Placing a rodent in a chamber with substrate and marbles views as a very limited habitat. How long before each mouse becomes confused or exibits minor irritability? If you included a wheel food and water, how many overeat or run tenaciously? It is a very interesting article to observe, is there somewhere to find more writing?
Drugs developed using these mouse models have failed in phase III clinical trials (Mangialasche et al., 2010; Braidy et al., 2012; Saraceno et al., 2013). These failures question not only our accurate understanding of the disease (Castellani and Perry, 2012) but also the validity of the animal models upon which the drug discovery efforts are rooted (Windisch, 2014; Nazem et al., 2015).
Agree that not all animal models as useful as others, but we should not use specific failures to condemn all animal models / trials, a subject we addressed here: www.understandinganimalresearch.org.uk/news/communications-media/how-to-distort-0004-of-the-statistics/
Look at all the people suffering from medication damage somehow scientists and doctors seemingly have tried to seep all the damaged lives and deaths of young kids in mental hospitals from the effects of dangerous and very flawed drugs based k. Animal experiments, most antidepressants have the eceects of suicidal thoughts causing Aggression, and metabolic and brain disruption, not in a good way either! The longer people are on them or the more drugs each patient is prescribed at illagl and extreme high doses the sicker the patients become, mental health systems and staff have been in denial for some time of exactly what has been goinf on! Clearly to hide the damage of their drugs or they believed the myth of the Chemical imbalance, what they are doing is causing chemical imbalance, mainly because the drugs act as poisons on the system and they haven't a clue what they're doing because they never do any tests for serontin or doppmaine levels or mri for function or brain chemistry they make a lot of false assumptions, false hypothesis and hide aeevis3nce of harm just as it seems pharma was doi g with their animal experiments! Clever merketong pushed the one side effect they want while they try to minimise the others, when people complain of horroc symtoms doctors tell them to carry on they'll get better! They don't get better they get worse, these drugs have created horrific symtoms and many new disease like akathesia tardive dyskinesia, causes suicides and sudden death! Medicine is not meant to make people sick!
Alzheimer's disease is not just defined by its symptoms but by specific proteins that build up in the brain. So, mouse models also develop these protein build-ups, and scientists can better study how to stop this from happening. You can test different forms of memory and normal/abnormal behaviour in mice - just because it's not in the same way as you would for humans, it still demonstrates changes. We don't know enough about Alzheimer's & these models help us. They're not perfect, but they help.
I work in an animal cognition laboratory and what I can say is that what you can see in the video is all true. Animals are treat on average better than in many private home. This is due simply because of the standards of the ethical commettee that of course supervises animal laboratories but not private home.
Yes but we've seen the experiments, watching animal behaviour in a false environment doesn't really give any indication of the disease in Humans because we've seen the people damaged by prescribed drugs none more so than antidepressants and antipsychotics that cause movement disorders, metabolic disorders, suicidal thoughts suicides, Aggression and sudden cardiac dsth, these symtoms all sound like how toxins behave in the human body, artificially I dicing diseass I. Animals has no correlations to human disease as ca. Ben seen with all the physical health deterioration caused by not side effects but effect of drugs created, animal cells and human cells react differently to various chemical, the point of animal experiments was to prevent harm to humans and yet the evidence of short and long term use of those chemical drugs is often dismissed and ignored by doctors who were duped by pharma their drugs were medicine when they actually behave like poisons and cause new disease check out the drugs and the people suffering medication damage conveniently dropped by heath care as they tried to hide all those harmed by the flawed drugs created from very flawed animal experiments, not one measure serontin or dopamine levels in animals or humans for that matter!
@@drdoolittles6145 i bet you got a PhD in neurobiology and yiu can apport so many references about your sentence. A suggestion: write a scientific paper about it. This is not the right place to discuss about how to interpret biomedical data
As far as I'm aware - and I filmed and interviewed the scientist and wrote the script, there are no lies. Simplification, yes. An animal model is just that, a model, not identical, but similar enough to test potential medicines.
how about your graduation in biology? :) try "alzheimer + mice" in the ncbi pubmed, there are as many as 7,000 publications. Choice at least one of them and just READ IT
Oh, sure.. I am an assistant professor of neuroscience, with 17 years experience in animal research and I would never say that "I understand animal research very well". Frankly, I don´t think I´ve ever met any serious colleague who would describe themselves that way and I´ve met many luminaries including three Nobel prize awardees. You just demonstrated that you are a deluded person, both in terms of your self-evaluation and in terms of the conclusion you draw based on your limited knowledge. Dunning-Kruger at its "best".
@@vecernicek2 Hello, how are you? Please, I want to help you. I am a university student majoring in biology. I have research on Alzheimer’s disease, and I have an article about an experiment to treat Alzheimer’s disease, but I did not understand it very well. Can you help me?
![I.N "HALLUCINATION" | [Stray Kids : SKZ-PLAYER]](http://i.ytimg.com/vi/n5B5q1Hwt_U/mqdefault.jpg)
Placing a rodent in a chamber with substrate and marbles views as a very limited habitat. How long before each mouse becomes confused or exibits minor irritability? If you included a wheel food and water, how many overeat or run tenaciously? It is a very interesting article to observe, is there somewhere to find more writing?
Drugs developed using these mouse models have failed in phase III clinical trials (Mangialasche et al., 2010; Braidy et al., 2012; Saraceno et al., 2013). These failures question not only our accurate understanding of the disease (Castellani and Perry, 2012) but also the validity of the animal models upon which the drug discovery efforts are rooted (Windisch, 2014; Nazem et al., 2015).
Agree that not all animal models as useful as others, but we should not use specific failures to condemn all animal models / trials, a subject we addressed here: www.understandinganimalresearch.org.uk/news/communications-media/how-to-distort-0004-of-the-statistics/
Look at all the people suffering from medication damage somehow scientists and doctors seemingly have tried to seep all the damaged lives and deaths of young kids in mental hospitals from the effects of dangerous and very flawed drugs based k. Animal experiments, most antidepressants have the eceects of suicidal thoughts causing Aggression, and metabolic and brain disruption, not in a good way either! The longer people are on them or the more drugs each patient is prescribed at illagl and extreme high doses the sicker the patients become, mental health systems and staff have been in denial for some time of exactly what has been goinf on! Clearly to hide the damage of their drugs or they believed the myth of the Chemical imbalance, what they are doing is causing chemical imbalance, mainly because the drugs act as poisons on the system and they haven't a clue what they're doing because they never do any tests for serontin or doppmaine levels or mri for function or brain chemistry they make a lot of false assumptions, false hypothesis and hide aeevis3nce of harm just as it seems pharma was doi g with their animal experiments! Clever merketong pushed the one side effect they want while they try to minimise the others, when people complain of horroc symtoms doctors tell them to carry on they'll get better! They don't get better they get worse, these drugs have created horrific symtoms and many new disease like akathesia tardive dyskinesia, causes suicides and sudden death! Medicine is not meant to make people sick!
It also raises question to the methods used to assess memory and cognitive impairment in these mouse models.
You can understand Alzheimer's though a music project now, it's called Everywhere at The End Of Time.
could you suggest free articles on this topic please?
thanks for the upload by the way!
Alzheimer's disease is not just defined by its symptoms but by specific proteins that build up in the brain. So, mouse models also develop these protein build-ups, and scientists can better study how to stop this from happening.
You can test different forms of memory and normal/abnormal behaviour in mice - just because it's not in the same way as you would for humans, it still demonstrates changes.
We don't know enough about Alzheimer's & these models help us. They're not perfect, but they help.
I work in an animal cognition laboratory and what I can say is that what you can see in the video is all true. Animals are treat on average better than in many private home. This is due simply because of the standards of the ethical commettee that of course supervises animal laboratories but not private home.
Yes but we've seen the experiments, watching animal behaviour in a false environment doesn't really give any indication of the disease in Humans because we've seen the people damaged by prescribed drugs none more so than antidepressants and antipsychotics that cause movement disorders, metabolic disorders, suicidal thoughts suicides, Aggression and sudden cardiac dsth, these symtoms all sound like how toxins behave in the human body, artificially I dicing diseass I. Animals has no correlations to human disease as ca. Ben seen with all the physical health deterioration caused by not side effects but effect of drugs created, animal cells and human cells react differently to various chemical, the point of animal experiments was to prevent harm to humans and yet the evidence of short and long term use of those chemical drugs is often dismissed and ignored by doctors who were duped by pharma their drugs were medicine when they actually behave like poisons and cause new disease check out the drugs and the people suffering medication damage conveniently dropped by heath care as they tried to hide all those harmed by the flawed drugs created from very flawed animal experiments, not one measure serontin or dopamine levels in animals or humans for that matter!
@@drdoolittles6145 i bet you got a PhD in neurobiology and yiu can apport so many references about your sentence. A suggestion: write a scientific paper about it. This is not the right place to discuss about how to interpret biomedical data
could you suggest free articles on this topic please?
Dear Joshie, tragically thalidomide was not tested on pregnant animals. Regards, Richard, UAR
As far as I'm aware - and I filmed and interviewed the scientist and wrote the script, there are no lies. Simplification, yes. An animal model is just that, a model, not identical, but similar enough to test potential medicines.
how about your graduation in biology? :) try "alzheimer + mice" in the ncbi pubmed, there are as many as 7,000 publications. Choice at least one of them and just READ IT
Too vague 😢
I think I understand animal research very well, it is exceptionally cruel, unjustifiable on any level and should be banned.
Oh, sure.. I am an assistant professor of neuroscience, with 17 years experience in animal research and I would never say that "I understand animal research very well". Frankly, I don´t think I´ve ever met any serious colleague who would describe themselves that way and I´ve met many luminaries including three Nobel prize awardees.
You just demonstrated that you are a deluded person, both in terms of your self-evaluation and in terms of the conclusion you draw based on your limited knowledge. Dunning-Kruger at its "best".
@@vecernicek2 Hello, how are you? Please, I want to help you. I am a university student majoring in biology. I have research on Alzheimer’s disease, and I have an article about an experiment to treat Alzheimer’s disease, but I did not understand it very well. Can you help me?
@@radja1412 did he helped you ?
@@peaceeoutt2875 no he did not
@@radja1412 ohh 🙁
❤️💜