And of course after the '50s there was the rock star diet where all solid foodstuffs were simply substituted with cocaine, perhaps amphetamines or possibly heroin or sone combination of these. Very effective and popular among the young.
You left out a big part of the Fen-Phen study. Michael Weintraub in the early 1990s was an Office Director at the FDA and went around to different meetings “promoting” it. Even when the FDA told him to cool it, he was unapologetic. He was eventually asked to resign. I know I was there during this.
A kid I knew growing up got a > $7,000,000 from the Fen-Phen settlement back in the early 2000's. Yepp...He was livin high on the hog for about 1 year and was COMPLETELY broke. He blew it all on trucks, 4-wheelers, dirt bikes, OxyContin and cocaine. Lots and LOTS of Oxys & coke. Doctors told him he probably only had 5-10 years to live. (hence the settlement) He was 19-20yo then and is still alive today.
Extended release stimulants can still be abused pretty easily. If someone feels good on adderall, then vyvanse and Addy XR will as well. Won't get peak effects instantly tho
I lost 25KG in 2022 without any need for medication. I dieted quite strictly, and I exercised a reasonable amount. I started at 130kg and reached 105kg within the year. This year, 2023 I found it somewhat difficult to maintain my weight of 105kg, but through monitoring my weight it was possible, although I did momentarily approach 110kg again, now I sit more at about 100kg. All this is to say a miracle drug would merely treat the symptom, not the cause of your weight. You still have to FOREVER change your diet and exercising habits, not just for a bit.
@@PainterVierax well for me personally I don't think I need a nutritionist, but rather a psychologist. My problem stemmed from depression, thus I overate and abused alcohol. I also felt like I would have to put in the work on my own, and after somehow managing to motivate myself to change things, at the cost of temporarily greatly increased levels of stress, I now feel that I can get no further in my recovery without getting professional help. That being said I got very far on my own, dropped alcohol almost completely, and am on the search for said professional help. Sorry if this seems like "trauma dumping", I'm just trying to to document my journey, and maybe motivate someone else. I made it very far on my own mentally and physically, but there's no shame in getting help, and getting it earlier is probably always better.
@@hummel6364 No worries. In fact that's interesting as psychology is a factor I completely forgot. And ironically i suffer long term depression myself. Good job quitting alcohol without help though. That's a huge victory by itself.
@@PainterVierax the only help I had with the alcohol was a friend who quit at the same time as me. He didn't drink in over 260 days, me on the other hand I still drink on occasion, but not in a substance abuse like manner, just on birthdays and the like. Psychology is honestly the biggest part whether it's caused by depression or not, your mindset needs to change.
He also missed an old drug from Victorian era to help women fit into the corsets, it was a capsule that contained the eggs of tapeworms which of course would help you lose weight because you've got serious dietary deficiencies get take hold of
Hey man, there are some added complexities to the effects of DNP that are important to discuss which you missed. The body actually stores fats into two broader categories, known as brown and white fat. The type of fat you typically think of, which is primarily used as tapable energy storage, is white fat. The function of brown fat which is relevant to this discussion is as a major mechanism of thermoregulation. DNP specifically induces metabolism of the body's brown fat, which even in healthy individuals largely produces heat rather than usable energy. This not only doesnt aleviate many of the worst impacts of obesity (e.g. insulin insensitivity), but over time can leave the body's ability to regulate its temperature dangerously incapacitated
DNP is known to be deadly. I took it for a few months and did lose weight. Besides it's obvious drawback of heat, I just wondered how unhealthy it would be long term... Cataracts was only seen in females.
@@YourCapyFrenBigly_3DPipes1999 That this is the subject that is close to my heart and I know also something about it? "Christ" was from shock of seeing topic that I know so much of being covered here. Why are you so hostile?
@@jannegrey593 well I hope you didn't have any bad effects from the study but I guess I take a little issue with presentations like this that claim that these hyper-trash politicians have our best interests at heart and somehow they're the experts on anything which if you have any life experience at all, you would know how utterly ridiculous that is. Trusting these Congressional pieces of trash over ourselves is probably the worst mistake any of us can make in our lives. I'm sure some studies aren't done properly but without doing studies how is any medical researcher supposed to gain knowledge about any proposed medication or OTC supplement? That's all I meant.
Please do a video on Hi-Fi a/v systems and such that came to a high point in the early 2000s then crashed due to smartphones. I'll be sure to ask you about this again. Oh but this weight loss video was fascinating to see how long ago these drugs were being ministered but also taken off the market like modern versions.
Aaaah yes, the good old days of Obetrol and Desoxyn....Preludin was still available in the early 70s. Then there was dinitrophenol....if you survived it you sure did lose weight! You described it's discovery quite well - it was an intermediate in the production of picric acid, which is a little easier to make than TNT, so it was used despite it's tendency to react with metals forming picrate salts, some of which are quite sensitive, leading to accidental detonation, not a desirable situation. It was phased out after WW I. Nice video, thank you kindly. Cheers...
Yes. About the only thing he struggled with was the pronunciation of DNP! Hint: try di-nitro-phenol. :) Apart from DNP there is another famous poison that short-circuits the body's energy production process, in a different way: Arsenic. Arsenic, being the next element down from Phosphorous, ends up in the ATP energy cycle in place of phosphate. But these analogues spontaneously hydrolyse quite easily, wasting the body's energy as heat. I recall being told that the administration of Arsenic (when they did such things!) was accompanied by a pleasant feeling of warmth due to this process. Paradoxically, Arsenic has apparently been used in poultry and swine production to improve weight gain until fairly recently. How this works, I can't explain at the moment.
...For anyone interested in picric acid, I feel like I should clarify that it isn't just "quite sensitive", it's *extremely* sensitive. A feather landing on it can set it off.
@@SyndicateOperativeNo. I'm afraid I have to disagree. I made picric acid as a teenager (we all did things in our youth). As per the literature, I could not get it to explode at all. It is metal salts, especially heavy-metal salts which are very sensitive. I then tried making some lead picrate, which is supposed to be very sensitive. I could not get that to explode either, at first. This is probably because it was hydrated. Disappointed, I tried drying it further, wrapped in tissue paper and placed on the external heat vent from the family AGA stove. Much of it ran through the paper onto the stainless steel surface which was probably ~100 degrees Celsius or more. I abandoned it for a few days, and then finally put a blow torch on the residue. It detonated, breaking the top of the vent and taking some of the mortar out of the brick wall. Fortunately, my parents were away for the weekend. After recovering from the shock, my brother and I did some ingenious work with some metal sheeting and plasterwork to repair the damage. My parents never noticed. Don't try this at home, kids.
I got a DOGO ARGENTINO in 2021, I’m back down to a size 4/6. People ask me where I work out when I’m walking my dog and I say, you’re looking at it. She’s my gym.
10:04 "Today we use diethylene glycol to make solvents, plasticizers, and antifreeze. They gave children antifreeze". They shouldn't have given children diethylene glycol because it metabolizes into a strong poison, not because some people also use it to lower the freezing point of water. Propylene glycol is also used as antifreeze and it happens to also be safe to eat due to metabolizing into harmless lactic acid. Idk, this part just gave me "chemical used in yoga mats" vibes.
also, water is a wonderful solvent. all on its own, too. about a third of water is oxygen. why would i drink water when my body need anti oxidants? this is all one big scare tactic if you dumb
25:20 this anti-THC drug was visibly made out of good faith and to minimise adverse health effects... But then the human body also makes a little THC and if it all get blocked, well depression happens as it was found out.
Yeah rimonabant is really interesting since it's an inverse agonist of the cb1 receptor rather than just an antagonist. Not only does it block endogenous cannabinoid ligands, it causes the inverse signal to fire which causes directly opposing pharmacologic activity compared to a typical agonist such as THC. Causing decreased appetite, stomach discomfort, depressed mood, and inflammatory effects such as flu like symptoms.
It's important to remember that a lot of "medical" weight loss techniques hinder anabolism or force catabolism. While this is good for losing fatty tissue, it also causes you to lose lean tissue that you very much want to keep, especially if you're older. Ozempic, for example, causes people to lose as much if not more lean tissue as it does fatty tissue. Considering high amounts of lean body mass works as a reserve of resources for the body to pull from as you get older or when you're sick, causing people to lose lean tissue like this will likely lead them to as early a grave as obesity. Ideally you'd want to build as much lean tissue as possible (which is metabolically active) and your body will choose to support that tissue in a slight calorie deficit by depleting your fat stores. But progress this way is slow and requires at least some discipline if not good old fashioned hard work, so people don't do it.
Really depends on what else they do while on Oz, if they just keep upping the dose and eating whatever used to and not exercising, yeah it won't get to better metabolic health. If used at the least effective dose, eating as instructed along with exercise, it could be an excellent aid.
You loose muscle tissue because you sit on your ass and do not eat protein. The end. It's mostly women who stop eating anything on Ozempic and sit on their ass all day.
The people taking Ozempic will often continue over eating, no doubt. Most probably won't bother excersizing enough, if at all. Save for people who physiologically cannot process food correctly, it's more or less a willpower issue in the first place to even become obese. Think about how much WORK it takes to even make yourself that huge. It takes even more to undo it.
I've had an eating disorder for almost all my life 12 to 44, mainly bulimia and laxatives so I knew how to eat and I also was always on the heavier side.(my mum and older sister are both overweight) but when I hit menopause, I thought I was going insane that I completely switched to IF and zero sugar as well as no carbs and processed foods and also no alcohol. I'm modelesq now at 5' 7" and 120. I was blown away how easy it was..and I've kept it up now for 4 years (48)
when the adhd kids medicated with Amphetamines for years while growing and developing their minds become adults we will see the long term side effects of this treatment.
On the bright side, speed is actually quite fun! :-) Keep up the excellent work, Asianometry, I never miss a show. D.A., J.D., NYC (subscriber/patreon)
"easiest way to change obesity is lifestyle change" not exactly, that is the most efficient, but i would say also the hardest way. changing lifestyle is nearly impossible, even when it is known to be good by the one should do the change.
For me who was 90kg (198lb) now 67kg (148lb) over 5 years, the hardest was the first year as your body really wants you to go back to the old stability. Once that hurdle was over it was a breeze, as your body's adaptation is mostly complete. Had to do it slowly over the years though.
@@rulu1828 yeah the hardest part is the starting months when your stomach didn't regain a normal size and the hunger makes you break up the diet. That's why it's crucial to start by consulting a nutritionist. BTW congrats for your weight loss. Dunno your size but you seem to be at a maintainable BMI now. :)
amphetamines are extremely effective if you realise that after them you HAVE to still eat less or get an activity to burn calories, good kickstart still there are a lot of other side effects so
Yeah, no poor people eating shitty food from food deserts. Middle class folk really want to wear their college-aged clothes. Hey, better this than money wasted on stuff that doesn't work.
@moodfm5673 Because the R&D and regulatory costs to get said drugs to market are billions of dollars, not to mention that successful drugs need to not only recoup the cost of their own development but also the development of other drugs that fail to make it to market. On top of that due to drug cost caps imposed by other countries, the US market has to pick up the slack, effectively subsidizing the cost of drugs for the rest of the world at the expense of US citizens. If a drug can't turn a profit there is no motive to produce it, as the company will fail eventually and a failed company can't produce or invent new life saving drugs.
I love your content . out of all my subscriptions, this channel , is one which I never get bored of, you have so many well researched topics , and often you just deliver the information without bias very good .
There exist these very effective weight-loss drugs combination that have been passed down by our wise older generations, namely "healthy diet" and "physical exercise"
Blame must be laid on Ancel Keys, who advised a high carb, low fat diet. He was enough of a True Believer to suppress a study of his own that did not confirm his pet theory.
i was in bodybuilding before and used dinitrophenol a bunch of times, felt not great while using it but afterwards definitely felt more energetic and resilient
@YourCapybaraAmigo_17yrsago It's DNP for short and used in explosive manufacturing, like TNT. Makes your body burn extreme amounts of fat, to the point where you can die from overheating. Its dangerous but no other drug works as fast and well for losing weight FAST.
Lol. Couldn't get people to put a little bit of fabric on their face, you really think you're gonna get them on a yoga mat or wearing Lycra bicycle shorts?!? 😂 Good one!
Authoritarian policy is not viewed nicely in America (THE target demographic). Better to convince people they want/need than to coerce. You can take this horse to water but you cannot make it drink. Source: all American politics since 1776
@@MegaRad666 these danish weightloss drugs (ozempic and wegovy) was not just made for the american market, but generaly for worldwide sales just like every other Novo Nordisk product so far
Love this perspective. I personally know people on glp-1 agonists who have developed gastroparesis, it's looking a lot like this round may be more of the same
If they couldn't make a safe weight loss drug in over 100 years, what makes this one safe? Maybe the benefits can outweigh the drawbacks this time, but i would guess probably not...
Drug trials for new medications are tested on people numbering in the thousands. After FDA approval and marketing if the new drug is popular millions of people are prescribed it. Problems not seen or rarely seen in drugs trials start being reported when millions are using it.
This shows a history of stupidity among people, rather than changing habits of eating and exercise, they prefer to dangerously mess with the body chemistry out of sheer laziness
Hey! You mentioned Chile. If only in a drug you don't recommend. (The green star means that it's very controlled medication. You need to give your recipe at the pharmacy and have a copy at all times in case, you never know, police requires it (otherwise it counts as a drug). Looked up the price, it's roughly 11 US dollars.
I was hoping to hear something about ozempic, a type 2 diabetes drug, which is unscrupulously used for weight loss by many. There are serious concerns by some experts about the health risks. Maybe in a future video as a sequel to this one.
I remember benzedrine being used as a fuel additive in drag racing in the 1960's. Those engines turned into literal grenades. It was banned by the NHRA shortly thereafter.
What was the mechanism? It’s not an oxidiser. You’re mixing it up with a similar sounding chemical I think mate, amphetamine would have no impact on combustion when added to fuel
@@causewaykayak Yup, you can use straight hydrazine or hydrazine hydrate as a liquid propellant in either a bipropellant or monopropellant (with a catalyst) system. Straight hydrazine is bonkers toxic and reactive with just about everything. Highly recommend the book "Ignition! An informal history of Liquid Rocket Propellants" by John Drury Clark. Its a frankly scary insight in to the "throw things at the wall and see what gives high impulse" era of rocketry.
I’m taking the best weight loss combination now… decaf coffee with collagen and vitamins, diet sodas, sriracha hot chili sauce by the teaspoon all day. I can go 22 hours a day without anything else. Then a single meal with a protein, veggies and fruit for less than 1000 calories a day.
Please consult a nutritionist. A single meal per day is a bit extreme, you should make at least two and eventually snack those fruits and vegetables instead of sriracha spoons, especially if you exercise correctly. What you can do is progressively remove the soda to get your brain use to a less sugary diet and the gaseous drinks restrain the stomach to shrink. Get flavored water if you can't stand the plain one.
Less than 1000 calories a day is not healthy or safe for most people. Please consult a medical professional, as this sounds like an eating disorder to me. I wish you well.
Modern lifestyle is sickening, we need to change the lifestyle, eat much much much healthier, less stress in the city and health will improve much more than with using dangerous chemicals / drugs. Best wishes.
Ah, yes, Orlistat aka Xenical… not covered by my provincial health care plan, so $129 a month… it’s a fat blocker, eg it prevents you from absorbing and metabolizing 1/3 of the fat you consume… didn’t work that well for me… “significant an*l leakage” was mentioned as one of its effects… and it did… a weaker version may be still available as “Ally” ( don’t know if still on the market or not ?) what ultimately did work for me was gastric bypass surgery in 2004 ( roux-en-Y) , sadly you can fail after having the surgery, too-eg you are approved for the surgery, you have the surgery, you lose the weight for a while then you gain most of it back.. lucky for me that hasn’t really happened - still it’s major surgery, and only approved for people with high enough BMI’s ( body-mass index) … followed up with a panniculectomy in 2005-2006 ( more surgery) so more complications , as both are major surgeries, but they both seem to work well enough- there’s also the sleeve gastrectomy…
"Rainbow pills" are on prominent display in Hubert Selby Jr.'s novel "Requiem for a Dream" and the film adaptation. In one scene, son (Harry) rightly tells his mother "Ma! you are on amphetamines!"
Meth.. helping people lose weight since Sept 1st 1939 😂 But seriously, I wish I could gain weight. My metabolism along with my lifestyle and occupation, I average 4000-5000 calories a day and I can't get above 160lbs. I'm 5'11
Same here. I'm 6'2" and 154 lbs. The only thing that helped me is Mirtazapine. I used to weigh only 144. In SI units I'm 1.88 meters tall and weigh 70 Kg. Used to weigh 65.5 Kg.
You could buy cocaine, medial clean!!!!! Cocaine at the pharmacy instead of going to the middle eastern young man at the shady Corner at the playground. More civilized Times 🥺🥺🥺
If you do not have any complications I can tell you how to lose weight. Do not eat any highly/ultra processed foods and limit your added sugar intake to no more than 25 grams a day. Eat whole foods sensibly and I promise you will lose weight.
What i find odd is im considered technically obese. (5'0, 168 lb) but i am not percieved as such socially. Just a bit "chubby", and i have no health or mobility issues related to my weight aside from some acid reflux.
The fatter the country, the more it takes for you to be noticed. Why is it my 600lbs life and not my 300lbs life? Cause You don't want to step on the toes of your many 300lbs viewers. Always show worse , ideally worst, so they can think : at least I'm not that fat / poor/ dumb / evil/ mean. Still. Unless you are super muscular n that's the reason, you are better off losing the weight. Know your blood pressure?
Heh. Best weight loss medicine I’ve ever found is weed. I’m serious. It did help. My body is a wreck, and weed provides me the pain relief I need to be able to move. Superb work. Absolutely superb. You do an incredible job.
I used to be 350lbs, made the mistake of going cold turkey off my high dose of dexedrine that I was forced to take as a kid, long story short I got huge and failed at life. Now I understand my brains wired for this medication and I will just fail at life without my medication. I don't like this medication, makes it nearly impossible to succeed at social interaction & build human relationships but I understand without I will be a lazy fat POS so being anti social weirdo is my choice. Not that taking almost every Adhd medication as a kid was my choice but eh. It's crazy how this medication can make a happy outgoing person into a zombie, especially on the doses I was forced to take.
"Easiest way to lose weight" is a bit misleading when it comes to lifestyle/dietary changes. For some people, yes that's all that's needed. But many people are forced into these things but it wont ever change for them because that's not whats causing their issue. Many fat people have issues that we can starve ourselves and work out until we collapse, it won't change for us. Even if it did, it would be temporary. There can be several medical issues behind why someone may be fat. While I understand your intent certainly wasn't meant to shame these people, it adds to it regardless. We are told our entire lives by people who know nothing about the why that we just need to try harder, many of us even as kids. And eventually it gets drilled into many so intensely that it takes years of struggling to escape from disordered eating and harmful lifestyle choices. Even if it were a choice, I'd much prefer someone to be fat and happy but live a happy life than someone be skinny and miserable.
Thank you for this video. Interestingly, they might have looked on obesity in ancient and medieval times differently. For these people, being fat was more of a moral problem, while Hippocratic and Galenic medicine taught that health derives from the balance of the human body's components. Hence, overeating and obesity was probably thought to have been a problem because it was immoral and it also created an imbalance. Vomiting and laxatives prescribed by these ancient and medieval physicians was supposed to solve this imbalance by the removal of unnecessary nutrients. On the other hand, theriac was an ancient and medieval cure-all, originally formulated against envenomation by snakes and other venomous animals. Not sure how it was supposed to work against the fat.
You can choose to eat healthy. Most people have options. People who order McDonalds online can order fresh veggies from online grocery stores instead. Walmart delivers your online order to your door!
You could also mention the tapeworm diet which had been popular in the late 1800s and is still around for over 100 years.
And of course after the '50s there was the rock star diet where all solid foodstuffs were simply substituted with cocaine, perhaps amphetamines or possibly heroin or sone combination of these. Very effective and popular among the young.
😢😮😮
Been popular since the Triassic Period
@@alphar9539 As a parasite sure, but not as a solution to lose weight.
should bring tapeworm diet back, it has benefits for those with allergies too as many parasites cause mild immunosuppression
You left out a big part of the Fen-Phen study. Michael Weintraub in the early 1990s was an Office Director at the FDA and went around to different meetings “promoting” it. Even when the FDA told him to cool it, he was unapologetic. He was eventually asked to resign. I know I was there during this.
I remember my mom talking about fen-fen when I was a kid in the 90's.
Me too. My parents took fen fen or ephidrine.
A kid I knew growing up got a > $7,000,000 from the Fen-Phen settlement back in the early 2000's. Yepp...He was livin high on the hog for about 1 year and was COMPLETELY broke. He blew it all on trucks, 4-wheelers, dirt bikes, OxyContin and cocaine. Lots and LOTS of Oxys & coke. Doctors told him he probably only had 5-10 years to live. (hence the settlement) He was 19-20yo then and is still alive today.
Awww poor guy. At least the vehicles were assets
what a degenerate 7 mill blown
Extended-release stimulants don't cause addiction very easily. Ask the people with ADHD who regularly forget to take them.
Extended release stimulants can still be abused pretty easily. If someone feels good on adderall, then vyvanse and Addy XR will as well. Won't get peak effects instantly tho
I know people that are prescribed and hooked.
Can confirm. Can't count how often I forgot my meds and only realized later that day when my brain wouldn't work as requested.
I forgot my erectile dysfunction meds, my wife noticed.
I lost 25KG in 2022 without any need for medication. I dieted quite strictly, and I exercised a reasonable amount. I started at 130kg and reached 105kg within the year.
This year, 2023 I found it somewhat difficult to maintain my weight of 105kg, but through monitoring my weight it was possible, although I did momentarily approach 110kg again, now I sit more at about 100kg.
All this is to say a miracle drug would merely treat the symptom, not the cause of your weight. You still have to FOREVER change your diet and exercising habits, not just for a bit.
That's the spirit people have to commit. Congrats for your results! Keep up the good work and don't hesitate to consult a nutritionist.
@@PainterVierax well for me personally I don't think I need a nutritionist, but rather a psychologist.
My problem stemmed from depression, thus I overate and abused alcohol. I also felt like I would have to put in the work on my own, and after somehow managing to motivate myself to change things, at the cost of temporarily greatly increased levels of stress, I now feel that I can get no further in my recovery without getting professional help. That being said I got very far on my own, dropped alcohol almost completely, and am on the search for said professional help.
Sorry if this seems like "trauma dumping", I'm just trying to to document my journey, and maybe motivate someone else.
I made it very far on my own mentally and physically, but there's no shame in getting help, and getting it earlier is probably always better.
@@hummel6364 No worries. In fact that's interesting as psychology is a factor I completely forgot. And ironically i suffer long term depression myself.
Good job quitting alcohol without help though. That's a huge victory by itself.
Even "worse" You have to change your mindset!
@@PainterVierax the only help I had with the alcohol was a friend who quit at the same time as me. He didn't drink in over 260 days, me on the other hand I still drink on occasion, but not in a substance abuse like manner, just on birthdays and the like.
Psychology is honestly the biggest part whether it's caused by depression or not, your mindset needs to change.
The breadth of the topics you cover is amazing.
I find them all interesting and educational.
Thanks...
That kings of Leon joke was smooth.
As a pharmacist, I really appreciate this history overview.
He also missed an old drug from Victorian era to help women fit into the corsets, it was a capsule that contained the eggs of tapeworms which of course would help you lose weight because you've got serious dietary deficiencies get take hold of
@@weedmanwestvancouverbc9266 YIKES !
@@weedmanwestvancouverbc9266that's hot did they fuck afterwards? And did she keep the worm in her family? Did she name him
Hey man, there are some added complexities to the effects of DNP that are important to discuss which you missed. The body actually stores fats into two broader categories, known as brown and white fat. The type of fat you typically think of, which is primarily used as tapable energy storage, is white fat. The function of brown fat which is relevant to this discussion is as a major mechanism of thermoregulation. DNP specifically induces metabolism of the body's brown fat, which even in healthy individuals largely produces heat rather than usable energy. This not only doesnt aleviate many of the worst impacts of obesity (e.g. insulin insensitivity), but over time can leave the body's ability to regulate its temperature dangerously incapacitated
Oh wow, that's especially important information to note. And fascinating.
DNP is known to be deadly. I took it for a few months and did lose weight. Besides it's obvious drawback of heat, I just wondered how unhealthy it would be long term... Cataracts was only seen in females.
Christ. I took part in "Weight Loss" drugs trials 20 years ago.
Rip bro
@@YourCapyFrenBigly_3DPipes1999 That this is the subject that is close to my heart and I know also something about it?
"Christ" was from shock of seeing topic that I know so much of being covered here. Why are you so hostile?
@@YourCapyFrenBigly_3DPipes1999What’s the point of *your* comment?
@@jannegrey593 well I hope you didn't have any bad effects from the study but I guess I take a little issue with presentations like this that claim that these hyper-trash politicians have our best interests at heart and somehow they're the experts on anything which if you have any life experience at all, you would know how utterly ridiculous that is. Trusting these Congressional pieces of trash over ourselves is probably the worst mistake any of us can make in our lives.
I'm sure some studies aren't done properly but without doing studies how is any medical researcher supposed to gain knowledge about any proposed medication or OTC supplement? That's all I meant.
@@Girvo747he’s a fanboy of big pharm.
Please do a video on Hi-Fi a/v systems and such that came to a high point in the early 2000s then crashed due to smartphones.
I'll be sure to ask you about this again. Oh but this weight loss video was fascinating to see how long ago these drugs were being ministered but also taken off the market like modern versions.
This channel is outrageously good. 👍
Asianometry slowly moving toward becoming a speed fiend's channel of choice with all the meth content, haha.
Hear... hear...
Dope pipes
Aaaah yes, the good old days of Obetrol and Desoxyn....Preludin was still available in the early 70s.
Then there was dinitrophenol....if you survived it you sure did lose weight!
You described it's discovery quite well - it was an intermediate in the production of picric acid, which is a little easier to make than TNT, so it was used despite it's tendency to react with metals forming picrate salts, some of which are quite sensitive, leading to accidental detonation, not a desirable situation.
It was phased out after
WW I.
Nice video, thank you kindly. Cheers...
😢😮😮😮
Yes. About the only thing he struggled with was the pronunciation of DNP!
Hint: try di-nitro-phenol. :)
Apart from DNP there is another famous poison that short-circuits the body's energy production process, in a different way:
Arsenic.
Arsenic, being the next element down from Phosphorous, ends up in the ATP energy cycle in place of phosphate. But these analogues spontaneously hydrolyse quite easily, wasting the body's energy as heat.
I recall being told that the administration of Arsenic (when they did such things!) was accompanied by a pleasant feeling of warmth due to this process.
Paradoxically, Arsenic has apparently been used in poultry and swine production to improve weight gain until fairly recently. How this works, I can't explain at the moment.
I’m low-dosing DNP for about a year now and it works pretty damn great! Crypto finally has a use. 😂
...For anyone interested in picric acid, I feel like I should clarify that it isn't just "quite sensitive", it's *extremely* sensitive. A feather landing on it can set it off.
@@SyndicateOperativeNo. I'm afraid I have to disagree. I made picric acid as a teenager (we all did things in our youth).
As per the literature, I could not get it to explode at all. It is metal salts, especially heavy-metal salts which are very sensitive.
I then tried making some lead picrate, which is supposed to be very sensitive. I could not get that to explode either, at first.
This is probably because it was hydrated.
Disappointed, I tried drying it further, wrapped in tissue paper and placed on the external heat vent from the family AGA stove. Much of it ran through the paper onto the stainless steel surface which was probably ~100 degrees Celsius or more.
I abandoned it for a few days, and then finally put a blow torch on the residue. It detonated, breaking the top of the vent and taking some of the mortar out of the brick wall.
Fortunately, my parents were away for the weekend. After recovering from the shock, my brother and I did some ingenious work with some metal sheeting and plasterwork to repair the damage. My parents never noticed.
Don't try this at home, kids.
At the age of 65, I found the BEST way to lose weight. I got a Boxer puppy. Lost 20 pounds in 2 years.
That's quite a powerful fur missile.
I'm trying to get all my vaccines up to date so I can start walking dogs at my local animal shelter. Hell of a lot cheaper than a gym membership
I got a DOGO ARGENTINO in 2021, I’m back down to a size 4/6. People ask me where I work out when I’m walking my dog and I say, you’re looking at it. She’s my gym.
10:04 "Today we use diethylene glycol to make solvents, plasticizers, and antifreeze. They gave children antifreeze". They shouldn't have given children diethylene glycol because it metabolizes into a strong poison, not because some people also use it to lower the freezing point of water. Propylene glycol is also used as antifreeze and it happens to also be safe to eat due to metabolizing into harmless lactic acid. Idk, this part just gave me "chemical used in yoga mats" vibes.
Yeah that was a silly statement.
Is this the same stuff from that sweet wine scandal from back in the day? Austrian, I believe.
also, water is a wonderful solvent. all on its own, too. about a third of water is oxygen. why would i drink water when my body need anti oxidants? this is all one big scare tactic if you dumb
@@amandahugankiss4110 Your body doesn't need more antioxidants. They have advantages and disadvantages in the chemistry of the body.
@@pizzablender thank you, dr popular profile picture. enjoy your vaccine.
25:20 this anti-THC drug was visibly made out of good faith and to minimise adverse health effects... But then the human body also makes a little THC and if it all get blocked, well depression happens as it was found out.
Yeah rimonabant is really interesting since it's an inverse agonist of the cb1 receptor rather than just an antagonist. Not only does it block endogenous cannabinoid ligands, it causes the inverse signal to fire which causes directly opposing pharmacologic activity compared to a typical agonist such as THC. Causing decreased appetite, stomach discomfort, depressed mood, and inflammatory effects such as flu like symptoms.
It's important to remember that a lot of "medical" weight loss techniques hinder anabolism or force catabolism. While this is good for losing fatty tissue, it also causes you to lose lean tissue that you very much want to keep, especially if you're older. Ozempic, for example, causes people to lose as much if not more lean tissue as it does fatty tissue. Considering high amounts of lean body mass works as a reserve of resources for the body to pull from as you get older or when you're sick, causing people to lose lean tissue like this will likely lead them to as early a grave as obesity. Ideally you'd want to build as much lean tissue as possible (which is metabolically active) and your body will choose to support that tissue in a slight calorie deficit by depleting your fat stores. But progress this way is slow and requires at least some discipline if not good old fashioned hard work, so people don't do it.
Really depends on what else they do while on Oz, if they just keep upping the dose and eating whatever used to and not exercising, yeah it won't get to better metabolic health.
If used at the least effective dose, eating as instructed along with exercise, it could be an excellent aid.
@@punkdigeratidoes the target audience exercise?
@@alphar9539 and does the target audience eat their vegetables, stop snacking or ingesting large portions?
You loose muscle tissue because you sit on your ass and do not eat protein. The end.
It's mostly women who stop eating anything on Ozempic and sit on their ass all day.
The people taking Ozempic will often continue over eating, no doubt. Most probably won't bother excersizing enough, if at all. Save for people who physiologically cannot process food correctly, it's more or less a willpower issue in the first place to even become obese. Think about how much WORK it takes to even make yourself that huge. It takes even more to undo it.
I've gotten so many shitty Ozempic commercials and I find out what it actually does in the title of a RUclips video from YOU?
I've had an eating disorder for almost all my life 12 to 44, mainly bulimia and laxatives so I knew how to eat and I also was always on the heavier side.(my mum and older sister are both overweight) but when I hit menopause, I thought I was going insane that I completely switched to IF and zero sugar as well as no carbs and processed foods and also no alcohol. I'm modelesq now at 5' 7" and 120. I was blown away how easy it was..and I've kept it up now for 4 years (48)
A real use for amphetamines is for people with adhd, helping them focus better. It’s pretty good stuff.
It's definitely turned my life around.
I think it's better to figure out what causes "the chemical imbalace" in the brain.
Amphetamines have to many side effects.
Pretty good unless you develop an addiction, then it is a unique hell I wouldn’t wish on my worst enemy.
@@CordeliaWagner1999 i mean sure, once they do, but there are good indications that it’s simply a differently wired brain, not an imbalance.
when the adhd kids medicated with Amphetamines for years while growing and developing their minds become adults we will see the long term side effects of this treatment.
Remember those weight loss bars called "AYDS" from the 1980's?
On the bright side, speed is actually quite fun! :-) Keep up the excellent work, Asianometry, I never miss a show. D.A., J.D., NYC (subscriber/patreon)
It also results in reduced penis size. See the song by KoRn, "helmet in the bush", which is exactly about that phenomenon regarding taking speed.
"easiest way to change obesity is lifestyle change"
not exactly, that is the most efficient, but i would say also the hardest way. changing lifestyle is nearly impossible, even when it is known to be good by the one should do the change.
For me who was 90kg (198lb) now 67kg (148lb) over 5 years, the hardest was the first year as your body really wants you to go back to the old stability. Once that hurdle was over it was a breeze, as your body's adaptation is mostly complete. Had to do it slowly over the years though.
@@rulu1828 yeah the hardest part is the starting months when your stomach didn't regain a normal size and the hunger makes you break up the diet. That's why it's crucial to start by consulting a nutritionist.
BTW congrats for your weight loss. Dunno your size but you seem to be at a maintainable BMI now. :)
Everytime I come across the history of industrial medicine and agriculture I am bewildered about what a mess it is, we are literally being poisoned.
Lost 75 pounds in six months just giving up all sugar. Kept it off for over a year now.
The bandwidth of the topics you cover is amazing, thank you
amphetamines are extremely effective if you realise that after them you HAVE to still eat less or get an activity to burn calories, good kickstart
still there are a lot of other side effects so
What’s with all the weird comments on the video? Are they bots?
It's AI 😂😢
I lost it when you said that Sancho the fat performed sex on fire
This is why there is a currently a law in the United States that Medicare cannot cover weight loss drugs.
why isnt there a law stopping pharma from charging people 10 grand a month for life saving drugs that pennies to make?
Yeah, no poor people eating shitty food from food deserts.
Middle class folk really want to wear their college-aged clothes.
Hey, better this than money wasted on stuff that doesn't work.
all these drugs are made here in Denmark and even we dont get it covered by our healthcare (unless you are diabetic)
@moodfm5673 Because the R&D and regulatory costs to get said drugs to market are billions of dollars, not to mention that successful drugs need to not only recoup the cost of their own development but also the development of other drugs that fail to make it to market. On top of that due to drug cost caps imposed by other countries, the US market has to pick up the slack, effectively subsidizing the cost of drugs for the rest of the world at the expense of US citizens. If a drug can't turn a profit there is no motive to produce it, as the company will fail eventually and a failed company can't produce or invent new life saving drugs.
I miss ephedra, stuff actually worked.
I love your content . out of all my subscriptions, this channel , is one which I never get bored of, you have so many well researched topics , and often you just deliver the information without bias very good .
11:11 'negative social behaviors' is putting it mildly 😂😂 I need to use that phrase more often in my daily life
There exist these very effective weight-loss drugs combination that have been passed down by our wise older generations, namely "healthy diet" and "physical exercise"
Yoo, you can't spill our secrets just like that. Delete this comment or I will have to inform the elders.
Thank you for the KoL reference - they gotz some phat beats
Your content is incredibly enriching, thank you for your work.
Blame must be laid on Ancel Keys, who advised a high carb, low fat diet. He was enough of a True Believer to suppress a study of his own that did not confirm his pet theory.
i was in bodybuilding before and used dinitrophenol a bunch of times, felt not great while using it but afterwards definitely felt more energetic and resilient
Is it legal? What is it?
@@YourCapyFrenBigly_3DPipes1999 dnp
@YourCapybaraAmigo_17yrsago It's DNP for short and used in explosive manufacturing, like TNT. Makes your body burn extreme amounts of fat, to the point where you can die from overheating. Its dangerous but no other drug works as fast and well for losing weight FAST.
Instead of giving people another crutch so they can function, why don't we demand the citizens follow a required exercise regimen?
Lol. Couldn't get people to put a little bit of fabric on their face, you really think you're gonna get them on a yoga mat or wearing Lycra bicycle shorts?!? 😂 Good one!
Authoritarian policy is not viewed nicely in America (THE target demographic). Better to convince people they want/need than to coerce. You can take this horse to water but you cannot make it drink. Source: all American politics since 1776
@@MegaRad666 these danish weightloss drugs (ozempic and wegovy) was not just made for the american market, but generaly for worldwide sales just like every other Novo Nordisk product so far
During the 1990’s, the Silhoute Kwarenta weight loss soap was shown in home-tv shopping shows.
Love this perspective. I personally know people on glp-1 agonists who have developed gastroparesis, it's looking a lot like this round may be more of the same
For how long were they using it?
A powerful history and analysis well presented. Thank you.
If they couldn't make a safe weight loss drug in over 100 years, what makes this one safe? Maybe the benefits can outweigh the drawbacks this time, but i would guess probably not...
Fun Fact: Like DNP, Formaldehyde/Methanal also disrupts the function of mitochondria. Also like DNP it damages the eyes first.
That's Vyvanse in the thumbnail but they are often giving that out with Ozempic.
In the graphic at 16:05, the structure for amphetamine is not correct
Drug trials for new medications are tested on people numbering in the thousands. After FDA approval and marketing if the new drug is popular millions of people are prescribed it. Problems not seen or rarely seen in drugs trials start being reported when millions are using it.
This shows a history of stupidity among people, rather than changing habits of eating and exercise, they prefer to dangerously mess with the body chemistry out of sheer laziness
You may also want to mention drugs that hinder absorption of fats (orlistat) or carbs (like acarbose)
Olestra gives you diarrhea 😉
Hey! You mentioned Chile. If only in a drug you don't recommend. (The green star means that it's very controlled medication. You need to give your recipe at the pharmacy and have a copy at all times in case, you never know, police requires it (otherwise it counts as a drug). Looked up the price, it's roughly 11 US dollars.
I was hoping to hear something about ozempic, a type 2 diabetes drug, which is unscrupulously used for weight loss by many. There are serious concerns by some experts about the health risks. Maybe in a future video as a sequel to this one.
I remember benzedrine being used as a fuel additive in drag racing in the 1960's. Those engines turned into literal grenades. It was banned by the NHRA shortly thereafter.
What was the mechanism? It’s not an oxidiser. You’re mixing it up with a similar sounding chemical I think mate, amphetamine would have no impact on combustion when added to fuel
I think you're thinking of Hydrazine (N2H4)
@@alistercrowe8531H.Hydrate was a rocket fuel wasn't it ?
@@alistercrowe8531 Or nitromethane or nitro-anything.
@@causewaykayak Yup, you can use straight hydrazine or hydrazine hydrate as a liquid propellant in either a bipropellant or monopropellant (with a catalyst) system. Straight hydrazine is bonkers toxic and reactive with just about everything.
Highly recommend the book "Ignition! An informal history of Liquid Rocket Propellants" by John Drury Clark. Its a frankly scary insight in to the "throw things at the wall and see what gives high impulse" era of rocketry.
I’m taking the best weight loss combination now… decaf coffee with collagen and vitamins, diet sodas, sriracha hot chili sauce by the teaspoon all day. I can go 22 hours a day without anything else. Then a single meal with a protein, veggies and fruit for less than 1000 calories a day.
Please consult a nutritionist.
A single meal per day is a bit extreme, you should make at least two and eventually snack those fruits and vegetables instead of sriracha spoons, especially if you exercise correctly.
What you can do is progressively remove the soda to get your brain use to a less sugary diet and the gaseous drinks restrain the stomach to shrink. Get flavored water if you can't stand the plain one.
Less than 1000 calories a day is not healthy or safe for most people. Please consult a medical professional, as this sounds like an eating disorder to me. I wish you well.
why the sriracha sauce? i noticed that spicy food helps me eat way less. is that why?
why do so few people take CHAGA mushroom under consideration??? it helps greatly in loosing weight!!!
Sounds very scrupulous:
Intentionally profiting despite big concerns.
Fascinating stuff, very well explained as always, interesting change from silicon.
Modern lifestyle is sickening, we need to change the lifestyle, eat much much much healthier, less stress in the city and health will improve much more than with using dangerous chemicals / drugs.
Best wishes.
As a pharmacist, I appreciate you 🙏
Many thanks for an important pharmaceutical history lesson.
It would be interesting to see the studies compare these weight loss drugs to sugar, and it's effects.
What's the bet, sugar is worse.
Cocaine addiction never fails.
Ah, yes, Orlistat aka Xenical… not covered by my provincial health care plan, so $129 a month… it’s a fat blocker, eg it prevents you from absorbing and metabolizing 1/3 of the fat you consume… didn’t work that well for me… “significant an*l leakage” was mentioned as one of its effects… and it did… a weaker version may be still available as “Ally” ( don’t know if still on the market or not ?) what ultimately did work for me was gastric bypass surgery in 2004 ( roux-en-Y) , sadly you can fail after having the surgery, too-eg you are approved for the surgery, you have the surgery, you lose the weight for a while then you gain most of it back.. lucky for me that hasn’t really happened - still it’s major surgery, and only approved for people with high enough BMI’s ( body-mass index) … followed up with a panniculectomy in 2005-2006 ( more surgery) so more complications , as both are major surgeries, but they both seem to work well enough- there’s also the sleeve gastrectomy…
Wow! You did it again. Great detailed look at weight loss drugs. Much appreciated..
I lost 40 methadone pounds in 2021...lemon water and a new dog that I potty trained. Walking A LOT, and lemon water. At 60. It is possible.
Very interesting and well explained video!
80% is what you eat and the last 20% is training, so if what you do don’t work, do something else ie eat different
"Rainbow pills" are on prominent display in Hubert Selby Jr.'s novel "Requiem for a Dream" and the film adaptation. In one scene, son (Harry) rightly tells his mother "Ma! you are on amphetamines!"
Another interesting topic well presented.
Meth.. helping people lose weight since Sept 1st 1939 😂
But seriously, I wish I could gain weight. My metabolism along with my lifestyle and occupation, I average 4000-5000 calories a day and I can't get above 160lbs. I'm 5'11
Dam
Same here. I'm 6'2" and 154 lbs. The only thing that helped me is Mirtazapine. I used to weigh only 144.
In SI units I'm 1.88 meters tall and weigh 70 Kg. Used to weigh 65.5 Kg.
@@mikebarushok5361 wish I was that tall
1900's medicine was beyond wild! it gets me every time what was available then!
You could buy cocaine, medial clean!!!!! Cocaine at the pharmacy instead of going to the middle eastern young man at the shady Corner at the playground. More civilized Times 🥺🥺🥺
Hey man, would love to see some content about Brazilian electric car Gurgel. It's an obscure topic Asianometry style.
Exercise and eat well balanced diet is the best. No taking short cuts.
Eat less , move more
This vídeo should be called HOW PHARMA HIDES METH
Incredible video. Thank you
If you do not have any complications I can tell you how to lose weight. Do not eat any highly/ultra processed foods and limit your added sugar intake to no more than 25 grams a day. Eat whole foods sensibly and I promise you will lose weight.
Im worried about a potential growth of cyclic vomiting from ozempic. We shall see.
I'm surprised you didn't mention leptin or bupropion-naltrexone
When it comes to subject matter you sure get about!
What i find odd is im considered technically obese. (5'0, 168 lb) but i am not percieved as such socially. Just a bit "chubby", and i have no health or mobility issues related to my weight aside from some acid reflux.
The fatter the country, the more it takes for you to be noticed. Why is it my 600lbs life and not my 300lbs life? Cause You don't want to step on the toes of your many 300lbs viewers. Always show worse , ideally worst, so they can think : at least I'm not that fat / poor/ dumb / evil/ mean. Still. Unless you are super muscular n that's the reason, you are better off losing the weight. Know your blood pressure?
In a short:Mc Donalds and Pharmacy works together,
Great video man, shows how current craze is nothing new.
Heh. Best weight loss medicine I’ve ever found is weed.
I’m serious. It did help. My body is a wreck, and weed provides me the pain relief I need to be able to move.
Superb work. Absolutely superb. You do an incredible job.
I thought that it increase your desire to eat, no?
@@ashenmintthc is supposed to improve appetite while cbd is supposed to reduce appetite. So it all depends on what your consuming
@@ashenmint
For me it didn’t, but I also don’t get addicted to opiates. Cigarettes are a BIG problem though.
Weed keeps me moving!
I used to be 350lbs, made the mistake of going cold turkey off my high dose of dexedrine that I was forced to take as a kid, long story short I got huge and failed at life. Now I understand my brains wired for this medication and I will just fail at life without my medication. I don't like this medication, makes it nearly impossible to succeed at social interaction & build human relationships but I understand without I will be a lazy fat POS so being anti social weirdo is my choice. Not that taking almost every Adhd medication as a kid was my choice but eh. It's crazy how this medication can make a happy outgoing person into a zombie, especially on the doses I was forced to take.
"Easiest way to lose weight" is a bit misleading when it comes to lifestyle/dietary changes. For some people, yes that's all that's needed. But many people are forced into these things but it wont ever change for them because that's not whats causing their issue. Many fat people have issues that we can starve ourselves and work out until we collapse, it won't change for us. Even if it did, it would be temporary. There can be several medical issues behind why someone may be fat. While I understand your intent certainly wasn't meant to shame these people, it adds to it regardless. We are told our entire lives by people who know nothing about the why that we just need to try harder, many of us even as kids. And eventually it gets drilled into many so intensely that it takes years of struggling to escape from disordered eating and harmful lifestyle choices. Even if it were a choice, I'd much prefer someone to be fat and happy but live a happy life than someone be skinny and miserable.
Fat and cholesterol are not your enemy, processed sugar is the culprit!
Calories in calories out, that is a steam machine not the human body
the voice sounds a bit different...is it a new mic or something?
It’s sad how we live in a world where people have no motivation to change themselves and just pop a pill to fix things….
great channel. clear, succinct.
Can't stop man I just keep eating,deer meat red beast thank you lord for this feast
WOW Great video!! thank you
thank God the layman still has access to crystal meth thanks to the hard work and dedication of our southern friends
Thank you for this video. Interestingly, they might have looked on obesity in ancient and medieval times differently. For these people, being fat was more of a moral problem, while Hippocratic and Galenic medicine taught that health derives from the balance of the human body's components. Hence, overeating and obesity was probably thought to have been a problem because it was immoral and it also created an imbalance. Vomiting and laxatives prescribed by these ancient and medieval physicians was supposed to solve this imbalance by the removal of unnecessary nutrients. On the other hand, theriac was an ancient and medieval cure-all, originally formulated against envenomation by snakes and other venomous animals. Not sure how it was supposed to work against the fat.
We are living stressful meaningless lives and are bombarded by shit food every moment of our lives.
Our environment is quite different
You can choose to eat healthy. Most people have options.
People who order McDonalds online can order fresh veggies from online grocery stores instead. Walmart delivers your online order to your door!
Being lazy is a Moral problem.
You'd really think a bored king would have invented the barbell and flexed on his underlings but nah.
Beeing on stimulats like ritalin is realy killing your apetide.
Cracking up at the Sex on Fire joke😂
No mention of Adderall starting as a weight loss drug and still on the market?
Say, wonder how SB-F is doing these days, now that you mentioned it....
Isn't it ADHD drug?
Yes, Adderall is an ADHD drug, but it's just amphetamines
Are you a Berkeley alum by any chance? Never heard anyone else call Stanford “Stanfurd”
The easiest way I lost weight was to have a bicycle and do all of my shorter in town trips on it instead of a car.