Mitochondrial Dysfunction in FTD-ALS Spectrum Disorders

Presented by Jane Wu, MD, PhD; Dr. Charles Louis Mix Research Professor in Neurology and Psychiatry, Neurology and Psychiatry at Northwestern Medicine
Dr. Wu is the Dr. Charles L. Mix Research Professor of Neurology and Psychiatry. Her group has been studying molecular pathogenesis of frontotemporal lobe dementia (FTD)- amyotrophic lateral sclerosis (ALS) spectrum disorders. Recent studies from her group and others have uncovered the link between nuclear RNA binding proteins and mitochondrial dysfunction in FTD-ALS spectrum disorders. She will discuss about recent advances in our understanding of molecular mechanisms underlying mitochondrial impairment in ALS and the implications in developing therapeutic approaches for ALS.