I give my senior dog her arthritis medication every month. Theoretically it takes 24 hours to take full effect but she perks up right away when I give her the shot. She knows the medicine makes her feel better so when she gets a shot she starts feeling better right away!
When I was in the hospital for gallstone pancreatitis I would feel immense relief as soon as the nurse came in with my painkillers, even though I was still in a lot of pain I felt so good knowing I was going to be getting the medicine any minute.
13:47 Representation is so important. It is extremely valuable to see people you respect, who "have their shit together," also appear to struggle with having pet hair stay on their clothes in professional settings.
placebo is genuinely great. but it's not great for every use, and that's okay. we just need to apply it appropriately and not force it on patients who it clearly isn't working for, like the studied success rate of most SSRIs.
Hypnobirthing. I had a friend who swore by it. I was skeptical, but during peak (back-to-back) contractions I was briefly able to not feel ANY pain. Our brains are very powerful.
I think my cat has the nocebo effect. I take her for a monoclonal antibody treatment each month for her arthritis. She gets so psyched out about going to the vet and spends the day acting like something terrible happened when it's no worse than any random vaccine.
hey neuro transmissions! would you want to do a video about the at-home ketamine therapy companies? while there's decent videos online about ketamine's general benefits and risks, i don't see anyone digging into these more affordable at-home practices and the safety based research. just a suggestion if you're interested!!
@@neurotransmissions I think many of us whom have dealt with or know someone dealing with MDD would love to see a video covering ketamine’s use in psychiatry. How did this once “party drug” become approved for depression? It’s rather fascinating.
Thanks for such an informative talk. I didn't expect to learn anything, thinking the little I knew for decades about placebos was all there was. I guess you could say Dunning and Kruger recommended this video to me LOL.
The little we know about the Placebo effect allows us to postulate that it is possible that when more research has been done on the subject, we will be able not only to make more extensive use of it, but also to better understand the way in which the human brain manages the mental correlate of "reality". I believe that it would be valuable to know if there is evidence of the effective functioning of the placebo effect when the placebo is applied to a non-human animal. My congratulations for the video.
Had a friend whose parents were members some kind of Indian cult where they used homeopathy. So my friend got homepathy pills for all sickness and pains as a kid and he thought it really worked. I'm assuming these were belly aches and coughs, so that's pretty innocent. I think just the fact that their mom could do something for any ache and pain was really comforting. It felt safe. Luckily, my friend never had a serious disease growing up, but it could have ended really badly. Their mom passed away from Cancer when we were teens. I always wondered if the homeopathy had something to do with that.
Homeopathy is so popular in France that their national healthcare covers the cost of it.* *ohh actually I just looked it up and they stopped paying for it in 2021. About time lol. At least 25% of French people believe in it according to most surveys.
Homeopathy *does* work. You do have to have the correct homeopathic remedy, though, or it will do nothing. (If you understood how homeopathy works vs allopathic medicine, you'd understand why.)
@@kj3d812 Yes I understand why it seems to work. As long as it's not a treatment for serious illness but that's up to each individual so therefore I am very uncomfortable with it.
@@kj3d812 There is no logical or scientific reason for homeopathic medicine to "work." Its origins are frankly bizarre as are its theories of operation. But if someone wishes to use homeopathic remedies it is, after all, their choice.
Thanks for this! Interesting parallel with psychedelic treatment modalities, and now you've got me curious about placebo effect on less than mainstream medical treatments...I think the same can be said about the anecdotal "life-saving" advice attributed to podcasters and wellness gurus shilling unsubstantiated protocols and greens powders. Feeling like a lifestyle change has made a difference, likely will make a difference in how one feels, rather than the protocol itself or the supplement du jour. Is there an "aspirational placebo"? Anywhooo, great content as always! :)
I can absolutely attest to it to some degree, one of the ADHD medications i take was unavailable for a while, then i got a notice it could be ordered, went and picked it up. i did not realize the capsules where a smaller amount than normal because they looked the same externally unless you looked close. Now my normal dose for this would be 30-45 MG, not knowing these where much lower dose capsules to be taken in multiples as substitute what i took was more like 10. and i felt absolutely wired all day, then after i got home and read the label devolved into a laughing fit. No ones immune, especially if you think you are lol
The placebo effect extends beyond medicine! A good example are the various audiophile gadgets for improving sound, that audiophiles claim actually work. And it seems that the more expensive the gadget, the better it works...
Yes! It's also seen with wine. If you buy a ten dollar bottle of wine and tell someone it's a $700 bottle of wine, they're going to enjoy it significantly more. This is actually one of the functions of decanters - to elevate the appearance of lower-quality alcohol to enhance people's enjoyment.
For diseases such as ulcerative colitis, effective treatment can be the difference between a bowel section and a relatively normal life. Experimenting with a
When I was a little child, I asked my mom how come that getting kissed when you fell and scraped your knees open on the sidewalk made it better. She explained to me in very simple terms that it was because of the placebo effect. I asked "will it stop working now that I know it does nothing?" And she said: "well, the placebo effect does something." So after that day anytime I fell and got hurt I would seriously ask my mom for "a placebo kiss" and it kept working LMAO
And then i got the shingles vaccine. First shot, no problem. I never worried, and was then totally blindsided when the second one knocked me on my butt. I had expected to be fine. To date this is the only vaccine that made me sick.
weren't there a few studies that showed that a majority of the benefit from SSRIs comes from placebo, or if not the majority at least a large part especially with sertraline..... I maybe shouldve watched more than 2 minutes before commenting LMAO
I've been on SSRIs for years and think there's certainly some benefits to them but I just recently learned that consensus agrees that the 'chemical imbalance' model of depression is totally wrong.
It would obviously be IMMENSELY unethical to run this test, but I would be interested to know how many people felt improvement while taking actual anti-depressants without knowing they're taking them, compared to people taking placebos while thinking they're taking anti-depressants. It would literally mean no consent, informed or otherwise, so obviously there's no way we would ever run the study, but it would be very interesting to know if a placebo is better than medication we don't know about. (I suspect that the unknown medicine is better than the placebo, but it's an interesting thought)
What you are describing is exactly how every study goes before a new drug hits the market. People who produce the drug need to know how efficient it is or if it works at all. No antidepressants are sold without going through such trials first. It's not exactly unethical. The people taking part in the study know that it's experimental and might not work. And also that 50% of the participants will be in the control "placebo" group. I hope I could explain in well.
@@0203mariam you've fundamentally misunderstood what I said. I'm describing administration of a drug without any knowledge of the patient whatsoever. As in "they don't know that they are taking a drug or that they're even in a study at all"
That would be a study that would have worked great using a prison population as the subjects. I mean, I'm glad that stuff like that can't (legally) be done anymore but it would be super interesting.
didn't this channel make a video about the dearth of null results in published research a while back? it seems to me an apparent "placebo effect" is exactly what you see from a bias towards publishing placebo-affirming results. you can make statistical noise look like anything if you filter it enough.
As a patient, my thinking is : "GIMME SOME OF THAT PLACEBO, PLEASE! LOTS OF IT! (and, then, if it doesn't work, give me your big pharma chemicals with all their side effects). Now, I know, it's easyer said than done but it seems to me that ifwe did that, we would improve people's lives at a lower cost and with lesser side effects (wich, in turn, need to be treated with other meds, which have their own side effects...). I think, that would be the most rational and pragmatic approach... (Big Pharma might not like it, though)
Really bothered by Drs who willynilly refer to 'depression' as if all depressions are the same. It's like talking about treatment for cancer and picking out studies for the treatment of specific cancers and specific cohorts of people but always saying just cancer.
Anyone still using the antidepressants work as well as a placebo argument is a channel that needs to have more creative and well thought out arguments.
Throughout human history, ingestion of exogenous material or topical application there of has always had a belief associated with such practice or ritual in an attempt to alleviate or heal discomfort. This was only hijacked by science and at times atrophied. But the reality is its just mere exploitation of natural occurrence/mechanisms for benefit and should not always be dismissed or labeled “quackery”.
Discrimination based on intelligence isn't classism, there are intelligent people in all classes. Inferring that the poor are unintelligent is the opposite of what you meant to do, I think. I know you meant well with the comment though.
You are correct that there are intelligent people in all classes, but it is still a classist belief because, for most of recorded history, formal education was something that was only accessible to the wealthy. Those who were poor were not educated to the same degree and, therefore, were seen as unintelligent and those in the upper crust believed that people were poor because they are unintelligent.
Do you might think that at an time when our health care is in such deplorable condition that this concept might be pushed? Perhaps it’s gust a Coincidence, no?
There can be some health benefits to removing a small amount of blood infrequently (no more than a pint every 6-8 weeks). That mostly has to do with iron levels and temporarily removing some old red blood cells or reducing blood pressure. For those reasons, it's used for diseases like hemochromatosis and polycythemia. And donating blood infrequently is not considered a health risk and could even have some cardiovascular benefits. But bloodletting entailed removing large quantities of blood, sometimes multiple times in a short period, and it didn't treat the underlying issue it was intended to treat. Instead, it often led to people developing anemia, extreme weakness or dizziness, and sometimes people even died. Overwhelmingly, it was a harmful practice. So yeah, let's not conflate the two. As I said in the video, removing a bunch of your blood *isn't* good for your health.
This is extremly dangerous. Just because you can explain something, it doesn't mean you can control it. This is the same as those who get hypnotised and ond those who don't/ Just because you want you want placebo to work it doesn't mean that it will. There are people who can't feel pain or have high threshold for pain and carry on while their biological state gets worse. It is unethical to promote it.
What makes it unethical? If someone knows it's a placebo and isn't using it in lieu of effective medication, what's the issue? If it works, great. If it doesn't, nothing lost.
@ransmissions As, I pointed out a lot of people have high pain thresholds. If Placebo is given for pain and it does make the pain go away, they won't find the source of the pain. There is a function to pain. That is to alert you of something needing attention. Besides, just because doctors can't diagnose what is wrong it is not that the pain is in you head. I would have thought doctors would have learned that by now, not that this woman was a doctor anyway. I knew of a woman who couldn't feel pain in her stomach and ended up bleeding and died of sepsis. Placebo effect and medical treatment should never be mixed as an excuse for ignorance of a doctor. I have no doubt that the brain has the capacity tu cure everything but that shouldn't be mistaken with placebo effect. It is far more complicated than that and it is no baisis for generalisation. Furthemore, placebo effect is often temporary. It is like self hypnosis and just because it enables you to do something for a while it is doesn't mean that it has cured you. It is part of the survial instinct or it is very difficult to seperate from it. People get shot and feel no pain because they are in shock that in itself will cause death later. This problem of simplification of not understanding the exact mechanism of how the brain works has always been part of the problem in medicine. Hence treatment of symptoms rather finding the root cause that has become engrained in western medicine. Even the divisions of organs are arbitrary and specialisation is the biggest bane in medicine. This is why it is unethical to promote it.
i was skeptical of hypnotism and also am a paranoid person, so my expected outcomes were 1. nothing or 2. brainwashed by hypnotherapist. i was shocked when it actually helped with the pain i was getting it for since i was skeptical it would even work.
I would re visit that onion thing, toxins leave via the feet and onions attract bacteria seems legit. Also, the best way to treat a fever is to leave it alone unless it’s over 100,let it do it’s job. Not elaborating on these points is irresponsible for a “science” channel
![I.N "HALLUCINATION" | [Stray Kids : SKZ-PLAYER]](http://i.ytimg.com/vi/n5B5q1Hwt_U/mqdefault.jpg)
I give my senior dog her arthritis medication every month. Theoretically it takes 24 hours to take full effect but she perks up right away when I give her the shot. She knows the medicine makes her feel better so when she gets a shot she starts feeling better right away!
Placebo effect has been documented in pet care givers and zoo keepers as well as veterinarians
When I was in the hospital for gallstone pancreatitis I would feel immense relief as soon as the nurse came in with my painkillers, even though I was still in a lot of pain I felt so good knowing I was going to be getting the medicine any minute.
13:47 Representation is so important. It is extremely valuable to see people you respect, who "have their shit together," also appear to struggle with having pet hair stay on their clothes in professional settings.
placebo is genuinely great. but it's not great for every use, and that's okay. we just need to apply it appropriately and not force it on patients who it clearly isn't working for, like the studied success rate of most SSRIs.
"Ask your doctor if Placebo™ is right for you..!"
Hypnobirthing.
I had a friend who swore by it. I was skeptical, but during peak (back-to-back) contractions I was briefly able to not feel ANY pain.
Our brains are very powerful.
I think my cat has the nocebo effect. I take her for a monoclonal antibody treatment each month for her arthritis. She gets so psyched out about going to the vet and spends the day acting like something terrible happened when it's no worse than any random vaccine.
hey neuro transmissions! would you want to do a video about the at-home ketamine therapy companies? while there's decent videos online about ketamine's general benefits and risks, i don't see anyone digging into these more affordable at-home practices and the safety based research. just a suggestion if you're interested!!
This is a topic we’ve talked about! You’ll probably see it in the near future!
@@neurotransmissions oh that's amazing!! can always rely on you for good, nuanced info. ❤️❤️
I'd really like to see one!
@@neurotransmissions
I think many of us whom have dealt with or know someone dealing with MDD would love to see a video covering ketamine’s use in psychiatry. How did this once “party drug” become approved for depression? It’s rather fascinating.
Getting a blood test makes me feel like my body is falling apart. I can't imagine thinking I'm getting better from a bloodletting 😭
7:33 Picture is of Henry Ward Beecher (clergyman), and not of Henry K. Beecher (anesthesiologist)
Thanks for such an informative talk. I didn't expect to learn anything, thinking the little I knew for decades about placebos was all there was. I guess you could say Dunning and Kruger recommended this video to me LOL.
The little we know about the Placebo effect allows us to postulate that it is possible that when more research has been done on the subject, we will be able not only to make more extensive use of it, but also to better understand the way in which the human brain manages the mental correlate of "reality".
I believe that it would be valuable to know if there is evidence of the effective functioning of the placebo effect when the placebo is applied to a non-human animal.
My congratulations for the video.
Really good point. Id like to know the same
@@Misslayer99 Weird, I remember seeing one of your comments recently on Satan's Guide to the Bible lol.
@@chucklebutt4470 That was definitely me lol. Such a good video!
Had a friend whose parents were members some kind of Indian cult where they used homeopathy. So my friend got homepathy pills for all sickness and pains as a kid and he thought it really worked. I'm assuming these were belly aches and coughs, so that's pretty innocent. I think just the fact that their mom could do something for any ache and pain was really comforting. It felt safe.
Luckily, my friend never had a serious disease growing up, but it could have ended really badly. Their mom passed away from Cancer when we were teens. I always wondered if the homeopathy had something to do with that.
Homeopathy is so popular in France that their national healthcare covers the cost of it.*
*ohh actually I just looked it up and they stopped paying for it in 2021. About time lol. At least 25% of French people believe in it according to most surveys.
Homeopathy *does* work. You do have to have the correct homeopathic remedy, though, or it will do nothing. (If you understood how homeopathy works vs allopathic medicine, you'd understand why.)
@@kj3d812 Yes I understand why it seems to work. As long as it's not a treatment for serious illness but that's up to each individual so therefore I am very uncomfortable with it.
@@kj3d812 There is no logical or scientific reason for homeopathic medicine to "work." Its origins are frankly bizarre as are its theories of operation. But if someone wishes to use homeopathic remedies it is, after all, their choice.
Thanks for this! Interesting parallel with psychedelic treatment modalities, and now you've got me curious about placebo effect on less than mainstream medical treatments...I think the same can be said about the anecdotal "life-saving" advice attributed to podcasters and wellness gurus shilling unsubstantiated protocols and greens powders. Feeling like a lifestyle change has made a difference, likely will make a difference in how one feels, rather than the protocol itself or the supplement du jour. Is there an "aspirational placebo"? Anywhooo, great content as always! :)
Love the science. Great video. But, how can I bottle the placebo effect so it can heal depression? 😊
I can absolutely attest to it to some degree, one of the ADHD medications i take was unavailable for a while, then i got a notice it could be ordered, went and picked it up. i did not realize the capsules where a smaller amount than normal because they looked the same externally unless you looked close.
Now my normal dose for this would be 30-45 MG, not knowing these where much lower dose capsules to be taken in multiples as substitute what i took was more like 10. and i felt absolutely wired all day, then after i got home and read the label devolved into a laughing fit.
No ones immune, especially if you think you are lol
The placebo effect extends beyond medicine! A good example are the various audiophile gadgets for improving sound, that audiophiles claim actually work. And it seems that the more expensive the gadget, the better it works...
Yes! It's also seen with wine. If you buy a ten dollar bottle of wine and tell someone it's a $700 bottle of wine, they're going to enjoy it significantly more. This is actually one of the functions of decanters - to elevate the appearance of lower-quality alcohol to enhance people's enjoyment.
For diseases such as ulcerative colitis, effective treatment can be the difference between a bowel section and a relatively normal life. Experimenting with a
If a Dr. gives you a placebo instead of real medicine, do you still get charged as if you got the real medicine?
When I was a little child, I asked my mom how come that getting kissed when you fell and scraped your knees open on the sidewalk made it better. She explained to me in very simple terms that it was because of the placebo effect. I asked "will it stop working now that I know it does nothing?" And she said: "well, the placebo effect does something." So after that day anytime I fell and got hurt I would seriously ask my mom for "a placebo kiss" and it kept working LMAO
If you or a loved one has taken placbos and been effected in a negitive way you are entitled to compensation
And then i got the shingles vaccine. First shot, no problem. I never worried, and was then totally blindsided when the second one knocked me on my butt. I had expected to be fine. To date this is the only vaccine that made me sick.
Thanks for such an informative video.
All hail the Algorithm
weren't there a few studies that showed that a majority of the benefit from SSRIs comes from placebo, or if not the majority at least a large part especially with sertraline..... I maybe shouldve watched more than 2 minutes before commenting LMAO
I've been on SSRIs for years and think there's certainly some benefits to them but I just recently learned that consensus agrees that the 'chemical imbalance' model of depression is totally wrong.
I would hazard a guess that the neurosis of the US population has something to do with their higher response to placebos.
Excellent episode! Thanks for covering this!
It would obviously be IMMENSELY unethical to run this test, but I would be interested to know how many people felt improvement while taking actual anti-depressants without knowing they're taking them, compared to people taking placebos while thinking they're taking anti-depressants.
It would literally mean no consent, informed or otherwise, so obviously there's no way we would ever run the study, but it would be very interesting to know if a placebo is better than medication we don't know about. (I suspect that the unknown medicine is better than the placebo, but it's an interesting thought)
What you are describing is exactly how every study goes before a new drug hits the market. People who produce the drug need to know how efficient it is or if it works at all. No antidepressants are sold without going through such trials first.
It's not exactly unethical. The people taking part in the study know that it's experimental and might not work. And also that 50% of the participants will be in the control "placebo" group.
I hope I could explain in well.
@@0203mariam you've fundamentally misunderstood what I said.
I'm describing administration of a drug without any knowledge of the patient whatsoever.
As in "they don't know that they are taking a drug or that they're even in a study at all"
That would be a study that would have worked great using a prison population as the subjects. I mean, I'm glad that stuff like that can't (legally) be done anymore but it would be super interesting.
didn't this channel make a video about the dearth of null results in published research a while back? it seems to me an apparent "placebo effect" is exactly what you see from a bias towards publishing placebo-affirming results. you can make statistical noise look like anything if you filter it enough.
Your background music is just a little too loud. ty
Just WOW
so is thinking about eating more pez giving me diabetes?
As a patient, my thinking is : "GIMME SOME OF THAT PLACEBO, PLEASE! LOTS OF IT! (and, then, if it doesn't work, give me your big pharma chemicals with all their side effects). Now, I know, it's easyer said than done but it seems to me that ifwe did that, we would improve people's lives at a lower cost and with lesser side effects (wich, in turn, need to be treated with other meds, which have their own side effects...). I think, that would be the most rational and pragmatic approach... (Big Pharma might not like it, though)
Really bothered by Drs who willynilly refer to 'depression' as if all depressions are the same. It's like talking about treatment for cancer and picking out studies for the treatment of specific cancers and specific cohorts of people but always saying just cancer.
I thought the nocebo effect was when you don't believe the real treatment will work, therefore it doesn't.
I'm trying to listen to the talking in this video but the music drowns it out!
Anyone still using the antidepressants work as well as a placebo argument is a channel that needs to have more creative and well thought out arguments.
Throughout human history, ingestion of exogenous material or topical application there of has always had a belief associated with such practice or ritual in an attempt to alleviate or heal discomfort. This was only hijacked by science and at times atrophied. But the reality is its just mere exploitation of natural occurrence/mechanisms for benefit and should not always be dismissed or labeled “quackery”.
Wait. Doing stuff that makes you feel good, makes you feel good?!
Shonk!
Great
18:38
Discrimination based on intelligence isn't classism, there are intelligent people in all classes. Inferring that the poor are unintelligent is the opposite of what you meant to do, I think. I know you meant well with the comment though.
You are correct that there are intelligent people in all classes, but it is still a classist belief because, for most of recorded history, formal education was something that was only accessible to the wealthy. Those who were poor were not educated to the same degree and, therefore, were seen as unintelligent and those in the upper crust believed that people were poor because they are unintelligent.
Do you might think that at an time when our health care is in such deplorable condition that this concept might be pushed?
Perhaps it’s gust a Coincidence, no?
Not true, removing blood can actually be good for the body.
There can be some health benefits to removing a small amount of blood infrequently (no more than a pint every 6-8 weeks). That mostly has to do with iron levels and temporarily removing some old red blood cells or reducing blood pressure. For those reasons, it's used for diseases like hemochromatosis and polycythemia. And donating blood infrequently is not considered a health risk and could even have some cardiovascular benefits. But bloodletting entailed removing large quantities of blood, sometimes multiple times in a short period, and it didn't treat the underlying issue it was intended to treat. Instead, it often led to people developing anemia, extreme weakness or dizziness, and sometimes people even died. Overwhelmingly, it was a harmful practice. So yeah, let's not conflate the two. As I said in the video, removing a bunch of your blood *isn't* good for your health.
This is extremly dangerous. Just because you can explain something, it doesn't mean you can control it. This is the same as those who get hypnotised and ond those who don't/ Just because you want you want placebo to work it doesn't mean that it will.
There are people who can't feel pain or have high threshold for pain and carry on while their biological state gets worse. It is unethical to promote it.
What makes it unethical? If someone knows it's a placebo and isn't using it in lieu of effective medication, what's the issue? If it works, great. If it doesn't, nothing lost.
@ransmissions As, I pointed out a lot of people have high pain thresholds. If Placebo is given for pain and it does make the pain go away, they won't find the source of the pain.
There is a function to pain. That is to alert you of something needing attention.
Besides, just because doctors can't diagnose what is wrong it is not that the pain is in you head. I would have thought doctors would have learned that by now, not that this woman was a doctor anyway.
I knew of a woman who couldn't feel pain in her stomach and ended up bleeding and died of sepsis.
Placebo effect and medical treatment should never be mixed as an excuse for ignorance of a doctor.
I have no doubt that the brain has the capacity tu cure everything but that shouldn't be mistaken with placebo effect. It is far more complicated than that and it is no baisis for generalisation.
Furthemore, placebo effect is often temporary. It is like self hypnosis and just because it enables you to do something for a while it is doesn't mean that it has cured you.
It is part of the survial instinct or it is very difficult to seperate from it.
People get shot and feel no pain because they are in shock that in itself will cause death later.
This problem of simplification of not understanding the exact mechanism of how the brain works has always been part of the problem in medicine. Hence treatment of symptoms rather finding the root cause that has become engrained in western medicine. Even the divisions of organs are arbitrary and specialisation is the biggest bane in medicine.
This is why it is unethical to promote it.
i was skeptical of hypnotism and also am a paranoid person, so my expected outcomes were 1. nothing or 2. brainwashed by hypnotherapist. i was shocked when it actually helped with the pain i was getting it for since i was skeptical it would even work.
Gaslighting people with sham surgeries 🤦🏼♀️
That mic is ridiculous I’m sorry
You don’t like my fluffy mic? It’s like a cat! Same size, even!
It's so distracting, lol
floofy friend
I would re visit that onion thing, toxins leave via the feet and onions attract bacteria seems legit. Also, the best way to treat a fever is to leave it alone unless it’s over 100,let it do it’s job. Not elaborating on these points is irresponsible for a “science” channel
No.
www.medicalnewstoday.com/articles/323116#:~:text=After%20testing%20each%20sample%2C%20they,the%20body%20through%20the%20feet.
www.healthline.com/health/foot-detox
health.clevelandclinic.org/foot-detox