4 MYTHS about Pawpaws (Asimina triloba)

We planted our first pawpaw trees in 2002, and have been actively growing & fruiting them here on our microfarm for 10 years now. We have dealt with them from seedling to fruit and have noted a few common myths floating around. Here we attempt to address them.
Links:
www.mdpi.com/1... (An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill.)
www.sciencedir...
Anti-cancer:
www.frontiersi... (Selective Acetogenins and Their Potential as Anticancer Agents)
Solubility/digestion:
www.ncbi.nlm.n... (Bio-Guided Isolation of Acetogenins from Annona cherimola Deciduous Leaves: Production of Nanocarriers to Boost the Bioavailability Properties)
"The majority of the ACGs are then degraded by the strongly acidic medium present in the gastric phase"
(ANTICANCER AND NEUROPROTECTIVE PROPERTIES OF PAWPAW FRUIT EXTRACTS AND ACETOGENIN BIOAVAILABILITY) portal.nifa.us...
Acetogenin is not water soluble. (www.researchga...)
"Annonaceous acetogenins (ACGs) are lipophilic polyketides isolated exclusively from Annonaceae. They are considered to be amongst the most potent antitumor compounds. Nevertheless, their applications are limited by their poor solubility."
"Experimental data available in 2010 were considered by the French food safety agency (Agence française de sécurité sanitaire des aliments) to be insufficient to conclude that human consumption of soursop caused atypical parkinsonism in Guadeloupe" (Environmental Factors in Neurodegenerative Diseases)
"An average soursop fruit has been estimated to contain ~ 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 µg, such that an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion (Champy et al., 2005)."
plants.usda.go...