Antibiotics in pediatric sepsis

For baby age 28 days or younger …
Most common bugs:
Group B Streptococcus
Escherichia coli
Listeria monocytogenes (age less than 7 days)
Empiric abx: Ampicillin + gentamicin
(can swap gentamicin for cefotaxime/ceftriaxone in suspected CSF penetration → meningitis)
For baby age over 28 days …
Most common bugs:
Streptococcus pneumoniae
Neisseria meningitidis
Experic antibiotics:
Ceftriaxone
± Vancomycin (if meningitis or MRSA is suspected)