Growing mini brains to discover what makes us human | Madeline Lancaster | TEDxCERN
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- Опубликовано: 11 июн 2024
- Madeleine Lancaster delves into the age-old question of what makes us human with a new approach -- by growing cerebral organoids from stem cells in a petri dish and studying their development
Madeline Lancaster is a developmental, stem cell and neuro biologist at the Medical Research Council Laboratory of Molecular Biology. She leads the research group studying human brain evolution in cerebral organoids, which use stem cells to generate brain tissue clumps in a dish. These "mini brains" are the first 3D models of a developing human brain and could help uncover the secrets of what makes our brain unique.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at ted.com/tedx
I read her paper today it was very interesting and talked a lot about how the development of these organoids was essentially the same as the embryo and displayed mostly all the markers of a developing brain
actully? i’m skeptic because many people don’t think her organoids especially if they aren’t connected to the overall body can actully help much
@@Usernamesarestupid77 oh great the person never having worked with them is skeptical
One day it may be possible to vascularize these organoids to increase size/volume, remove waste products, provide nutrients, promote internal cell viability, and increase gas exchange.
gas exchange where
within the organoid. shaker methods only promote gas diffusion thru approximately 200 microns of tissue. This leaves organoids that are greater than 400-450 microns in diameter at risk of increased core cell death. i think future vascularized organoids could promote greater gas exchange and possibly reduce internal core cell death.
Have your ready any papers about ghost organs? Basically they decellualrize a heart for example and all thats left is the extracellular matrix. I'm curious if they could decellularize a brain feed nutrients through the vasculature of the brain and then recolonize the brain with neural stem cells
Burning question? Did you try using these tiny brains for computation? Could be very interesting to see a little blinking LED controlled with a tiny brain.
biological computing is a thing.... a brain is too complex to be used for mere computation
Yet...
What are the ethical outcomes of this experiment?
ozguneren There aren't
Can you test if those brains have consciousness by attaching organs like eyes or nose or ears to them?
They are organoids, not whole brains, too small to develop consciousness. To build bigger organoids (closer to the size of the human brain) you have to solve the problem of how to feed the cells deeper. In mammals this happens using a circulatory system that feeds them using blood. The researchers working on organoids haven't achieved this yet. If they try to build bigger organoids the cells inside die because they don't get any oxygen or nutrients.
@@tasosalexiadis7748 what if they grew the cerebral organoids with stem cells that are programmed to grow into a functioning heart and arteries and have it all fuse together automatically through dna coded algorithmic processes?
@@catminion1425 I think we will need to have a meta-program that control these processes, for example nano-robots that are programmed in a Turing-complete programming language that can integrate organoids that are grown from the subject's own DNA.
@@tasosalexiadis7748 you know, it's funny you mentioned nanobots as the other day i ruminated the same concept regarding this topic. Hopefully advancments in nanotechnology is taking significant progress so that what you say might possibly come to action!
Rots of ruck dealing with the complexity barriers....
Can you please make a big brain much bigger than a man's like a super big brain and then we could connect brains of all the people (on a voluntary basis) to this biggest brain and this Brain you made will have billions of eyes, ears, and micro-services(our human brains) and become a more advanced consciousness altogether.
We can use something like neuralink to connect us to this brain.
haha i have thought about this a lot. i call the mega brain "motherbrain" after metroid samus. Lets hop super brains dont go the way of the video game tho lol... they wont... i hope
In Genesis 1:27 we read that ‘God created mankind in his own image, in the image of God he created them’...
imagine when they can make full human brains, they will literally become brains in a vat.
Oh they all didn't know back then that Trump will become a nightmare for America
I think he's a great president :-)
she's Doctor Frankenstein
@@torineg.847 By understanding the differences in brain development you can better understand developmental disorders such as autism, macroencephaly and microencephaly. This could have big clinical implications. Pathways and mechanisms involved in the difference between different species are likely also involved in differences within a species - especially when comparing brains of primates (which are genetically very similar). Without curious people asking why, science wouldn't happen!
Ignorance at its best.
"we found something we can play with" is this a childish game? just that? Who gave you the right to play with the organoids? a kid with a grown up question is named inadequate.
Madeleine Lancaster:....growing cerebral organoids from stem cells....The BRAIN and the MIND are 2 different things. We are UNIQUE with our CONSCIENCE! And CONSCIENCE can only come from A HIGHER INTELLIGENCE.....A CREATOR! And this Creator Is BEYOND our OWN Understanding! (65Yrs. In Gen. Sciences)Friendly Yours...GUY!
Guy Durocher :(
WHY do you CAPITALIZE random WORDS?
@@Autepify BeCaUsE iT lOoKs CoOlL
The conscience is hard to explain, especially the part of any living thing that is responsible for tracking of time and dimension (ik it's a completely different thing, ignore that if you want, but I hope your brain wants to learn). Yet we cannot jump to conclusions right away. Saying it was a higher being is like quitting, believing what was said, but if you want to reveal an answer, you must ignore that temptation of saying it was a God or Creator, and to keep on searching even if it seems impossible.
From a standpoint of an atheist, God could have been a being that some person wrote in so that people can use him as someone to put the responsibility onto. Someone to be there when you are alone, because the brain has convinced itself of such a feature in this world. The contrasting effect, though, can be found darker and more menacing, for relaxing is the barrier between us and discovery, for in some cases, relaxation is giving up and letting go. It's as if the brain is challenging itself via this aspect of the imagination.
Otherwise, if you are a religious member of society, then you can say that God (or whoever you see as fit creator) is challenging you to not give up. He's telling you to "give it a try and see how thigs are," but if you don't want to, he'll become the answer for you.
@@kitria2854 shhhh.. you will scare him
Rots of ruck dealing with the complexity barriers....