In the beginning of the lecture around 3:00 time stamp, pin point constricted pupils diff diagnosis, someone said antipsychotics. How does antipsychotics give pinpoint pupils when they usually have anticholinergic actions on the side?
@haywire ...Many antipsychotics, particularly the older typical antipsychotics, have anticholinergic properties.. While anticholinergic effects more commonly cause mydriasis (pupil dilation), in some cases, they can paradoxically result in miosis. This is due to the complex interactions of neurotransmitters in the central nervous system. Alpha-Adrenergic Blockade Some antipsychotics, such as chlorpromazine and thioridazine, also block alpha-adrenergic receptors. The blockade of alpha-1 adrenergic receptors can lead to miosis. This occurs because alpha-1 receptors normally mediate the contraction of the dilator pupillae muscle (which dilates the pupil). When these receptors are blocked, the constrictor pupillae muscle, which is controlled by the parasympathetic nervous system, predominates, resulting in pupil constriction. it depends on which antipsychotic is in use
@levo..As such there is no role. However if excessive poison intake then there can be marked coagulpothy with severely deranged inr,appt platelets. Here we may hv to give FFP. Also before doing procedure
In the beginning of the lecture around 3:00 time stamp, pin point constricted pupils diff diagnosis, someone said antipsychotics. How does antipsychotics give pinpoint pupils when they usually have anticholinergic actions on the side?
@haywire ...Many antipsychotics, particularly the older typical antipsychotics, have anticholinergic properties.. While anticholinergic effects more commonly cause mydriasis (pupil dilation), in some cases, they can paradoxically result in miosis. This is due to the complex interactions of neurotransmitters in the central nervous system.
Alpha-Adrenergic Blockade
Some antipsychotics, such as chlorpromazine and thioridazine, also block alpha-adrenergic receptors. The blockade of alpha-1 adrenergic receptors can lead to miosis. This occurs because alpha-1 receptors normally mediate the contraction of the dilator pupillae muscle (which dilates the pupil). When these receptors are blocked, the constrictor pupillae muscle, which is controlled by the parasympathetic nervous system, predominates, resulting in pupil constriction.
it depends on which antipsychotic is in use
Sir is there any role of FFP transfusions in OP compound poisoning
@levo..As such there is no role. However if excessive poison intake then there can be marked coagulpothy with severely deranged inr,appt platelets. Here we may hv to give FFP. Also before doing procedure