DMT in the Brain: A Pharmacologist's Perspective
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- Опубликовано: 5 окт 2024
- Dimethyltryptamine, or DMT, is a potent psychedelic drug commonly found in nature. Some suggest DMT is also produced by our brains and contribute to a wide variety of experiences. Scientists have also been intrigued by the possibility that DMT would be involved in, for example, psychiatric disorders and the generation of psychedelic experiences or dreamlike states. In this video, I will briefly examine the physiological function of putative endogenous DMT from a pharmacological perspective.
I'd be happy to hear your thoughts about this matter and continue the discussion down below in the comments section.
For more in-depth videos related to neuropharmacology, subscribe to my channel!
IG: @neuropharmacist
Twitter: @samuelkohtala
www.neuropharmacist.com
Further reading:
N,N-dimethyltryptamine and the pineal gland: Separating fact from myth
David E Nichols
PMID: 29095071 DOI: 10.1177/0269881117736919
The Eye of Horus: The Connection Between Art, Medicine, and Mythology in Ancient Egypt
Karim ReFaey, Gabriella C Quinones, William Clifton, Shashwat Tripathi, and Alfredo Quiñones-Hinojosa
PMID: 31355090 DOI: 10.7759/cureus.4731
N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function
Steven A Barker
PMID: 30127713 DOI: 10.3389/fnins.2018.00536
--- Added 26.7.2023
*A study of DMT in the Rat brain:
Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain
Jon G Dean et al.
PMID: 31249368 DOI: 10.1038/s41598-019-45812-w
*A Critique of the study of DMT in the Rat brain by the Nichols: www.aliusresea...
#dmt #pinealgland #psychedelic
I spent a little bit more time editing this than usual and I'd be happy to hear if that shows and is something I should pursue. I really enjoy putting extra effort in making a solid video, but it also means I might have to reconsider my posting schedule.
@@jackhannon4322 Thank you! Really appreciate the feedback.
Excellent video! Very informative and editing very much compliments it. 👍
@@everready2903 Thank you for your feedback! :)
Has Neropharmacist ever partaken of DMT, outside of normal Pineal production?
@@Khaymen223 I'm sure he's an expert from all perspectives.
isn't it funny how humans talk and make themselves sound so intelligent when the actual truth is we have absolutely no clue on the bigger picture of any of this. the millions of things on the past we can't explain from past civilizations that knew far more than we did but we like to talk and explain the world like the world revolves around us
I think about this almost everyday. Even had a heated discussion with someone regarding how old dinosaurs were, he kept mentioning a machine that could tell the year. Like come on now, were you or the machine actually there with the dinosaurs? Nobody truly knows anything, we only know what we see and are taught.
@@jaylapearson3256 It's this. It'a all related, every single thing. Let's start with this, christanity. Jesus was a central figure in bringing the enlighthment that people should try to be nicer to each other cause spiritually it is neccesary, when you die if you live your life in an incorrect and hellish manner that involves things like lying stealing cheating and all the things that are inherently bad thats present in all these religions. Dmt when you go off will remind you of those actions and it won't be fifteen min this time, it might feel like an eternity, depending on who you are as a person. In christanity it introduced that figure and then, there was this person. In the times of christ there was wine and adultry and those are things they took from jesus as holy tho it wasn't what jesus represented, jesus preached what every prophet preached, the common good of man. In Deuteronomy 18:17-19, Moses(as) prophesied:
“And the Lord said unto me. They have well spoken that which they have spoken, I will raise them up a prophet from among their brethren like unto thee, and will put my words in his mouth; and he shall speak unto them all that I shall command him. And it shall come to pass, that whosoever will not hearken unto my words which he shall speak in my name, I will require it of him.” when the prophet mohammed came he seperated the men and women then, he banned alochol as he seen that it made people stray away from their religion and commit acts of adultry, as well as provide a way to maintain cleanness of body, when muslims pray they cleanse their body with water before that. As they pray it affects the pinal gland, INMT which is thought to be the pivotal enzyme in the DMT production from the biogenic amine tryptamine, and therefore can indicate the sources of DMT. However, INMT methylates other substrates, and therefore its presence can only imply DMT production. Now lets keep going, in islam there is a term for the black spot present from said spot that produces dmt.
The zebibah, Arabic for raisin, is a dark circle of callused skin, or in some cases a protruding bump, between the hairline and the eyebrows. It emerges on the spot where worshipers press their foreheads into the ground during daily prayers. It marks them as devout muslims in belief and mannerisms with people. That is also present in hinduism a completely alien culture to the muslims. People who are said to have the capacity to utilize their third eyes are sometimes known as seers. In Hinduism and Buddhism, the third eye is said to be located around the middle of the forehead, slightly above the junction of the eyebrows, representing the enlightenment one achieves through meditation.
@@jaylapearson3256we can measure the time by the earth surface back then… we can measure the time that passed quite good, but yea there’s many weird stuff in our unknown history
@@TheMohammedAlmashaqbeh No, wrong. Let's not start with Christianity. Why are people so obsessed with continuing this delusion? Christianity is a massive fraud perpetrated by Rome in the fourth century, and had nearly nothing to do with the teachings of Ye'shua. The bible is historically invalid. That you believe this crap shows clearly that you have not studied the beginnings of your religion, the precedents, the history of the bible, the wider social and political issues of Roman Palestine, anything relevant. Islam is just as bad. DMT is one of the best methods of acquiring the awareness that transcends religion and renounces deluded beliefs.
Holy shit cringe thread detected.
Some situations are beyond words and thus can't be explained without a thesis through experience to the non experienced
Yes
Took dmt in the middle of a 5tab lsd trip. My cousin did as well.
After coming back from what I'll call an unexplainable high which was pleasant. My cousin and I sat and a had a conversation for about 5 hours.
After talking someone text me and I looked at my phone... we were only talking for 15 mins... I asked him and he said we were talking for about 5 hours and I agreed... when I told him it was 15 mins we just realized that Time is just an idea that we don't have to subject ourselves to.
It was a dope REALLY DOPE experience
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The first and only time I took DMT and broke through, I was unfortunately drunk and already tripping on acid. So I remember little. What I do remember was immensely beautiful. I was in a diamond hall (I say "hall" because I need to give it reference, although it seemed we were inside a space, the space was infinitely big and expanding) standing in a square of 3 other beings. These diamond light blinds radiated pure love. I, being the English yob I am, reached my hand out to shake theirs. We embraced into a massive ball of mystic love, pure euphoric love, and then I woke up crying, being cradled by my friend
Please keep producing these videos as they are very informative and interesting. I am especially grateful for those referencing Ketamine, as I have received Ketamine treatments for depression this year and have been greatly helped as a result. Steve Whitfield.
I've had ketamine infusions for my bipolar disorder. Been amazing! Has come back but the longest remission period I've had ever. Shrooms are also great. Jessika
Universe is fractal. Energy speaks a Language of logos, out of body , spiritual experiences are similar to DMT trip. You cannot possibly study the physical aspects of this substance to understand consciousness. You have to experience it.
Would love to hear how you talk about the spiritmolucule after a nice trip to lizard land.
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Sounded like a synthetic melatonin ad. This lad has to understand that there is more than one can comprehend at this point.
having had hundreds of psychedelic experiences over 30 years:
lsd: 500+ experiences
mdma: 100+
psilocybin: 300+
dmt: 2 dozen
i would rate DMT the most profound in it's effect on the psyche, with lsd a close 2nd.
DMT is heavy. magic in the brain. sometimes it feels as if it tries to suck you back into the trip as it is ending. my 'breakthroughs' are just blinding white bliss. no elves, no waiting room, nothing.
once, on shrooms, i used DMT - it enhanced the shrooms and put me into a breakthrough that was white light, but also imbued with geometric patterns. like i said, HEAVY.
lsd is more like a wondrous dazzling, though still impactful.
Man's on telegram
@@Nathankruse-do3tz thanks but i don't buy illegal shit online, lolol
Very interesting I was wondering how this differed. Things sure have changed since the 90's. 🤔
that is crazy
I'm not a scientist, but i have a sophomoric hypothesis that it since doesn't seem to have a specific receptor it acts upon with an immediate and obvious function, it serves to regulate sensitivity to all those commonplace workhorse chemicals that do. Kinda like tuning volume knobs on a studio sound mixer board.
Dr. Samuel, brain function & neuropharmacology are quite fascinating. Perhaps the hypothetical holographic nature of the brain is involved so that trace amounts of DMT (or any molecule) would have a profound subjective effect. I had just recently revisited reading "The Holographic Universe" by Michael Talbot. I highly recommend that book as the implications are rather profound and additionally, are pertinent to your work. Thank you for your content (found your channel this morning). Professional quality production and content.
I am interested in neurology regarding advancements/innovations for pain management (perhaps for future videos). Thanks & Cheers from Seattle! 🍻
I just had a very psychedelic meditation experience, it was amazing and a life changing experience , it was induced by the pineal glad meditation, grateful for this experience, truly beautiful and magical, I just smoked three inhales of a normal weed and it triggered it maybe.
I already had trance meditation states of canalizing energy but it was never powerful as this
So you only smoked weed but had a psychedelic experience?
@@chandlercameron9977dabs can produce a psychedelic experience
I fully believe dmt is part of our afterlife in some way. I overdosed about a month ago and had a sezuire and almost died. During the od I had a dream I was looking at myself in the mirror and it was like I was tripping BALLS. Never even tripped that hard irl. My face was all distorted and different colors😂. The fact that happend in the middle of a sezuire and OD kinda blows my mind because I almost never have dreams when Im high, i would assume i wouldnt either when im half dead in a overdose?🤷♂️ Life is honestly amazing and Im glad i was given a second chance at it.
Are you sure you had an overdose and it wasn’t just you having a breakthrough on the drug?
@@markomclane475 I'm sure I overdosed. I was on all kinds of shit and had a seizure and was turning blue from the lack of oxygen I had. If my friend weren't there, I'd be dead.
@@markomclane475I agree - you cannot overdose on DMT itself. You may have ego death though. If combining with other stuff? Yeah, for sure.
Interesting, and well explained man, thanks for sharing your time and studies
Thanks!
I've been having spontaneous psychedelic experiences since I was a child, and they were very similar to what is described as a typical DMT trip, with whole spaces of fractal geometric patterns that are 3D and constantly moving, sometimes with the loss of sense of orientation (not knowing where's up or down and a rocking feeling). Most often happened right before the REM phase of sleep. Interestingly, I know multiple people with similar experiences, and to all of us these can still happen spontaneously. I always thought that it was dimethylotryptamine release in the pineal gland that caused it, now it seems I need to revise that theory. What else could it be?
What you are describing sounds like "Alice in Wonderland Syndrome" in which it is common for people to experience at occasional points in life, especially during childhood and before sleep. The DMT experience is very different as it breaks down what makes you "you" and not just geometric visuals and such. It's a much more profound experience that cannot be fathomed into words.
@@enlightenedhermes I had ego deaths too, visions in which I couldn't remember or describe what is "me", where even the concept of "me" didn't exist
I had the same thing and learned to induce it before sleep. Its beautiful but can't seem to control it. Only difference is what i see is closer to visuals from a mushroom trip, not dmt. Ive done both thereafter having it. Wiki calls it closed eye visualisations?
Alice in wonderland syndrome is just another cop out diagnosis
@@camiel61 I wasn’t saying it was indeed the case of Alice in Wonderland Syndrome, I was just saying that it very well could be, due to the fact that all the things he describes perfectly fit the terms of an Alice in Wonderland Syndrome experiences.
Besides that, the guy hasn’t even tried DMT, so how would he know what’s similar or not to a trip? As someone who has had the same experienced as said in the op, and done DMT, they are vastly different.
Because of its role in nervous system signaling, DMT may be a useful experimental tool in exploring how brain works, and may also be a useful clinical tool for treatment of anxiety and psychosis.
There is no evidence of endogenous DMT playing any role in nervous system signaling.
NDE Vs DMT - PhD Pascal Micheal Greenwich University worth a read. Also Dr Rick Strassman (The Spirit molecule Book) notes it as The Seat of the Soul. To note it is close to NDE from experience. And if I may quote my favourite line from the Book - “Everyone is an Atheist up until 0.04mg”
Psychiatric illness can very easily be misunderstood since knowledge of other dimensions and realities are not understood by most people especially those in "professional" fields with outdated concepts of what reality really is.
Do you think there will be more research on endogenous DMT?
I'm sure there are some people interested in pursuing this line of work.
There should be a study on the knockout out of the ability to synthesize DMT in mice . Would be cool to see how that effected their brains.
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The shirt goes perfect with the subject matter
Haha!
Apparently, In all kingdoms, melatonin is produced from the aromatic amino acid tryptophan. In the mammalian system, biosynthesis then proceeds via hydroxylation to 5-hydroxytryptophan followed by decarboxylation to form serotonin (5-hydroxytryptamine). it is in this way very closely related to other tryptamines such as Psilocybin and DMT.
Curious if you have researched the brilliant man Terrence McKenna and his experiences with DMT. Great channel!
He was an intriguing character for sure! I know some of his hypotheses and find them interesting, but perhaps not so scientifically thorough. He had a brilliant way with words in reporting his experiences.
all that i have to say is that it is so good
for those of you who are curious to try be careful
So my ex was pretty skitzo and started having a lot of delusions.
He also started to “meditate” super seriously, and often him meditating would trigger him to start seeing intense experiences and delusions.
I started to do a little web surfing and I saw that skilled meditation, especially ones that focus on the pineal gland, they say they can trigger the pineal gland by focusing and in some rare cases can release dmt.
I know it sounds like a long shot but I have a theory that it really
Is connected. Maybe skitzo causes the pineal gland to be like hyper sensitive or something, or triggering the pineal gland can lead to skitzo, idk. He was also in his 30’s and had done a lot of a certain extra curriculars, so maybe too much of that caused some effects to his pineal gland which causes his delusions/skitzo episodes. He broke his brain or something, but I do feel some of these things are linked- it would make a lot of sense. If I were a doctor I would study correlations to these kind of phenomena.
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Is dreaming equal to hallucinating? If so, could that be something to do with the small amount of DMT
wow 😮 i wouldn’t doubt it
Enjoying your channel man! Id be interested to see a video on Kava.
Thank you! Might look into it at some point.
Hope to see a video from you on mdma and mda compound.
Maybe in the near future!
So scientists don’t know exactly why dmt is found in mammals and what really is the function of mammals?
The why can be speculated - that DMT is a tryptamine closely associated with many other biologically active molecules and pathways, and thus it may just exist as a side product of those machineries. The function of endogenous DMT is unknown as far as I know, suggesting it may not be relevant for any major function. But as I mention in the video, it could still have some physiological role waiting to be discovered.
DMT is not just endogenous in mammals, it is present in almost all lifeforms. I suspect you meant to ask 'what really is the function OF DMT in mammals'. The 'function of mammals' is a huge, vague, irrelevant issue.
@@Neuropharmacistand thus
@@tracemagace8434 yes
DMT consolidates our sensory, emotional, thought and memories to create experiences. The various inputs arrive at different times and must be buffered then consolidated. For example we watch a ball bounce and hear it bounce. What enters our eyes is traveling at the speed of light whereas the sound arrives at 700 miles per hour are brain buffers this then consolidates the experience. If the sound takes more than 200 thousandths of a second to arrive the two cannot be synchronized. That is the buffer size. So the further away the bottle is being bounced it will eventually desynchronize and we will notice the delay. DMT synchronizes all of our senses and those experiences into one. If you take enough. That's it
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I’m very sensitive to thc as it is. I can’t imagine what DMT will do to me . Especially I’m still recovering from Christian belief system that’s still programmed in me. I no longer practice or am Christian anymore . If I smoke a a lot I am faced with the real issues. Panic and anxiety of what I need to do to change my life for the better .
the pineal gland is most likely not the only part of the body that can produce it though, there is a possibility that the lungs and other part can produce it as well afaik.
If we take a cue from how DMT changes our perspective, i imagine it has something to do with how we process our world around us and project the images from our eyes into a 3D space.
DMT is actually produced in the lungs
I put more weight on the studies coming from Dr Andrew Gallimore and Dr Strassman then I would from you. Your condescending monotonous tone does not make you an authority on the subject.
I respect both scientist, but I have to note that I don't think Dr. Gallimore has published any studies concerning DMT in the brain, and neither have I.
I'm merely a neuropharmacologist interested in the subject matter. I certainly don't think I'm an authority on most of the topics I talk about, but I do hope that presenting my perspective may be insightful to some people. I sincerely hope that people would not evaluate anyones authority on any subject based on the tone of their voice.
@@Neuropharmacist apologies for coming off harsh
@@riseofmerlin3111 No worries!
Interesting channel, thanks !!! Psychedelics saved my life but I have a question; I heard of piezoluminescence happening when DMT crystals strike each other, and that this might even occur in the pineal gland. Is this even possible in the pineal gland because I would think dmt is in liquid form in the pineal gland (Is this true ?). I also tried to shake 22 grams of very pure NN-DMT but no piezoluminescence. Is this one of those fantasy (confirmation bias) stories dreamt up by someone tripping balls ??? Thank you for the great uploads, and I wish everybody a healthy, happy, and magical life 🌎☮
Some chemicals like DMT can elicit piezoluminescence under the right conditions. However, it does not happen in the wetness of the brain.
dr joe dispenza look it up he actually can answer ur Q
@@travissimpson1353 👍 Thank you.
The main problem with science, lacks wisdom
If we don't know why it's in our bodies, which is extremely strange seeing as we know everything else, what are the hypotheses to its meaning? I'm confused as to why we would've evolved to develop a useless compound.
I think you are overestimating the level of knowledge regarding even basic cellular functions. To illustrate this, there are hundreds of receptors in the human genome, the function of which remain unknown.
With the current knowledge, it remains plausible that DMT is playing some role in some biological function, but I find it hard to believe it would have a significant neuromodulatory effect in the brain. It is possible it is formed as a byproduct of metabolic pathways, with no immediate function. A lot of enzymes that transform and modify compounds are not spesific to a single substance, and there is no reason to expect that every enzymatic transformation creates only important products.
I believe a stark reason for why people find it so hard to accept that endogenous DMT would not have some transcendent role in the brain is because of the potency of the altered states it produces when administered in high doses.
Nevertheless, I want to emphasize that I'm not against the idea of DMT having a major role. It's just that there's really no solid scientific evidence to support such a role at this time.
Um not hating on you or anything, but wouldn't it be convincing if very trustworthy known scientist or you can try and see if it makes a difference.
I'm very curious
Try what?
@@Neuropharmacist DMT
@@Neuropharmacist dmt obviously
Why would you assume that I haven't or that it would make a difference?
@@Neuropharmacist Because I am curious
I respect you opinion. I'm of the school of thought that we as homo-sapiens our physical bodies were created with a purposeful design consisting of biological and chemical processes based upon function. I do not subscribe to the lazy interpretations that lead to the thought of junk DNA nor do I believe certain ideas should be dismissed as insignificant because of a lack of knowledge and understanding. The pineal gland as tiny as it is contains photo receptors similar to our eyes as well as is made up of rhombohedron shaped Crystal's that oscillate at particular frequencies that determine specific functions
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How did you become a neuropharmacologist? I'm so fascinated by psychedelics and their potential to revolutionize the way we deal with mental health issues. I have a B. Pharm degree and I'm a psychonaut 😂
Just continue to study and go for science!
Accepting life, I started with a B.Pharm. Just do a bit of recon and find a uni that has a neuropharm unit (preferably part of their School of Medicine or a pharmacy school that is more than 50y.o. - the type where you learn proper compounding and has a pharmacology, chemistry and biology - 3 prong focus). Then do the unit (beat all the med students), befriend the lecturer and ask if there are any volunteer positions available and go from there (at least that's what I did - I was running the tutes for the elective "Neuropharmacolgy 551/552" for final year B.Med/Surg students the following year.
I would also recommend not coming at it as in interest in hallucinogenics, bro the fun is in learning new and beautiful cascades that ultimately dictate how the rest of the flesh bag works. Psychonautics is fun but narrow and limiting.
What would cause a kid to have a DMT trip? I had an experience when I was young.
It is not uncommon for people to experience altered states of consciousness without any psychoactive substances. I think the implication that it was qualitatively a "DMT trip" is already making a lot of assumptions.
Thanks for sharing your thoughts!
Thanks for the informative video! I have some questions: Could it be possible that the pineal DMT production changes? I mean, can the gland produce biologically large amounts of DMT because of a sudden, critical event? Is it equipped to handle that? And how is DMT even produced in the pea-sized gland?
Thanks again!
The video states that there is no way of measuring that
@@XenoTravis yet...
You can see the air. Everything looks like a mosaic.
What is your source that the Pineal gland only produces 0,03mg of Melatonin?
See first reference in the description.
These people that think that because DMT is present it must be for mystical reasons are the same people that found out about NAD/NADP and its role in energy relocation and decided that swallowing large amounts of analogues would mean you have more youth and energy.
Yep
For a million likes, did you ever try DMT?
I believe answer is no. Once you try it we'll be interesting to see if you think the same way. Like Mackenna would say "I wouldn't it believe it, but believe it because I have seen it"
Your beliefs are wrong!
@@NeuropharmacistLol so direct and to the point
I believe mystical experience is caused by the up regulation of tryptophan and melatonin to dmt and pinoline and certain other biochemicals. This can only be done under certain conditions, proper diet, certain times of the month or year. I have had a few myself. Kelly Marie Kerr teaches about this. It's quite interesting and worth researching
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what i want to know is what is going on in the brain while under the effects of both low as well as high dose Iboga(not ibogaine alone) one thing that stands out to me is the fact that music becomes sped up yet speech doesnt even if they are happening simultaneously. the vocals in the music are sped up as well but if someone is speaking while the music is on they sound completely normal in speed while the music doesnt slow down its bizarre
DMT is the most amazing drug ever existed...
I’d appreciate your comment
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Thank you for sharing evidence.
The pineal gland has a functioning lens and a retina, hence the term the 3rd eye
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Cool shirt, man.
Thanks, man.
You know nothing, my friend! Or trying to keep the truth away! Everyone should experience DMT!!
so when we dream we release dmt? i had dream once taking lsd 3 tabs but never got visuals
No evidence for that.
Have you encountered many books or sources on the uses of drugs in ancient history?
I'm interested to know exactly what receptors dmt binds to at exactly what points in the brain/body. Where do I learn that
DMT: 4.00 5ht7, 3.97 5ht1d, 3.91 5ht2b, 3.53 Alpha2B, 3.53 Alpha2C, 3.51 D1, 3.42 5ht2c, 3.28 5ht1e, 3.25 5ht6, 3.16 5ht5a, 3.13 Imidazoline1, 2.95 Alpha1B, 2.75 Alpha2A, 2.70 Alpha1A, 2.58 5ht2a, 2.37 SERT, 2.23 Sigma1; 0.00: 5ht1a, D4, D5, Beta1, D2, D3, DAT, NET, 5ht1b, Beta2, Sigma2, CB2, KOR, Ca+Channel, M1, M2, M3, M4, M5, H2, CB1; ND: H1, DOR, MOR, NMDA
journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019
A good start
DMT binds to the Sigma 1 receptor which is responsible for the synthesis of over 900 mammalian proteins 👍
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It seems like you didn't quote it but there was a 2019 article published on Nature (S. Rep.) on finding DMT in rat brain tissue which well stated the concentrations they found were comparable with serotonin levels and "under basal conditions, they are comparable to the extracellular levels of all known monoamine neurotransmitters measured by in vivo microdialysis in rat brain".
The same paper also noted that rats which had the pineal gland removed still had DMT in their brains at similar concentrations.
The same paper also noted "A significant increase of DMT levels in the rat visual cortex was observed following induction of experimental cardiac arrest, a finding independent of an intact pineal gland"
It is a shame a paper which was already published 2 years before your video basically counters all your ideas and you could have had a much better video on the subject had you read the up to date literature on the subject you are trying to inform people on.
Thank you for your comment. I'm aware of that paper, but I also didn't find it to change my opinion much.
Did you read this excellent critique of that study by the Nichols: www.aliusresearch.org/nichols-nichols-endogenous-dmt.html
@@Neuropharmacist That critique is simply saying there are other possibilities besides DMT which is... obvious? With the lack of the criticizers own empirical data to counter anything, only conjecturing that a bunch of other factors may be more important, or solely responsible for the effects, the critique is simply stating obviousness that goes without saying. Neither do they recognize that despite the amount of other variables at play, the endogenous production of DMT may still be necessary but not sufficient regardless of comparable quantity?
@@Neuropharmacist Wow, you have sadly ignored science that disproves a lot of your arguments which are pulled from the Nichols paper. Steven Barker wrote an excellent rebuttal as well. www.frontiersin.org/articles/10.3389/fnins.2018.00536/full
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DMT is the tether to THIS DIMENSION & REALITY hence why other creatures have it.
it grows as u sun gaze without glasses on ur face
I wonder if Naturally occurring DMT could be responsible for childrens lucid nightmares.etc.
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hi nice video can you make a video about ibogaine?
Is it true that at birth and death we produce (?) dmt in our brains in bigger amounts?
I will soon have a baby and I want to know if my baby will be tripping when it first sees me. I couldn’t find research or papers. But this urban legend is being told over and over.
No real evidence to support either.
What a silly ass question
Man kann dmt sogar aus zb pferde Hirnen extrahieren allerding zu geringe Mengen als das es sich nicht lohnen würde
Could be awkward for the horse
What are your thoughts on the studies about schizophrenics and autists having elevated levels of DMT in their urine?
I've seen one very small study, and a lot of speculation. I don't find it too convincing.
@@Neuropharmacist I found this one today: www.ncbi.nlm.nih.gov/pmc/articles/PMC6370651/ that suggests altered MAO-A functioning is involved. maybe not convincing but still interesting research.
Electrifying
u said micrograms when ur acronym said mg (milligrams) u should have written "0.03 µg of melatonin" i think right ? Also I always thought your brain naturally produced dmt when u were born , dreaming , and dying ?
psychedelics really helped me with my anxiety and help me overcome a lot with the help of a mycologist i met
sporesdan
Bottom line, you've never had it and discount any objective significance it may have. Try between 20 and 30 micrograms and then get back to me Dr.
20-30 micrograms of DMT? Great advice.
The proof is in the pudding.
1. Look up your natal moon
2. Refrain from sex, drugs, eating red meat etc. during your moon phase (2.5 days)
3. Prepare to experience healing like never before
4. Wonder why there is so much resistance to this long lost secret
Ok you can say all this and big words!!! But if you have not done it!!! What are you going on about!? And no I have not done it. But how do you know without doing it for yourself!? If you did I bet you would have had a different take on it.
It's called science.
During the Dr Strassman interview on Joe Rogan, Dr. Strassman said DMT amounts have only been measured in the blood, liver, and lungs.
It has never been accurately measured in the actual brain or spinal fluid during its release.
If this is indeed a factual statement, then to assume it's amount is so trivial and small, that there isn't any affect without other chemicals isn't accurate. Strassman says by the time it's being measured in the blood, liver and lungs, then the body has already metabolized and destroyed most of the DMT.
Until we get an accurate measurement then I think you may need to rethink your position, or at least be open to endogenous DMTs effects on its own.
I think David Nichols scientific writings are a more trustworthy source of information on chemistry and pharmacology than Strassman's Rogan interview.
@@Neuropharmacist I'm not concerned with Rogan...Im specifically talking about Strassman and his quotes.
I'm going to assume because of DMT being his life's work, he is studying the same papers you are reading and probably even more. I'm going to also assume he has access and connections to people currently studying DMT that you don't have.
Therefore I'm going to assume Strassmans quotes to be accurate. Even more accurate than your quotes?
Alot of assumptions sure, but am I completely off base that you holding one man's papers as the absolute final word on the subject as being the final truth?
@@Khaymen223 There is no final truth, I have never claimed that. What I explicitly state, is that there is no clear evidence for endogenous DMT playing any significant role in generation of any subjective experience! Until someone provides me evidence proving otherwise, in the form of peer-reviewed scientific studies, I will not be changing my opinion.
@@Neuropharmacist I got that....And that is what I'd call a 'typical' way for a scientist to respond. However a more honest video would have stated or led to the conclusion - *We have no idea what role DMT plays because it has never been measured at its source, let alone what the source even is.
You , and most scientists lead the viewer into the belief there most likely isn't any role because of the small amounts measured. That in my opinion (while you are currently correct there isn't any current evidence) is disingenuous at least and in a way misleading the viewer.
You never said in your video, 'DMT has never been measured at its source, so we don't know.'
I do thank you for taking the subject on however.......kudos.
@@Khaymen223 There's a good chance it is a side product of INMT, without any further source, release and storage mechanisms. Rodent studies certainly give some insight into the levels of endogenous DMT, and even during asphyxiation, the levels seem to be upregulated less than those of serotonin, which has a higher affinity for 5HT2A receptors than DMT.
Anyone who has ever experienced bad alcohol withdrawal will understand the visionary properties of glutamate and subsequent heightened neural activity. Pretty shocking and vivid hallucinations. I don’t know if I’d attribute this condition to ALL religious beliefs, but…
My experience on psychedelics was the best experience of my life time I'm glad I discovered this online store where I usually order mine from, they ships all kinds of psychedelic products discreetly
On Instagram as
@mycokevin
amazing
I am guessing this guy has never done DMT , if he did , he would have a different opinion.
I fail to see the logic.
@@Neuropharmacist I have done DMT and mushrooms and I have seen things that I did not learn in school, my mind is not that complex to come up with, for example, I am not any good at math or understanding geometry, that is what I see , one time I felt like I was in a clock with moving parts and wheels , I could focus on different parts of this clock, I was in a different world.
I can say i experienced the effects of dmt naturally coming out of a dream state im sure of it.....i listen to the experiences others have by taking it and its was the same.....the feeling is unexplainable.....i was confused because i thought it was just a dream but it was too wonderful to be just a dream.....it never happened again
I experienced it 30 years ago when i was 21, and it happened upon entering the sleep-state, in a state called the hypnagogic state. It is believed to be an optimal state for problem solving/higher thinking and creativity, and can give/produce, some trippy psychedelic like experiences. Its a state that happen upon entering sleep, and when coming out of sleep, (the state when coming out of sleep is called the hypnapompic state).
The brain waves activity measured in this state, is of equal high activity between Alpha and Theta. And it is usually also in relation to this state, that people will suddently wake up, with a solution, to a problem they have recently been pondering on. Usually illustrated by a person sitting upright in the bed, while saying: Heurica! i got it.
look into astral projection :)
DMT. As told by Count Dracula.
😎
2:17 it’s true
Have you ever personally done DMT sir? I'm just asking because your shirt suggests a person who is not a stranger to psychedelics.
Seems like that shirt is telling a lot!
Very interesting channel. Im a psychic and can confirm that we all travel to different dimensions, we all have this ability.
Ive done DMT too and I found it works but it can be too much.
That why you should micro dose
Imagine if we increase our DMT levels naturally through prayer, fasting, and studying the Bible.
If you saw the study where they put people in an MRI and studied their brains as they spoke, prayed, and prayed in tongues. The study showed the part of the brain responsible for the emotion ecstasy is the same place that lit up when they spoke in tongues . Imagine if this is being caused by our body’s release of DMT during prayer in tongues.
Also! If DMT and melatonin are both produced in the pineal gland, I’ll bet that is not a coincidence. I’ll bet they work together for dreams.
Increasing levels would be futile since we metabolize and destroy it so fast. I'm sure our bodies have a naturally evolved method of balancing and producing to immediate need.
Any attempt at associating bible study with spiritual evolution or DMT results is absurdly futile. The bible is not a historically valid document, and none of the Abrahamic religions promote actual healthy spirituality. Christianity specifically is a massive fraud perpetrated by Rome, in the fourth century. It has nearly nothing to do with Ye'shua. DMT is one of the best methods of acquiring the awareness that transcends religion and renounces delusions like biblical relevance.
Why would anyone want to base their life and worldview on a bunch of lies that hurt people?
@@godisincontrol7407Check out the ecstatic states of St. Teresa of Avila
@@shepberryhill4912The common drug user should also ask those questions.
What a waste of life, my man.What a waste of life you wasted my time thank you
You're welcome!
DMT is the only thing that has 'filled my soul'
Mromicare™™~
💥✨Bit of a bad ass video this mate👏💪💪👊✨💥
@jenny_jane6 do one
Later???? Egypt is poly national
It was last born and later you didnt created the Asian third eye concept or European studies on dissecting
Can you clarify your point?
you flew the coop at 4:00 when you said dmt serves no purpose in the brain. What a quack
Of you paid attention when they taught physics DMT wouldnt be so confusing. The main thing it does is drastically raises your vibration. Different realities are on different wavelengths (just like radio) change your frequency=change yoir reality. Water, as it traverses the stages of matter (solid, liquid, gas) remains H²O the entire time. The difference is that it is vibrating faster. Ome or 2 hits of a cart and youll feel like youre swimming in fluid. When you blast off, when you are forced to ground, eyes closed, motionless and leavimg your body its because you are now in a gas state. Its why your consciousness has to leave your body. You are not your body. You are (energy) aka consciousness, only inhabiting this suite.
mycotripper1
On instagram
….?¿
They have the best shrooms dmt lsd and other psychedelic edibles and ships discretely to any location.
@@CamilleSwisher never had it.