Professor, your presentation was insightful. It reminded me of a quote by Professor Henry that says *"A model must be wrong, in some respects, else it would be the thing itself. The trick is to see where it is right"*
Thank you so much Professor. I learnt understanding the subtle yet significant errors in computational protein modeling is essential for researchers pursuing drug discovery, as it can greatly inform and improve their research endeavors.
Thank you for your question. It definitely could. However, I believe our structures are cryo-EM stuctures, not Xtal, and they are Fab's, not Scvf. The structures in our Cell paper are PDB Ids 8GAJ, 8FLW, and, 8FL1.
There are predictions that AF is good at, and there are things where it is not. The latter may improve with time, or new methods may have to be developed. My personal opinion is that the Nobel Prize to Deepmind/Demis Hassabis & John Jumper is well deserved. When I have corresponded with John about PSP he has always been a good scientist and a perfect gentleman.
![[TALK 21] AlphaFold: Use and Applications - Sami Chaaban](http://i.ytimg.com/vi/yJKfn6rvHmg/mqdefault.jpg)
Thank you for sharing your knowledge and this zoom meeting with us
It's very helpful :)
Professor, your presentation was insightful. It reminded me of a quote by Professor Henry that says *"A model must be wrong, in some respects, else it would be the thing itself. The trick is to see where it is right"*
Thank you so much Professor. I learnt understanding the subtle yet significant errors in computational protein modeling is essential for researchers pursuing drug discovery, as it can greatly inform and improve their research endeavors.
Prof I noticed that the crystal complex contains Scfv, whereas in AF3 it is Fab. Would this affect the AF3 precision?
Thank you for your question. It definitely could.
However, I believe our structures are cryo-EM stuctures, not Xtal, and they are Fab's, not Scvf. The structures in our Cell paper are PDB Ids 8GAJ, 8FLW, and, 8FL1.
Thanks for sharing this video
My pleasure
I wonder if the Nobel committee has seen this presentation
There are predictions that AF is good at, and there are things where it is not. The latter may improve with time, or new methods may have to be developed.
My personal opinion is that the Nobel Prize to Deepmind/Demis Hassabis & John Jumper is well deserved. When I have corresponded with John about PSP he has always been a good scientist and a perfect gentleman.