I'm retired, and if I won the lottery, I would go back to school and study health sciences. I spend the better part of my spare time watching microbiology, anatomy & physiology, pharmacology, pathology, biochemistry etc. etc. etc. lectures and demonstration videos. In the past two and a half years I must have about three thousand pages of notes. IT ALL COSTS ME NOTHING! I cannot understand for the life of me, with the technology we have, why an education costs a king's ransom. A handful of people at the top of the educational hierarchical pyramid are stiffing the majority at the bottom.
my professor said you can also regulate step 1 of the TCA cycle.... citrate synthase can be inhibited by ATP, NADH, and succinyl CoA.. I guess its just a difference in textbooks
Hello there Mr. AK. Great job as always. Want to thank you and congratulate you on wonderful content. One more thing and maybe I am mistaken but I thought I read somewhere that citrate synthase is regulated too.
yes not just that but also the whole TCA cycle is regulated even by the conversion of the pyruvate to acetyl CoA whiich is very imp. step since it determines the flux of the whole cycle and this regulation take place by regulate the pyrruvate dehydrogenase thru. its 3 main subunits E1,E2 and E3
Hi, Love the video and all other video are amazing. One question couldn't you regulate the TCA cycle the same way with the citrate synthase via similar mechanism.
According to Principles of Biochemistry by Moran et al., citrate synthase is inhibited by ATP in vitro. Still, changes in ATP concentration are unlikely to affect citrate synthase in vivo. Some bacteria c. synthases are activated by alpha-ketoglutarate and inhibited by NADH. Knowing that your comment was posted 3 years ago, I hope it might be useful for anybody else browsing through.
At 8:43 when he says ADP produces a positive feedback loop by enhancing the affinity of isocirate dehydrogenase, thus increasing the production of ATP wouldn't this be a negative feedback loop? More ADP triggers a cascade that increases ATP?
Im paying 9 grand a year for uni and I prefer watching your lectures which you give out for free, you are amazing !
I'm retired, and if I won the lottery, I would go back to school and study health sciences. I spend the better part of my spare time watching microbiology, anatomy & physiology, pharmacology, pathology, biochemistry etc. etc. etc. lectures and demonstration videos. In the past two and a half years I must have about three thousand pages of notes. IT ALL COSTS ME NOTHING! I cannot understand for the life of me, with the technology we have, why an education costs a king's ransom. A handful of people at the top of the educational hierarchical pyramid are stiffing the majority at the bottom.
You are the best! You deserve many many more subscribers!
You are the master of entire biochemistry. Thank you sir.
Love the way you explain concepts. So clear. Thank you so much for this
You saved my life man!
Thank you. You are so clear and accurate.
thank you..ur such a very good teacher..i have fully understood ur explanation..AK lectures are best!!
u are a lifesaver. thank you for clarifying these difficult concepts for MCAT studying!
great video, will definitely donate once I have a job
extremely conceptual good job sir
You make clear points :) Thank you!
really clear and concise good stuff man
Just wanted to pop in and say thank you for these videos.
One of my favourite teachers
Thank you very much for the wonderful video. It is very educative
How can a lecturer be so fking AMAZING!!!!!!!!
my professor said you can also regulate step 1 of the TCA cycle.... citrate synthase can be inhibited by ATP, NADH, and succinyl CoA.. I guess its just a difference in textbooks
Hello there Mr. AK. Great job as always. Want to thank you and congratulate you on wonderful content. One more thing and maybe I am mistaken but I thought I read somewhere that citrate synthase is regulated too.
yes not just that but also the whole TCA cycle is regulated even by the conversion of the pyruvate to acetyl CoA whiich is very imp. step since it determines the flux of the whole cycle and this regulation take place by regulate the pyrruvate dehydrogenase thru. its 3 main subunits E1,E2 and E3
In step 4, for a-ketoglutarate dehydrogenase, at 10:40, it is CoA-SH that is oxidized, rather than a-ketoglutarate
THANK YOU SO MUCH
thank yoooouuu you are the best
Thank you !!!!
Thank you so much
Hi, Love the video and all other video are amazing. One question couldn't you regulate the TCA cycle the same way with the citrate synthase via similar mechanism.
Good work Master
According to Principles of Biochemistry by Moran et al., citrate synthase is inhibited by ATP in vitro. Still, changes in ATP concentration are unlikely to affect citrate synthase in vivo. Some bacteria c. synthases are activated by alpha-ketoglutarate and inhibited by NADH. Knowing that your comment was posted 3 years ago, I hope it might be useful for anybody else browsing through.
tnx a lot
Very nice
you are the goat
12:21 for the screenshot!
That is typical of Muslims
👌👍🙏
Mr. Andre please take all my money
Am I the only who comes here only during exams?
Nope, got a biochemistry test in 4 hours.
Nope
At 8:43 when he says ADP produces a positive feedback loop by enhancing the affinity of isocirate dehydrogenase, thus increasing the production of ATP wouldn't this be a negative feedback loop? More ADP triggers a cascade that increases ATP?