AOA. Sir Swiss target is showing this messege . Please guide. Checking the validity of the query molecule. This takes about 2 seconds. Please, wait. You are submitting molecules that are too large. Please, respect a limit of 200 characters per SMILES.
Dear Professor, I hope you are doing good. I am very thankful to you for sharing such a nice scientific information. I have a question. Can you please guide me in this respect. I want to know that my ligand has a Vina docking score of around -7.00 using CB-Dock2. Can I consider it a potential drug target and go further on wet lab experiments?
Dear Professor, I want to know that my ligand has a Vina docking score of around -7.00 using CB-Dock2. Can I consider it a potential drug target and go further towards wet lab experiments?
Great work Dr Shab! I would like to request for some videos on SNP genotyping, exom sequencing and whole genome sequencing data (Next Generation Seq) analysis.
hello sir, why is there a need for further target prediction as the target was already selected in the previous lecture. I am a little confused here. It would be really helpful if you solve this doubt. thanks.
Great work... Thanks alot for helping us sir, sir please lecture on virtual screening, docking, simulation, pharmacophore finding... Means the whole process from protein to drug development ( m.d simulation).
Sir you already select the target in your first lecture which was ACE2.So i donot understand in this lecture target prediction called protease.In your 1st lecture you told that you design drug against ACE2.Plz clear the problem sir.Thanks in advance
Sir today i have dock between receptor and ligand with the help of autodock vina , after command prompt i have the the result of docking like that -9.8 affinity kcal/mol.... Sir but maine ek hi ligand ko select kiya , but result main aesa aara hai.. -9.8 -9.7 -9.2 -8.5 -8.1 Sir ye samaj nahi aaya....
@ Dr. Muhammad Naveed. If we want to target bacterial enzyme how can we select bacterial species because here is no option for bacteria or we can use other tool please name that tool, because I want to check phytochemical against bacteria as drug
I checked with smiles it predicted human cell proteins or enzymes as it s is designed for human and mouse base algorithms. If you found online server that predict bacterial target please share with us.
AOA. Sir Swiss target is showing this messege . Please guide.
Checking the validity of the query molecule. This takes about 2 seconds. Please, wait.
You are submitting molecules that are too large. Please, respect a limit of 200 characters per SMILES.
Dear Professor,
I hope you are doing good. I am very thankful to you for sharing such a nice scientific information.
I have a question. Can you please guide me in this respect.
I want to know that my ligand has a Vina docking score of around -7.00 using CB-Dock2.
Can I consider it a potential drug target and go further on wet lab experiments?
yes
Dear Professor,
I want to know that my ligand has a Vina docking score of around -7.00 using CB-Dock2.
Can I consider it a potential drug target and go further towards wet lab experiments?
yes can be
did you use discovery studio for visualization in CADD?
yes
Great work Dr Shab!
I would like to request for some videos on SNP genotyping, exom sequencing and whole genome sequencing data (Next Generation Seq) analysis.
We will try
@@Prof.Dr.MuhammadNaveed bundle of thanks.
hello sir,
why is there a need for further target prediction as the target was already selected in the previous lecture. I am a little confused here. It would be really helpful if you solve this doubt.
thanks.
because we predicted on the base of literature and might be possible some other target is more compatible to studied one
@@Prof.Dr.MuhammadNaveed thanks a lot sir, really appreciate your help and the lectures you are putting out for us students.
Great work... Thanks alot for helping us sir, sir please lecture on virtual screening, docking, simulation, pharmacophore finding... Means the whole process from protein to drug development ( m.d simulation).
keep watching as my next lectures will cover these contents
Sir how can we contact you via FB or WhatsApp?? If we wanna clear some queries regarding to computional work???
@@Prof.Dr.MuhammadNaveed how can we contact with you sir? For our queries?
Sir , please can you tell which file you import for Swiss Target prediction?... because dsv file format is not supported.
Csv
Aoa sir, any others tools or website which can do target prediction because this website is not working right now.
active now
Sir you already select the target in your first lecture which was ACE2.So i donot understand in this lecture target prediction called protease.In your 1st lecture you told that you design drug against ACE2.Plz clear the problem sir.Thanks in advance
Yes dear as some time its delayed in our result so shared protease but later lecture got that
Sir today i have dock between receptor and ligand with the help of autodock vina , after command prompt i have the the result of docking like that -9.8 affinity kcal/mol.... Sir but maine ek hi ligand ko select kiya , but result main aesa aara hai..
-9.8
-9.7
-9.2
-8.5
-8.1
Sir ye samaj nahi aaya....
you select one ligand but it give you results in many site of active site of protein so you choose -9.8 for further analysis
@@Prof.Dr.MuhammadNaveed thank you so much sir
Sir i am looking for cisplatin but it's failed what's the possible reason and how to resolve? Thanks
check its 2-D structure
@ Dr. Muhammad Naveed. If we want to target bacterial enzyme how can we select bacterial species because here is no option for bacteria or we can use other tool please name that tool, because I want to check phytochemical against bacteria as drug
go with enzyme name directly or design it structure by smiles
@@Prof.Dr.MuhammadNaveed OK thanks a lot Dr sab
I checked with smiles it predicted human cell proteins or enzymes as it s is designed for human and mouse base algorithms. If you found online server that predict bacterial target please share with us.
Sir kindly make a comprehensive video on cabx flex 2 and how to change protein id .please sir
noted
can we use canonical smiles given in PUBCHEM for a compound
yes if compatible
@@Prof.Dr.MuhammadNaveed thank you sir
Sir how to download and install autodock 4.2.6 software.... And please make a video on chimera tool in depth....
link shared in autodock video and sure will do
@@Prof.Dr.MuhammadNaveed
Sir vina and autodock 4.2 both are different software naa
Sir pyrx virtual screening (multiple ligend selection) pe video hogi aapki koi
will try to make on it
@@Prof.Dr.MuhammadNaveed
Sir please ek din apna busy schedule nikal kar iski help se docking btaiyega aap....
Nice video
Thanks
sir if we have probability of same percentages for all ,then what does it mean?
choose first one
Thanku sir
welcome
Sir from which city you are?
Lahore
Waiting
you can view after 3 hours
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