Penicillin - Periodic Table of Videos
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- Опубликовано: 27 сен 2010
- Why is penicillin a bit like a mousetrap?
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Legend has it, Neil can pluck individual bacterium out of his body and never needs antibiotics.
This was an amazing video! Makes me sad that because of decades of overprescribing, the bugs we killed in their infancy have now waited until puberty to strike.
Now they have tattoos, piercings, and anger issues. :(
Bacteria develop antibiotic resistance with or without antibiotics. The difference is that without antibiotics, the mutation for resistance is selectively neutral. When antibiotics are present, that mutation then becomes beneficial. The other strains are wiped out, while the resistant strain becomes much more prevalent. This is why it is so important to only use antibiotics when absolutely necessary. Unfortunately, most of the antibiotics in the US are misused in healthy farm animals.
Keep these coming their amazing!
I'm spreading the word of Periodicvideos to my Organic class. I think this is an amazing video to get them started.
Just to let you know... This was an amazing video!
My current favorite RUclips channel is periodicvideos.
Very interesting and informative.
'Tis a shame because I'm allergic to both amoxicillin & penicillin... although I react just fine to cephalexin & the cephalosporins, so you guys should do a video on those :P
Excellent video, all involved should be heartily applauded! This type of presentation makes chemistry understandable. Antibiotics surely are wonderful molecules, truly world changing. Thanks for posting.
I remember studying this for my final year at University, and as soon as I saw the molecule I knew every part of it!
Great video.
It's similar to food allergies in that it can be life threatening. The first time some people are exposed to an antibiotic in the penicillin family their body develops antigens that react to it. Any further exposure to penicillin based antibiotics cause these antigens to stimulate your immune system. This can cause a simple rash or full anaphylactic shock.
You should read a book (there are several) on the history of Penicillin. As you said, lots of luck-when US agreed to help Britain scale up production, they assigned it to the one lab that had the perfect growth medium, corn steep liquor, in vast quantities. That, and finding a particular moldy cantaloupe, after literally searching all over the world, increased production like 1,000,000 fold over original methods.
This was the best explanation of penicillin and antibiotics I've ever seen. Thanks for this, it was fascinating!
I like these demostrations, very cool!
Brilliant presentation !
~thanks
Superb explanation!
I love how when he mentions mouse trap, they find the need to show us a picture of a mouse trap. Same with the spring.
Really enjoyed the video though. Makes chemistry entertaining.
I love the periodic videos but I really love, like this, the videos on molecules.
@666T3mplar
The book written by Ibn Sina(Avicinnea) was the main textbook in medicine in Europe hundreds of years after it was written.
Al-Khwarthmi developed Al-Jabr(Algebra), the language of mathematics, chemistry and physics.
Dear Periodic Videos, you make me want to become a chemist. Excellent work!
Thanks for doing this video.
Could you recommend some books, or journals about what was said in the video??
Wow, Interesting enough today in class I spoke about penicillin. If i had seen this before, Things would've gone much better. Nice video!
I'm a 2nd year pharmacy student and this video was really an inspiration!
Wonderful!
Your output's been much higher than usual. Me likee.
Excellent video. Periodic table of videos is really successful
My daugther is in the hospital right now.
Thank science for this beatiful wonder. saved the most important thing in my life.
@Giggyjunior08 That's the key-the 4 member ring is very weak, thus cell walls made with penicillin in them fall apart, and the bacteria swells up and dies.
We need more of these. I never knew that's how Penicillan worked. Nature is smart.
The real heroes are Florey, Chain et al. Fleming stopped working on penicillin and doesn't appear to have understood its full potential. These other guys saw the possibilities of penicillin and did all the hard work.
As always, the media prefers a Eureka moment story to one of methodical and insightful investigation eventually yielding a result and Fleming was all too willing to play the role of lone genius and ignore the contribution of others.
So I gather.
the periodic videos are like science class, except it's much more fun, and I learn a lot more.
Happy Birthday!!!
Particularly interesting for me as I have been prescribed two courses of Penicillin in the last month Flucloxacillin for an infected bite on my toe and phenoxymethylpenicillin for a bout of tonsillitis. It quite annoying actually because it wa sthe first time I had to go to the doctors in about 9 years.
more vids like this! This is what I want to see! XD
please do a video on thc!
I'd like to hear something about the dangers of antibiotics. What are we going to do once a resistance to antibiotics is built up?
Extraordinary.
@Gozaburo1 It's not a four membered carbon ring. It's a beta lactum ring. There's a nitrogen in the ring. Still, I see what you're saying do. Even with the nitrogen there it still would seem unstable.
Hi there!
Can you make a video about hydrogen peroxide for the molecular video series?
So it does what it does basically because of the way it's shaped?
thats amazing
@cpovey1 Ah yes. Sorry, a bit of miscommunication there. I'm not sure if it's the amino acid it could be the petidoglycan or the phospholipids I'm not completely sure. Biology wouldn't be my strong point.
I'd be more interested in who invented the bread poultice.
Where do chemists get the molecule model parts?
@CrazyMrChris Yeah, I know that it is the misuse of antibiotics that causes the problems. I'm allergic to penicillin myself, but I still try to avoid using antibiotics anyway. I think there will always be a misuse issue, so we must prepare for what could happen. Bacteria has been here for much longer than we have and we should be conscious of the fact that it could continue to evolve and thwart our efforts to kill it.
The professor is so adamant in the beginning that they didn't plan to make the video on the anniversary of Penicillin, as if he is hiding the face that it was intentional.
i would really like to know about allergies to penicilin...
Essentially, yes. When a bacteria plugs a molecule of Penicillin into a cell wall, that's like putting a brick made of styrofoam into a wall in place of a regular brick-in other words, the bacteria made a mistake because of the shape. When the cell wall gets big enough, the foam bricks crumble (the beta-lactam ring breaks) and the cell wall breaks apart. The bacteria then swells up from osmotic pressures, bursts, and dies.
2:15 penicillin, nature's navy seal.
If only my chemistry classes had been like this. Finding covalents wouldn't have sent me to sleep so quickly as there would have been some sort of point..
to bad im allergic to it
It was a great discovery indeed. Also, I've never been in more pain than being injected with huge doses of it twice a day for a week and a half.
@colinstu Lol have you ever studied microbiology? Many bacteria have peptidoglycan cell walls outside their cell membranes (or a more complex system of intercalting peptidoglycan walls and membranes depending if they're gram positive or negative). So yeah, there's nothing wrong with the info given on the video.
No, there are lots of different antibiontics today. Penicillin was only the first to be used and is seldom used today, because of better alternatives.
I was on amoxacillin. Unfortunately the bacteria was resistant so they put me on a Sulfa antibiotic. Bacteria is evolving and we need to stay a step ahead.
Okay, this has been bugging me for a while and this seems like an appropriate place to ask: Myself and several family members are fairly allergic to anti-biotics, especially ones that are ingested or injected and Penicillin is one of the worst ones. Any idea what might cause it?
Hello, i have a quick question. I have a strong interest in radioactivity, i mean strong. What jobs are there that involve that part of science?
Isn't it amazing how sometimes poor lab practices can lead to some of the biggest discoveries?
Intresting video
I would love to see a video in which a bacterium "pops" under the microscope.
does pennecilin actually cure gonorrhea?
@bobbyt2012 Don't misuse them, don't take more than you need, and always finish your course of antibiotic when given. And we will keep on finding more antibiotics, but there is a finite limit. If you follow these instructions, we don't have to keep searching for these new antibiotics, and we have less superbugs to go around
I mean, psh. Who needs videos?
@natemcgraw I'm, allergic to it too, it sucks.
does Penicillin effect yeast ?
@RupertsCrystals - Yeah, but it was that slob, Fleming who said, "Screw it - I'll clean up the lab when I get back."
Don't get me wrong Brady, I love your videos, but I am a little disappointed not to hear a word about antibiotic resistance and how important it is that everybody takes their damn medicine until the box is finished and not just stop when they feel better.
what does it mean if your allergic to penicillin?
@bobbyt2012 Dangers of -the improper use- of antibiotics.
You didn't understand me: When a bacteria makes a cell wall using Penicillin in place of the amino acid (?) that it wants to use, the cell wall will eventually collapse because the beta lactam ring will eventually break because it is so weak. Thus, the bacteria swells up from osmotic pressure and eventually bursts open and dies.
@cpovey1 'Cell walls made with penicillin'? I'm no microbiologist but I'm fairly sure that's there's no cell wall made with penicillin, it interferes with the bacteria's ability to synthesis a cell wall and a bacteria without a cell wall isn't much of a bacteria.
Awesome rate, 312 views and already 37 comments.
Not so. I have a penicillin allergy and have taken antibiotics safely dozens of times since I found out. That's because there are probably more antibiotics unrelated to penicillin then those that are. I make sure my doctor and close relatives know and I wear a penicillin allergy bracelet in case of an emergency where I can't communicate to anyone I'm allergic. But your doctor must have told you all this when you found out you were allergic. This comment is for those who don't already know.
Animal cells don't have cell walls, just membranes.
@riggsae Yes, I know that the improper use is what makes them "dangerous," but I was just throwing it out there for discussion. I have heard that our current antibiotics will no longer be effective within the next decade.
On another note, what's the reason behind the smell of amoxicillin?
lol watch this with captions on its hilarious...
so antibiotic is an inhibitor.
i have a question are the molecules the same in lets say fish penicillin as the ones used by humans? this new prepper tv craze is what drove me to ask.
So what happened in ancient Egyptian that made that treatment be forgotten? How many billions of people's lives were cut short because they didn't investigate that.
@njimko23 it wouldn't have worked
@TomMarAlem1987 So you'd like to believe :)
does this make a difference if i watch it in "HD"?? lol
its was compleatly by chance that is was discovered a swell
Aw that's sweet :3
im allergic to penicillin after 10 years old but was not allergic to it before...
weird...
better hope that bacteria doesn't coevolve beside this now that it's so prevalently used and develop a resistance. this is already starting to happen
@lamboroghini
it comes from mold.
biochemistry
Too bad im allergic to it
thats why the government should not cut funds for chemistry research....
Narrated Usamah ibn Sharik: I came to the Prophet (peace_be_upon_him) and his Companions were sitting as if they had birds on their heads. I saluted and sat down. The desert Arabs then came from here and there. They asked: Messenger of Allah, should we make use of medical treatment? He replied: Make use of medical treatment, for Allah has not made a disease without appointing a remedy for it, with the exception of one disease, namely Old age. (Book #28, Hadith #3846) Sunan Abi Dawood.
i'm actually allergic to amoxicillin i get a rash under my arms
lol everyone is allergic to this except me :)
im allergic D:
Shame they can't make penicillin medications taste any worse.
it's cool.
i'm allergic to it though.
If the ancient Egyptians were using mouldy bread as an effective antibiotic...
One is to wonder why God - in his infinite wisdom - chose not to instruct the Ancient Israelites to do the same.
I guess he hated them lol
You picked a fine time to leave me
Louise
Four junkie children
And a social disease
I may be willin'
But I can't take penicillin
This time thehurtin'
Won't ease
You picked a fine time
To leave me
Louise !
With apologies to civilized people everywhere
ha haa u feel the beauty of molecules too huh? LOL "This is a beautiful molecule"
i thought that it was a bacteria or mold
@colinstu wow....
bacteria have cell walls....
get your facts straight duurrrr