Extracellular Matrix and Tumor-Immune Interactions: Challenges & Opportunities | Oncotarget

Oncotarget #published this #trending review on November 7, 2024 in Volume 15, entitled, “Understanding the interplay between extracellular matrix topology and tumor-immune interactions: Challenges and opportunities” by researchers from the Department of Biomedical Engineering, Texas A&M University, College Station, TX; Translational Medical Sciences, Texas A&M University Health Science Center, Houston, TX; Center for Theoretical Biological Physics, Rice University, Houston, TX; Department of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, TX. ‪@tamuhealth‬ ‪@riceuniversity‬ ‪@mdanderson‬
#cancer #cells #tumor #immunotherapy #review #research #openaccess #openscience #peerreview #journal #publication #publishing #meded
DOI - doi.org/10.186...
Correspondence to - Jason T. George - [e-mail]
Abstract
Modern cancer management comprises a variety of treatment strategies. Immunotherapy, while successful at treating many cancer subtypes, is often hindered by tumor immune evasion and T cell exhaustion as a result of an immunosuppressive tumor microenvironment (TME). In solid malignancies, the extracellular matrix (ECM) embedded within the TME plays a central role in T cell recognition and cancer growth by providing structural support and regulating cell behavior. Relative to healthy tissues, tumor associated ECM signatures include increased fiber density and alignment. These and other differentiating features contributed to variation in clinically observed tumor-specific ECM configurations, collectively referred to as Tumor-Associated Collagen Signatures (TACS) 1-3. TACS is associated with disease progression and immune evasion. This review explores our current understanding of how ECM geometry influences the behaviors of both immune cells and tumor cells, which in turn impacts treatment efficacy and cancer evolutionary progression. We discuss the effects of ECM remodeling on cancer cells and T cell behavior and review recent in silico models of cancer-immune interactions.
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Keywords - cancer, ECM, tumor-T cell evolution, tumor microenvironment
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