PHM-NP student here, and I am very grateful your efforts and content. I finally understand both of these medications to give enough rationale when I begin prescribing and offering recommendations. I will definitely be going to the your website to sign up for the content lectures on the various classes of psychotropic medications that you are offering education on.
Talk about scary. Quillivant and Dyanavel taste like pure candy. I get the man of 8oz Dyanavel currently, and use 6oz or less per month. Feel for anybody who starts to abuse these ultra expensive medications because without any impulse control, or addictive qualities, the ease of use is insane based on flavor alone. There’s a claim about XR meds being less desirable for abuse, but the two Tris formulations begin working in the body well before the hour mark.
Flavoured stimulants. The rave scene is really lacking in choice. Kids these days..... Hahaha In all seriousness thanks for the video series. Really helping me make sense of why all the different brands for the same type of drug
@@PsychoFarm From what I understand, it's supposed to have less of a bad comedown/fewer side effects compared to regular amphatamine due to it working more on the Central rather than Peripheral Nervous System. Is this a myth?
@@BCantley It's, at best, a collection of semi-consistent anecdotes. The human data on therapeutic use is very limited cf. amphetamine. The are a few relevant mechanistic points: (i) it's very similar to amphetamine when used at therapeutic doses as prescribed; (ii) it is slightly more lipophilic, indeed suggesting greater central vs. peripheral effects; (iii) it is metabolized slightly more slowly, suggesting a potentially slower offset and longer duration of action; and (iv) its pharmacodynamics are slightly different, with slightly more dopamine and serotonin release induction than amphetamine, but still with an overall bias toward norepinephrine. There is, however, (v) an apparently slightly higher neurotoxicity risk, and probably a higher cardiotoxicity risk. I'm comparing only the dextrorotatory enantiomers in all cases. Insurance will probably not cover it unless pretty much everything else is tried and failed. The DEA manufacturing quota is way, way lower than for amphetamine. You can find anecdotes of people who claim it worked better for them. That's the best argument available-such anecdotes-over the more popular drugs. TheKicksShrink, I believe, has said he's prescribed it before. He's a psychiatrist also on RUclips.
@@BCantley No doc is going to risk it regardless. I think like a lot of drugs the negative effects are dose dependent, with say 5mg cool, but 25mg bad (or something).
@@benzapp1this is 104% BS. Complete and total conjecture. It’s prescribed the same way any other stimulant is(ADHD/Narcolepsy) and just like any other controlled substance, it’s safe when used correctly. My prescriber didn’t know what Dyanavel XR was, or knew anybody that had prescribed it. The same thing happened when I brought Dronabinol to his attention as well as its off label PTSD uses. Go online and people will SWEAR up and down that "Marinol/Dronabinol can only be prescribed for cancer/AIDS patients", and "no doctor would ever" yap yap yap… This isn’t breaking bad, it’s medicine.
PHM-NP student here, and I am very grateful your efforts and content. I finally understand both of these medications to give enough rationale when I begin prescribing and offering recommendations. I will definitely be going to the your website to sign up for the content lectures on the various classes of psychotropic medications that you are offering education on.
In the Netherlands we can only get, dexamphetamines or methylphenidate instead of Addereall. Which I just need..
Talk about scary. Quillivant and Dyanavel taste like pure candy.
I get the man of 8oz Dyanavel currently, and use 6oz or less per month. Feel for anybody who starts to abuse these ultra expensive medications because without any impulse control, or addictive qualities, the ease of use is insane based on flavor alone.
There’s a claim about XR meds being less desirable for abuse, but the two Tris formulations begin working in the body well before the hour mark.
They made stimulant syrups with flavor?
Sippin on some Quillivant XR
Fkn delicious
Flavoured stimulants. The rave scene is really lacking in choice. Kids these days..... Hahaha
In all seriousness thanks for the video series. Really helping me make sense of why all the different brands for the same type of drug
When you're 30 with ADHD and you find out you don't get the bubblegum flavor. Awww man 😂
Never too old for bubblegum flavor
What about Desoxyn :( ?
Brand name meth. I haven’t met a doctor who’s prescribed it.
@@PsychoFarm From what I understand, it's supposed to have less of a bad comedown/fewer side effects compared to regular amphatamine due to it working more on the Central rather than Peripheral Nervous System. Is this a myth?
@@BCantley It's, at best, a collection of semi-consistent anecdotes. The human data on therapeutic use is very limited cf. amphetamine. The are a few relevant mechanistic points: (i) it's very similar to amphetamine when used at therapeutic doses as prescribed; (ii) it is slightly more lipophilic, indeed suggesting greater central vs. peripheral effects; (iii) it is metabolized slightly more slowly, suggesting a potentially slower offset and longer duration of action; and (iv) its pharmacodynamics are slightly different, with slightly more dopamine and serotonin release induction than amphetamine, but still with an overall bias toward norepinephrine. There is, however, (v) an apparently slightly higher neurotoxicity risk, and probably a higher cardiotoxicity risk. I'm comparing only the dextrorotatory enantiomers in all cases.
Insurance will probably not cover it unless pretty much everything else is tried and failed. The DEA manufacturing quota is way, way lower than for amphetamine. You can find anecdotes of people who claim it worked better for them. That's the best argument available-such anecdotes-over the more popular drugs. TheKicksShrink, I believe, has said he's prescribed it before. He's a psychiatrist also on RUclips.
@@BCantley No doc is going to risk it regardless. I think like a lot of drugs the negative effects are dose dependent, with say 5mg cool, but 25mg bad (or something).
@@benzapp1this is 104% BS. Complete and total conjecture. It’s prescribed the same way any other stimulant is(ADHD/Narcolepsy) and just like any other controlled substance, it’s safe when used correctly.
My prescriber didn’t know what Dyanavel XR was, or knew anybody that had prescribed it.
The same thing happened when I brought Dronabinol to his attention as well as its off label PTSD uses. Go online and people will SWEAR up and down that "Marinol/Dronabinol can only be prescribed for cancer/AIDS patients", and "no doctor would ever" yap yap yap…
This isn’t breaking bad, it’s medicine.
Any plans for a patch amphetamine at some point?
I was on Daytrana. Pretty wild. The mechanism releases more when the body/ambient temperature rises.
@@BCantley I like the idea of patches tragically they are not commonly available outside the US
@@redsolaris1 Yeah, super rare. My doc was open minded though.
Xelstrym is a Dextroamphetamine patch.