Metal Hydride Reduction || Pharmaceutical Organic Chemistry ||
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- Опубликовано: 5 окт 2024
- QUIZ
1. Define metal hydride reduction reaction?
2. which organic compounds can not reduced by metal hydrides?
3. Name the steps of metal hydride reduction reaction?
![Reduction with Lithium Aluminium Hydride [ LiAlH4 ] # Organic Reagents](http://i.ytimg.com/vi/x3cFCtKuKwA/mqdefault.jpg)
Q#1
Aldehyde and ketones are converted to primary and secondary alcohol by metallic hydrides such as lithium aluminum hydride (LiAlH4) and sodium borohydride (NaBH4) such reaction is called Metal hydride reduction reaction
Q#2
These metallic hydrides do not reduced carbon-carbon double and triple bond.
Q#3
Steps involved in reaction are
1 nucleophilic attack by hydride ion
2 The alkoxide is protonated
Purwashi Mukesh 34
1.The reaction involving the reduction of a carbonyl compound (aldehyde or ketone) into corresponding primary or secondary alcohol when treated with metallic hydrides such as lithium aluminum hydride (LiAlH4) and sodium borohydride (NaBH4) called metal hydride reduction.
2.alkanes esters amide and acids
3.nucleophilic attached by hydride ion
Alkoxide protonation
1.the conversion of aldehyde and ketone to 1°and 2° alcohol by metallic hydride such as LiAlH4 and NaBH4. This reaction known as metallic hydride reduction reaction .
2.alkane .Ester. amides.acids.
3.step involve in metal hydride reduction reaction mechanism are.
1.nucleophilic attack by the hydride ion .
2.Alkoxide prolongation
Q:1
the reaction in which aldehyde and ketones are converted into primary and secondary alcohol in presence of metals hydides such as (lialh4) the reaction is so called metal hydride reduction reaction
Q:2
the compound which can not reduced are alkane and others are esters amides and acids
Q:3
consisted of 2steps
1.nucleophilic attack by hydride anion
2.the protonation of alkoxides ion
by (Areeba arif Qureshi )
1.Aldehydes and ketones are converted to primary and secondary alcohols by metallic hydrides such as:LiAlH4 and NaBH4 such a reaction is called metal hydride reduction reaction.
2.Double and triple bonded organic compounds dont reduce by this reaction.
3.Two steps are involved:
a_nucleophillic attack by the hydrogen anion form alkoxide ion.
b_Alkoxide ion is protonated to Alcohol.
1- It is a reaction in which aldehydes and ketones are converted in to primary and secondary alcohols by the action of metallic hydrides such as lithium aluminum hydride and sodium borohydride.
2- these hydrides can't reduce carbon carbon double or triple bonds but liAlH4 can reduce carbon carbon multiple bonds with an aromatic system.
3-
*Nucleophilic attack by hydride ion.
*Alkoxide protonation.
Q1) Aldehydes and ketones by reacting with metallic hydrides such as LiAlH4 and NaBH4 are reduced into primary and secondary alcohols, this reaction is called as metal hydride reduction
Q2)Metal hydrides cannot reduce the compounds having double or triple bonds between carbons such as alkenes, alkynes.
Q3) Steps/Mechanism of metal hydride reaction;
1: Nucleophillic attack by the hydride anion
2: Protonation of alkoxide.
1: Aldehyde and ketone are converted to primary and secondary alcohols by metallic hydrides such as lithium aluminum hydride and sodium borohydride .
2: Alkanes, esters, amides and acids
3: step 1 nucleophilic attack by the hydride anions
Step 2: the alkoxide is protonated
1_Aldehyde and Ketones are converted to primary and secondary alcohol by metallic hydrides such as lithium aluminum hydrides and sodium borohydry.Such reaction is called metal hydrides reduction reaction.
2_Organic compound with double and triple bond (alkene and alkyne) can't reduce by metal hydrides.
3_Steps involved are:
1: Nucleophile attack by hydride ion
2_Alkoxide ion is protonated
Q1 Aldehyde and ketone are converted into primary and secondary alcohol by metallic hydride
Q2 These metallic hydrides do not reduced carbon carbon double and triple bond
Q3 steps are nucliophillic attack by hydride ion and alkoxide is protonated
Q1
The aldehyde and ketone are converted into primary and secondary alcohol by matlic hydride LiAlH4 and NaBH4
Q2
Double and triple bond of carbon can't be reduced in this reaction by matlic hydride
Q3
1:nucleophile attacking by hydride ion to foam alkoxide
2: alkoxide are protonated to form primary or secondary alcohol
Q:1
Aldehyde and ketone are converted into primary and secondary alcohol by metallic hydride.
Q:2
The organic compound which have carbon carbon double or triple bond not reduced by metallic hydride.
Q:3
Step involved in reaction is
1: Nucleophile attack by hydride ion.
2:The alkoxide is protonated
Q1
Aldehyde and ketone are converted into primary and secondary alcohol by metallic hydride
Q2
The organic compound which have carbon carbon double or triple bond not reduced by metallic hydride
Q3
Step involved in reaction is
Nucleophile attack by hydride ion
The alkoxide is protonated
Question no:01
Aldehydes and ketones are converted to primary and secondary alcohols by metallic hydrides such as lithium aluminum hydride (LiAlH4) and sodium borohydride (NaBH4). Such a reaction is called metal hydride reduction reaction.
Question no:02
Double and triple Bounded organic compounds (alkene & alkyne) can't reduced by metal hydrides.
Question no:03
•Steps of metal hydride reduction reaction :
•01: Nucleophilic attack by the hydride anion.
•02: Alkoxide ion is protonated.
Question no:1
Aldehyde and ketone are convert primary and secondary alcohol by metallic hydride such as lithium aluminum hydride (LiALH4) and sodium borohydride (NABH4)
Question no:2
These metallic hydride do not reduce carbon -carbon double and triple bond
Question no:3
2 step involved in reaction
1.Nucleophille attack by the hydride anion
2. The alkoxide is protonated
Q1. The reaction in which aldehyde and ketones convert into primary and secondary alcohol in the presence of metallic hydride (LiAlH4)&(NaBH4) such reaction is called metal hydride reduction reaction.
Q2. Metal hydride do not reduce such compound which contain double or triple bonds .
Q3. 1. nucleophilic attacked by hydride anion .
2. Alkoxide is protonated.
Q1=Aldehyde and ketones are converted to primary and secondary alcohols by metallic hydrides
Q2= Metallic hydride do not reduce Carbon-Carbon double or triple bonds.
Q3= The step of metal hydride reduction reaction are
1 Nucleophilic attack bt the hydride ion
2 The Alkonide is protonated
Q#1 The conversion of aldehyde and ketones to primary and secondary alcohols by metallic hydride (LiAlHa4, NaBH4) such reaction is known as Metallic hydride Reduction Reaction .
Q#2
Alkanes , ester , amides , acids
Q#3 steps involved in Metal hydride Reduction mechanism are
1. Nucleophillic attack by the hydride ion
2.Alkoxiide protonation
Ans1
Aldehydes and ketones are converted to primary and secondary alcohol by the reaction with metal hydrides such reaction is called metal hydride reduction reaction.
Ans2
C -C double and triple bond are not reduced by metal hydrides.
Ans3
Steps involved are
1 Nucleophilic attack by the hydride anion
2 The alkoxide is protonated.
Q1. Aldehyde and ketone are converted into primary and secondary alcohol by metallic hydride.
Q2. The organic compound which have carbon to carbon double and triple bonds are not reduced by metallic hydride.
Q3. Step involved reactions are
1.nucleophillic attack by hydride ion
2.the alkoxide is protonated
In this, carbonyl compounds like aldehyde and ketone are converted into 1° and 2° alcohol respectively by metallic hydrides like LiAlH4 and NaAlH4.
2. Double and triple bonded organic compounds don't reduce by this reaction.
3. 2 steps are involved.
a.Nucleophilic attack by the H- anion, form alkoxide ion.
b. Alkoxide ion is protonated to alcohol.
Q1) Metal Hydride Reduction is a reaction in which aldehyde and ketone is converted into primary and secondary alcohol.
Q2) The organic compounds which can not be reduced by metallic hydride are those which have carbon-carbon double or triple bonds.
Q3)
1 Nucleophilic attack by hydride anion
2) The Alkoide is protonated.
Ans1. Metal hydride is reduction of aldehyde and ketone to primary and secondary alcohol by metallic hydride such as liAlH4 and NaBH4. And 2. Alkanes ester amide and acid can't reduced by metal hydride.Ans 3. Nucleophilic attack by hydride anion and alkoxide is protonated
Ans. The conversation of aldhyde and ketones i to primary and secondary alchols by metyalic hydride (liAIH4.NaBH3)..such reaction is known as mettalic hydride reduction reaction.
Ans .Alkanes,ester,amides,acid.
Ans 1 nucleophillic attack by yhe hydride ion.
2 Alkoxides protonation...
Q1 the reaction in which aldehydes and ketones convert into primary and secondary alcohol in the presence of metallic hydride (LiAlH⁴ and NaBH⁴) called metal hydride reduction reaction.
Q2 metal hydride donot reduce such compound which contain double or triple bond(alkene and alkyne).
Q3 step 1 nucleophilic attecked by hydride anion
Step 2 alkoxide is protonated.
Ans 1: Metal hydride is the reduction of aldehydes and ketones to primary and secondary alcohols by metal hydrides such as LiAlH4 and NaBH4. Ans : alkanes ,esters ,amides and acids cannot reduced by metal hydride. Ans 3: steps involve in metal hydride reduction are 1 : Nucleophile attack to hydride ion 2: Alkoxide protonation .
Q 1 : aldehyde and ketones are converted into primary and secondary alcohol by metallic hydride
Q 2 : the organic compounds which have carbon carbon double and triple bonds not reduced by metallic hydride
Q:3 : steps involved in reaction are
1 nucleophilic attack by hydride ion
2 the alkoxide is protonated
Ans:01
Definition
Aldehyde and ketone are converted to primary and secondary alcohol by metallic hydride such as lithium aluminium hydride (LiAlH4) and sodium borohydride (NaBH4). Such a reaction is called metallic hydride reduction reaction
Ans:02
Metallic hydride don't reduce carbon-carbon double and triple bonds
Ans:03
Steps
1. Nucleophillic attack by hydride anion
2. Alkoxide protonation
Q1
Ans . This is the organic reducing reaction in which reduction of aldehyde and ketone that are carbonyle containing compound They will reduce in the presence of metallic hydride that are lithium almunium hydride and sodium boron hydride this is called metallic reducing reaction
Q2
Ans . In this reaction double and triple bond are not reduce
Q3
Ans . 2 steps are involve in this reaction
1)nucleophile attack by the hydride ion
2) Alkoxide is protonated
Qno:1
Ans: Aldehyde and ketones are converted into primary and secondary Alcohol by metallic hydride
Qno:2
Ans: The organic compound which have carbon carbon double bond and triple bond not reduced by metallic hydride
Qno:3
Ans: Steps involved in reaction are
i) Nucleophillic attack by hydride ion
ii) The Alkoxide is protonated
Q:1 DEFINITION OF METAL HYDRIDE REDUCTION REACTION:
ANS:
METAL HYDRIDE REDUCTION is a reaction in which carbonyl containing compound (aldehyde and ketone) are converted into 1° and 2° alcohols by metallic hydrides such as {liAlH4} and {NaBH4}.such type of reactions are called metallic hydride reduction reaction.
Q:2
ANS:
THOSE ORGANIC COMPOUNDS HAVING C-C DOUBLE AND TRİPLE BONDS ARE NOT REDUCED BY THIS REACTION.
Q:3
AND:
TWO STEPS ARE INVOLVED IN THE METALLİC HYDRIDE REDUCTION REACTION MECHANISM:
1) NUCLEOPHILLIC ATTACK BY THE H-ANION FROM ALKOXIDE ION
2) ALKOXIDE ION IS PROTONATED TO ALCOHOL.
Q#1
The conversion of aldehyde and ketones to primary and secondary alcohols by metallic hydride ( LiAlH4, NaBH4) such reaction is known as Metallic hydride Reduction Reaction
Q#2
Alkanes, ester , amides, acids
Q#3
Steps involved in Metal hydride Reduction mechanism are
1. Nucleophillic attack by the hydride ion
2. Alkoxide protonation
Question 01.
Ans: The Metal hydride reduction is defined as the reaction in which aldehydes and ketones are converted into primary and secondary alcohols by metallic hydrides such as lithium aluminum hydride and sodium borohydride.
Question 02.
Ans: those organic compounds are not reduced by metallic hydrides which contain C-C double and triple bond.
Question 03.
Ans: 2 steps involved they are:
1) nucleophillic attack by the hydride ion
2)The alkoxide is protonated.
Ans 1 Aldehyde and ketone are converted into primary and secondary alcohol by Metallic hydride. Ans 2 The organic compounds which have carbon carbon double and triple bonds not reduced by Metallic hydride. Ans 3 Step involved in reaction are One nucleophilic attack by hydride ion. 2 The alkoxide is protonated.
Q1
Ans: Aldehydes and ketones are converted to primary and secondary alcohols by metallic hydrides This reaction is an excellent method of making alkenes from aldehydes and ketones. Ylide is a molecule with adjacent opposite charges. Phosphorus ylides are prepared from alkyl halides and triphenylphosphine.
Q2
Ans: The metals of group 7, 8, and 9 do not form hydrides.
Q3
Ans : Preparation of unsaturated alcohol from unsaturated carbonyl compounds.
Reduction of ester to alcohol.
Reduction of carboxylic acid to alcohol.
Reduction of acid halide to alcohol.
1 nucleophilic attack by hydride ion
2 alkoxide is protonated
Q1) Aldehydes and ketones by reacting with metallic hydrides such as LiAlH4 and NaBH4 are reduced into primary and secondary alcohols, this reaction is called as metal hydride reduction
Q2)Metal hydrides cannot reduce the compounds having double or triple bonds between carbons such as alkenes, alkynes.
Q3) Steps/Mechanism of metal hydride reaction;
1: Nucleophillic attack by the hydride anion
2: Protonation of alkoxide.
Q#1
Aldehyde and ketones are converted to primary and secondary alcohol by metallic hydrides such as lithium aluminum hydride (LiAlH4) and sodium borohydride (NaBH4) such reaction is called Metal hydride reduction reaction
Q#2
These metallic hydrides do not reduced carbon-carbon double and triple bond.
Q#3
Steps involved in reaction are
1 nucleophilic attack by hydride ion
2 The alkoxide is protonated
Question no:01
Aldehydes and ketones are converted to primary and secondary alcohols by metallic hydrides such as lithium aluminum hydride (LiAlH4) and sodium borohydride (NaBH4). Such a reaction is called metal hydride reduction reaction.
Question no:02
Double and triple Bounded organic compounds (alkene & alkyne) can't reduced by metal hydrides.
Question no:03
•Steps of metal hydride reduction reaction :
•01: Nucleophilic attack by the hydride anion.
•02: Alkoxide ion is protonated.
Q1. Aldehyde and ketone are converted into primary and secondary alcohol by metallic hydride.
Q2. The organic compound which have carbon to carbon double and triple bonds are not reduced by metallic hydride.
Q3. Step involved reactions are
1.nucleophillic attack by hydride ion
2.the alkoxide is protonated