How Do Cilia and Flagella Move?
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- Опубликовано: 9 мар 2020
- xvivo.com/examples/mechanism-...
The XVIVO team collaborated on a project with Dr. Daniela Nicastro, Associate Professor at the University of Texas Southwestern Medical Center. Dr. Nicastro and her research colleagues had completed some complex and ground-breaking research into how cilia and flagella generate their whip-like motion, and they asked XVIVO to help them visualize the results.
Dr. Nicastro’s group used a novel technique to visualize the molecular machines inside flagella to better understand how they work and, in the process, they confirmed a previously unproven hypothesis. Their research showed that flagella get their whip-like motion by a coordinated activation of motor proteins on one side of the flagella and inhibition of motor proteins on the opposing side.
XVIVO was tasked with taking the research results and creating a 3D animation that helped viewers better appreciate how the motor proteins in flagella work. The final animation steps through the process of flagellar beating by diving into the flagella structure and bringing the research to life.
Learn more about this animation in our blog: xvivo.com/blog/activate-inhib... 
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The caption should be "Movement mechanism of flagella", yes Cilia and Flagella have similar internal structure but they differ in their pattern of movement.
You are correct regarding their different movement patterns. This video aims to introduce the Switch-inhibition mechanism shared by cilia and flagella with 9+2 axonemes for beating generation.
the animation is so much better than a verbal approach to understanding this sort of thing thanks
I'm very much overwhelmed to learn in the ways our older generations couldn't even imagine ❤️
Excellent !! plz come again and again with such awosome and appreciable stuff..
This was very Informative and visually appealing!
professional job.! I give you a win medal... thanks for this high level formation..
This kind of stuff absolutely fascinates. It's great to be living in the future.
we live in the present
You lived in the past
Yo this type of shit has been going on for roughly 3.5 billion years
You clearly do not know what "future" is.
Beautiful video, keep uploading such content 😊
That's great work... Thank you
Everything perfect but for a thing: This is the *eukaryotic* flagellum. The bacterial type is totally different. Otherwise, a wonderful, clear and insightful animation.
Appreciate your comment. But when eukaryotic flagella are mentioned together with cilia, the word "eukaryotic" is often omitted for conciseness.
@@jianfenglin7450Well, if conciseness is the key, then all stuff about dyneins and mechanisms so on has no place. However, I still believe it is the best animation available on the issue.
Reading about this in the "Microbiology for Dummies".
The video is very, very helpful.
Good work - thank you!
It's a great job! Thanks!
Do not know what is more amazing: the reality or tha capability of getting to know all this mechanisims by human scientists.
Wow, now I understand! Thanks. Especially the spatio/temporal coordination of Dynein movement is shown perfectly and correctly. There is one little mistake in it though, I think...(And I am only writing this in order to check my own understanding). The system would not work if all activated Dyneins "walked" synchronously, as shown in the animation. Because then the bent would immediately relax when they all let loose at once. Am I wright? Best wishes and thanks again for this beautiful and clear animation.
Excellent! More videos, please!
Great concise visual presentation! Very informative, much appreciated!👍
EXACTLY what I needed. Whoever made this animation is beautiful
But whoever made this machine? It's out of the blue.
@@rabiulhasaneeeWho made the machine? The machine made itself, through genetic mutation and natural selection.
@@intensecutn that's god engineering
@@CherifHadji09 God only exists in your narrow mind.
@@sporksto4372 كي جيك ساعة فماك تفهم شكون لي مخو صغير يا سي طوني
best explanatory video ever
Such a good video thank u sm!
This is a superb video and lucid explanation that gave me new insight into this process and will be useful in my textbook writing in anatomy and physiology. I love seeing this application of cryo-EM to deeper functional insight. However, the video is titled "Mechanism of Cilia," yet speaks only of flagella. It leaves me wondering how much of this translates to, or would be different in, cilia. This is in light of the difference between the corkscrew motion of a sperm tail propelling a mobile cell, versus the cilia on a stationary epithelial cell (as in the trachea or uterine tube) undergoing a stiff power stroke and limp recovery stroke.
greatly animated....❤
Super teaching
Amazing!
Amazing
This is a truly bad-ass video!
WHOAAAA u guys helped me SOOOOO muchhh
Great stuff
Thank you!!!!
Excellent video and description
amazing
Thanks I was wondering how was axoneme a part of flagella
Great help
thank you
Amazingggg❤
Awesome
fantástico...
It kinda moves like snakes...or electric eels. I like it, by the way, I want to see more of it. This is so cool
BEAUTY
Me and my girlfriend will try the mechanism. Thanks!
Animation 💯
perfect>..
Rishab Sir❤
pleaSe include closed caption for HH
Awesome video. Thanks. But I am thinking the opposing side to side firing mechanism illustrated would cause side to side bending, not up and down movement? Correct me if I'm wrong.
Still amazing graphics
Yeah it must beat side to side
WOW !
You can't stop me from moving
Wow
how do atp's provide power, do they have to be there for each tiny, tiny, tiny action, or do they merely 'heat up' The general environment & allow chemistry to do it's thang. ( sic ) ?
lots and lots of ATP
If it depened on action potential
سبحان الله الذي أتقن كل شىء
روعه
What was the bathroom flagellum
breathtaking! The beauty of creation
Nice. But the colour change confused me a little.
Now, how does it know where it's going? It must have programing directing it to a target destination.
sperm chemotaxis
when u typed these letter, your actin and myosin doesnot know where o0r which way too fire, like that, their firing direction is dependant on other aspects of physiology( not brain per-se but chemotaxis or so
@@jeherulislam6903 The movement of sperm is directed by chemotaxis; a biochemical pathway responds to concentration gradients of chemicals released by egg cells. It takes these oocyte-released chemicals as input, and the reactions we see in this video are the outputs. Imagine a simple little robot built to move in the direction of a stimulus (like light); the same thing is happening here. Without the stimulus (chemoattractants), the sperm would presumably just move around in random directions.
Taurus Londoño So basically, the cell can smell where it’s going?
@@FutureAIDev2015 yes, for layman term something like guide by smelling. To understand how it works u need to dig deeper aspects of chemistry.
👌👌👌👌
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Don't the flagella move in a chorkscrew-shaped way making the action potential round?
that's so in prokaryotes, in eukaryotes it's like this
No, you're thinking of bacteria like E-Coli and Salmonella. This is a sperm cell, a eukaryote, totally different organism.
my brother
No rotating motor?
Left me confused. Bacteria have rotary motor coupled to the flagella. Our own cilia are back and forth motion like the one described.
Billions of years allowed life to create such complex systems and integrate them with many others to create living beings on one (or more) planet of this universe. Amazing!
go girl my lion my bear my cilia
If you have ever gotten baked off your ass and watched yo Gabba with a favourite nephew ....You are going too love get baked and watching cellar science animation.
Electromagnetic plasmoid dynamos of the organism that is the Universe transmuted under high pressure not machines!
A powerful example of intelligent design!!
created , no doubt about it
God is amazing. He creates in ways we could never.
The unviese created these things. Universe is the one and only creator. God is just another word for it.
it’s like a biological engine
so we were similar as sperm form??
God is a perfect designer that we can witness even in a fallen world because of sin. Mesmerizing
GOD is the BesT
Result of Intelligent Design and not darwin's evolution.
You should be studying the Bible or such creationism, don't waste time in science.
Fr
سبحان الله
Nature indeed is intelligent at making micro molecular mechanisms
Interesting fact is that these micromachines working on molecular level evolve faster than your “spiritual lot” 😅
Bro it's not that deep 💀
More evidence of Intelligent Design. Molecular machines are the biggest and most blaring evidence of intentional design for an intentional purpose. All glory to the Creator.
Yes say that to a gay
And who created this apparent creator who should be even more complex? If you're gonna say he always existed you have to prove it, as there are way better explanations with concise and plentiful evidence to support evolution and to disprove intelligent design. The intelligent design is a classic example of argument from ignorance.
Amazing!!!