Remarkable when I saw the figure showing MITE insertion primarily 1kb upstream of promoters. That region is THE hot spot for all cis regulatory activity in the genome! These little guys are diversifying transcriptional regulation, which is the basis for all complex traits
I believe that TE insertions may have similar frequency in intron, exon, UTR or promoter. The fact that we "observe" lower frequency of insertion in exon is because these insertion may cause protein malfunctioning or pre-mature stop codon that are detrimental to the individuals, which are dead or not germinated before we observe any phenotypic or trnascriptional change.
Actually exons are more or less 1:1 with specific protein domains. And the mechanism of exon shuffling as a means of genome and protein evolution might be mediated by transposons. There's probably selection against mid exon transposition.
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Remarkable when I saw the figure showing MITE insertion primarily 1kb upstream of promoters. That region is THE hot spot for all cis regulatory activity in the genome! These little guys are diversifying transcriptional regulation, which is the basis for all complex traits
Interestingly this video uploaded 9 year ago when I was in 7th grade
Now I am msc molecular genetics student
Very helpful talk and easy to understand
Such a great talk! Very helpful to understand TE!
I believe that TE insertions may have similar frequency in intron, exon, UTR or promoter. The fact that we "observe" lower frequency of insertion in exon is because these insertion may cause protein malfunctioning or pre-mature stop codon that are detrimental to the individuals, which are dead or not germinated before we observe any phenotypic or trnascriptional change.
Actually exons are more or less 1:1 with specific protein domains. And the mechanism of exon shuffling as a means of genome and protein evolution might be mediated by transposons. There's probably selection against mid exon transposition.
Any ideas about the effects of histone accessibility on MITE distribution?
1:06:30 very interesting! Thanks for uploading!
This is great
Very interesting talk! I learned something new.
Feb, Thank you!
I see now what Prof. Malcolm meant about using MITES as a form of biological carbon dating.
my first question was convergent evolution.😭
really interesting
great presentation, but it would be more nice if she could give more general speech over the topic rather than some specific papers in her lab.
that was the part 1, the existence of which is implied in "part 2" in the title of this video.