Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19
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- Опубликовано: 26 сен 2024
- COVID-19 Update 68 with critical care specialist and pulmonologist Roger Seheult, MD of www.medcram.co...
A Kawasaki disease like syndrome has been reported in growing numbers of children in a variety of communities including New York and parts of Europe. Dr. Seheult reviews what we know about Kawasaki disease and its possible connection to endothelial/vascular damage from COVID-19. A recent CDC report on racial and ethnic differences in the severity of coronavirus infection and possible explanations are also discussed.
Links referenced in this video:
Johns Hopkins - coronavirus.jh...
www.worldomete...
AVD - www.ncbi.nlm.n...
Circulation - www.ahajournal...
CBS News - www.cbsnews.co...
www.mymed.com/...
Some previous videos from this series (visit MedCram.com for the full series):
-Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor • Coronavirus Pandemic U...
-Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19 • Coronavirus Pandemic U...
-Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors) • Coronavirus Pandemic U...
-Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update • Coronavirus Pandemic U...
-Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) • Coronavirus Update 59:...
- Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion) • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: • Coronavirus Pandemic U...
- How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: • How Coronavirus Kills:...
Many other videos on COVID-19 (coronavirus outbreak, corona virus symptoms, influenza, Kawasaki disease, coronavirus epidemic, coronavirus updates,) and other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com
Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)
Media Contact: customers@medcram.com
Media contact info: www.medcram.co...
MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus
Thank you for supporting our frequent COVID-19 updates by subscribing and seeing all of our videos at www.MedCram.com (clear explanations of over 60 medical topics). We also offer CMEs for medical professionals, and group rates for medical programs and institutions.
All links referenced in this video are in the video description. Quick links to our previous updates on the coronavirus pandemic:
- Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor: ruclips.net/video/JOlVkES_kC8/видео.html
- Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19: ruclips.net/video/OudhmwulJHY/видео.html
- Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors): ruclips.net/video/gzx8LH4Fjic/видео.html
- Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update: ruclips.net/video/Z2hfGcTokiY/видео.html
- Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? ruclips.net/video/Aj2vB_VITXQ/видео.html
- Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? ruclips.net/video/DtPwfihjyrY/видео.html
- Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress: ruclips.net/video/22Bn8jsGI54/видео.html
- Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? ruclips.net/video/fn2yk5SbGiw/видео.html
- Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC): ruclips.net/video/NM2A2xNLWR4/видео.html
- Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion): ruclips.net/video/nO4xgcIaPeA/видео.html
- Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? ruclips.net/video/2U4DAQ3kjRs/видео.html
- Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? ruclips.net/video/PgDjVEpEOdQ/видео.html
- Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: ruclips.net/video/8NffZAGELGg/видео.html
- Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing? ruclips.net/video/kgzFAdYwYLM/видео.html
- Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse? ruclips.net/video/o8aG63yigjA/видео.html
- Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: ruclips.net/video/qc6VV7ue4cE/видео.html
- Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: ruclips.net/video/E7MufS6dnJw/видео.html
- Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: ruclips.net/video/fya6Zwxch88/видео.html
- Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): ruclips.net/video/uaIzj3s3p4A/видео.html
- Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: ruclips.net/video/JN-8bGB1cLM/видео.html
- Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu: ruclips.net/video/H1LHgyfPPQ8/видео.html
- Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine: ruclips.net/video/EFRwnhfWXxo/видео.html
- Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention: ruclips.net/video/G1zsE9_85i4/видео.html
- Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful? ruclips.net/video/A4eu-h_owaI/видео.html
- Coronavirus Pandemic Update 43: Shortages, Immunity, & Can a TB Vaccine (BCG) Help Prevent COVID-19? ruclips.net/video/LqKwAIIy-Mo/видео.html
- Coronavirus Pandemic Update 42: Immunity to COVID-19 and is Reinfection Possible? ruclips.net/video/q4P91VrfPGw/видео.html
- Coronavirus Pandemic Update 41: Shelter In Place, FDA Investigates Hydroxychloroquine for COVID-19: ruclips.net/video/hPz5KxgI_K4/видео.html
- Coronavirus Pandemic Update 40: Ibuprofen and COVID-19 (are NSAIDs safe?), trials of HIV medications: ruclips.net/video/dT6mHi_8V5E/видео.html
- Coronavirus Pandemic Update 39: Rapid COVID-19 Spread with Mild or No Symptoms, More on Treatment: ruclips.net/video/AToF8O5T86s/видео.html
- Coronavirus Pandemic Update 38: How Hospitals & Clinics Can Prepare for COVID-19, Global Cases Surge: ruclips.net/video/MoisrCTu0SY/видео.html
- Coronavirus Pandemic Update 37: The ACE-2 Receptor - The Doorway to COVID-19 (ACE Inhibitors & ARBs): ruclips.net/video/1vZDVbqRhyM/видео.html
- Coronavirus Pandemic Update 36: Flatten The COVID-19 Curve, Social Distancing, Hospital Capacities: ruclips.net/video/vww1nIIoqmw/видео.html
- Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments: ruclips.net/video/vE4_LsftNKM/видео.html
- Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown: ruclips.net/video/U7F1cnWup9M/видео.html
- Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: ruclips.net/video/Mm7UrZeu-74/видео.html
- Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? ruclips.net/video/Eeh054-Hx1U/видео.html
- Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? ruclips.net/video/7YI2tOoVVpk/видео.html
- Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention: ruclips.net/video/gmqgGwT6bw0/видео.html
- Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran: ruclips.net/video/XjEacUyp4vY/видео.html
- Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate: ruclips.net/video/quDYb_x54DM/видео.html
- Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases: ruclips.net/video/xQwfuJgJ9lo/видео.html
- Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic? ruclips.net/video/bV1CZxJ-uvU/видео.html
- Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends: ruclips.net/video/UImSVhLLeGY/видео.html
- Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms: ruclips.net/video/wFoj2L2LpNA/видео.html
- Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats: ruclips.net/video/JGhwAGiAnJo/видео.html
- Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing: ruclips.net/video/OqpHvK0XADY/видео.html
- Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?: ruclips.net/video/9BYaywITXYk/видео.html
- Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins: ruclips.net/video/Ka48UZDDzLY/видео.html
- Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials: ruclips.net/video/4HK9QEy1KJ8/видео.html
- Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips: ruclips.net/video/vE4pBkslqS4/видео.html
- Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19): ruclips.net/video/wlbM6VVkVZM/видео.html
- Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19): ruclips.net/video/qqZYEgREuZ8/видео.html
- Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19): ruclips.net/video/o804wu5h_ms/видео.html
- Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks: ruclips.net/video/pDnmHu8x9C4/видео.html
- Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada: ruclips.net/video/0UgrPgJdzp0/видео.html
- Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV: ruclips.net/video/GT3_A1bf9pU/видео.html
- Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine): ruclips.net/video/pfGpdFNHoqQ/видео.html
- Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV): ruclips.net/video/gPwfiQgGsFo/видео.html
- Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate: ruclips.net/video/8Hjy3UfaTSc/видео.html
- Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA: ruclips.net/video/GpbUoLvpdCo/видео.html
- Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding: ruclips.net/video/nW3xqcGidpQ/видео.html
- Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period: ruclips.net/video/UGxgNebx1pg/видео.html
- Coronavirus Update 5: Mortality Rate vs SARS / Influenza: ruclips.net/video/MN9-UXsvPBY/видео.html
- How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: ruclips.net/video/okg7uq_HrhQ/видео.html
- Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine: ruclips.net/video/SJBYwUtB83o/видео.html
- Coronavirus Symptoms, Diagnosis, Treatment: ruclips.net/video/UCG3xqtcL3c/видео.html
- Coronavirus Outbreak - Transmission & Updates: ruclips.net/video/9vMXSkKLg2I/видео.html
Is the difference in oxidative stress among "races" better explained by the difference in blood-type distribution? Or, are the two factors orthogonal?
MedCram - Medical Lectures Explained CLEARLY I still think Vascular Endothelial Growth Factor is the crux in this disease doctor after researching more into your hypothesis. VEGF is shown in high levels in kawasaki disease and in COVID. Since it’s main role is angiogenesis and permeability, any elevation should, hypothetically, induce the severe symptoms noted in both diseases. VEGF is the single factor consistent in all the co-morbidities for COVID as well. Modulation of VEGF is key I believe. The cocktail I previously prescribed as an adjunct modulates VEGF while still increasing NO production. ADAMTS13, in an attempt to achieve homeostasis from elevated vWF, also elevates VEGF in a way I still don’t fully understand but am working on. Please look into this pathway. There’s a single trial already underway focusing on this pathway.
@@randyross5630 Only possible response to that is LOL
www.targetedonc.com/view/leronlimab-shows-further-promise-for-covid-19-treatment-study-shows
"A cohort of 10 critically ill patients with coronavirus disease 2019 (COVID-19) received more effective immune response after leronlimab (PRO 140) treatment compared with healthy controls, announced CytoDyn, developer of the drug."
"To disseminate results that can inform the public health in response to COVID-19, CytoDyn announced the publication of their findings in a pre-print manuscript, which has been submitted for publication and is currently under peer review.
A cohort of 10 critically ill patients with coronavirus disease 2019 (COVID-19) received more effective immune response after leronlimab (PRO 140) treatment compared with healthy controls, announced CytoDyn, developer of the drug.1
Patients treated under the FDA’s emergency Investigational New Drug (eIND) program with leronlimab experienced reversed hyper immune activation, inflammation, and immunosuppression. To disseminate results that can inform the public health in response to COVID-19, CytoDyn announced the publication of their findings in a pre-print manuscript, which has been submitted for publication and is currently under peer review. CytoDyn also shared the manuscript with the World Health Organization.
“We are now most hopeful the entire medical community will understand the potential benefit leronlimab can provide critically ill COVID-19 patients,” said Nader Pourhassan, PhD, president and chief exectuvie officer, CytoDyn, in a statement. “Moreover, this discovery by Dr. Bruce Patterson that leronlimab decreases plasma viral load may have tremendous long-term positive ramifications to bring this pandemic under control. We are grateful that we are able to release this research at such a critical time for patients throughout the world.”
Patients with critical COVID-19 were treated with leronlimab at the Montefiore Medical Center (n = 10) under the FDA’s eIND program. Patients showed evidence of lymphopenia with liver and kidney damage and had significant pre-existing co-morbidities. They received intensive care treatment including mechanical ventilation or supplemental oxygen. Patients received leronlimab on the 14-day study period.2
Four patients died during the treatment period due to disease complications and severe constraints on medical equipment.
At baseline, all 10 patients had elevated levels of inflammatory cytokines IL-1β, IL-6, and IL-8. Plasma CCL5 levels were elevated among these patients compared with those in both healthy controls and patients with mild or moderate COVID-19.
All patients received a subcutaneous 700 mg dose of leronlimab after baseline blood collection. Patients were monitored longitudinally for 2 weeks after treatment. As early as 3 days after therapy, investigators noted a reduction of plasma IL-6, which returned to healthy levels by day 14. More variable levels, however, were observed with IL-1β, IL-8, and CCL5. There was a marked restoration in CD8+ T cell ratio in the blood following leronlimab treatment.
A high sensitivity digital droplet PCR was used to quantify the plasma at baseline, in which SARS-CoV-2 was detected in all 10 patients, underscoring the severity of COVID-19. However, investigators noted a decrease in SARS-CoV-2 plasma viremia in all patients at day 7 following treatment, indicating that leronlimab may be effective in anti-viral immunity.
To establish an unbiased gene repertoire, investigators performed 10X Genomics 5’ single cell RNA-sequencing of peripheral blood mononuclear cells in order to evaluate the transcriptional changes between an uninfected, healthy person and 2 patients with severe COVID-19. They identified 2,890 differentially expressed transcripts, showing that the 2 patients had a greater abundance of myeloid cells upregulating inflammatory-interferon, and chemokine-related genes. Chemokines (CXCL8, CCL4, CCL3), inflammatory and immune activation genes (IL-1β, CD69), and the IFN-related genes (IFI27, IFITM3) were among the most notable overexpressed genes in the COVID-19 samples.
A downregulation was observed in the effector molecule granzyme A, as well as the immunoregulatory gene KLRB1 in patients with COVID-19 compared with the healthy control.
Investigators also aimed to identify markers that could inform the effectiveness of leronlimab. Approximately 2,037 differentially expressed transcripts were identified out of the 4,105 cells at baseline and 4,888 cells at the 7-day post-treatment timepoint in the longitudinal single-cell dataset. IL-6 transcripts were downregulated between day 0 and 7 in monocytes, which remains consistent with previous reports. Myeloid cells expressing chemokine and IFN-related genes were downregulated at day 7 post-treatment compared to baseline. There was also an increases expression of granzyme A, which suggests improvement in the antiviral function of leronlimab."
"These transcriptomic findings further underscore the potential impact of leronlimab- mediated CCR5 blockade on the inflammatory state in COVID-19,” the authors wrote. “In summary, we show here for the first time, involvement of the CCL5-CCR5 axis in the pathology of SARS-CoV-2, and present evidence that inhibition of CCL5 activity via CCR5 blockade represents a novel therapeutic strategy for COVID-19 with both immunologic and virologic implications.”
Did anyone measure levels of Vitamin D in discrepancies between blacks & whites?
You not only give updates but also explain the pathophysiology behind it, the logic behind the potential treatment and the proof for that logic in terms of articles.
This is really informative.
Even though I'm care staff (insulin, stomas, medications) Dr Seheult I agree is good.
Dr Scott Jensen doctor's are given huge perks to claim covid and it's legal now he and other doctors have been out with this for months the CDC and WHO are now backed by Robert Redfield who has a corrupt history also R Kennedy Jr Valuetainment youtube May 2 Spanish flu was vaccines libraries with pictures youtube too sorry no insult intended
I don’t think it’s crazy to put this video series in the short list for Pulitzer consideration.
I think a Nobel Prize for Dr Sehault, Michael.
Nah, it will be Greta winning it
Same way Obama won peace prize while breaking a record on drone assassinations.
Would be thoroughly deserved.
@@Hunter_Bidens_Crackpipe_ highly likely. LOL!
@@0mekyam0 ccp trolls everywhere....
The Best and at this point nearly only update I watch/look up. When people tell me about the virus, its so full of surmise and supposition I just refer them to your updates. You fill your updates with research, current thought, logical attack, and reasoned/measured approach. Thank you.
You're absolutely right, BookWorm84! I've learned so much from Dr. Seheult's videos, and I've never really delved into science my whole life. He's such an extraordinary teacher that I find myself actually understanding the chemistry - the lives of the cells! How he does all this research while attending to severely ill patients is beyond me.
Linda McDougall
Im a history guy. And I can follow these conversations easily. While reading about Henry the VIIIth or some such foolery. Truly a gifted teacher he is.
I second that.
I agree 100% on that. People get angry though, swarming me, saying i would never be capable of understanding Medcram's content, because i don't have a medical degree. They ultimately decide all content is hypothetical, and it would take months, even years to be proven correct.
But they're very likely dutch state sponsored. They want to keep us dutch people as ignorant, in the dark and pliable as possible. Don't know why. More and more dutch medical practitioners are complaining about information restrictions, everything has to be according RIVM and thus WHO guidelines. Only the use of Quercitin is allowed, luckily.
Agreed. I so appreciate having a science based resource that isn’t trying to gain viewership with frightening speculation or flexible facts. Thank you Dr. For sharing this invaluable patho analysis as well as a positive spin on what we should and should not do with our ever changing understanding of this pathogen. You’re keeping me and mine informed without unnecessarily increasing our stress. Your COVID series is Therapeutic indeed.
This series is amazing. I found MedCram doing a search for my students to review lab tests. I am so impressed with Dr. Seheult that I wish he was on the task force.
I watch all of your episode for now worldwide the best update you can get is medcram
I worked as a nurse case manager in pediatrics before retiring and there were quite a few cases of Kawasaki...not as rare as some claim
I have been discussing how COVID-19 and ROS seem intimately related with clients who are aerospace & chemical engineers, geologists, exercise physiologists with the caveat that this is speculation and research is underway. Tonight I brought it up with a veterinarian with 1000s of hours of research experience and she became extremely interested. Her experience with feline corona virus exactly matches everything you have been describing. Healthy pink lungs surrounded by fibrosis in older cats. Younger (3 yo) felines full of thromboses. Cats have a particularly virulent form that fills the perineum with fibrotic tissue. All the fibrotic tissue of endothelium. Told her that absence of Angiotensin 1,7 was implicated and her response was “that’s what I’ve been saying!” She lamented that too many clinicians get lost in the symptoms that they lose sight of the root cause. Your work is paradigm changing and thank you for for sharing this with the world. Should the state of Texas allow me to return to my vocation supporting your group is at the top of my priorities.
Sincerely,
Tony Le Cara Jr LMT, LMTI
NasaTRXster PLLC
Houston, TX
Good info Doc. I have grandkids and the one bright spot of this CV was it didn't seem to affect kids. Now I know it may, in some way, affect them so I can advise my son to keep an even closer eye out and what to watch for. Thanks again from a retired Grandparent
Still doesn't. The number of this weird (but already known for other diseases) inflammatory reaction in children is almost equal to... Zero, statistically.
@@ChristmasLore Correct. Lets hope it stays that way!
@@golfinguy423 , as I wrote, these children inflammatory reactions to a virus are already known, and always had been a very rare and peripheral occurrence, so there's a good chance it will stay that way (but indeed, time always is a great teacher).
Dr Scott Jensen he and other doctors are offered huge perks to claim covid anything CDC and WHO are corrupt look up Robert Redfield who is Trump health advisor he has a very bad history himself
As a layman, I'm curious as to how these hypotheses are integrated into the medical community for peer review, and consideration as a valid understanding of the workings of this virus. There appears to be a significant understanding presented by Dr. Seheult, of the characteristics of COVID19 that differ from the original assumptions. One would hope that the efforts presented here, along with other like studies, can be disseminated within the medical community toward an accurate and up to date understanding of this virus' effects. And as a layman, I fear the political aspects of this crisis may cloud some of the more innovative presentations of the pathology and treatment of the COVID19 virus. In other words, I hope there are people out there listening to this stuff. Dr. Seheult is my goto source for objective, analytical information that I can begin to comprehend. It's been many years since Dr. Rossmore's microbiology class at Wayne State, but I seem to be able to follow along quite well. Thanks so much for your efforts.
Yes, researchers and physicians around the world are discussing these things. LOL
@@peliROJO Laugh if you must, but I'm not hearing of it. I would sincerely hope so, however.
@@moebeddah2288 the problem is that 1. they are discussing it and assessing it. no sense in giving people false hopes and I am sure there have been many other such discussions that ultimately didn't pan out. basically, don't report until there is something to report. 2. why would the news report that? is it new worthy? yes. is it profitable, sensational? no. If its not a cure or it doesn't kill people, they aren't interested, thus we never hear about it. the vast majority of science is, to most lay people, boring. Its collecting, organizing and analyzing data and making predictions. rinse, repeat.
but the main reason *incoming rant*
the term "fear pron" is going around for a reason and with CBS being caught having nurses line their cars up to make it look worse and NYT's getting caught using photos of Italian hospitals in their coverage of NYC hospitals you can see why they don't talk about work being done. remember, RUclips is saying they will demonitize anyone who is not following WHO guidelines and harshly slamming non "authoritative" sources like CBS and NYT. MedCram is a godsend. you will have to find that stuff from other sources, they actually banned doctors while upholding journalists as "experts". hope is anathema to the fear pron they push. nuff said.
@@MrKago1 My concerns, exactly. Frankly, I pay attention to my State's recommendations (Ohio), and faithfully monitor the Med Cram update. A godsend, indeed. Common sense and caution go a long way in navigating the current landscape. The 'If it bleeds, it leads' mentality of the media be damned. Thank you for your reply.
@@moebeddah2288
Perhaps you haven't heard of it because you aren't in the community. But he's literally citing research papers. That's a form of sharing. There's also conference calls. And they watch each other's RUclips channels. And as well written as you are, wouldn't you think that some of the smartest and most compassionate of professionals would be trying to solve this by discussing among each other?!? What would imply that they are acting as Lone Rangers? There's literally centuries of sharing between dozens, hundreds, of disciplines to get where we are today. Just by being able to watch this video and chat with me proves that. So rest easy. They are sharing their ideas with each other.
These are fascinating lectures and show just how complex this virus is to deal with.
I think both Medrcam and also Dr John Campbell have been a tower of strength during the pandemic for that very reason.
@@ph8323 Agreed, I knew this already and fully checked his background before subscribing to his channel. I also sourced the press release for the University that awarded his PhD (for his method of teaching human anatomy) as well as the UK nursing register to confirm his status, which included authority to dispense drugs in clinical settings as at March 2020.
His Pathophysiology Notes is a great read and I would highly recommend it.
The U.K.'s John Campbell has stated many times in his daily RUclips™ discourses on COVID-19 that 'dark skinned' people generate vitamin D in sunlight more slowly than the 'light skinned'. As a result they are more likely deficient in this vitamin. I believe vitamin D sufficiency is important in the body fighting this virus. No one else that I've read has linked this cause to the effect.
Yes, a number of studies now show this explicitly in relation to Covid, an Indonesian study, a Philippine study, and 2 earlier studies, one in Ireland, and a meta analysis on vitamin D and respiratory studies published on April 2nd.
Word Carr, as a hypothesis, vitamin D deficiency, as it relates to CoVid 19 and the worse outcomes observed amongst the Afro-Caribbean population in Europe and North America, is rapidly gaining traction and to me makes perfect sense which is why as a dark skinned physician, I take supplementation myself and have done so for several years now and actively encourage my patients to have their levels checked also. Here in the UK (and in most other places), supplemental vitamin D is available over the counter (without prescription).
Racist. 🤢🤥🙄
Dr Scott Jensen and others are saying doctor's are now legally offered huge perks to claim covid anything R Kennedy Jr Valuetainment too Also Robert Redfield has a very bad Rep for insane practices Trumps Health person please look these The CDC and WHO are corrupt and China is also in this too - The world is too
offered money for lying to you Dr Donald Yealy please look this up as other doctors who are not getting heard have done actual honest tests on this disease please research this and please !! pass this around I'm doing my best not easy thanks?
Try @PeakProsperity... Dr. Martenson as also been covering the importance of vitamin D (May 8th video) along with other supplements.
Comment #2 / Medicine, like music, can be seen as a "foreign language"! So many new terms and processes to understand. Thank you Dr Medcram and Team Medcram for all the great work you do!!
I continue watching to, at least, hear these terms and phrases, but I am at a near total loss. Even the short-hand gets crazy (even letters e.g. capital i, lowers-case l, and numeral 1).
@LouFazio - doctors study for YEARS and Dr Medcram is talking about his specific area of expertise. Most non-medical people probably "kind of" understand, while medical people are already familiar with a lot of the terms. It's a lot to take in, brand new, all at once!!
Thank you Doc for alll these videos much appreciated !
you're welcome - thank you for your support
So grateful for your work! Thank you! I want to stay informed and you are so good at explaining all this. I can barely watch the news for an hour, but I could listen to you all day. May you stay healthy - your efforts are saving lives!
Amazing! Excellent lectures! I’ve learned a lot about this virus and it’s mechanism. Thank You Dr. Seheult!
Mr Allsopp here from the UK. Right from the "get-go" I was fascinated by MedCram's stuff and I'm just a senior carer Abel. Have a great day sir!
Thanks so much for your report. I really love the cross-mixture of technology and accessibility.
That said, I believe that perhaps the endothelial oxidative stress, modulated by NADPH Oxidase Nox2 observed in blacks is in actuality, primarily due to the fact that "NADPH Oxidase Nox2 Mediates Vitamin D-Induced Vascular Regeneration."
"Data from NHANES III show that, in the southern states, 53%-76% of non-Hispanic blacks (depending on sex and age) compared with 8%-33% of non-Hispanic whites had 25(OH)D concentrations below 50 nmol/L in the winter (4). The lower 25(OH)D of blacks and other groups with dark skin results primarily from the fact that pigmentation reduces vitamin D production in the skin."
In fact, many studies point to Vitamin D playing a strong role in Black health, "In a controlled trial of African women, a low dose (800 IU a day) of vitamin D resulted in a three-fold reduction in cold and flu symptoms compared to those given placebo"
In short, all dark skin people should be taking a vitamin D3 supplement.
www.ncbi.nlm.nih.gov/pubmed/27399878
academic.oup.com/jn/article/136/4/1126/4664238
www.lifeextension.com/magazine/2010/1/startling-findings-about-vitamin-d-levels-in-life-extension-members
I agree. Indigenous African populations like the Maasai in Kenya and Hadza in Tanzania (who live in an equatorial, tropical climate and spend hours outside in the sun) have an average vitamin D level of 119 and 109 nmol/L respectively. That is between 40-50 ng/ml www.ncbi.nlm.nih.gov/pubmed/22264449
From an evolutionary perspective, this may be the ideal vitamin D level we should all be aiming for.
You're very clear, and there are a few things I can actually follow. I just wish I understood the chemistry better. When it gets down to electrons and ions and such I'm lost, but that's okay. You do a great job, and obviously many people do follow what you're saying. That's just terrific!!!
The difference between races is there because of Vitamin-D deficiency. A new Indonesian study shows that Vitamin-D deficiency increases risk of death by *10 times.* Since Vitamin-D is produced in the skin from UV-B radiation and the efficiency depends on skin tone, age, weight, location etc...
Yup dont forget D receptor SNPs
@Skeptical Caveman. Please can you supply a link to the study you mentioned. Tia.
The amount of sun a white person needs to acquire sufficient VitD is 3-6hrs per day naked under 12noon sun for 7-14 days. (per my endocrinologist). In other words, most people wont get proper VitD with sun exposure.
Deficiency also is more on how we barely go out now because hot sun and how our work is indoors. Diet is next.
The thing is, vitamin D can help, but its not everything. Genetics, lifestyle, and environment also has a major effect on body response to disease and pathogens.
What? Race isn't a social construct? Are you sure?
@@poopsiedear1127 This is one of the reasons anthropologists and others (I am an anthropologist) don't want to get rid of race as a biological descriptive...ridding only the social construct from which you speak.
Those whose ancestors lived in sunnier areas developed more pigment in the sun through evolution . This filters the sun some because not as much is needed for Vitamin D production and it also protects from the sun more. However, those in more northern regions of Europe didn't get as much sun exposure and lost their pigment over time. This made vitamin D absorption easier because it was needed to create the same balance. It is the body's ability to adapt to its environment. However, this is over a generational evolution that is necessary for these changes to be substantial.
Although those with darker skin are in many ways no different than anyone else, their bodies are different. Race is more like the clothing we wear, as a non-literal example. Someone in Namibia may be no different than myself in the mountain West of the US, but if I dressed as they do in January I would freeze to death. I would be super hot if I wore my warm clothes there. This is where an understanding of race differences in biology can be helpful.
Thanks for keeping is informed.
One minor detail: G6PDH can really be considered part of the glutathione redox system, since it is what snatches electrons from glucose-6-phosphate to reduce NADP+ --> NADPH. NADPH, in turn is the electron donating cofactor used by glutathioine reductase to regenerate the reduced GSH from the oxidized GSSG.
One other point: ONOO- is peroxynitrite, not -nitrate.
Your updates are so timely! Thank you!
MedCram is the only update I can watch without panicking. Much appreciation Dr Seheult
Thank you for your great work Dr Seheult
I viewed Dr. John Campbell discussing a paper published in the U.K. that showed that blacks as well as Bangladeshi, Pakistanis, all with dark skin were also suffering at increased rates. He theorized that it might be due in some part to Vitamin D deficiency in those groups.
Dr. Seheult, many thanks for looking into Kawaski desease, I have been wondering about this for while since I have children ranging from 5 to 17 years old. Always good to have you take the time to review relatively old but pair reviewed articles that are of some help in looking at the BIG picture. Have a great weekend! Salutations de Montréal.
Excellent information, presented in a way a layperson without a medical background can understand. You are doing a great service to everyone by providing these videos!
As you probably know, when eNOS becomes uncoupled, it generates O2- INSTEAD of NO, which can happen when the levels of its cofactor, tetrahydrobiopterin (BH4) become limiting.
I read about Kawasaki disease many years ago and saw that the earlier treatment was started the better the out come, and just read this on the Harvard website {The sooner treatment with gamma globulin is started, the better it works. For example, complications of Kawasaki disease, including coronary artery aneurysms, may be prevented with early treatment.}
It was 29 degrees centigrade in Sydney Australia today - not winter!
Pissing down with rain and 15 degrees in Melbourne, so speak for yourself!
8 degrees here in Perth.
I hope you can talk about the study out of Mount Sinai that showed a dramatic reduction in mortality among ventilated Covid19 patients who were given anti-coagulants.
Link?
@@Medcram
www.mountsinai.org/about/newsroom/2020/blood-thinners-may-improve-survival-among-hospitalized-covid19-patients-pr
@@Medcram
Here's a link to the pre-proof in the Journal of the American College of Cardiology
www.sciencedirect.com/science/article/pii/S0735109720352189
@@Medcram hehe, you should read more comments :) I posted that paper in previous video comments
and Thank you for all that you are doing, stay safe and healthy!
racial differences in vitamin D , does it have an impact?
I would think so due to pigmentation and sunlight absorption or lack thereof.
Especially in northern latitudes.
Evolution wise, I don't imagine lighter skin pigmentation would have been so naturally selected for in northern climates if vitamin D production didn't play a significant role in preventing death before reproductive age.
@@Daz19 Skin pigmentation variation by latitude as an evolutionary response to the UV radiation of the sun? To much UV decreases folic acid and not enough decreases Vitamin D, a balance was necessary to achieve a higher successful birth rate in hunter gatherer societies.
Statistically yes, in northern latitudes. Actually healthier in their native latitudes.
‘Thanks for joining us!’ 👏🏼
On minorities:
I think the reason we see a higher CFR in black and brown communities is mostly socioeconomic and political.
I understand that there is a possibility of people of African descent having a genetic tendency towards increased oxidative stress in vascular tissues, hypertension and uterine fibroids etc but the reason for a higher CFR in those communities is overwhelmingly socioeconomic!
N.B. You have to stratify all the social and economic confounders for you to begin to hypothesise on a genetic cause for a higher CFR in black communities.
Very interesting content and you one fabulous educator, thank you for such great content!! I am rediscovering my formal education and curiosity for molecular biology. After your last video, I am very curious about fibrinogen in this context...
Thank you, sir!
This is really interesting, but if these racial differences play such an important role, how come the morbidity and mortality in Africa is so low?
Could be lifestyle difference if people there spend much more time outside and diet is different. You'd have to think that the diet in Africa is much closer to the original diet we are adapted for, the real 'paleo diet' if you will.
I’m concerned that the US curve flattening you show is deceptive. States like NY, WA and CA that have been aggressive in closures have seen decreasing numbers, while other places are seeing sharp increases.
Stop watching the media , it’s all lies.
Why is no one talking about the fact that darker skin makes vitamin D more slowly so darker skinned people are more likely to be vitamin D deficient?? And as we all know by now, low vit D levels are associated with more severe cases of ARDS and other more severe complications.
Breauna S I got banned for posting on a website because I said this re darker skin colours. Go figure.
Same with me asking about Niclosamide from university of Austin Texas, pulverizing tablets and snorting, or dissolve in hot water and inhale?
Breauna S. I totally agree with you. Why aren't the public being advised to take Vitamin D and C supplements to boost the immune system. There's very little downside and unlikely to overdose even on high doses.
Breauna S Sun’s out, buns out.
@blessed14real The fact that major milk companies went bankrupt this year and a lot of people don't drink it, maybe talking about Vitamin D is a good thing.
Thank you for covering this!
Love this channel as well as Doctor Mike Hansen's. Would be cool to see a joint video done of some sort.
Thank You
I heard kids started to show these symptoms from early April.
You are a beautiful girl.
It will be just fake profile pic..
@@abimanyu17 What make you think it is fake, i saw a ugly face in your profile so as inner personal, She is beautiful and also caring about kids, that is what i see. hope you learn something.
My son had these symptoms back in late Dec last year. He couldn’t eat well because his tongue was just like the pic above. He got so skinny with non-stop coughing for two weeks. He got tested negative for both flu A and B and the strep throat. I thought the symptoms were so bizarre. Do you guys think it might be related to Covid 19? He had a contact with a kid with bad coughing at some science museum in Dec.
Michael Mai thanks, Mike. It is my real face with the filtering effect! Not a fake one, though:)
I just want to add that majority of Australia during winter only encounters a fairly mild temperature drop. Myself in north QLD sees our daily summer averages drop from 35°c (with high humidity) to low 20’s°c. Also our wet season occurs during summer. So overall we still do a lot outdoors, so our vit D levels and access to fruit and veg doesn’t change much
Brilliant lecture! Thanks for info.
Thank you!
You're welcome!
Always clear, always informative. Thank you!
This Video brought to my mind the Research of Prof. Martin Pall from Washington State University about a NO/ONOO cycle. He works with megadoses of Vitamin B12. Could this be helpful in the Covid 19 disease too?
Why isn't vitamin-d deficit being considered. The darker the skin, the slower d is made leading to deficit.
I'm reading that African Americans don't need as much calcium and vitamin D as whites for bone health. I don't know if that extends to the other benefits of D. americanbonehealth.org/nutrition/african-americans-need-less-vitamin-d-and-calcium/
Racist
@@poopsiedear1127 colored people love it that we are r3xognized as colored...never an offense to simply be yourself...it requires no blaming and naming...try it. Btw. I am a race of a human descent...does that make me a racist!?😂✌
It's not a lack of vitamin D or sun exposure, likely, but the ability to activate that and the protein binding problems of our individual genomes. That's why some people can take higher doses of vitamin D supplements and still have low blood levels of 25(OH)D. It's just one more consideration in what's happening with this virus that seems to turn on/off genes.
Africa has fewer cases of coronavirus infection and death than Europe, Asia, and North America. The clusters of cases that are there are in areas heavily populated by European and Asian residents on the Continent.
Thank you so much for each and every video you posted sir.Resepct and best wishes from India.
I was hoping you might address the Kawasaki disease stories. Well presented interesting and logical sounding hypothesis.
Thankyou
Watched a very lengthy video UCSF Covid 19 update epidemiology, virology, drugs and Vaccines and UCSF's Experience in Navlio Nation at 1:38 a list of drugs that may work in therapeutic treatment. It is a collaboration of 4 experts, the most interesting part is the co-operation of scientists all over the world. I find Medcram the most educational and I can understand so much more.
As I understand , the Kawasaki is often treated with high doses of Aspirin as the best medicine to stop the inflammation. This NSAID is not a good choice by Covid?
Good point?
Only in cases where fever is the result as it mask the effects of pyrexia and dampen immune response. Aspirin is fine to reduce inflammation but steroid therapy should be used as an alternative
Both Covid-19 and Kawasaki makes blood clots in arteries and veins. It seems like they use Aspirin on Kawasaki to reduce the inflammation.
They try to avoid the platelets to stick together. Blood clots in the lungs are widely a problem on both virus attacks. May be a bad choice on Covid-19, but mainly described as the best medicine for Kawasaki.
Susan Kay yes in children it’s contraindicated with Kawasaki’s, I was merely stating antipyuretics should be avoided
From the reference article mentioned in this video (www.ncbi.nlm.nih.gov/pmc/articles/PMC3595783/), "To investigate this hypothesis, they analyzed bacteria isolated from the oral cavity and duodenal mucosa, and clarified that gram-positive cocci with superantigen activity and gram-negative bacteria, which produce heat shock protein 60 and induce inflammatory cytokine production in peripheral blood monocytes in pediatric patients, were isolated from children with Kawasaki disease at a high rate, suggesting that these microorganisms act together and induce Kawasaki disease.50)"
The pathogens involved were gram positive cocci and gram-negative bacteria. The gram+ve cocci induced inflammatory cytokine storm which causes vasculitis in multiple organs.
What is the proof that there is a cross reaction with SARS-CoV-2 virus? Our body can generate cytokine storm in reaction to infection (from virus and bacteria), is this the case of co-morbidity?
From the same article, “The involvement of an infective factor in the development of Kawasaki disease has been assumed, but the cause is still unclear. A nationwide epidemiological survey of Kawasaki disease has been continued from 1970, and the total number of registered patients exceeds 240,000. The peak onset age is one year, and 70% of pediatric patients develop the disease at 3 years of age or younger. More than 10,000 patients have been reported annually in recent years, and the number of patients is still increasing.5) After Furusho et al.6)"
Note that most of the patients are under age of 5, peak onset age is 1 year, this is the time that children start getting vacinations, sometimes receiving multiple vaccines at the same time. How do we know that this is not the over reactions of immune response from vaccination?
Thank you for your informative video.
Would love to get your take on treating with recombinant ACE2 or ADAMTS13 (BAX930). There's an ongoing study looking at rhACE2 (Apeiron Biologics) that looks very promising, where the rhACE2 theoretically acts as a decoy for the virus to bind to AND provides the typical protective functions you've discussed about ACE2 in previous updates. Would love your thoughts on this.
Wow, Great Work !
Excellent ! Interesting link to Kawasaki Dis. It would be interesting to see a short episode on what sort of routine sources you use Dr. Seuheult in order to prepare these videos. Thank you again for your work here.
As an unrelated note, I see that Dr. Gundry in his Longevity Paradox book compliments the Seventh Day Adventists and their food choices that put them in the “Blue Zone” category of people who live exceptionally long times.He mentions his time in Loma Linda as very educational for him .
Keep up the good work buddy! Paediatrics is a challenging speciality you tackled it well! An inspiration for my channel!
Another good video. However Australia and New Zealand where I live are still experiencing lovely weather. We don’t really get into winter until June. I call flu season vitamin d and sun deficiency and have for 20 years. Test don’t guess and get your levels tested.
It's cold in Tasmania and the South Island by now. Having said that, Tasmania has quite a few cases considering their low population. Definitely get your vitamin D levels tested. And for good measure, zinc too.
If this also affects okder children *like adolescents) I WANT TO KNOW IMMEDIATELY! I am 17 and frankly frightentd!
You really do a superb job teaching, thank you.
Calling superoxide bad/dangerous is half the story, it serves very useful functions.
If you have covid-19 would it make sense to take oral superoxidase supplements ?
You did not mention whether these children manifesting Kawasaki like have tested positive for the coronavirus ???!!!
This is very concerning. My grandson had Kawasaki disease about 3yrs ago, he has since recovered. They treated him with heart medication since they said it creates holes in their heart but since they are so young they heal quickly. His follow up visits cleared him of any danger.
I have just heard he is now having fevers and vomiting with pain in his abdomen. They had a video visit which the doctor prescribed a medication for the nausea. He is still running a fever. I hope this isn’t a recurring thing.
A few weeks ago, at first in the UK and some days later in Belgium, there suddenly were several cases of little children with Kawasaki too.
This series is so brilliant in presenting understandable explanations of a very complex subject! You are working with California patients. I'm a New York City resident. They suggest now that CA and NY are experiencing different strains of coronavirus. What do you think? If so, what is that difference?
Thanks for the knowledge 👍
It seems to me that nutritional status should be investigated as a possible cause of racial differences in COVID deaths. Can’t that be ascertained by a blood test for levels of vitamins, minerals, protein, etc.?
You seem to have missed two important points about "hot-cold" therapy. First, it is called "banya" and to be most effective it is extreme. A dry sauna at 150F for 10-15 min, a cold dunk in sub 50F water for 5 min, repeat two more times. I do the hot sauna for 15-7 min, but take a cold shower for 5 min each time. I doubt that a 14 min warm-cool shower regimen would produce much benefit. Second, you never explain how it helps immunity. Conventional wisdom is that it "squeezes" the lymphatic system, gets it moving and cleansed. It is the cellular level sewer system that cleans out inter and intra cellular debris. Perhaps you could explain this better.
They are reporting numbers late or not at all to prep for opening the country. Here in Arizona numbers are off by hundreds if not 1,000's because in a state of 7.2 million they have tested 120,000 total. They have almost 11,000 cases and 517 deaths.
That is parenteral penicillin, daily imi, for a month or so, monitored closely by ESR, at the time, and monitoring of the fever. Typically, active RHEUMATIC fever, maintains an elevated ESR, and a persistent low pyrexia. Cardiologist opinion is a MUST. I myself was very fortunate for DR TARAZI, later to become an important TEAM MEMBER at the CLEVELAND CLINIC OHIO USA, and author of important pioneering articles and experiments on HYPERTENSION, and one of the first to use GANGLION BLOCKERS as arguably the MOST EFFECTIVE treatment of Hypertension.
Thanks
You are doing more than trumpist CDC's job educating the masses, to whoever cares to learn, about this disease. Please take great care of yourself first, take necessary rests in between your hospital responsibilities & upkeeping this video series. We are forever endeavored to your dedication to help fighting this pandemic. Love & respect from all of your students and viewers around the world.
A very keen observation and an intelligent correlation...pls let us know any comments on monoclonal antibodies in news, if any lives can be saved currently using them.
Thanks.. I read up about the growing new Kawasaki like symptoms arising in the younger CoVid-19 children in NY, but a larger amount, of course in the UK prior.. and so I saw vasculitis, inflammations..and many recognizable issues you have been talking about in regards to the covid19 cases..I kinda figured there was a relation here somewhere along the lines of The innate system..but I knew you'd go more in detail with it.. 👍👍
Over my pay grade, but thank you for being here.
Thoughts about supplementation of something like L-Citrulline to help with NO production?
Its called diet.... Need to eat your raw greens people get that nitrous oxide up.
Nitric Oxide (NO) is what you want. NOT Nitrous Oxide ( N2O also known as laughing gas)
Hi Dr. Seheult. When you mentioned Kawasaki's disease, you had my rapt attention. Over 40 years ago, my 4 month old niece suddenly got sick after having had a series of vaccinations. She ended up in a Boston hospital, where she died 2 weeks later. Her Drs were baffled by her illness and death, but sometime later, my sister received a letter from the hospital, saying they thought she may have died from a strange new syndrome called Kawasaki's disease, and that hers was one of the first cases in the country. We always felt it was related to the vaccines, and years later saw an article about a rash of Kawasaki's in the children of a village in Africa that had been traced back to vaccines they had received. I don't know if this information has any connection or significance whatsoever to these current findings, but I thought I would share it just in case. I have learned so much from your postings about Covid 19 even though I sometimes struggle to understand everything because I am not in the medical field and I thank you for your work. Stay well.
Sharon, what a tragedy, so sad! It's criminal that vaccine companies have NO liability, it prevents important discoveries. Their fear of lawsuit ends up hurting families & especially children. I've lost a dear niece to violence due to the corruption of the criminal justice system in Florida. Again, my condolences.
Thank you for the update doctor!
Thank you! Great info!!
Can someone explain the mechanism by which ACE inhibitors upregulate ACE 2? I am still unclear on this. I understand the effect on AT II, but I still do not understand the way "prils" would increase ACE 2 activity.
Absolutely incredible! Where the hell do you find the TIME. As an actively ‘jobbing’ physician here in the UK, I am almost completely reliant on your daily updates. Keep ‘em coming. Thanks 👍🏾
Kawasaki, rheumatic fever, share the same classically enunciated diagnostic criteria. Etiology of Rheumatic fever / Scarlatina paradigm, "allergic- immune response, following acute inflammatory response to streptococcus pharyngitis/ tonsilitis..in Rheumatic Fever, synovitis of large joints, ( knees ) are also a major feature, and Cortisone was first used in the fifties, to reduce that inflammatory DOLOR RUBOR loss of function.. CARDIAC COMPLICATIONS IN RHEUMATIC FEVER INCLUDE VALVULAR LESIONS.AND ENDOCARDITIS.
I thought Kawasaki disease was cat-walking a sport bike while wearing shorts and flip-flops. Now there’s 2 of them! Wonder which one has a higher mortality rate?
🤣 how do you cat-walk a sports bike?
Very informative videos for doctors and rest of technical staff. However, you talk at length about the causative issues, like how oxidative stress is occuring, but you give no time or just skip the issue about possible practical ways and means to reduce this stress. After all,Covid maybe new but oxidstive stress, cutokine storms are not new phenomenon. While you go many years back to dig out articles showing causative factors, many of us will appreciate you more if you fo equal justice to current therapeutic options to mitigate oxidative stress, cytokine storms, thrombosis etc etc.
Wonderful video. Which software or app do you use
Thanks for the interesting update on Kawasaki disease. I just heard about this and was glad to get a better understanding of it. By the way, you mention that new cases in the US are fairly flat. I suspect that the data on that is somewhat skewed due to the doubling of testing lately.
Really appreciate you breaking the information down to a understandable level. I share this channel with other paramedics and it is well recieved. Thanks!
As I take notes , to prepare to school my mother on cov2
Dr. Seheult, i have question. We've seen COVID-19 circulating for several months, how come this correlation between this virus and Kawasaki disease starts now all in a sudden? Shouldn't it be some cases of Kawasaki patients by the time this virus started spreading?
always interesting. just glad i'm not being tested!
What do we know about long term damage to children with COVID-19? Will they have developmental problems, higher rates of heart disease or damage to reproductive organs?
In areas where deaths from COVID-19 are on the decline, are there data available to show what can be attributed to those declines? Is it a matter of fewer infections? Improving capacities in previously overwhelmed medical facilities? Better therapeutics? I think that'd be some good info for the public to have.
CDC is evaluating it. wwwnc.cdc.gov/eid/article/26/8/20-1093_article
I agree it would be great to get more public exposure to know that staying home decreased the numbers.
Thank you for all the updates. Could the vasculitis discussed be the cause of the stroke seen in Covid 19 patients ?
fascinating and curious ........ and fits
Love your updates! Keep your eye on New Zealand as well as Australia. We have a colder winter across NZ (even in the subtropical north) than parts of Australia do, which would confound their numbers a bit. Ultimately, though, looking at these two countries may not say much as even if the virus is seasonal, because they've been so successful at suppression and may continue to be so because of their determination. It doesn't seem to be taking off in the rest of the Pacific, though, where a few countries have cases (Fiji, etc.), and it doesn't seem to be taking off much in Africa, either.
As for Asia & Africa, it may be because of the BCG (TB) vaccine they use there. Need wide spreading testing of populations to be able to say how many people have been infected but not shown any symptoms. All that kind of research will come eventually.
@@ELee-zv5ud The president of Tanzania holds a doctorate in chemistry and so proofed the tests sent to Tanzania. He discovered the tests provided false positives on non-human and inorganic samples, meaning the tests were either faulty or pre-contaminated.