#DNA

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  • Опубликовано: 7 сен 2024
  • Nucleic acids are large biomolecules that are crucial in all cells and viruses.[1] They are composed of nucleotides, which are the monomer components: a 5-carbon sugar, a phosphate group and a nitrogenous base. The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). If the sugar is ribose, the polymer is RNA; if the sugar is deoxyribose, a variant of ribose, the polymer is DNA.Nucleic acids RNA (left) and DNA (right).
    Nucleic acids are chemical compounds that are found in nature. They carry information in cells and make up genetic material. These acids are very common in all living things, where they create, encode, and store information in every living cell of every life-form on Earth. In turn, they send and express that information inside and outside the cell nucleus. From the inner workings of the cell to the young of a living thing, they contain and provide information via the nucleic acid sequence. This gives the RNA and DNA their unmistakable 'ladder-step' order of nucleotides within their molecules. Both play a crucial role in directing protein synthesis.
    Strings of nucleotides are bonded to form spiraling backbones and assembled into chains of bases or base-pairs selected from the five primary, or canonical, nucleobases. RNA usually forms a chain of single bases, whereas DNA forms a chain of base pairs. The bases found in RNA and DNA are: adenine, cytosine, guanine, thymine, and uracil. Thymine occurs only in DNA and uracil only in RNA. Using amino acids and protein synthesis,[2] the specific sequence in DNA of these nucleobase-pairs helps to keep and send coded instructions as genes. In RNA, base-pair sequencing helps to make new proteins that determine most chemical processes of all life forms.Nucleic acid was, partially, first discovered by Friedrich Miescher in 1869 at the University of Tübingen, Germany. He discovered a new substance, which he called nuclein and which - depending on how his results are interpreted in detail - can be seen in modern terms either as a nucleid acid-histon complex or as the actual nucleid acid.[4][5][6] In the early 1880s, Albrecht Kossel further purified the nucleid acid substance and discovered its highly acidic properties. He later also identified the nucleobases. In 1889 Richard Altmann created the term nucleic acid - at that time DNA and RNA were not differentiated.[7] In 1938 Astbury and Bell published the first X-ray diffraction pattern of DNA.[8]
    In 1944 the Avery-MacLeod-McCarty experiment showed that DNA is the carrier of genetic information and in 1953 Watson and Crick proposed the double-helix structure of DNA.[9]
    Experimental studies of nucleic acids constitute a major part of modern biological and medical research, and form a foundation for genome and forensic science, and the biotechnology and pharmaceutical industries.[10][11][12]t.me/Bio9934#n...
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