First Pass Metabolism - Pharmacology Lect 6

First Pass Metabolism: Definition and core concepts. Learn pharmacology with my other videos below:
(1) Pharmacokinetics & ADME: • Pharmacokinetics for S...
DRUG ABSORPTION Videos:
(2) Drug Absorption Overview: • Absorption of Drugs - ...
(3) Bioavailability: • Drug Bioavailability O...
DRUG DISTRIBUTION Videos:
(4) Drug Distribution Overview: • Distribution - Pharmac...
(5) Volume of Distribution: • Volume of Distribution...
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DRUG METABOLISM Videos:
(6) First Pass Metabolism: • First Pass Metabolism ...
(7) Phase I Metabolism: • Phase I Metabolism - P...
(8) Phase II Metabolism: • Phase II Metabolism - ...
(9) First Order and Zero Order Kinetics: • First Order & Zero Ord...
(10) Drug Half-life: • Drug Half-life | An Ov...
(11) First-order elimination rate constant and half-life-details: • First Order Eliminatio...
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DRUG ELIMINATION / EXCRETION
(12) Drug Clearance: • Clearance and Rate of ...
(13) Renal Excretion of Drugs: • Renal Excretion of Dru...
(14) Ion Trapping: [not yet posted]
(15) Dosage Regimens: [not yet posted]
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Factors That Affect Drug Metabolism:
(16) Enzyme Induction: • Enzyme Induction - Pha...
(17) Competitive Inhibition Overview: • Competitive Inhibition...
(18) Competitive Inhibition of Statins: • Competitive Inhibition...
(19) Acetaminophen toxicity (Clinical Correlate): [Not yet posted]
(20) Pharmacogenomics Overview: • Pharmacogenomics | Asi...
(21) Slow Acetylators - Pharmacogenomics: [not yet posted]
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[@LS-gh8sz]

anyone who is doing pharmacy and wants to pass their exam, this is the key video to success. The professor has explained pharmokinetic principles soooooo well!
GREAT STUFF;)

[@taratolbert1857]

Wish we had more teachers like him in pharm school!

[@irumhabib452]

why don't we have good teacher like u in our medical school..where are good teachers?why medical schools don't need them..perfect explanation..thanq sir..highly appreciated..make more videos

[@edenbray7012]

You are amazing! I am writing a pharmacology essay using pharmacokinetics and i have spent the last week researching paracetamol and trying to understand pharmacokinetics in general by reading journal articles and textbooks. FINALLY (being a visual learner) I UNDERSTAAND!!!!!! thanks!!! awesome teacher.

[@taratolbert1857]

This was a great review for my NAPLEX. I had to take a 3 year break before finishing pharmacy school and this was a great summary to jog my memory. Wish we had more teachers like you in school! Please keep up the amazing work!

[@TaraSohrabi]

I am preparing myself to teach drug metabolize tomorrow and reading the book but unable to analyze by myself. Your video and explanation is great and made it very easy to understand the subject. Please do more video.
Thank a lot,
Tara

[@cornelius588]

Rectal drugs inserted lower down avoid first pass metabolism, only when it rises is it subjected to first pass metabolism, there is no distinct point where one point starts and the other ends but generally we say suppositories avoid first pass metabolism

[@noorjahan9584]

Seriously, become personal tutor. That was BRILLIANTLY explained. Thanks a lot Aero!!!
Made Nursing (well the pharmacology sector) soo much Simpler.
Deffo recommend to people!
Noor

[@meltafea868]

love love love your lectures, My coarse for Paramedic Pharmacology is online and the lectures go for 2 hours at a time, your little quarter hour videos are so much better!!!

[@TheSMZ2009]

Thank you so much , for uploading these videos , you have no idea how helpful your explanation is .

[@lizkosin1958]

LOVE your videos! They have helped me understand Pharm so much better. Keep up the good work!!! THANK YOU!!!!!

[@ceero6091]

You saved me with this lecture!~ Thank you! I have now subscribed..... You are my best friend this semester! Just got a B+ on my practice quz. Tomorrow is the test and I feel much more confident with this info!

[@lisahammerle6431]

Wonderful lecture... you have a gift!

[@mr.abdulrahmansaleh8405]

Thank you for your effort. Your structural explanation was amazing, which is high standard of teaching.

[@danypetrix]

GREAT EXPLANATION, CLEAR PRONUNCIATION, KEEP IT UP!

[@dadernator]

I've been looking at a lot of videos and texts and this was the best explanation - thanks!

[@MsJanewalee]

Thank a bunch !!!!!! It is super super good lecture you make it so simple to understand please do more lectures :D

[@JaneLaferla]

Thank you so much for explaining everything is simple terms. it has helped so much in preparing my clinical pharmacology exam

[@georgepraizodhis7313]

Thanks for the excellent presentation of concepts step by step.Saved me in pharmacology class!!

[@onyapidi5174]

Wow, the part about the 2 circulations for once made sense to me! Thanks

[@drabhishekparihar]

Very well illustrated

[@thoreric86]

i might be able to help with that... yes, the main purpose is to 'add in polar group'... addition of hydroxyl group would increase the polarity of the compound... the hydroxylation reaction, overall, is a redox reaction ^^

[@allnaturalsingh6705]

RECTAL bypasses the liver as well, not completely but mostly it does.....

[@nothingspecial1415]

now this makes me love pharmacology. thank you so much, sir. my medlife becomes way easier. i find the last part funny, tho. hahaha. and i needed to repeat the last part of the video bc i could not answer the last 2 Qs. 😂😁

[@mira_150mira8]

Thank you so much sir for these awesome so understandable videos, these are extremely helpful. Please and please keep making more videos.

[@ProfDrThiagoSantana]

Congratulations! I'm a professor and I'm guessing what type of software that you used in the presentation. Thank you for this video.

[@theunderdoc2334]

great overview of liver metabolism! Definitely shared this on my page!

[@bluerain716]

if I don't fail my pharmacology exam tomorrow, it will be because of these videos. :D

[@GeorgeM705]

cheers mate, really really interesting, well presented and easy to be comprehended

[@the_fitdoctor]

youtube saves my life again!!! thx for doing this!!

[@tiffanyedwards5674]

This really helps me understand better. Thanks.

[@xokizza]

wow!... im just looking ahead before nursing to see what im getting into

[@farzanabibi8109]

Understood it better than in the lecture

[@georgerodriguez7433]

Great video you teach in a way that is easy review in my case and easy to under stand as well !😀

[@OJASVIVYAS]

awesome.....thank u soooooooooooooo much...plzz make videos on routes of drug administration also...and plzz continue this process...plzz plzz

[@jhankusona]

Just Superb.helped me a lot.Thanks a lot.please upload more videos.

[@Chatterbox968]

so helpful and easy to comprehend, thank you!!

[@tagordavivi1046]

Thank you so much, this is what I’ve been looking for!

[@andrewsannoh8161]

Hello sir, your videos are really nice. thank you for making them available. when are you going to do lectures 14 and 21? if you have already done it, please share the link. thank you very much for your good work.

[@niallkenny0000]

Thanks for great video, just what i need to simplify stuff.

[@Bindasjhakyass]

Hey what is the bioavailability of the prodrug when given intravenously?

[@michaeladove7269]

Very interesting Video! I wonder what would happen if one takes a medication via the nose.

[@atifahabib4097]

you said first pass include rectal but others say otherwise including wikipedia. WhAT IS CORRECT?

[@imenfdoc1381]

Thanks

[@anoshaangel]

Why dont you post more vds on cology and related medicine vds ur vds help me a lot with my pharmcy exam fpgee thumbs up for u

[@Sherirose1]

Wonderful indeed.

[@manushoganyan6302]

Thank you very much for explaining so clearly!

[@torliber8889]

amazing explanation! top job!

[@rahul61203]

Sir please also provide video for all kind of receptors and their mechanism. ..how drugs bind please sir

[@solarpaneling]

Very clear! Thank you!

[@kapilkafish]

Thank you so much for this video. It was super helpful.

[@Joe-ij1ls]

Awesome video, super helpful.

[@danagreenberg945]

perfect! yes, everything makes sense.

[@beau9207]

Great video, thank you Areo!

[@kerryvp]

Truly wonderful

[@emilydunn6710]

Fantastic video - thankyou so much!!

[@406356690]

thank you, really nice explanation

[@Veeo669]

This was so helpful, thank you!

[@silvergirl6265]

you saved me... thank you so much !!!

[@FrenchCanada1]

Merci beaucoup!

[@emilymah8957]

Excellent!

[@meeeunshin7313]

thank you for great lecture!

[@isaurawhite3300]

I really like these videos! But I have a question: (IN MINUTE 5, 38 SECONDS APROX) Isn't the Superior mesenteric vein the one that gets to the portal vein?

[@fei-gl4kg]

Can I get the reference about definition of first pass metabolism? thank you !!

[@abdullahKhan-ot2ns]

great video

[@mynnzero]

Superb, thank you!

[@aisyahAAZ]

LOL MY LECTURER USED THE EXACT WORDS AND DIAGRAMS ON THIS VIDEO IN HER LECTURE NOTES!!!!

[@samtconn]

these are great!

[@solacasasola]

amazing...many thx

[@asmawazir3408]

great job

[@farshidrazavi7966]

its fantastic

[@JasoniGR]

Don't suppositories avoid undergoing first pass metabolism?

[@mhofmann]

Very nice!

[@AHAASSIRI]

Hi I'm asking about CYT P450, is it responsible for hydroxylation reaction rather than just oxidation-reduction reactions in phase1? Cheers

[@mistyb4987]

very helpful. thank you

[@liyadsalem192]

best

[@MaherKhaldi]

Excellent work ! Thank you and keep the good work up.

[@preranagangawane7907]

Ty for sharing

[@creosotegirl]

Thank you soooooooo much!

[@Dsany783]

Thanks!

[@abbysingh1]

great video.. thanks a lot...! :)

[@rahul61203]

Got it thanx...

[@sylviakazi5629]

thanks a lot

[@gevetteocasio6840]

awesome

[@hamzeali6081]

Can i get answers?

[@soneelita]

PLIZ DO MORE VIDEOS

[@melina7916]

I hope it will help me pass my pharmacology exam tomorrow😭😂

[@krishnareddy-jx8ep]

Excellent

[@americanbee]

why you are not teaching at my school?? :))

[@HafizahHoshni]

Thanks XD

[@AHAASSIRI]

Hi

[@rahul61203]

How to subscribe you

[@user-zs4gb4sp2m]

just click on subscribe botton

[@ashaali7198]

Thanks