Thank you So much. It was fantastic explanation! I was looking for this and I couldn't find it anywhere. Please keep posting more such videos. It helps us change get healthier with the right knowledge.
🤯Holy cow is this good stuff. It does seem the overall reality is complex af and individually variable. I too am trying to guess, what causes what . . I'm an unusual case.
Great video. Just one question that I still don’t understand: what causes the first step of insulin resistance? What’s the mechanism that inhibits the signal transduction so that there’s no expression of the GLUt-4 receptor?
What about choline, inositol, vitamin d3, vitamin k2. All these taken at night can reduce a fatty liver? Especially vitamin k2 from research.. what do you think about these?
This was extremely informative but I have a question and I’m wondering if you would know the answer? I know that metformin was proven to help this but studies have shown berberine to be as effective as metformin with none of the side effects. Do you know if berberine would be as effective to help w diabetes? Or insulin resistance?
Honestly, part of me regrets how I presented this video... really my intention was to introduce some of these concepts to those interested in health and research and to be a starting point for others to research these topics on their own... and I regret making it seem like a “medical advice” video.. everything in biology is x1,000,000 times more complex than can be explained in a 1 hour video... and I regret perhaps using a reductionist approach on a highly complex topic... personally occasionally I will avoid fructose for a week or so... and for various reasons I try to not overdo it with meat... personally I think it’s more important to manage obesity and exercise... but health is complex and sometimes it feels like genetic predispositions are under discussed in “medical advice” videos... and did not discuss other very important topics like beta cell dysfunction and cellular senescence which GWAS show plays a big role in diabetes... and I’ve updated my evolutionary perspective on fructose (although still agree with health consequences)...
@@sciencesimplified3890 Thank you so much for a very thorough and in-depth explanation of IR. This is the first time all these elements are in one place and explained coherently.
The theory is that fruit has a complex fibrous matrix slowing the absorption of fructose through the intestines -> portal system -> liver… however when you drink a high fructose sugar drink, you quickly absorb all that fructose flooding the liver with fructose overwhelming metabolism contributing to fatty liver.. to be 100% honest, this was my belief for a while but there are human radio labeled isotope tracer studies that show it maybe more complex and this paradigm may not be 100% accurate, there seems to be a link between fructose consumption and fatty liver, but I’ve seen different mechanism of how that process manifests itself and it’s a very complex topic. My belief is that natural physiological fruit consumption is generally safe especially in the context of a healthy diet and physical activity.
I probably should have clarified that a lot of the information presented in this video is new data, so it will take several more years for a lot of the data to be replicated and confirmed before it becomes standard of care and medical consensus.. for the fatty liver, the truth is no one knows there is no consensus and there is a lot of debate around many of these topics.. my impression is that it depends on different factors and for some people it starts at the liver and for others it starts with obesity when subcutaneous tissue spills out lipids (essentially the person continues to eat food, but th embody runs out of places to store that energy and begins storing it in places it shouldn’t). There are also people who can’t store fat subcutaneously so they end up storing all their excess energy(fat) ectopically in other tissues and these people have terrible insulin resistance, so I think in biology their is no one simplistic generalized answer and it probably depends on many factors
I don't think you should focus on obesity. Obesity is a symptom of a poor diet coupled with sedentary lifestyle. If a person's insulin and leptin are functioning properly obesity won't occur in the first place. Metabolic syndrome begins in the liver and is caused by a dietary intake that damages insulin/leptin mechanisms (fructose, bcaa, alcohol..)
I understand your perspective and to be honest I’m also still trying to figure these things out... for me the etiology of my perspective came from the fact that the majority of type 2 diabetics are obese, and how excess stored energy is stored as lipid derivatives in tissues, and there are biochemical mechanistic explanations of how these lipid derivatives changes insulin receptors to cause insulin resistance.. we also know how inflammatory products cause these same changes to insulin receptors, but causes of inflammation are extremely complex and we do know obesity also causes systemic inflammation.. and we know people with mutations who can’t store fat safely in adipose tissue store fat ectopically in cells, which causes extreme insulin resistance.. so personally it seems to explains a lot of these factors
Personally, I think it’s because food companies spend billions of dollars on food scientists to make junk food that high jacks the reward centers to make food “addicting” for the lack of a better word, fueling the obesity epidemic, that coupled with our modern lifestyle that allows people to be more sedentary.. and the truth is, sometimes I’m glad I get to be sedentary.. and no one is putting a gun to my head forcing me to eat garbage food, but I think awareness is fair
One thing I would have changed is to emphasize more time on beta cell dysfunction... and there is genetic evidence that genes involved in beta cell insulin production plays a role in why one person gets diabetes while another person in similar circumstances doesn’t get diabetes
I know there are some researchers who believes it all begins in the liver, and I strongly believe liver dysfunction plays a huge role. But can I ask, are you saying that you believe it is liver damage that leads to insulin/leptin dysregulation that then leads to obesity that leads to insulin resistance? I know dr lustig and others believe that for certain populations it’s liver fat is at the root of insulin resistance... and how liver fat is a better predictor of diabetes even better then subcutaneous and visceral fat I think I mentioned that and I actually tend to agree it plays a role for certain demographic populations
@@sciencesimplified3890 Yes I agree with a lot of Lustig's points. If leptin is functioning properly it becomes hard to over-consume calories, and any excess calories get burned off through sympathetic nervous system activation. Thus if one can avoid foods that hijack the leptin mechanism (fructose particularly) it becomes a lot harder to gain weight. I never knew about beta cell overload in the pancreas--pretty interesting.
Thank you So much. It was fantastic explanation! I was looking for this and I couldn't find it anywhere. Please keep posting more such videos. It helps us change get healthier with the right knowledge.
Best and authentic video on this topic
🤯Holy cow is this good stuff. It does seem the overall reality is complex af and individually variable. I too am trying to guess, what causes what . . I'm an unusual case.
OK, now where is 'show transcript'?
Great video. Just one question that I still don’t understand: what causes the first step of insulin resistance? What’s the mechanism that inhibits the signal transduction so that there’s no expression of the GLUt-4 receptor?
Free fatty acids...but there might be other things involved too .
Great video- thank you for your efforts. Yes very complicated and many have fatty liver despite exercising, being lean and eating a healthy diet!
Hey, how come 'show transcript' doesn't seem to work?
OOPS, never mind. There it is over there . .
😷💕💕
One more thing do you think a liver flush such as suggested by dr clark could help decrease a fatty liver… ?
What about choline, inositol, vitamin d3, vitamin k2. All these taken at night can reduce a fatty liver? Especially vitamin k2 from research.. what do you think about these?
Please, may I see the spoken words written down simultaneously?
The graphics seem to
have been corrupted
Can I ask what do you mean the images have been corrupted..? When you use that word is there a technical meaning? Thank you for notifying me of this
@@sciencesimplified3890 top third or so of the page was rendered as a mass of brightly coloured little tentacles.i will try to get a screen dump.
This was extremely informative but I have a question and I’m wondering if you would know the answer? I know that metformin was proven to help this but studies have shown berberine to be as effective as metformin with none of the side effects. Do you know if berberine would be as effective to help w diabetes? Or insulin resistance?
So, would some key take aways would be: less fructose, less meat/dairy, less alcohol?
Honestly, part of me regrets how I presented this video... really my intention was to introduce some of these concepts to those interested in health and research and to be a starting point for others to research these topics on their own... and I regret making it seem like a “medical advice” video.. everything in biology is x1,000,000 times more complex than can be explained in a 1 hour video... and I regret perhaps using a reductionist approach on a highly complex topic... personally occasionally I will avoid fructose for a week or so... and for various reasons I try to not overdo it with meat... personally I think it’s more important to manage obesity and exercise... but health is complex and sometimes it feels like genetic predispositions are under discussed in “medical advice” videos... and did not discuss other very important topics like beta cell dysfunction and cellular senescence which GWAS show plays a big role in diabetes... and I’ve updated my evolutionary perspective on fructose (although still agree with health consequences)...
@@sciencesimplified3890 I think I understand. Metabolic syndrome is complex and simplifying to dietary advice in a sentence isn't realistic.
@@sciencesimplified3890 Thank you so much for a very thorough and in-depth explanation of IR. This is the first time all these elements are in one place and explained coherently.
Thank you so much ☺️ for brief explanation sir. You are the best 👌
Is consumption of fruits same as consuming fructrose ?
The theory is that fruit has a complex fibrous matrix slowing the absorption of fructose through the intestines -> portal system -> liver… however when you drink a high fructose sugar drink, you quickly absorb all that fructose flooding the liver with fructose overwhelming metabolism contributing to fatty liver.. to be 100% honest, this was my belief for a while but there are human radio labeled isotope tracer studies that show it maybe more complex and this paradigm may not be 100% accurate, there seems to be a link between fructose consumption and fatty liver, but I’ve seen different mechanism of how that process manifests itself and it’s a very complex topic.
My belief is that natural physiological fruit consumption is generally safe especially in the context of a healthy diet and physical activity.
This makes sense as studies show fruit consumption is correlated with decreased insulin resistance
Tq for the video. May i know is insulin resistance cause fatty liver or fatty liver cause insulin resistance? I am a bit confuse. Pls advice.
I probably should have clarified that a lot of the information presented in this video is new data, so it will take several more years for a lot of the data to be replicated and confirmed before it becomes standard of care and medical consensus.. for the fatty liver, the truth is no one knows there is no consensus and there is a lot of debate around many of these topics.. my impression is that it depends on different factors and for some people it starts at the liver and for others it starts with obesity when subcutaneous tissue spills out lipids (essentially the person continues to eat food, but th embody runs out of places to store that energy and begins storing it in places it shouldn’t). There are also people who can’t store fat subcutaneously so they end up storing all their excess energy(fat) ectopically in other tissues and these people have terrible insulin resistance, so I think in biology their is no one simplistic generalized answer and it probably depends on many factors
Tq dear
Thank you. Very helpful
I don't think you should focus on obesity. Obesity is a symptom of a poor diet coupled with sedentary lifestyle. If a person's insulin and leptin are functioning properly obesity won't occur in the first place. Metabolic syndrome begins in the liver and is caused by a dietary intake that damages insulin/leptin mechanisms (fructose, bcaa, alcohol..)
I understand your perspective and to be honest I’m also still trying to figure these things out... for me the etiology of my perspective came from the fact that the majority of type 2 diabetics are obese, and how excess stored energy is stored as lipid derivatives in tissues, and there are biochemical mechanistic explanations of how these lipid derivatives changes insulin receptors to cause insulin resistance.. we also know how inflammatory products cause these same changes to insulin receptors, but causes of inflammation are extremely complex and we do know obesity also causes systemic inflammation.. and we know people with mutations who can’t store fat safely in adipose tissue store fat ectopically in cells, which causes extreme insulin resistance.. so personally it seems to explains a lot of these factors
Personally, I think it’s because food companies spend billions of dollars on food scientists to make junk food that high jacks the reward centers to make food “addicting” for the lack of a better word, fueling the obesity epidemic, that coupled with our modern lifestyle that allows people to be more sedentary.. and the truth is, sometimes I’m glad I get to be sedentary.. and no one is putting a gun to my head forcing me to eat garbage food, but I think awareness is fair
One thing I would have changed is to emphasize more time on beta cell dysfunction... and there is genetic evidence that genes involved in beta cell insulin production plays a role in why one person gets diabetes while another person in similar circumstances doesn’t get diabetes
I know there are some researchers who believes it all begins in the liver, and I strongly believe liver dysfunction plays a huge role. But can I ask, are you saying that you believe it is liver damage that leads to insulin/leptin dysregulation that then leads to obesity that leads to insulin resistance? I know dr lustig and others believe that for certain populations it’s liver fat is at the root of insulin resistance... and how liver fat is a better predictor of diabetes even better then subcutaneous and visceral fat I think I mentioned that and I actually tend to agree it plays a role for certain demographic populations
@@sciencesimplified3890 Yes I agree with a lot of Lustig's points. If leptin is functioning properly it becomes hard to over-consume calories, and any excess calories get burned off through sympathetic nervous system activation. Thus if one can avoid foods that hijack the leptin mechanism (fructose particularly) it becomes a lot harder to gain weight. I never knew about beta cell overload in the pancreas--pretty interesting.