to be present to create man where did this knowledge come from.
Highly Structured, Highly Designed "MACHINES" ... not by Accident and NOT by Chance... #DESIGNED ... #ENGINEERED ... millions of these machines in each LIVING CELL ... #LANGUAGE #DNA #RNA #mRNA #ProgrammingLanguage - #coding, #decoding, #manufacturing
Douglis Do you know what is self-assembly nanotechnology ? Do you understand that you can power up any circuit remotely via radio waves if a circuit comprises of an antenna ? Now think, our body contain iron molecules and these molecules can be assembled using proteins into electric circuits. I’m not saying this is how it is but rather that such technology exists already.
@@MontyQueues no, things YOU can't explain CAN be explained by God. It's not like we don't know the answer and just give up by putting God in all the gaps. Even atheists have to admit that God is at the very least a possibility, even if they choose not to believe it (unless they're irrational). If God is a possibility, then you would have to compare how likely it is for the universe to pop into existence randomly by chance billions of years ago when a random unexplained dot of energy farted the universe into existence. Is it more likely that everything came from nothing, or everything came from something? God being an uncaused cause that answers how even that dot could come into existence, even if the bible didnt write it that way but that's another discussion. God gives an explaination for things evolution does not. Evolution takes you as far back as the dot of energy billions of years ago. It doesn't explain how the dot got there or any other obvious questions that come with this. God explains it. He is the more likely answer. Idc what you think about the science or anything like that after that. I waste no time and start at the beginning. If atheists can't give me a good answer then the rest if the arguments are pointless. You can't have an issue with what the bible says unless you admit God is the more likely cause for his creation. He is more likely to exist than not exist. I do not shoehorn God into things I can't explain. You are triggered any time the word God is mentioned. Then you attempt to discredit any argument for God as some kind of wild card. It's a childish way to shut down an argument before it can be made.
@@MontyQueues lol good to know your only response is to stick your nose up at my response with an insult to top it. Can't say I'm surprised. God bless ❤
its amazing how there are some people that say that this insanely complex and ridiculously unfathomable process is a result of random chance of molecules coming together in soup, a few billion years ago :P
It didn't happen by chance. Evolution is more complex than this. Saying we were created by some greater being is just taking the easy way without pursuing the truth. We do not know the truth of our origin. We only have theories. Implying you know is not knowing at all. Admitting to now knowing is knowing a great deal. Think about it.
of course evolution didn't happen by chance :P im talking about abiogenesis. how did the first cell get here. and it had to have been able to reproduce so it had to have had this process.
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In a word, yes. There is also a helper molecule called EF-Tu that makes sure that the wrong matches bounce away when they happen to come to the A site, and makes sure the right matches stay in and don't just bounce out. The principle behind this is thermodynamics: everything is happening randomly, but only one road leads to Rome.
Thats only for the procaryotes though isnt it?
Thanks for the info!!! Helped me understand how translation works!!!
WOAH It's ChrisFix! *Never* would have thought to see you here! That's quite awesome really. Thanks for being so helpful with car information by the way.
Interesting comment. Translated. I was always curious why the Bible story said ENOCH WAS TRANSLATED. also, God said Enoch was the " great artificer" who surprised God w his intellect. ( just talking about the book),
It finally dawned on me that perhaps Enoch invented artificial intelligence way back when and that was what impressed God in this book and that was what he meant when he said he said Enoch was the great artificer. ai may be ancient, would explain simulations. Of
Course we also have stories in the fifteen hundreds of Simon Magus who made an automobot. Or Android and Thomas Aquinas destroyed it. Your translated comment triggered this, lol
ayee chris
@Mgbraixen 0
Based chris
WOW!!! I wish I had these videos 25 years ago when I was studying! we studied from black and white text books with not so great diagrams.
"Like a computer tape" Oh ok
Right? Computer tape was already 50 years old in the early 2000s, when this video was produced. It *is* a decent analogy, but it doesn't really work if nobody in the audience understands the comparison. Then again, nobody really knows what a "powerhouse" is anymore and that hasn't stopped biology teachers keen on spreading the news about mitochondria.
Sounds like we are very high tech robots
DAT is still used for archives
Hahahaha
Omg I 😂 so hard to this comment! Thank you !
This is really just good for sparking interest in genetics, I'm sure if this was truly 'advanced' I'd be leaving this video with a completely blown mind. I have no idea what these students are talking about below me, about the subunits and release factors, as the only videos that would probably explain those things are painfully dull 2 hour long lectures in 240p resolution.
It may spark an interest in genetics, but there would be no need to label the video as "advanced" if that is the intent. I'd bet it would be far better at grabbing the audience you describe if it had a title something like "basics" or "digging a little deeper" or something like that.
I thought “advanced” meant we would see all the factors in the same process. The factors functions aren’t complicated, most of them just provide energy to help the molecules move. Having them named helps me retain them better while studying but it’s not super complex stuff
This video is as advanced as 10th grade biology goes
It's grade 12 / first year uni level bio i think. First year uni goes into a little more depth of course. This is kind of a brief overview.
Thank you. And indeed, this is as advanced as it gets (without getting into the molecular nitty-gritty)...worth noting is that the translation begins at the 5' side of the mRNA...just to be complete :)
Before clamping down, the ribosome scans the mRNA strand from the 5' end (the "front") toward the 3' end (the "back"). It looks for the start codon. This ensures translation begins at the correct location and not in the middle of the message.
@@neom0nk thanks for this extra info, I struggled with recognising front (5') and back (3')...
This video has caused me to go into an existential crisis. How tf are my teeny tiny cells SO MUCH SMARTER THAN ME.
Space Lizards: Wow signal just detected from Alpha Centauri
Covid-19 is only a distraction for the PCR Tent Clowns
*0.0004 is not a Pandemic it is Panning for gold*
Aliens........
Ask Billy Goats
One explanation: God
@@Amelia.B-12 Whatever floats your boat.
"For we are fearfully and wonderfully made"
Was not prepared for the snarkiness of people saying "not advanced enough" lmao
Were AP Students....
@@spectroxis6418 if so, why have you used were instead of we're
@@realixt872 I thought he meant "they were AP students" lol
@@marinarosabarbosa *Were*
Until they got the bill for 400 page texts
Where is the *B117* → That is the Russian Ducks invade Nederland's
Minks are history already ~ this animation is slowed about 1 Million-x for humans ~ Badges? We ain't got no badges! We don't need no badges! I don't have to show you any stinking badges!
Stores are packed, people are traveling all over the country coming to visit..... Downtown Nashville ! - 0.0004 ain't no Pandemic
@@ChiDraconis What the fuck?
This is actually a good visual representation of the whole thing to help you digest the topic. This is not to spoon feed you with everything. If you want detailed info, read a book.
The DNA learning center that this channel is representing is for middle and high school students. It's listed as advanced because it's geared towards the more advanced of the students that attend classes there, not in general.
this is additional material in my university entrance course
This is a more basic version, definitely. The Large prokaryotic subunit is 50S (Svedberg Units, or sedimentation rate). It has 5SRNA (120 nucleotides) 23S RNA (2900 nucleotides) and 34 proteins. Small subunit is 30S with 16SRNA -1540 nucleotides and 21 proteins. 16S is the site of antibiotic action. Eurkaryotic is 60S and 40S.
The steps are initiation, propagation and elongation, and wow I just realized that this video missed so much information.
What builds the proteins that make up the ribosomes? And why are ribosomes different in the three domains of life?
I thought this was supposed to be advanced...
No discussion on initiation or elongation factors, nothing about release factors, nothing about wobble, aninoacyl-trna synthetase, the polarity of the tRNA, 30s 50s ribosomes subunits...
FlashGamer1Fable !!!
Chill out, it's only three minutes long. They go in to that in other videos.
+FlashGamer1Fable In a 3 minute video, are you trolling?
+nygeek64 It's a RUclips comment.
I'm pretty sure this was ripped from PBS secret life of DNA. Animation is almost the same and the script is almost the same
Thank you so so SOSOSOSOSO much for having a transcript.
I’m here because this was uploaded 10 years ago and today we in a pandemic COVID-19
Vaccine using this technology. Not sure what to think of about this.
Quantum Lewis dot notation then come back to this
@@ChiDraconis where focus flows energy goes
@@microska2656
To speak for others there must be a Conspiracy
Conspiracy Theories are often negative;
- More than 1 in 3 Americans believe that the Chinese Bat Lady engineered the coronavirus as a weapon yet if I try to look into that Baseball Bats are the only bat that I am likely to find ~ As a painter you may be interested in Quantum chromodynamics
If the concern is about engaging with DNA, then don't be worried; It works without the such engagement. It simply does what the weakened virus versions would do, but without the infector as a whole, but with a part of it, responsible for creating virus spikes and/or triggering the immune system to create antibodies, without the immune system having to fight in a COVID-19. Don't take my word for it though, I'm not very qualified in this area. I just have read the topic a bit.
LOL "this technology", its anatomy, its the basic function of life. Ribosomes just makes things, they're little machines. Every virus ever uses them to make more viruses. The covid vaccine is just a small portion of the virial DNA, and only encodes for the proteins that coalesce and form the outer spike of the virus. Which then causes an immune system reaction and anti-bodies to generate. Its not rocket appliances
Holy kittens, I can't believe I have this going on in my cells basically all the time. It looks like a perfectly choreographed ballet. I've been searching for this because I want to be able to explain how the mRNA vaccines work to people who still don't understand why I'm so enthusiastic about this new development in the history of vaccines, but now I'm so fascinated that I need to dig deeper.
This is absolutely brilliant! Perfect for my AP Bio class! Thank you!
You remember that when you get sick, and your CD8 stops working. Remember when you wanna silence those who disagree with the jabs.
Beautiful! This is incredible!
Absolutly: Inteligent Design !!!
i need to know how deep did they do to the realism on this animations.
pick any episode of the Simpsons to find out...
Most people don't know that, originally, RNA was the preferred form of genetic material. Evolution switched to DNA because it was less prone to base mutations and hydrolysis; RNA already existed as the "go-between" between DNA and polypeptides. The process is ridiculously unfathomable, but all the more wonderful for it :)
Shellie Archibald that's so cool! Thanks for sharing :)
You are assuming RNA first. Where's your hard evidence?
Strange, as RNA is very unstable and “temporary”. The turning on and off of DNA genes determines its production, which in turn determines the production of proteins/enzymes. Scientists weren’t there to observe what you described. It is just conjecture.
I watched this video to learn this for my microbiology class. Now 2 years later, this is happening right now inside my body after my vaccine :)
Good luck see how you are in a couple years
@@wouldntyouwantotoknow2602 the fact that you say this is, already thinking negative and bad things for someone is sad. Hope you make it :)
U fell for the trap :( this is sad
@@chris_maejor Which trap?
@@victorriverieulx2297 taking the shot...
wow, I wish I knew how cool bio is, I would have been way more interested in school!
10 years later and I am still waiting for the advanced bit.
great video, but it would have been nice if you talked more about the P,A,E sites as well as the different enzymes used in translation. also Translation first starts on the P site when Trna transfers the metiyonin aminoacid over to the AUG codon located on the P site to start translation. overall Great video thank you
Does dna only code for protein? Is everything that makes us work just because dna coded for a specicfic protein?
How do ribosomes know what to do?
@@Kal-EL_Volta Yes, most of our bodies vital functions occur due to proteins, which make structures and molecular machines, or enzymes, which catalyze reactions. None of these parts really "know" what to do, but basically, the ribosome forms around a "start" sequence on the mRNA, and then waits for a tRNA molecule with the proper matching sequence on it to click into place. Whenever matching sets of RNA letters come together, A-U, and G-C, a small amount of energy is released and this energy drives forward the ribosome's action. Then another tRNA comes into place on the next available site, and the matching of 3 base pairs again provides enough energy to drive to the next step, which is fusing the two amino acids, after which the first tRNA is ejected. Basically, the video isn't showing all the wrong tRNA pieces coming in and going out, unable to provide the necessary energy, and only shows the correct pieces going in and driving the reaction
As someone who has done programming, I can say that the process shown here is quite similar to it.
RNA = script
ribosome = interpreter
protein = output
I got a 100%!!! I couldn't believe it. I thought there was a typo haha :D This video helped me.
This is a very basic animation over translation. It only simply mentions eukaryotic cells. It does not show how the Translation begins with EIF's which is attracted to the cap at the 5 prime end. This then attracts a methianine tRNA which will attract a 40s SSU ribosome bottom followed by the 60s LSU top of the ribosome. This is just the initiation of translation of eukaryotic cells.
Good video but not "advanced" enough. Didn't mention Elongation factors or proof reading CCA arm, editing site, active site etc. If the latter isn't a part of the translation itself, EF's are. The EF's that bring the tRNA to the ribosome for instance. Or am I wrong?
Initiation factors bind to the 5' cap of the mRNA and guide it into the small ribosomal subunit. And they hold it in place while the small subunit scans for the start 5'AUG3' codon. Then a tRNA carrying an elongation factor with an anti codon 3'UAC5' carrying a methionine comes and binds to the mRNA, the large subunit then joins the complex and begins the process
This is a marketing video intended to sell this misguided intellectualism to the general self despising public.
You're right. For eukaryotes, eEF1A brings charged tRNA to A/T site. If base pairing is successful, eEF1A would hydrolyze its GTP, dissociate, and leave the A/T tRNA in the A site. Then after peptide bond formation and 40S head rotation, eEF2 would come and help with translocation. The overall process is similar for prokaryotes, but instead of having eEF1A and eEF2 they use EF-TU and EF-G. On top of that there are initiation factors, most importantly eIF2, eIF3, eIF4E and eIF4G and release factors (eRF1 and eRF3), as well as other proteins that either promote ribosome re-initiation, recycling or hibernation.
Thank you for the teaching of mRNA translation.
Bless you.
This process right here is hard af to describe with words and this is just the "basics of basics" holy shit lol
This is a clear evidences of existence an an Intelligent designer of bioquimic facts .
Great vids. Would be helpful if there was some kind of numbering attached to help new viewers sort out which to view first and in which sequence.
It's not about being humble or not, it's a misleading title for a college student seeking extra info like me. I was expecting visual representation of say, EF mechanisms or IF1,2,3. So yeah, sorry but this should not be labelled as advanced.
Amazing. This is no accident or random actions. It's by intelligent design. :-)
God is great!!
who made the designer?
@@JN-zr4ts Those are things that aren't usually answered, or even discussed. If there is any creator like God, then I believe he started the universe, or something where our universe is at, because such things as evolution, forming of complex stable structures is possible, and at studying that we probably are quite advanced and correct. Otherwise, it's hard to tell to a human that something can appear not as expected by our human comprehension.
What a lazy way out.
im working now with 5S rRNA the small RNA in the Large subunit in Leishmania major :) I used this video to show te ribosome to my friends. So they can got and idea about my work :D.
how do they know about this process in such a detail?
What is the methodology of gathering motion data of such a small units?
they use a tiny camera placed into a cell and record it all.
They were observed using x-ray crystallography. A neat way to tell the shape of really small objects.
@@shinji906 a microscopic Go-Pro? Bodycam? Lol
No, they use reverse engineering of area 57 technology and shrink a submarine filled with biologists and a film crew and get injected Into the mRNA Vaccine jab site.
Exit is usually by circumnavigation of the blood supply to be filtered into the kidneys where upon extraction - they are all reanimated with a reverse particle beam.
@@rickknight3823 hmmm🤔I like that
Absolutely fascinating! Thank you....
first trna actually attaches to the P site, then after that they all correspond and connect to the A site, going along the chain from A to P to E
A request for a technical issue: use of occasional slow motion images. Too hectic activity is to pay attention to. It'd be very nice if those processes were shown at slower speed for a short while to have a clearer look at each elements. Anything else, perfect!
this is crazy this going on right now INSIDE me!
reading this after having learnt programming is mind blowing.
Please explain
@@jungle1776 the DNA acting like code/parameter string and the ribosome acting like a interpreter. So many parallels to how programming works.
@@thexxmaster so you are saying they are trying to program is? I'm just trying to understand. I don't know coding.
@@jungle1776 yeah. So programming is the process of creating code which creates an output, which is a computer program. The DNA acts like the code, with it defining the output: a protein.
Software code is just a text. That text must be 'read' by something like an interpreter, that reads the text like a recipe and builds the software program. DNA follows the same process: the amenio acids are like words in the recipe, and the recipe is read to build a protein. The interpreter here is the ribosome.
A wikipedia search on computer compilers might be nice further reading.
Now I need to find a comparison vid between the two
The “central dogma” mentioned at the end of this video is actually false. DNA does NOT contain all of the instructions necessary for life to develop. Building proteins is only a (very small) part of the story. Developmental pathways cause different cells to express different genes. Some of those gene regulatory networks reside in the DNA, but a lot of the control and signaling mechanisms do not. Simply building proteins does not include the necessary instructions that tell each individual cell which genes to turn on, which to turn off, as each cell differentiates and specializes (e.g., becomes nerve or neuron or muscle or bone cells). THAT information actually resides in information external to DNA. And there is other heritable information that does not reside in DNA at all. There are many sources of heritable information that are not found in the DNA, and scientists are just now beginning to learn about some of those (e.g., the “sugar code” on cell membranes that has been estimated as containing even more theoretical information storage capacity than DNA, or the heritable information contained in centrioles, etc.). While forming proteins is of course important, and different cell specializations require forming different proteins and in different amounts, the instructions for what type of proteins to make, in what quantities, and when, is actually not contained within the genome alone. And this video doesn’t even get into the information and complicated machinery required to perform post-transcriptional editing of the raw mRNA strand to edit out sections and splice unconnected stretches together into the final mRNA that contains the linear sequence of amino acids to form the final chosen protein. The level of information required for life to exist at all, let alone develop and diversify and specialize, etc. is actually much more complicated than simply building the right proteins.
@@metaphyziks7579 Great question! I would recommend checking out the Discovery Institute's Summer Seminars on Intelligent Design. Those seminars connect you with scientists working in the fields of biology, chemistry, cosmology, engineering, information theory, paleontology, etc. And the people who you attend with are often themselves scientists working in the field, whom you can connect with to stay current on the latest discoveries. I do read the literature myself as well, but it helps to have contacts working in the field to help provide context and help make sure I am interpreting the results correctly.
A great book that discusses all of the many challenges to all theories of abiogenesis is The Stairway To Life, by Robert Stadler and Change Tan. It is an excellent book that balances technical accuracy with readability by the general public who may not have advanced training in chemistry.
Bruh,
Edits not attempted due to clunky YT editor
Oh yeah - Human ears evolved from fish-gills;
@@John-jg2km All I saw was “Bruh, “ and nothing else. Did you have a comment or question?
This video is so relevant today.
Even my Molecular Biology textbook by Lizabeth Alison doesn't say ''advanced'' when spending an entire chapter just for translation. In fact it goes and suggests further material to read at the end of the chapter to understand it in more detail. An advanced material would be something that would explain the process in detail so that you can read and understand journal articles about the process. SO PLEASE NAME THIS ... (BASIC - OVERVIEW). Many of us are university students
EXACTLY! -___- or go read the textbook. This actually helps with the basic understanding. You can fill in the rest by READING.
This is just amazing/mind-blowing/genius! aghh life is so complex... the biological processes that occur in living systems are highly complex and ordered. However these reactions are characterized on the basis of simple laws and principles. Whether divinely orchestrated, determined via evolution or both (which i believe)! there is no argument that this is genius.
Differential equations cause all this. And no, I do NOT believe in sentient gods.
And evolution is a confirmed fact.
The codons (on the template- such as AGCT) tell which anti-codon is required (anticodon is present on the tRNA, and is reverse of the codon- in this case it would be TCGA). As the template moves along in the RNA, different tRNA's enter into the ribososme through the A site, when the tRNA has the required anti-codon, it moves into the P site where the (protein is being made) and releases its amino acid to join the chain (that is the protein). After releasing the amino acid, the tRNA exits...
U mean AGCU? T is not present in mRNA or tRNA
This is very scary experiment on mankind
@@Ankit42aa it's human experimentation
@LughGarrick The thing is that on such small scales like this we're talking about, molecules move relatively very fast. This animation being showed is slowed way down so you can see what is going on. In reality ribosomes can make hundreds of proteins a second.
Yes, all happened by chance. Hahahaha! If there is art, there is an artist; a building, there is a builder; a writing, there is a writer. Nothing “intelligent” happens by chance. The message for today is the key in mRNA is in the message being sent. When this can be manipulated by man, watch out!
hmmm
the athiest broke the common sense so you cant convince them , because they don't agree on the common sense that God gave us
Good logic. Scott in Texas doesn't feel right about anything complex arising over time on its own given enough time and space, so it mustn't be true. Humans are capable of better logic than this.
@Scott: Just because you don't understand it doesn't mean daddy did it.
@@bestryfulhd2102 Which one of the gods?
@eliastop It is called ribosomal RNA and contains structures and enzymes necessary for the synthesis of proteins. I hope that helps a little :)
Amazing creation of our God Almighty! There is absolutely no way that such specific things in our body were made my accident/out of nowhere....Praise the Lord!
Amen!
Yes, praise Allah!
@@responsibleparty Allah is not called "The Lord" Jesus is. 😄
@@jakovpralas5696 So you say. Things can get a little wonky when you don't live with an evidence-based mindset.
Praise, Zeus
they forgot to mention precursor RNA is made first... which then changes to functional RNA by cutting out the intrones (RNA-splicing)
anyway, this video is wicked :D
REMEMBER: This is the realm where the upcoming vaccine will be functioning; using messenger RNA. Why not use a traditional vaccine?
traditional vaccine being?
It takes too long.
@@gustavo1979 too long? How long is too long?
“Turned into flesh and blood” god that’s chilling to think about, but really cool too
can someone explain wobble please, my lecturer is hopeless
Base pairing in the ribosome isn't constrained by the structure of a DNA duplex or DNA polymerase, so it's a bit more relaxed. The nucleotide on the 5' position (usually the base most on the right) is free to "wobble". G can basepair with C like normal, or with U. U can base pair with A or G.
Inosine, I is also incorporated. I can base pair with A,C,U.
So, something like this
mRNA CGU CGU
tRNA GCA GCG
This way, one tRNA can recognize multiple codons for the same amino acid so you don't need 1 tRNA for each codon. With wobble you only need 32.
Make sense? It does in my head. I can send you a textbook screenshot. I think my book explains it well.
I understand it, thanks so much :)
Seriously we are learning thia in school and its so easy... but ill explain it to you for something in return.....
lol noob leave.
ChaseTheSunSet I put $20 In a box and you put $20 in a box. Then I sell the box( with the $40 in it) to you for $30....... who made profit and how much?
Really helpful. It helps me in my higher studies.
Now I know how the vaccine works
According to Francis Crick, "Biologists must constantly keep in mind that what they see was not designed, but rather evolved"
You can see why he said that. If we once allow ourselves to be impartial, we would intuitively recognize the hallmark of design in the magnificent gene expression process.
Humans use CAM (computer aided manufacturing) systems to turn information into real objects.
The ribosome likewise, is the 3D print head that turns digital information into flesh and blood.
Very well done indeed.
+reality programmer It's amazing that braindead fucks like christurds find it "amazing" that others might have different opinions from them about untestable unquantifiable imagaring things such as other realms.
Well said, Mass Extinction!
OMG. That is crazy!
Did genetics many many years ago but wanted to remind myself how these new mRNA vaccines will work. What a machine!
When man acts like God or Nature it tends to mess it up Big time
@@freedomthrufaith agreed. Man can't even create a simple cell from scratch . What dose that tell us?
The only real medicine is holistic natural medicine..
@@freedomthrufaith on
On official Moderna site they claim that it's not a vaccine but operational system like on your computer.
@@denisviklov4596 oh really?! I heard this but thought it was another curve ball distraction. I'll check it out. 👍
Thank You for this excellent video.
All of science put together doesn't know how complex a single living cell is.
All of human literature, religion, politics, law, war, prisons, put together doesn't know how complex a single living cell is and has accomplished nothing to prove anything about them.
As far as I know, a total of 21 amino acids are used to synthesize protein in cells.
Therefore, there may be several types of t-RNA, each of which can only deliver a particular amino acid. This may be because the anticodon of the t-RNA must match the corresponding codon of the RNA that is intended to encode that particular amino acid.
At a given moment, a particular codon of RNA is located in the input chamber of the ribosome. Because only one t-RNA can fit into the ribosome at its site of entry, it is mandatory that the anticodon of the t-RNA match the current codon of the RNA.
The synthesis of the protein requires that only the t-RNA whose aticodone matches the current codon of the RNA enter the ribosome.
The question is, how do t-RNAs know when one can enter the ribosome? - so how do they know if their own anticodon matches the current codon of the RNA?
I have no training in this but my assumption would be simply random interactions. There are 21 different types of tRNA bouncing around in the cytoplasm at all times and protein synthesis cannot continue until the correct tRNA happens to collide with the A site. In the video it shows them hopping on one after the other but in reality it would be much messier and you’d have tons of collisions before the ribosome added an amino acid. I’m pretty sure this is how most cellular processes work.
@@berban Is it possible that a particular codon in RNA somehow attracts the complementary codon that can be linked to it (the so-called transport molecule of a particular amino acid)?
And can this attraction be felt outside the ribosome?
@@LaszloToth55 Hm, I doubt it... what sort of force could you use for the attraction, magnetism or something? Cells can be attracted to sites in the body through complicated signaling mechanisms that involve both the cell itself and the blood vessels, but even that is only making the cells more likely to stop as they randomly pass by in the blood vessels. I don't think anything like that would be possible with these tiny molecules. but I really don't think it's necessary either... these things move so fast it's hard to comprehend
@@berban When atoms are connected to each other, there are electron donors and there are electron acceptors (sometimes both). An electrical interaction between electron donors and electron acceptors is established within a reasonable distance.
It is conceivable that this phenomenon also plays a role in molecules: a codon (three base molecules) can be electrically attractive enough for a complementary codon. This may explain the rapid synthesis of proteins using ribosomes.
There are a few proofreading measures that the ribosome employs. First, a cognate match has to be made between the anticodon/codon pair on the tRNA and mRNA, respectively. Specifically the first two codons need to form precise Watson-Crick base pairs. This causes a conformation change on the small subunit of the ribosome which is then relayed and amplified to the large subunit.
The tRNAs are carried to the ribosome via a small GTPase called EF-Tu (elongation factor). If a cognate pair is made between the first two codons of the mRNA and the second and third anticodons of the tRNA (they run antiparallel to each other), then the conformational change that this induces in the ribosomal small subunit is carried to the large subunit and allows for a domain on the large ribosome called the Sarcin-Ricin Loop to interact favorably with a histidine residue on the EF-Tu protein. This interaction then allows a water molecule to hydrolyze the GTP bound to active EF-Tu, and the free GDP dissociates. Once GTP is no longer bound, EF-Tu dissociates and the tRNA is effectively docked into the ribosome and locked into place, allowing for its movement to the P domain where the peptide bond is catalyzed.
Our Father who art in Heaven,never ceases to amaze us.
your father in heaven sadly did not make the Messenger ribonucleic acid (mRNA)
this is perfect! thank you
Some of the "expert" commenting is amusing. The nerds of science may not understand that other professionals are just as interested in our health as they are in other areas that affect them. Like cooking! No one wants to eat half done collards or crunchy rice. So you learn the secrets of good food. Before learning how to cook you needed to know what to cook. In depth learning is always life changing...(BTW) Im a certified diesel mechanic and we remodel commercial and residential Real estate. But I don't want to take a vaccine that may not be safe. So I want better understanding so I don't think myself into an early grave or take the "mark" and end up in hell...🤦🏾♀️
Thank you. This has been very helpful
This is not at all advanced! In-fact, this is a greatly simplified version. Please label the video appropriately.
Using the true molecular structures is a nice touch though.
this can be said about any chemical reaction which doesn't explain a specific interaction between specific protein molecules.
God at work.
What a lesson. This was so helpful.!
To God be the glory.
this youtube channel is gonna be useful...i hope
Not very "Advanced"... covers what you might learn in a high school bio course.
Our bodies are amazing.
Had to look this up because of covid vaccine 😳
@DrStasso These are not simulations, these are animations, incorrect I may add. Both electron microscopy and X-ray crystallography allow one to see at least some of the events at a sufficient scale of details.
It's really difficult for me to look at all this cellular busyness and not believe that someone or something created it so. It would be like walking into a busy corporate building filled w working people and believing that its creation wasn't driven by intelligence. It's just not reasonable to me. What you do you folks out there have to say???
Stop making these pointless analogies, you are used to see lots of objects that have human creators around you. That doesn't mean that natural things must have a creator in the same way.
Your failure to see the big picture comes from ignorance regarding evolution, I believe. Also I can't understand how you don't realize that your assumption raises more questions than answers.
Just how can you jump to conclusions like that only by observing complex stuff?
If you feel like this is awe inspiring (which it is) then why don't you try to study how this process came to be today instead of giving all the credits to something "bigger"?
***** Lol, "Evolution of the Gaps" fallacy, all "scientists" have to say about it is that it is "advantageous" and therefore must have been "selected". Absolutely no explanation of how it came to be. We don't know how it evolved, but it evolved for sure! Hahaha you evolutionist cultists are hilarious.
Militant Anti-Leftist "Absolutely no explanation of how it came to be. we don't know how it evolved..."
What do you mean?
***** There is literally not a single biological structure for which the mutations required for its supposed evolution are demonstrated. Scientists will say "it evolved", but never will they say "how" it happened, because they would expose the absurdity of evolution.
Militant Anti-Leftist It seems to me like you are not familiar with the basics of the theory. Please explain briefly what you think evolution means. I will try to clear any confusion.
Very informative animation, thanks🙏🌹
And why do we need cheap, man made fairy tales, spiritualism and other's form of bullshit when all these processes are million times more magical than any spiritual crap?
That's a Fairy Tale!
a biochem course for a tenth grader? When did they start offering that...
When clicking this I was worried that I am only undertaking an MD and not a PhD and this would be a bit over my head... I feel worried for humanity now.
Please consider Osteopathy
And simple minded people continue to say we “evolved”? Seriously? This micro level complexity is greater than anything man can “create”. The God of Abraham, Isaac and Jacob is real. More proof Genesis 1:27 is not a fairytale. Isn’t it time you took a moment to look at the alternate world view of Creation? The puzzle pieces all begin to fit perfectly. 🎚
Other way around champion... no way a god could create such complexity. Even said it yourself: "complexity is greater than anything man can create". Funny how we have evolved such complex brains but people continue to be blinded and clouded by fake ideals and stories that were written thousands of years ago.
its the mark of hte beast
Is every component in a cell or body created through this process? Im just now beginning to understand what DNA really is. I had know it was "the genetci code" but until I saw transcription and translation I didnt understand how it was used. So now my question is does this process make everything? For example mitochondria, golgi apparatus etc - do all the parts needed to make those components need to be "3d printed" with this translation process?
lol i love how 90% of the comments are people that didn't comprehend anything in the video and are exclusively here to whine about vaccines because mRNA is in the title. i swear if they'd arbitrarily chosen to be upset about the water content of vaccines they'd be on videos about where municipal tap water comes from and whining about that instead
Thank you
I can understand now why ribosomes are granular
"advanced" lol
shut up nerd
@@atomwaffel but it's not advanced tho. This is a basic summary to be honest. I get that they have to keep it simple for those who are not well versed in the many factors that go into this natural process, but @Baiju Sharda is right. This is not advanced. Why are you concerned that we are saying that this is not advanced? Wouldn't you want your scientists of the future to consider as many factors as they can when they conduct their studies for the sake of accuracy? Or would you rather scientists who keep things simple for the sake of those who hate "nerds"?
In this vid they neglect ALOT of factors that are very important in the completion of this natural process in DNA transcription, so this is a relatively basic summary my guy. Keep up tho. As you learn more, you will agree with us who say this vid be quite basic. ;)
What happens to the MRNA strand after it passes through the ribosome?
Destroyed
@@sadismx2137 That's not really a satisfying answer, matter can't really BE destroyed.
@@eonhet7826 degraded then, if you will
Where did this information come from. Did evolution make trillions of stumbing mistakes to create life. As you know evolution can't think. It has to be random mutation. So evolution made trillions of random mutation mistakes and had to create woman too. Which came first man or woman. Imagine all knowledge had to be present to create man where did this knowledge come from.
Does the mRNA strand get destroyed after?
Highly Structured, Highly Designed "MACHINES" ... not by Accident and NOT by Chance... #DESIGNED ... #ENGINEERED ... millions of these machines in each LIVING CELL ... #LANGUAGE #DNA #RNA #mRNA #ProgrammingLanguage - #coding, #decoding, #manufacturing
mRNA is basically RFID chip that's why you need four doses of nanotechnology
Exactly, how do we know if mRNA in vaccines will not produce protein RFID ?
@@danieljust295 'protein RFID'? wtf is a 'protein RFID'? do you know what RFID is?
Douglis Do you know what is self-assembly nanotechnology ? Do you understand that you can power up any circuit remotely via radio waves if a circuit comprises of an antenna ?
Now think, our body contain iron molecules and these molecules can be assembled using proteins into electric circuits. I’m not saying this is how it is but rather that such technology exists already.
And you expect me to believe this evolved slowly over millions of years by chance without God??? 😐🙃🤣
anything we can’t explain is substituted with “God”
@@MontyQueues no, things YOU can't explain CAN be explained by God.
It's not like we don't know the answer and just give up by putting God in all the gaps.
Even atheists have to admit that God is at the very least a possibility, even if they choose not to believe it (unless they're irrational). If God is a possibility, then you would have to compare how likely it is for the universe to pop into existence randomly by chance billions of years ago when a random unexplained dot of energy farted the universe into existence. Is it more likely that everything came from nothing, or everything came from something? God being an uncaused cause that answers how even that dot could come into existence, even if the bible didnt write it that way but that's another discussion. God gives an explaination for things evolution does not. Evolution takes you as far back as the dot of energy billions of years ago. It doesn't explain how the dot got there or any other obvious questions that come with this.
God explains it. He is the more likely answer. Idc what you think about the science or anything like that after that. I waste no time and start at the beginning. If atheists can't give me a good answer then the rest if the arguments are pointless. You can't have an issue with what the bible says unless you admit God is the more likely cause for his creation. He is more likely to exist than not exist.
I do not shoehorn God into things I can't explain. You are triggered any time the word God is mentioned. Then you attempt to discredit any argument for God as some kind of wild card. It's a childish way to shut down an argument before it can be made.
@@nikkiburg you wrote a blog to justify your insecurity, well hope you still have a good sleep
@@MontyQueues lol good to know your only response is to stick your nose up at my response with an insult to top it. Can't say I'm surprised. God bless ❤
@@nikkiburg don't cry yourself to sleep, keep worshiping that deity bro
Wow, this helps. Thanks
This is too basic...
what will happen to mRNA after translation? reuse? or degraded?
degraded and ribonucleotids are being reused
its amazing how there are some people that say that this insanely complex and ridiculously unfathomable process is a result of random chance of molecules coming together in soup, a few billion years ago :P
If you're saying what I think you're saying, you're implying that humans didn't exist 7000 years ago. THAT's ignorance.
i never said that :P just that this couldn't possibly have happened by chance
It didn't happen by chance. Evolution is more complex than this. Saying we were created by some greater being is just taking the easy way without pursuing the truth. We do not know the truth of our origin. We only have theories. Implying you know is not knowing at all. Admitting to now knowing is knowing a great deal. Think about it.
of course evolution didn't happen by chance :P im talking about abiogenesis. how did the first cell get here. and it had to have been able to reproduce so it had to have had this process.
That's what we only have theories about. "A higher diety created the cell" is imo ridiculous and a lazy escape from the truth.
For "advanced" the video never mentioned initiation factors, elongation factors, Shine-Dalgarno sequences, N-formyl-met-tRNA...