Nazlee Zebardast, MD, MSc: Utility of Genetic Risk Scores for Glaucoma Onset

A new analysis presented at the 2024 Association for Research in Vision and Ophthalmology (ARVO) Meeting evaluated the utility of a polygenic risk score (PRS) for predicting primary open-angle glaucoma (POAG) onset in individuals with ocular hypertension.
In an interview with HCPLive, Nazlee Zebardast, MD, MSc, described how the cut-off PRS was able to separate people who were at high- or low risk of developing disease, specifically visual field loss or functional changes.
Even in a high clinical risk group at baseline, investigators could separate patients by PRS to determine who required early treatment from those who would not benefit.
"I think this is really important, not only from decreasing potential harms of excessive treatment to patients but also reducing cost and the need for monitoring of individuals that probably do not need to be monitored as aggressively,” Zebardast said.
Highlights
0:19 Genetic risk of glaucoma
1:33 Purpose of analysis
2:33 Link between PRS, glaucoma
4:35 Impact on clinical practice
6:00 Ongoing challenges in glaucoma
7:24 Final thoughts
Link to full article: www.hcplive.com/view/nazlee-z...
More ARVO coverage: www.hcplive.com/conference/arvo
#ophthalmology #glaucoma #conference