HIV vaccine approach succeeds in first clinical trial
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- Опубликовано: 14 июл 2024
- First-in-human clinical trial confirms novel HIV vaccine approach developed by IAVI and Scripps Research
The experimental vaccine primed the immune system as the first stage in the production of broadly neutralizing antibodies.
February 3, 2021
NEW YORK and LA JOLLA, CA-A phase 1 clinical trial testing a novel vaccine approach to prevent HIV has produced promising results, IAVI and Scripps Research announced today. The vaccine showed success in stimulating production of rare immune cells needed to start the process of generating antibodies against the fast-mutating virus; the targeted response was detected in 97 percent of participants who received the vaccine.
“This study demonstrates proof of principle for a new vaccine concept for HIV, a concept that could be applied to other pathogens, as well,” says William Schief, Ph.D., a professor and immunologist at Scripps Research and executive director of vaccine design at IAVI's Neutralizing Antibody Center (NAC), whose laboratory developed the vaccine. “With our many collaborators on the study team, we showed that vaccines can be designed to stimulate rare immune cells with specific properties, and this targeted stimulation can be very efficient in humans. We believe this approach will be key to making an HIV vaccine and possibly important for making vaccines against other pathogens.”
Schief presented the results on behalf of the study team at the International AIDS Society HIV Research for Prevention (HIVR4P) virtual conference today.
The study sets the stage for additional clinical trials that will seek to refine and extend the approach-with the long-term goal of creating a safe and effective HIV vaccine. As a next step, IAVI and Scripps Research are partnering with the biotechnology company Moderna to develop and test an mRNA-based vaccine that harnesses the approach to produce the same beneficial immune cells. Using mRNA technology could significantly accelerate the pace of HIV vaccine development.
HIV, which affects more than 38 million people globally, is known to be among the most difficult viruses to target with a vaccine, in large part because it constantly evolves into different strains to evade the immune system.
“These exciting findings emerge from remarkably creative, innovative science and are a testament to the research team’s talent, dedication and collaborative spirit, and to the generosity of the trial participants,” says Mark Feinberg, M.D., Ph.D., president and CEO of IAVI. “Given the urgent need for an HIV vaccine to rein in the global epidemic, we think these results will have broad implications for HIV vaccine researchers as they decide which scientific directions to pursue. The collaboration among individuals and institutions that made this important and exceptionally complex clinical trial so successful will be tremendously enabling to accelerate future HIV vaccine research.”
Learn more:
www.scripps.edu/news-and-even...
www.scripps.edu/
www.iavi.org/
IAVI Media Contact
Karie Youngdahl
+1 484 343 1731
KYoungdahl@iavi.org
Scripps Research Media Contact
Kelly Quigley
+1 858 784 2036
kquigley@scripps.org 
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To all the Scientists working to find a cure / vaccine, Thank You.
Vaccine not equal cure
Amen
Thank you scientists and doctors working on curing and treating diseases. Covid 19 was handled very very quickly. It could have wiped away half of humanity if we hadn’t seen this fastest research ever seen.
As a man who lived with HIV it's really a big good news for me
Is this vaccine us 100 % Cure for HIV or what ?
this is a vaccine, which is prevention, not a cure... meaning this only works for people who doesn't have hiv yet, and it prevents them from getting hiv. But this isn't a cure for people with hiv. So far there are only treatments, but not a cure yet, meaning so far there's nothing that can turn a pos to a neg. The best thing is still pos undetectable.
Vaccines are meant to prevent the disease, not cure it. So it is good news for non-HIV affected individuals more than for patients.
Me too.
So you’re cured??
Heal the world, make it a better place.. God bless
:D
Using science, no blessing required.
For you and for me and the entire human race…
God willing,
We'll push through
The phrase "I am vaccinated" would have a whole new meaning after this 😂
You guys should be so proud of yourself. Keep it up, you just might receive a Nobel Prize. Thank you all for your hard work
He will receive nobel.
As an HIV patient, I can’t wait for these vaccines to be publicly out there.
As someone who was born with hiv, I can’t thank the scientists enough who keep progressing this field. Truly grateful and I love Wills energy and dedication thank you :’) ❤️ (also it says he’s a PhD student so wow, can’t wait to see what he continues to learn and achieve!!)
Can a vaccine help a person if they get aids
how old are you now?
hey darling, i just found your channel, i love how you encourage and inspire people who live with HIV, i already subscribed your channel and i hope you make another great contents. love from Indonesia.
You can get born with it? I thought you needed to exchange blood to catch it like fricking or sharing needles
@@dyazkipritare you from Jakarta?
Thank you to these people and the others that are currently fighting this virus. To the people who are HIV positive, we love you, you matter and are the same people that you were, infected or otherwise.
Guys you will be helping milliones of people, God bless you!!!
The words are not enough to describe how happy you making us with this news. Knowing that we all can be cured one day puts a smile on our faces. Wanna thank you all from the very bottom of our hearts for your hard work. You are our heroes!!!
Even though this is wonderful news, it is not a cure for those who already have hiv; it only works as a preventative measure for HIV negative people.
what ???
@@rossmilner6780 exactly
@@rossmilner6780 you mean unfortunately there's no cure for HIV yet?
Even if this vaccine is just for prevention it’s a great step against this virus… and it gives hope that soon it might be a cure for those who live with the illness
Amazing the way this guy explains an extremely complicated problem in a way that can be understood! Amazing work for the many people that need it! God bless you all, keep up the great work!👍👏👏
Do fast doctors please many people are waiting for hiv vaccine 🙏🙏🙏🙏 u are god on the earth
This would be one of mankind's biggest and much needed breakthrough.
Thank you for your hard work
I've been positive for the past 6 years. Early detection. I am undetected. I hope we could discover it soon.
In god timings
Hiiii hope sooo
That’s some great news! I wish you all the best. 🤗
When did you dectect the HIV virus
After 6 years or you just detect it now
thank you so much for all of your hard work. now, were much closer to eradicating HIV. god bless you and your team!
This amazing! the human mind is literally limitless.
This concept makes sense against the many strains now existing with HIV. Over the years I’ve witnessed many potential cures for HIV, when possible availability is announced it’s always been “in five years”...I hope you can achieve this and thank you for your determination...
Vaccine. Not cure. No cure
@@queendiamond4286 No cure yet. I suspect though, that this vaccine, if it is eventually finished and released, would be as good as a cure, even in patients that are already infected. I'm not an expert, but from my limited knowledge of immunity I see no reason why a vaccine would work less effectively against a HIV infection that is suppressed by medication than against a new HIV infection coming in. At the very least it might mean undetectable viral load without antiviral treatment.
Some HIV patients have been fully cured already. Not with vaccines, but in very rare cases where they got leukemia and were given bone marrow transplants from rare donors who produce broad neutralizing antibodies. In theory, any vaccine that works to protect from HIV infection at all should be able to achieve the same result...
I will light a candle at home and say my prayers and grace for this invaluable effort done by the scientists, philanthropists, the volunteers. Hopefully everything will work eventually, in my lifetime. 🙏🏽 Thank you, thank you, thank you
What a great work! Wish you all luckies 🙏🏼
Thanks for hardworking of scientists who trying harder to developed vaccines for hiv god bless soon we will find the cure for hiv patients
This isn't cure. It's vaccine. If u got HIV u gotta wait on something else different to maybe happen one day.
@@queendiamond4286 He never said it was a cure. You lack reading comprehension skills lol.
@@andremh17 right
More POWER to your team!✨🙏
Simply amazing that we are finally making progress! Thank you so much to all the good people who have dedicated so much time, effort and money to help alleviate the world of this scourge.
Great job..Hats off
Sir plz save our life from this deadly virus.
Amazing work, this complicated concept is easily understood based on how simply you explained it. You discovery will be helping millions of people
Hope you guys find a cure 😔 my little niece has HIV cause her parents didnt know they had it. She's just an innocent child, talks about having a future and stuff and it hurts. goodluck guys!
With the treatments now (I worked in a lab for years) it is undetectable in a lot of people. Your niece will hopefully live a long, full, amazing life!
@@wanderlustendumado5396 will there ever be a cure?
Much eppriciated keep up the good work.
Clever approach and encouraging results! Are journal papers in review or already published? Conference talks are by nature not public.
God bless your team
Congratulations!
Thank you and your colleagues for your hardwork, creativity and diligence!
Thank you so muh for your service!
Super work done by all.God bless to all involved.
This news make us more hopeful. ❤️ Good luck from Bangladesh.
Wow there’s hope 🥺💕
Yeah ur right
Thankfully sir God bless you sir
Than you so much for your service to the world
This is great news. Thank you.
Hats of you sir please marketing in India pls save me life sir
Bagwan pe vrosa rakho
wow, thanks researchers
I am heartened by the scientific research and development
If they develop an effective hiv vaccine, i will be crying for happiness of at least week🙏
Great work, everyone! Research can be tedious and time-consuming, but this is how we achieve breakthroughs.
i hope you will succeed.. the world would thank you for that..
Job well done!!! Cheers! 💙
Now just another 20 years and they’ll put it into clinical trials.
Yup, and another 30 more years for FDA approval, love how fast government is.
@@dragonore2009 FDA approval can be quite quick, but they do require studies to show the efficacy and safety. So as to not roll out Millions of vaccine doses that kill people. That would be something you'd love a lot less, I imagine. In this particular case, they don't even have a full candidate vaccine for a clinical trial yet, they only tested the first stage on Humans in a very limited trial to see if this strategy would work at all.
It may be 2 years if HIV would spread like COVID.
@@Andreas-gh6is for covid 19 vaccin it wasnt like this
I know 1 year is a big progress and I hope in 2022 HIV/Aids is history In Jesus name I pray Amen.
Heal the World Sir! God bless all of you!
Thank you for working on the vaccine.
Thanks S R to your team and God bless please come in India
THANK YOU FOR AMAZING NEWS
This is good news. God bless scientists!!
Congratulations sir
It feels so real hearing this from a scientist actually doing the work. I hope future scientists hear this and think, I could do that!
THANK YOU ❤️
well done and great job sir
Good news! Hope this vaccine become successful
Thank u for all the scientist working hard to create a vaccine/ cure i hope this pulls through
How many years infected people have to wait for complete cure ??
Thank you for your commitment to developing a vaccine to fight HIV.
When it will come in india
Keep up!
You will help millions of people by this❤🥰
Thank God for saving the young and old people to free from the virus.
Amazing can hardly wait 4 the Jab !! TRust urs more than rest 4 sure !!
opp's thought it was 4 Covid not HIV but glad 4 that 2 happen also
God bless you and your team. 🙏
🙏🙏🙏🙏
Amazing..keep going
Wonderful news thank you ❤️
Thank you So much for Good News Sir.
真棒！加油！
Thank you sir and God Bless - Its a very expensive condition to live with :-( in North America
Just in America. In Canada medication is free
Thank you for all your amazing hard work, thank you for helping our community and putting yourself in the Frontline to battle with the HIV virus, you are truly amazing...
Thanks man , your a genius. It’s been 8 yrs now the rest will be saved
This is truly amazing. I hope this works. If it does then lets use the same concept for Cancer and get a vaccine for that it may just work.
It's about time. No disrespect to the difficulty but the severe lack of intrest and support for this vaccine only highlights the inequity of this world once again. Well done and congratulations on amazing work ❤
Thank you so much... Now I see a hope of new life... God bless you all.
That´s great. Any new developments? Cheers
listening to your video (bowing in honor) i projected myself into the future visioning receiving this vaccine, and suddenly i began to cry and tears wet my face. i think of all those i lost: john, alex, ron, peachie, leslie ernie ricky, i can't list them all, and i think how we hoped so for a cure, a vaccine. and here i am...
Good job 😇
Wow for a long time now has come
Thank you very much Sir
Thanks sir
Amazing super sir
Tanqu sir
Great news! Thanks to the scientists!
I wanna thank you guys
I really happy for all those who are fighting hiv
iam really happy for u guys
Love you all❤
hats off for you're team we are hoping to release it to stop stigma from phil.
Thank you.
If it works and cures me. I’ll rewrite my will with all my rental properties to be donated to this foundation for further reasearch in all diseases
Unfortunately vaccines are only for non-infected people to prevent the disease, it's not a cure. Hopefully, within 10-20 years there might be a technology to cure the infected too!
Fantastic.
Good research thank for all scientists
Thnkq sir please release the vaccine as soon as possible so many people are waiting thanq
Thank you sir👏🌈
I wish the scientists to get the cure of HIV
Many thanks 🙏🏽 to all scientists
Great news
This is wonderful that a vaccine is finally on the horizon for so many people world wide. It is scary that it has taken so long and with that the knowledge that is locked up in the vault of the chemists minds is aging with them. Please worker's stay safe in this process because the ones in the trenches have so much valuable info that the world can not afford to lose the treasures and knowledge only you guys hold. As with the time line it has taken to get to this place so have all you dedicated scientists has aged along with it. Lynn
"if" it does its probaly the medicine nobel prize
It is not just Nobel Worthy
It is equivalent to God
Because AIDS is the biggest Pandemic going on Right now
More than 25 million Humans have lost their Life due to this Virus
This is great news!
Thank you 🙏
Thankyou thankyou