Predicting OS with PFS in pancreatic cancer in the NAPOLEON-1 and -2 trials

Tsuyoshi Shirakawa, MD, PhD, Eikoh Hospital and Clinical Hematology Oncology Treatment Study Group, Fukuoka, Japan, explores whether progression-free survival (PFS) can serve as a surrogate marker for overall survival (OS) in pancreatic cancer treatments involving fluorouracil, leucovorin, irinotecan, and oxaliplatin (FFX) or gemcitabine plus nab-paclitaxel. Through an integrated analysis of the NAPOLEON-1 and NAPOLEON-2 studies (UMIN000043939), a strong correlation between PFS and OS for both 1st- and 2nd-line therapies was demonstrated. The findings suggest that PFS can reliably predict OS, aiding in treatment selection and prognostic estimation for pancreatic cancer patients. This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Annual Congress in Munich, Germany.
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