2-Minute Neuroscience: MDMA
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- Опубликовано: 27 сен 2021
- MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug with unique prosocial effects. In this video, I discuss the current understanding of how MDMA acts on the brain to produce its effects.
TRANSCRIPT:
MDMA, better known as ecstasy, molly, or one of a number of other street names, is a stimulant drug that is chemically related to amphetamine. Like other stimulants, MDMA causes increased alertness and a positive mood. But MDMA’s effects are also distinct from the effects of other stimulants, as the drug causes unique prosocial effects such as strong feelings of trust, openness, and closeness with others.
Although we don’t have a full understanding of the effects of MDMA on the brain, MDMA’s mechanism is similar in many ways to the mechanism of other amphetamines. MDMA inhibits the function of proteins called transporter proteins, which typically remove neurotransmitters like serotonin, dopamine, and norepinephrine from the space between neurons known as the synaptic cleft. By inhibiting transporter proteins, MDMA causes serotonin, dopamine, and norepinephrine to accumulate in the synaptic cleft, increasing neurotransmitter activity there. In contrast to other amphetamines, MDMA inhibits the serotonin transporter more potently than the dopamine or norepinephrine transporter. MDMA also uses transporter proteins to enter neurons; once inside, MDMA disrupts the storage of neurotransmitters in synaptic vesicles, causing the buildup of serotonin, dopamine, and norepinephrine inside neurons; then, MDMA facilitates the release of these neurotransmitters into the synaptic cleft, leading to increased neurotransmitter levels and activity. In addition to these mechanisms, MDMA also binds to a number of receptors directly, including specific subtypes of the serotonin receptor; these interactions may contribute to the effects of MDMA.
It’s not clear what mechanism accounts for the unique prosocial effects of MDMA. A number of studies have found that MDMA promotes the release of the hormone oxytocin, which itself has been linked to prosocial effects. At the same time, most studies have failed to find a link between increasing oxytocin levels and the prosocial effects of MDMA, leaving these effects still unexplained.
REFERENCES:
Dunlap LE, Andrews AM, Olson DE. Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine. ACS Chem Neurosci. 2018 Oct 17;9(10):2408-2427. doi: 10.1021/acschemneuro.8b00155. Epub 2018 Jul 12. PMID: 30001118; PMCID: PMC6197894.
Oeri HE. Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy. J Psychopharmacol. 2021 May;35(5):512-536. doi: 10.1177/0269881120920420. Epub 2020 Sep 10. PMID: 32909493; PMCID: PMC8155739.
Schenk S, Highgate Q. Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms related to its use and misuse. J Neurochem. 2021 Jun;157(5):1714-1724. doi: 10.1111/jnc.15348. Epub 2021 Mar 25. PMID: 33711169. 
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I tried MDMA once 20 years ago, and it was amazing! I couldn't imagine why it wasn't being used to treat depression. Fast forward to now I'm getting ready to take part in a medical study that will be researching MDMA as a possible treatment for PTSD. Really looking forward to getting to do it again even though it will be in a clinical setting. Can't believe they're paying me to do it lol
Is it the program by MAPS? Let us know how it goes?
@@HitEDCsh Yes, it is MAPS.
@@derekdalton1539 let us know how it goes!! Ik a lot is probably classified
Hey I’ll refer you to this mate online who sells em very reliable and ships discreetly,,
Chubbcrackzz.
This is fascinating! In college I did MDMA a few times and had unbelievably positive experiences. One thing I noticed was a distinct urge to speak with other people and to explain things to them (which I'm guessing was pretty annoying), not only because I wanted to connect with other people (prosocial effects) but also because everything seemed so clear to me. It felt like the neural circuits controlling the feeling of certainty must have been firing like gangbusters.
It was like having an "Aha!" moment over and over again about everything I could think of. Unfortunately, I didn't write any of it down so if I did make any major discoveries, they are lost forever haha
Did you not notice any of the other college kids looking like hell for a few days after rolling? Cause I remember that. I didn't take it because I am already predisposed to depression. If it is working for you then all good whatever, but people make it sound harmless and it is simply not harmless. You fry your freakin serotonin receptors.
I do it like a other week I ll take molly and go to work I work at a fast place and on busy days it helps I'm I damaged my Brian if im.pnly taking it once every other week
@douglasmatthews2334 taken in controlled and moderated doses it's actually quite beneficial to some people and can help with chronic social anxiety
@@abdinasirabdulsalaam1916 once a week is way too much. Safest guideline is one every 3 months
@@abdinasirabdulsalaam1916 pretty sure you should be rolling like a few times a year... not every other week. brain is fried.
The effects of MDMA usually begin about an hour after taking the substance. It tends to peak quickly, within about an hour after the effects first start to appear. You’ll feel a greater sense of euphoria, pleasure, social bonding, connection with the people around you, and your perception of sights and sound will change. MDMA is not a hallucinogen in the traditional sense, but it can make lights and colors appear more vibrant.
HIGHLY ADDICTIVE AND FUN
@@aronreed261 It's not addictive
I can't image a better high than MDMA. I would recommend only doing it with people you 100% trust as it acts like a truth serum and you can communicate without any fear; but still have full control of your safety decision making. You also need a proper dose. My friend took a half a pill of 400mg/100mg MDMA/Caffeine and it did nothing for him but weeks later we both took a full pill and it hit super hard and fast. 200mg should be a heavy dose but it wasn't for us 250lb male athletes. I felt mild effects for weeks after and when I get emotional I can let it go almost instantly now. It's like it rewired my brain somehow.
Take notes when using this drug👌🏽 pure mdma brings out your intelligence and actual sense of humor
experience with MDMA was impressive. I feel complete control over myself. looks like he managed to change my nervous system! My innate nature which was originally jovial, careless, childish is now able to think critically, more mature, a little wiser, and more alert.
hope this is a good start.
@Dune Zimmerman has joined
This channel is a treasure
I agree. Almost nobody else in the neuroscience communication RUclips world is as concise and credible at the same time.
Yes it is very educational
I'm a introvert but as I took it I never felt more alive and social.
I don't do it anymore but if you got self control, it's worth a shot once
Can somebody relate to my experience? I do not want to advertise anything. I have ADD. Last Saturday I took MDMA for the first time. What I experienced changed my life I feel. I saw and felt love to everybody. To myself also, this feels nice. Now I go through life and I feel beautiful and connected to every person. Today I sat in a park. I did not look at any people, I just felt them somehow. I was high on life. Love.❤ ADD: I speak very clear with clear thoughts since today I feel. I am 100 % positive. I feel like my medication got a boost. I feel love for myself and the world out there. I can just walk and I feel like I am in my world. I feel like the people around me would feel me. Somehow I feel positive and attractive. I am such a rational person, but I saw another world. World of love. I danced on Saturday for the first time like I wanted. Free! Now I feel I can dance without MDMA. Another thing: I listen to songs differently: I understand them. Have a good night everybody. EDIT: I can completely stand up for myself now. I feel harmony anyway. I lived with a narcissist. I could take away his power over me.8
I'll link you up mycologist specialists who's been my guide for some time now, they got Mushroom Dmt, Lsd, Mushrooms, MoonRocks, Chocolate Bars, Edibles, Polkadot, Salvia, MDMA, Psilocybin and more could also guide you through if you're a newbie, ship's locally and internationally discreetly?
They're on Telegrams & Instagrams as..
*@Pharmstain*
Just stumbled across this channel, I love it! The clarity of what is known and what isn't.. fantastic work!
MDMA is glorious and I say this not just as a user but a respecter of the drug, doing this drugs which includes many other you need to always take it in the right amount and from the right source, people sell shitty stuff to people out their so be careful and I have been on it for over 15 years and i am strong and it helps sex wise also, just respect the drug and you’ll find ecstasy
I have seen a lot of recommendations and I don’t trust the one above me
Tried it and they failed to deliver
@@maryanne8377 😅what are the chances!!!!
That is my source also
I love them
Where can I find this Biologistcrew guys?
It doesn’t get me high anymore
@@katelewis3245 Better stop using it. It only should be done maximum once every 6 months.
I used to do it and overdid it. Not fun.
MDMA is not for everyone. I've learned that the hard way. Took approx. 400mg during the night (4 doses 100mg each). While the experience itself was absolutely great the following comedown was a hellish experience. Severe insomnia, anxiety attacks, depersonalisation and the worst part - sudden brain zaps and whole body twitching while trying to fall asleep. It took me half a year to partially recover. It's almost a year now since I rolled and I still haven't got back to 100% my former self.
MDMA if not taken in a responsible way will fuck you up big time.
Same here. Long term comedown sucks.
ok call me crazy but that may have something to do with the fact that you took 4 times the recommended use
@@pyrefly7575 You are absolutely right. I took that much because at that time I didn't know any better.
I was simply assuming that it is safe to take as much as my friends did (2-3 pills at a party was a normal routine for them as they never developed any negative effects apart from a normal come down).
My fault also I didn't do any research prior to mdma fun regarding doses. Also I didn't ask about how strong the pills were.
@@Icheb82 also don't take pills without testing them . If you're gonna travel somewhere bring your test kit or something
@@Icheb82 how are you feeling nowadays ?
Just discovered your channel and it's very good. Thank you!
My fav yt channel by far
just found this, thank you for yet another really informative video:)
Thank you for this insightful and informative video keep up the great content
Great video as always! I‘d love to see a comparison to the effects of serotonin reuptake inhibitors.
Thanks, much appreciated!👍
Fascinating thanks!
Very useful video, just keep going
Bro people in comments motivating others to take drugs
Scary, right?
Those are mostly scammers
It’s like me encouraging you to take Tylenol .. or an SSRI.. 😂 drugs are everywhere, you’re just conditioned to think some are good and bad
Yall are ignorant
thank you sir . we missed you
This is awesome
Thank you
Great video!:)
Great video..
ありがとうございます！
Thanks!
MDMA is great and hopefully it will be appreciated more because it can help people.
I took MDMA one time and it cure my anxiety and depression. I never even had the desire to do it again. I’ve been great ever since. MDMA did for me what I wanted marijuana to do, but weed failed me bad.
I'll recommend you to this light specialist that guides me through my first experience they ship all kinds of psychedelic products discreetly
Psyche_pharma08
IN
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Yea mdma foster amazing experiences, but have fun being depressed for weeks afterward, depleting all your feel good chemicals comes at a cost
Definitely worth it I wouldn’t do it if I had a serious job the the next week
I’ve done MDMA many times before or what I thought was pure MDMA. It was also very prevalently speedy… Because the stuff I had recentlyis from Europe It’s amazing. It literally makes you feel like that scene in Family Guy, where peter feel like oh my God Brian your fur… it’s so soft. Lolol. I remember I was just like holding my body and comfort and joy. It was so great. it’s so weird that it’s Meths cousin… I remember back in the day in Florida. I got sold Meth as Molly one time. 3 days awake ending in a mental break n hospital visit
Mdma is great hopefully it will be appreciated more because it can help a lot of people.
I get them from andrews_clouds
Its illegal
@@yisroelbinstok1122 lololol. Oh nooo!!!
How was the high of meth? Did you get Addicted?
How is the jaw clenching explained?
That would be meth, or a you just like the way your mouth feels when it's clenched on them but I think you would know the latter
treasure amazing
Can someone tell me if mdma directly caused damage to kidney? One of my friend told me he can feel some dull pain from his kidney when he was consuming ~180mg , is that normal?
I believe im one of the cases where although i didnt take a high dose or too often,it somehow damaged me.Last trip was more than a year ago and havent taken anything ever since because lets say i have a permanent hangover(comedown)from that badtrip.Now i have constant and continuous headaches,very poor mood and im basically on anti depressants.
I'd appreciate your comment fam.
I could recommend you to a specialist who guided me through My MDMA experience he’s got all kinda psychedelics product like Dmt, Adderall, oxys, Mdma, ket, xan's, lsd, mushrooms, chocolate bars, edibles, polkadot, psilocybin an more could also guide you through if you're a newbie >^^>>
@ JUMASTRIP _--JUMASTRIP
ON TELEGRAM OR INSTAGRAM
It's always a pleasure with molly but after 21yrs the comedown is pretty brutal.
Sounds great how can I get some?
msg me
MDMA is beautiful, god sent. Life is so much more
@@alecturner-of1vl your a scammer
I took "brown" molly, got it from someone I know, my friend who I took it with started really sweating so much and felt shitty, automatically we felt like our shit was lased and while in the cab back I started seeing things outside the window that wasnt there, do yall know what it was ????
2cb if you were hallucinating maybe
@@packman902 what's that I tried googling it didn't find anything
I could've been mixed with other substances like LSD...
Could you maybe explain why MDMA should not be taken too often (like most recreational drugs)? I think it has to do something with the fact that the high concentration of neurotransmitters in the synaptic cleft leads to an increase in serotonin/dopamine receptors, which would lead to a lower potentiation of the neurotransmitters, causing possibly depression of some sort. Is this correct? or do you have another theory?
Isn't it simply that the processes in your body get used to having exogenous hormones, thus it stops feeling the need to create them manually?
Also bit of a personal question, but did you use to go to SNL?
@@Syrxen lol wie ben jij dan?
I thought it's because the replation of the stored serotonin?
@@RyeCA That's how it works in the short term(2-3 days) i think. You shouldn't use MDMA for multiple days because after like 24 hours all of your serotonin is depleted. However for the long term, I'm not certain why MDMA loses it's function if you use it like every week or so. I think the depletion of serotonin, the change in potentiation and the number of serotonin receptors are the most important variables in that regard.
@@Syrxen Hey ik ben nog steeds heel nieuwsgierig naar wie dit is, stuur me een berichtje aub!
For dutch festival fans its like a vitamin pill
Everyday i take ecstasy even im at home doing nothing but smoking weed and drink coffee thats my life
They're on Telegrams & Instagrams as..
I have done over 1000 hits and still fine 20 years later
Can it be purchased safely and legally?
You could reach out to em on telegram
Pharmco_trips
So essentially like an SSRI. So why do ssris effect the trip??
I get my from an online store his got shroom, psychedelic and microdosing products well refined also ships to anywhere discreetly, can also guide you on anything.
His on Instagrams, with also telegrams with,,
*Mycopete%
I’ve taken MDMA various times and it’s had no effect on me despite those around me having wonderful experiences. I can’t seem to find any answers as to why it doesn’t work for me.
l'll refer this mycologist who introduce MDMA, it helped me treat my depression and anxiety, check him out he also guide newbies on proper trips moments.
@novatripps
He's on Instagram
Some advice don’t do this drug too often. The comedown is the worst fucking shit known to existence. Two nights in a row, I did 300mg and 275mg. My dreams are hella crazy, the rem
Sleep is amazing but just waking up right after because it will always happen, you just feel slow and sluggish. It takes ages to recover from it
@@wayncold1431 scammer
I so wish this read newer. I have had multiple Sclerosis diagnosed since i was 23. I am now 48. I am blind in my left eye from optic neuritis sinxe the beginning. Fot roughly the last 5 years my left leg feels very weak and if i walk, or am on my feet moving for a solid 10 maybe 15 minutes, my leg will stop working, and I'm tired all the time. Two days ago my friend had gotten some ecstasy pills, and my husband and i split one. We went to a street fair and I walked for roughly 3 hrs and my legs were fine, and i wasn't tired at all. When I woke up the following morning my legs were good, but only for a little bit. More it's back to normal. Does anyone know why? Please help me if you do. Thank you
Psychedelics like shrooms, Lsd, Salvia, Dmt, psilocybin, Vape Pens, opens a portal to the mind sub consciousness so whatever dwells in yours is what you will experience during your trip. You can try out this specialist I got my trips from who ships discreetly worldwide
Operate on Telegram and Instagrams as?
PHARMSTAIN
@@StellaMcPhe I don't have either of them. I can give you my phone number or my Facebook account or my email. I will FaceTime you. I will pretty much do anything. I just need to check and see if this would change my life.
@@StellaMcPhe who is it?
Can you recommend a dealer?
liam_spores
That's the IG handle of the guy I got mine from
What can interfere with esctasy working?
@@excellentchoice301 where are you?
I suffered 2 hemorrhagic strokes at 30 years old. Due to AVM rupture in my basil ganglia.
Subscribed to your channel in hopes, more videos on psychedelics, and possible healing benefits?
Mdma is great hopefully it will be appreciated more because it can help a lot of people
I get them from andrews_clouds
I just picked up a gram of some really nice pinkish purple crystal Molly. Comes from Europe test around 90 to 91%
How I need some
@@angelharris4068 talk to ppl
I am currently on some as well I got pink supermans and blue they have really changed my life personality wise don't do them often but if I need a boost and I had to stay up all night to pull two shifts at work definitely helps
Has anyone ever gotten MDMA flashbacks?
At a time kitna lines Lena sahi hota h ??
Hey I'll refer you to the specialist who helped me treat my depression,ADHD and anxiety,he got shrooms ,LSD, DMT,MDMA,ket and more also helps in exploration of your human psych...
I’ve also watched someone completely shut down on mdma. They weren’t very happy
l'll refer this mycologist who introduce MDMA, it helped me treat my depression and anxiety, check him out he also guide newbies on proper trips moments.
@novatripps
He's on Instagram
2 diet coke contains the same mg of phenethylamine as 1 tab of mdma
i never tried molly nor have the intention to, but had a discussion with a guy who did it. like with any psychedelic (and some people classify mdma as one) you cannot really describe the experience...
Because you never done it how could you describe it
@@JayJay-tb5cw there exist numerous reports about people talking about different drug experiences they had online for anyone who is curious. of course it can only give you a superficial impression in contrast to experiencing the inebriation
Where does the brain damage occur from taking too much ecstasy?
Hey I’ll refer you to this mate online who sells em very reliable and ships discreetly,,
Chubbcrackzz ..
Reach on Instagram
@@jessicacarson6117 Not interested. Smh
Oxidative stress can damage cells and dna. That’s why it’s recommended to load up on a bunch of antioxidants before use.
First (hopefully)
liam_spores
That's the IG handle of the store I buy from online
🌹🌹🌹
5-ht1a agonism is why
Bad idea I'm a prisoner
So your saying it rips the serotonin sacks in your neurons. Lovely
anyone else watch videos about the drug that your on
Yep lmao
Ong I always look up what kind of xpill I have before I take it
My heart is fucking races, bro I’m praying for god to keep me safe 🙏
Watching this off molly and I still have no idea why he’s saying all these big words
They have the best shrooms dmt lsd and other psychedelic edibles and ships discreetly to any location
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trippy_psyche1
???
They're on INSTAGRAM
.....
Got it eh eh eh guy
Is anyone else on MDMA while watching this?
They're on Telegrams & Instagrams as..
*@Pharmstain*
From what I've read its wrong to take MDMA and amphetamines from a Biblical and society ethics perspective and I do not take those drugs. I wish people safe wishes in their decisions in relation to drug taking in any circumstance.
Yo listen ey, lemme ask you something bae, would you like to buy mdma?
the song was what got me here accidentally LOL
Y’all literally copied @Asapscience…
ruclips.net/video/jEAr7ThsYew/видео.html
☠️☠️🐍
😝😝😝
Alo alo
would love you to cover some demonic possession scientific reasons as they are rare to find on the web
Eh eh
Bhang try karo kabhi sab bhul jaoge
can't believe they made a whole drug after a song
For quality supplies and guide, I recommend you check
Healerrob
Hey, I'll refer you to this mate I usually buy from very reliable and ships discreetly
Chubbcrackkz
He's on Instagram
What damage can this cause over prolonged usage?
Getting depressed.
@christianagorge5597 scammer
Serotonin sickness, deprived of dopamine, long term come downs and body pain if abused, depression, anxiety dissociation of yourself/"the real world" please be careful when using the substance it is seriously no joke.
But it doesn't allow you to sleep
From a previous MDMA user, I'd recommend not to take this, it is more damaging than cocaine.
Did last night. Was amazing
Did over the weekend. Was amazing.
You're not supposed to do it like crazy. I do it once awhile and it is great. Abusing it will destroy... Like all drugs
@space ponder I agree . In a relationship with someone that o didn’t know used it daily . It makes him the devil . Paranoid and delusional and hyperactive , playing music all day and over trusting of people , telling others his business.
Look up the below handle on Instagrams, that's where I got my stuffs delivered discreetly
Prosocial. Right. Got it
@ JUMASTRIP _--JUMASTRIP
ON TELEGRAM OR INSTAGRAM
They've got all Mdma an other psych product can also guide you through if you're a newbie >^^>
Eh eh