This was helpful, thanks. I just subscribed. I am studying free radicals and grounding for an upcoming talk. After reading lots of info and watching lots of videos on missing electrons etc. your video made sense to me. I wonder why your video title though doesn't include the words inflammation or antioxidants. I'd love to see you do some tests on grounding as a way to flood in more electrons. Look at : Grounding - The universal anti-inflammatory remedy, ScienceDirect Feb 2023.
Is it necessary to have a variety of antioxidants, or is it adequate to have a single antioxidant supplement with every meal like say 2 grams of vitamin C?
Great question. Yes, we can't rely on a single antioxidant source. The antioxidants are packaged in different ways that dictate what part of the body they effectively reach, how and which cells they enter, how long they last, etc. For example, some antioxidants will have a harder time reaching the brain than others. Diversity of the antioxidant sources is important. Generally, a well-balanced diet should provide the needed diversity. But some people may need supplements, especially if their gut does not absorb vitamins easily. Some antioxidants, such as glutathione, have high efficient mechanisms for entering the brain. - Jarred Younger
@@youngerlabIsn’t methylene blue a potent electron donor and therefore a safe (well studied) alternative…also I think L-ergothioneine is also potentially 100’s of times more powerful than vitamin c and glutathione and therefore a potential biological superstar. I’m currently looking into them both. 🙂👍🏻
Perhaps you've heard of "Chronic Fatigue Syndrome"? This syndrome was launched in 1985 by two Incline Village doctors, Paul Cheney and Daniel Peterson who called the CDC for help with a "mystery disease" they couldn't figure out. The CDC couldn't figure it out either and coined a new syndrome, as if they intended to "solve CFS" When of course, they obviously didn't, for they walked away and did nothing further. Strangely enough, all CFS doctors did the same and never looked into what happened in Incline Village. If they had, they would have learned about the doctor who came before Cheney and Peterson. Dr Robert Cathcart. Whose theory was that oxidative "free radicals" was the cause. In the lack of any particular "cause" Dr Cathcart left it an open question. Never throw away those old theories. You never know when they might come back into fashion.
@@madbeggar If mold has set up camp in someone's body, the released mycotoxins would cause oxidative stress both directly, and by reduction of glutathione. Fatigue and reduced cognitive and physical resources would be primary symptom. I am not trained in how to detect or eradicate mold in the body, but IgE antibody tests or mycotoxin titers might be used for discovering issues. However, even if the original insult was mold, that doesn't mean that mold is still resident. It is equally possible that mold damages inflammatory pathways and causes chronic issues even after the mold is eradicated. That is one of the lines of research I am investigating. - Jarred Younger
I've been rationalizing that an antioxidant/polyphenol that can cross into the eye vessels, to clean up free radicals, such as Astaxanthin, may be able to cross the blood brain barrier as well. (?) I don't know. Nobody seems to make that hypothesis as I do. Or maybe they just don't talk about it.
Could this explain when I try to push hyper bear oxygen therapy long and hard it makes it worse on my body, the fatigue and brain fog I’m trying to combat PTSD and long-haul Covid with hyperbaric and LDN
Hey - remember that time that Younger solved the mystery of CFS? Me neither. He seems like a very nice guy. His (albeit infrequent) videos demonstrate a command of the science. He explains complex issues with ease. But, after a decade of research, the best advice to come out of his lab is... take some vitamin C if you think you have redox issues? We need readily available methods to detect neuroinflammation NOW. People need to know what is wrong with them NOW. Patients need interventions NOW. How many more $millions need to be funneled into this disease before someone actually DOES SOMETHING to help patients? We have plenty of patient samples in the locker. We have enough observations of the curiosities in those samples. (Everything is f'ed up. We get it.) We have more than enough hypotheses. What we need is someone who gives a f about the people who are suffering every day. One researcher/clinician - anyone with the keys to the lab - who will go in and DO SOMETHING. Not to get published. Not to get tenure. Not to get rich. Someone who will do the interventionist work that is necessary, whether on cells/tissues/patients, to definitively prove the mechanisms at play and to forge a path towards treatment. It's ridiculous that this is still unsolved after so many decades, while PhDs and admins in funding orgs have gotten rich. I now relinquish my soapbox. Feel free to step up and express your outrage - if you have the energy. (Watch your tachycardia.)
Yes the pace of strong developments is too slow. In particular, we need to have dozens of clinical trials happening now. There have been too few treatments tested. The NIH is having meetings for the rest of this year on how to get to treatments as quickly as possible. There will be webinars starting in August, and an NIH meeting in December -- all about ME/CFS treatments to prioritize. It is far too late happening, but it is only in the last few years that there was any funding available for ME/CFS research. That has changed, and the research is increasing now at an impressive rate. My next video is presenting the PET study we just had published showing neuroinflammation in those with fibromyalgia and ME/CFS. However, yes, I believe the #1 priority now should be testing potential treatments as quickly as possible. - Jarred Younger
you're doing great work and explain everything so clearly. It's really appreciated.
Thank you! - Jarred Younger
He's back hooray!
Thanks! - Jarred Younger
11:00 things you need to test to see whether there's inflammation in the body
HS CRP
ESR
IL-6
TNF Alfa
Ferritin
Fibrinogen
Thank you!
This was helpful, thanks. I just subscribed. I am studying free radicals and grounding for an upcoming talk. After reading lots of info and watching lots of videos on missing electrons etc. your video made sense to me. I wonder why your video title though doesn't include the words inflammation or antioxidants. I'd love to see you do some tests on grounding as a way to flood in more electrons. Look at : Grounding - The universal anti-inflammatory remedy, ScienceDirect Feb 2023.
thank you!
Is it necessary to have a variety of antioxidants, or is it adequate to have a single antioxidant supplement with every meal like say 2 grams of vitamin C?
Great question. Yes, we can't rely on a single antioxidant source. The antioxidants are packaged in different ways that dictate what part of the body they effectively reach, how and which cells they enter, how long they last, etc. For example, some antioxidants will have a harder time reaching the brain than others. Diversity of the antioxidant sources is important. Generally, a well-balanced diet should provide the needed diversity. But some people may need supplements, especially if their gut does not absorb vitamins easily. Some antioxidants, such as glutathione, have high efficient mechanisms for entering the brain. - Jarred Younger
@@youngerlabIsn’t methylene blue a potent electron donor and therefore a safe (well studied) alternative…also I think L-ergothioneine is also potentially 100’s of times more powerful than vitamin c and glutathione and therefore a potential biological superstar. I’m currently looking into them both. 🙂👍🏻
Brilliant!
Perhaps you've heard of "Chronic Fatigue Syndrome"?
This syndrome was launched in 1985 by two Incline Village doctors, Paul Cheney and Daniel Peterson who called the CDC for help with a "mystery disease" they couldn't figure out.
The CDC couldn't figure it out either and coined a new syndrome, as if they intended to "solve CFS"
When of course, they obviously didn't, for they walked away and did nothing further. Strangely enough, all CFS doctors did the same and never looked into what happened in Incline Village.
If they had, they would have learned about the doctor who came before Cheney and Peterson. Dr Robert Cathcart. Whose theory was that oxidative "free radicals" was the cause.
In the lack of any particular "cause" Dr Cathcart left it an open question.
Never throw away those old theories. You never know when they might come back into fashion.
So, you think people in Incline Village caught free radicals?
@@madbeggar If mold has set up camp in someone's body, the released mycotoxins would cause oxidative stress both directly, and by reduction of glutathione. Fatigue and reduced cognitive and physical resources would be primary symptom. I am not trained in how to detect or eradicate mold in the body, but IgE antibody tests or mycotoxin titers might be used for discovering issues. However, even if the original insult was mold, that doesn't mean that mold is still resident. It is equally possible that mold damages inflammatory pathways and causes chronic issues even after the mold is eradicated. That is one of the lines of research I am investigating. - Jarred Younger
@@youngerlab Well, for anyone to know, they would have to make some effort to find out.
Like asking how it happened.
How to test if increasing antioxidants would help me?
Very interesting! Do you also research Astaxanthin?
That is an interesting one. It is on my list to test! - Jarred Younger
@@youngerlab yay!
I've been rationalizing that an antioxidant/polyphenol that can cross into the eye vessels, to clean up free radicals, such as Astaxanthin, may be able to cross the blood brain barrier as well. (?) I don't know. Nobody seems to make that hypothesis as I do. Or maybe they just don't talk about it.
Could this explain when I try to push hyper bear oxygen therapy long and hard it makes it worse on my body, the fatigue and brain fog I’m trying to combat PTSD and long-haul Covid with hyperbaric and LDN
Inflammation markers to be tested
Methylene blue?
Hey - remember that time that Younger solved the mystery of CFS?
Me neither.
He seems like a very nice guy. His (albeit infrequent) videos demonstrate a command of the science. He explains complex issues with ease. But, after a decade of research, the best advice to come out of his lab is... take some vitamin C if you think you have redox issues?
We need readily available methods to detect neuroinflammation NOW. People need to know what is wrong with them NOW. Patients need interventions NOW.
How many more $millions need to be funneled into this disease before someone actually DOES SOMETHING to help patients?
We have plenty of patient samples in the locker. We have enough observations of the curiosities in those samples. (Everything is f'ed up. We get it.) We have more than enough hypotheses.
What we need is someone who gives a f about the people who are suffering every day. One researcher/clinician - anyone with the keys to the lab - who will go in and DO SOMETHING. Not to get published. Not to get tenure. Not to get rich.
Someone who will do the interventionist work that is necessary, whether on cells/tissues/patients, to definitively prove the mechanisms at play and to forge a path towards treatment.
It's ridiculous that this is still unsolved after so many decades, while PhDs and admins in funding orgs have gotten rich.
I now relinquish my soapbox. Feel free to step up and express your outrage - if you have the energy. (Watch your tachycardia.)
Yes the pace of strong developments is too slow. In particular, we need to have dozens of clinical trials happening now. There have been too few treatments tested. The NIH is having meetings for the rest of this year on how to get to treatments as quickly as possible. There will be webinars starting in August, and an NIH meeting in December -- all about ME/CFS treatments to prioritize. It is far too late happening, but it is only in the last few years that there was any funding available for ME/CFS research. That has changed, and the research is increasing now at an impressive rate. My next video is presenting the PET study we just had published showing neuroinflammation in those with fibromyalgia and ME/CFS. However, yes, I believe the #1 priority now should be testing potential treatments as quickly as possible. - Jarred Younger
What do you think about methylene blue? Or maybe etanercept? Or maybe cats claw?