The Path Towards Mammalian Whole-Brain Circuit Mapping

Andrew Payne, co-founder and CEO of E11 Bio, explores the transformative potential of precision brain mapping in this enlightening talk from LabWeek Field Building. Learn about the groundbreaking technologies E11 Bio is developing to enable scalable and high-throughput brain mapping, and discover how these advancements can revolutionize neurotechnology, brain-computer interfaces (BCI), AI safety, and the understanding and treatment of brain disorders. This talk delves into the critical role of molecular barcoding and multiplexed expansion microscopy, highlighting their applications in AI, whole-brain emulation, and human health.
Created by Protocol Labs and co-curated by Foresight Institute, LabWeek Field Building gathered leading individuals and teams from frontier science to drive progress. The weeklong conference took place at Edge Esmeralda, a pop-up event city in Healdsburg, CA, from June 10-16, 2024. For more info on LabWeek Field Building, go to www.labweek.io/24-fb.
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[@rockapedra1130]

This has amazing potential, wow! It wasn't clear to me how you make sure each neuron gets a different barcode. Maybe I missed it. If not, maybe here is an idea: somewhere I saw that neurons already have a mechanism for creating essentially globally unique IDs, presumably to allow for self/other discrimination. It involves a random selection process of introns/exons to create statistically unique proteins, if I remember correctly. Anyway, one can imagine either leveraging this process or, more likely, using a similar method to create statistically unique patterns of fluorescent protein expression. I'll go look at your website, my guess is you already figured this out on the first day, and ur reaction is like: YAWN! Haha.