Ma'am can you please clear one doubt that if 5HT3 antagonist (like ondansetron and alosetron) increase git motility , then why alosetron is used for diarrhoea predominant IBS?
Alosetron is a 5-hydroxytryptamine 3 (5-HT3, serotonin) receptor antagonist that blocks these receptors, thus inhibiting peristalsis and slowing colonic transit time to allow for more water reabsorption to allow for more formed stool. In patients with IBS-D, blockade of these receptors reduces pain, abdominal discomfort, urgency, and diarrhea. It also decreases visceral hypersensitivity by regulating the emotional component of visceral stimulation via diminished blood flow to emotional centers in the brain.
Ma'am can you please clear one doubt that if
5HT3 antagonist (like ondansetron and alosetron) increase git motility , then why alosetron is used for diarrhoea predominant IBS?
Alosetron is a 5-hydroxytryptamine 3 (5-HT3, serotonin) receptor antagonist that blocks these receptors, thus inhibiting peristalsis and slowing colonic transit time to allow for more water reabsorption to allow for more formed stool. In patients with IBS-D, blockade of these receptors reduces pain, abdominal discomfort, urgency, and diarrhea. It also decreases visceral hypersensitivity by regulating the emotional component of visceral stimulation via diminished blood flow to emotional centers in the brain.
Thanks maam
Good morning maam
Mam ecg and abg ka ek concise video..please maam🙏
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