Ewing Sarcoma, a paradigm for cell reprogramming in cancer

Keynote of Prof Olivier Delattre, Institute Curie, Paris France
at the 1st Young Scientist Cancer Congress (YS2C), 05 of october- Toulouse France.
Olivier Delattre, MD, PhD was trained in pediatric oncology and in genetics. His research area mainly investigates the genetic and biology of pediatric cancers. In particular, his laboratory has identified the genetic alterations of a variety of childhood cancers including the EWS-FLI1 rearrangement in Ewing sarcoma, the SMARCB1 inactivation in rhabdoid tumors, the ALK activation mutation in neuroblastoma and the BCOR-CCNB1 fusion in Ewing-like sarcoma. He has also contributed identifying major tumor predisposing mutations or genetic susceptibility factors in neurofibromatosis type II, rhabdoid syndrome predisposition, neuroblastoma and Ewing sarcoma. His lab has also strong interest in deciphering the cellular origin of pediatric cancers and particularly Ewing sarcoma, neuroblastoma and rhabdoid tumors. Globally, the interests of his lab is to further understand the interplay between the genetic abnormalities and the specific background of the cell-of-origin. Olivier Delattre is a member of EMBO since 2011 and of Academia Europea since 2012. He received numerous awards including the Eurocancer award in 2007, Charles Oberlin award in 2009, the Leopold Griffuel award in 2016, the Grand Prix Inserm 2022, and was recently honored by the AACR-St. Baldrick’s Foundation award for outstanding achievement in pediatric cancer research.
Olivier Delattre is Director of the Cancer Biology and Genetics department Inserm U830 and Director of the SIREDO center, a pediatric center of international stature that was created in 2017 at Institut Curie. SIREDO (French for Care, Innovation and research for children, adolescents and young adults with cancer) gathers researchers and physicians in the oncopaediatrics, adolescent and young adult fields to bring new medications to patients as quickly as possible.