Let’s all endeavour to help those in need. We can all play our part even if it is something small. It is said that if we see someone in need and do nothing it is a sin. Let’s all show our love for one another and for our our Lord Jesus Christ!!
Great question. A score of 0 for ER (estrogen receptor) and PR (progesterone receptor) means the tumor tested negative for these receptors. This indicates that hormonal therapies are not likely to be offered.
im confused please help,, if the amount of estrogen in the body doesnt matter,,WHY are all the drugs geared to slow or shut down the ovaries from making estrogen,,thank you
It's understandable that this is confusing. The distinction is that one's own level of estrogen is not related to having breast cancer. Sometimes people tell us that they believe they have "too much estrogen" in their body as if there is something wrong with them. That is not the case. There is a normal physiologic level of estrogen. When treating breast cancer, however, we do either block estrogen (tamoxifen) or decrease the production of estrogen (aromatase inhibitors). This basically uses the fact that doing so will decrease the risk of cancer coming back or developing in the first place or decrease the amount of cancer in the body for many people with metastatic breast cancer. But none of this is related to how much estrogen your body makes. We hope this helps!
@Yerbba - Breast Cancer Apologies, for asking, just I am feeling a little unsure and scared. I am living in a Foreign Country and about to start treatments after lumpectomy. I was just looking through your questions and saw you answered a question that sounded similar to my questions. I found the lump on Dec. 22nd which turned out to be HER2 HR+ and PR+ with a 2.2cm tumor, I had a lumpectomy which confirmed the findings, and six lymph nodes were removed one confirmed... I don't know, I am in a foreign country and am not fluent. Does this sound reasonable to you? 1. Lumpectomy - Check 2. Six Sessions of Chemo with Trastuzumab - starts June 9th 3. Six Sessions of Radiotherapy 4. Six Sessions of Trastuzumab 5. Five Years of treatment you mentioned
Thanks for your question. This overall approach is in line with what the data from multiple studies would support. In other words, without knowing all of the details, the quality of your care appears to be excellent.
Madam In core needle biopsy, the pr status is positive and in surgical specimen negative. Kindly advise which report is accurate and correct and what to do.
What food to avoid when ur breast cancer was ER PR positive and her2 negative. I am done with chemo surgery and radiations. It’s just finished. I want to focus on safe food. Any suggestions pls 🙏
Thanks for your question. In general, the guidance about diet after breast cancer is the same as with other health conditions. We recommend avoiding alcohol, eating a lot of fruits and vegetables, and keeping portion sizes for meat smaller than many of us eat. There are no specific foods that you need to avoid. Everything in moderation is also good guidance.
@@mehvishaftab6687 Hi Doll, hope all is well. I was diagnosed with the same last week. I'm trying to figure out what treatment options are best, I don't want to DO the hormonal therapy at all. The side effects are horrible. I rather them zap it and keep it moving. I'm not sure whats the best option for me yet. I'm 44 and just did the genetic testing yesterday. I wish you the best of luck! God bless you all❤
Thanks for the question. Technically, this is not a triple-negative breast cancer because the PR is positive. We do tend to offer more treatment to people with ER-negative, PR-positive disease than in people with breast cancer that is both ER and PR positive.
im stage 2b breast cancer er-pr+her2- i finish 6 cycle chemo but i have no maintenance because im er- my onco said im considered tripple negative im so worried
Whether you can work during chemotherapy varies greatly depending on your individual reaction to the treatment and the nature of your job. Rest is important, but many continue to work as they feel able. We have a video on this topic you may find helpful: ruclips.net/video/4q-Cu3RwOMw/видео.html.
i dont mean to be off topic but does someone know a method to log back into an instagram account..? I was dumb lost my account password. I would appreciate any tricks you can give me
@Aaron Bobby Thanks for your reply. I got to the site through google and Im in the hacking process now. I see it takes quite some time so I will get back to you later when my account password hopefully is recovered.
Hi, my mother is ER positive allred score 8. PR positive allred score 7. Her2 positive 2.60 sigmal strength. Would trastuzumab and pertuzumab added to chemotherapy for 6 cycle benefit her.
If the pathology lab is interpreting this as a HER2-positive tumor, we generally do recommend chemotherapy with trastuzumab. The particular treatment depends on the size of the tumor and the status and number of lymph nodes that are positive.
I was told that my breast cancer was 2% estrogen receptor positive but I want to have another baby. Will I likely have to take tamoxifen for such a low positive? TIA
The decision about tamoxifen will be based on your risk of the cancer coming back, but in general, the desire to have another child will outweigh the benefits of tamoxifen in your case. Please talk this over with your medical team and let them know your wishes.
My biopsy showed Er weak positive and pr negative. Her2 negative. Since lumpectomy the pathology on the tumor said Er,Pr,her2 all negative. How can 4 sites on biopsy stain er +, but the excised tumor shows er-. ? I thought we had a treatment course all plotted out but now I'm totally lost as to what we will be doing. Triple negative is quite different than er positive treatment wise. ☹️😢
With a low level of estrogen receptors, it is not surprising that other parts of the tumor are ER-negative. We do see differences between the biopsy specimen and the surgical specimen frequently enough that this is not surprising. Wishing you the best as you sort out both the treatment plan and your own emotional response to everything going on.
People with this type of cancer will generally be offered chemotherapy and HER2-targeted therapy. This can include medications like trastuzumab (Herceptin), pertuzumab (Perjeta), and other HER2-targeted therapies. It's best to discuss your specific case with your oncologist to understand the best treatment plan for you.
What about er allred score 4 .pr score 3 .her 2 was negative.this was a lobular cancer. It was mentioned er focal weak positive and pr weak positive .since for lobular is this rare because usually er most ppl have high estrogen but in this case the allred score is low.is this considered like triple neg. Neo adjuvant chemo did not have any effect on the tumour it remained same size
Great question. The ER and PR would have to be negative, along with the HER2, for it to be triple-negative. You are right--ER and PR being low is uncommon for lobular carcinoma. We are wishing you the best through your treatment and beyond.
Thank you for writing. Chemotherapy before surgery is often given in people who have a so-called "triple negative" tumor. It can be so gratifying to see the tumor get smaller while you're on chemotherapy. It can take several weeks to see a difference, so don't worry if it doesn't seem to be getting smaller.
I have exactly same as you do have, I will hear sentence tomorrow from oncologist for if I will have chemo. May we contact to each other for how are we doing? How long your chemo takes? Runmei
Why are some cancers automatically treated with surgery first instead of chemo, surgery and then radiation. March 2024 diagnosed Er/Pr+ her2-. The red devil was brutal. Just curious!
The decision to use chemotherapy first vs. surgery first is based on several factors. You may find our video on neoadjuvant therapy to be helpful: ruclips.net/video/VinrBHrblY8/видео.html
Thank you so much for your video, learned a lot! I am now 46 years old and diagnosed with multifocal micro-invasive cancer with high-grade DCIS, (pT1mi(m)pN0(sn)), ER-negative, PR positive 5%, HER2 positive, left mastectomy, no chemotherapy, and radiotherapy. May I ask if a PR positive 5% benefit is only 5%, considering the side effects, especially the stroke (my mother died of a stroke), is it worth taking it for 5 years? Does not eating increase the risk of relapse? Does HER2-positive require treatment? Hope you can give some advice, thanks a lot!
The benefits of hormonal (also called endocrine) therapy depend on several things, specifically what type of surgery a person has had. If there is remaining breast tissue (because the person had a lumpectomy), there's more benefit to taking endocrine therapy, but the benefit is still quite small in people with DCIS. If someone wants to feel that they are doing "everything," we offer endocrine therapy. If the side effects are not manageable or if there is a reason not to use endocrine therapy, not taking it is also an option. Trastuzumab (Herceptin) is not used in the treatment of DCIS.
@@yerbba Thanks Reply! I had a left mastectomy and currently no endocrine therapy. Does multifocal micro invasion (more than 20) require chemotherapy? Will it be beneficial? Thanks again!
As with any medication, as long as you are on it, the side effects can be present. With tamoxifen, side effects tend to be the worst at 3 months but will often persist. Letting your medical team know about your side effects is therefore important because we can make changes to the medication and also help manage some of the side effects.
Hi Lucille - ER-positive tumors are considered hormone receptor-positive even if the PR is negative. In general, these tumors respond well to treatment with hormone therapy (with or without ovarian function suppression if the person is premenopausal). We do see higher “recurrence” scores in people whose tumors are PR-negative, suggesting that chemotherapy may be considered more frequently in tumors that are PR-negative. Because the prognosis is excellent, however, we generally do not consider PR-negative tumors to be aggressive.
Yes, I can not find any information about this as well. I am Er+ PR- Her 2 - Can you make a video on mammaprint and blue print? I scored high risk luminal B
@@ms.kathleencurry7220hi I am from Ireland I am the same. I am 35 breastfeed all my kids. Do not drink alcohol and still got breast cancer with no family history of it. I feel so alone because I don’t know anyone with the same type as me. I am due for left breast removal next week. I am a 2cm and 7mm tumour, so far from what they can see its not in my nodes
Hi! my mom is diagnosed with stage 1 breast CA. She had already undergone mastectomy. ER positive/ PR negative/ Her2 negative. she is 67 years old. What will be the best treatment option?
There are quite a few factors that help us make treatment recommendations. Without knowing your mother or other details of the tumor, it is not possible for us to make recommendations. If your mother lives in the US, she can use a Yerbba report from www.yerbba.com to get more information on specific diagnoses and treatment options.
Thanks for being part of this conversation 🌷💝🌷💝 god bless
And thank you!
Let’s all endeavour to help those in need. We can all play our part even if it is something small. It is said that if we see someone in need and do nothing it is a sin. Let’s all show our love for one another and for our our Lord Jesus Christ!!
Thanks for watching.
Thank you for your continuous support.
Thank-you so very much! Dr.Griggs, because I am +,+,- I, am ER, PR positive and HERS2-Negative
Thank you for watching and we wish you the best!
Estrogen Receptor : Percentage of tumor cells with nuclear positivity 81-90%. Allred score - 8/8.
Progesterone Receptor: Percentage of tumor cells with nuclear positivity 51-60%. Allred score - 7/8.
Her2neu: Negative.
Thanks for sharing your story with the Yerbba community. High levels of ER and PR predict for a good response to endocrine therapy.
j
Whats the meaning of er pr negative score 0
Great question. A score of 0 for ER (estrogen receptor) and PR (progesterone receptor) means the tumor tested negative for these receptors. This indicates that hormonal therapies are not likely to be offered.
im confused please help,, if the amount of estrogen in the body doesnt matter,,WHY are all the drugs geared to slow or shut down the ovaries from making estrogen,,thank you
It's understandable that this is confusing. The distinction is that one's own level of estrogen is not related to having breast cancer. Sometimes people tell us that they believe they have "too much estrogen" in their body as if there is something wrong with them. That is not the case. There is a normal physiologic level of estrogen. When treating breast cancer, however, we do either block estrogen (tamoxifen) or decrease the production of estrogen (aromatase inhibitors). This basically uses the fact that doing so will decrease the risk of cancer coming back or developing in the first place or decrease the amount of cancer in the body for many people with metastatic breast cancer. But none of this is related to how much estrogen your body makes. We hope this helps!
Outstanding information 🌺
Thanks for watching and your positive feedback!
@Yerbba - Breast Cancer Apologies, for asking, just I am feeling a little unsure and scared. I am living in a Foreign Country and about to start treatments after lumpectomy.
I was just looking through your questions and saw you answered a question that sounded similar to my questions.
I found the lump on Dec. 22nd which turned out to be HER2 HR+ and PR+ with a 2.2cm tumor, I had a lumpectomy which confirmed the findings, and six lymph nodes were removed one confirmed... I don't know, I am in a foreign country and am not fluent.
Does this sound reasonable to you?
1. Lumpectomy - Check
2. Six Sessions of Chemo with Trastuzumab - starts June 9th
3. Six Sessions of Radiotherapy
4. Six Sessions of Trastuzumab
5. Five Years of treatment you mentioned
Thanks for your question. This overall approach is in line with what the data from multiple studies would support. In other words, without knowing all of the details, the quality of your care appears to be excellent.
😊
Mmk
😮
😮
Madam
In core needle biopsy, the pr status is positive and in surgical specimen negative. Kindly advise which report is accurate and correct and what to do.
Thanks for writing. In a case like this, we usually work with the pathologist to help us decide which is more accurate.
Very good explanation Madam 🙏
Thank you
What food to avoid when ur breast cancer was ER PR positive and her2 negative. I am done with chemo surgery and radiations. It’s just finished. I want to focus on safe food. Any suggestions pls 🙏
Thanks for your question. In general, the guidance about diet after breast cancer is the same as with other health conditions. We recommend avoiding alcohol, eating a lot of fruits and vegetables, and keeping portion sizes for meat smaller than many of us eat. There are no specific foods that you need to avoid. Everything in moderation is also good guidance.
Hello sumiti
How r u feeling now
Mine r same breast cancer just recently diagnosed r u cancer free now
@@mehvishaftab6687 Hi Doll, hope all is well. I was diagnosed with the same last week. I'm trying to figure out what treatment options are best, I don't want to DO the hormonal therapy at all. The side effects are horrible. I rather them zap it and keep it moving. I'm not sure whats the best option for me yet. I'm 44 and just did the genetic testing yesterday. I wish you the best of luck! God bless you all❤
high mam im er-pr+her2- is considered tripple negative or not
Thanks for the question. Technically, this is not a triple-negative breast cancer because the PR is positive. We do tend to offer more treatment to people with ER-negative, PR-positive disease than in people with breast cancer that is both ER and PR positive.
@@yerbba is there any chance to get cured??
im stage 2b breast cancer er-pr+her2- i finish 6 cycle chemo but i have no maintenance because im er- my onco said im considered tripple negative im so worried
If you have chemo.. can you still work if your on chemo theraphy or stay rest
Whether you can work during chemotherapy varies greatly depending on your individual reaction to the treatment and the nature of your job. Rest is important, but many continue to work as they feel able. We have a video on this topic you may find helpful: ruclips.net/video/4q-Cu3RwOMw/видео.html.
Please discuss triple negative breast cancer for someone age 69 and the survival rate.
We have a Triple-Negative breast cancer video slated to come out in a few weeks!
Love your channel, music is distracting in this video though.❤️😊
Much appreciated. I’ve passed your suggestion to our editor ❤️🤗
i dont mean to be off topic but does someone know a method to log back into an instagram account..?
I was dumb lost my account password. I would appreciate any tricks you can give me
@Reece Andrew instablaster ;)
@Aaron Bobby Thanks for your reply. I got to the site through google and Im in the hacking process now.
I see it takes quite some time so I will get back to you later when my account password hopefully is recovered.
@Aaron Bobby It worked and I finally got access to my account again. I am so happy:D
Thanks so much you really help me out !
Hi, my mother is ER positive allred score 8. PR positive allred score 7. Her2 positive 2.60 sigmal strength. Would trastuzumab and pertuzumab added to chemotherapy for 6 cycle benefit her.
If the pathology lab is interpreting this as a HER2-positive tumor, we generally do recommend chemotherapy with trastuzumab. The particular treatment depends on the size of the tumor and the status and number of lymph nodes that are positive.
Good video 💯
Thank you for watching.
I was told that my breast cancer was 2% estrogen receptor positive but I want to have another baby. Will I likely have to take tamoxifen for such a low positive? TIA
The decision about tamoxifen will be based on your risk of the cancer coming back, but in general, the desire to have another child will outweigh the benefits of tamoxifen in your case. Please talk this over with your medical team and let them know your wishes.
My biopsy showed Er weak positive and pr negative. Her2 negative. Since lumpectomy the pathology on the tumor said Er,Pr,her2 all negative. How can 4 sites on biopsy stain er +, but the excised tumor shows er-. ? I thought we had a treatment course all plotted out but now I'm totally lost as to what we will be doing. Triple negative is quite different than er positive treatment wise. ☹️😢
With a low level of estrogen receptors, it is not surprising that other parts of the tumor are ER-negative. We do see differences between the biopsy specimen and the surgical specimen frequently enough that this is not surprising. Wishing you the best as you sort out both the treatment plan and your own emotional response to everything going on.
If Estrogen negative progesterone negative but Her2 postive what will happen mam??
People with this type of cancer will generally be offered chemotherapy and HER2-targeted therapy. This can include medications like trastuzumab (Herceptin), pertuzumab (Perjeta), and other HER2-targeted therapies. It's best to discuss your specific case with your oncologist to understand the best treatment plan for you.
Hi iam stage 4 breast cance I have ER + PR+ and her2-.
We hope that things are moving in the right direction for you.
tisaykuno How is now hope you are good
What about er allred score 4 .pr score 3 .her 2 was negative.this was a lobular cancer. It was mentioned er focal weak positive and pr weak positive
.since for lobular is this rare because usually er most ppl have high estrogen but in this case the allred score is low.is this considered like triple neg. Neo adjuvant chemo did not have any effect on the tumour it remained same size
Great question. The ER and PR would have to be negative, along with the HER2, for it to be triple-negative. You are right--ER and PR being low is uncommon for lobular carcinoma. We are wishing you the best through your treatment and beyond.
Mine is ER negative/ PR negative/ Her 2 negative....I am going through Chemo before surgery...I am 46 years old
Thank you for writing. Chemotherapy before surgery is often given in people who have a so-called "triple negative" tumor. It can be so gratifying to see the tumor get smaller while you're on chemotherapy. It can take several weeks to see a difference, so don't worry if it doesn't seem to be getting smaller.
I have exactly same as you do have, I will hear sentence tomorrow from oncologist for if I will have chemo. May we contact to each other for how are we doing? How long your chemo takes? Runmei
Why are some cancers automatically treated with surgery first instead of chemo, surgery and then radiation. March 2024 diagnosed Er/Pr+ her2-. The red devil was brutal. Just curious!
The decision to use chemotherapy first vs. surgery first is based on several factors. You may find our video on neoadjuvant therapy to be helpful: ruclips.net/video/VinrBHrblY8/видео.html
Thank you so much for your video, learned a lot! I am now 46 years old and diagnosed with multifocal micro-invasive cancer with high-grade DCIS, (pT1mi(m)pN0(sn)), ER-negative, PR positive 5%, HER2 positive, left mastectomy, no chemotherapy, and radiotherapy. May I ask if a PR positive 5% benefit is only 5%, considering the side effects, especially the stroke (my mother died of a stroke), is it worth taking it for 5 years? Does not eating increase the risk of relapse? Does HER2-positive require treatment? Hope you can give some advice, thanks a lot!
The benefits of hormonal (also called endocrine) therapy depend on several things, specifically what type of surgery a person has had. If there is remaining breast tissue (because the person had a lumpectomy), there's more benefit to taking endocrine therapy, but the benefit is still quite small in people with DCIS. If someone wants to feel that they are doing "everything," we offer endocrine therapy. If the side effects are not manageable or if there is a reason not to use endocrine therapy, not taking it is also an option. Trastuzumab (Herceptin) is not used in the treatment of DCIS.
@@yerbba Thanks Reply! I had a left mastectomy and currently no endocrine therapy. Does multifocal micro invasion (more than 20) require chemotherapy? Will it be beneficial? Thanks again!
Wait.. are these side effects for the 5 to 10 years of taking the pill???
As with any medication, as long as you are on it, the side effects can be present. With tamoxifen, side effects tend to be the worst at 3 months but will often persist. Letting your medical team know about your side effects is therefore important because we can make changes to the medication and also help manage some of the side effects.
@@yerbba and is it a must? I dont want to be suffering after cancer is gone :(
What if you have ER positive PR negative HER2 negative? No one ever mentions this type. Is this more aggressive?
Hi Lucille - ER-positive tumors are considered hormone receptor-positive even if the PR is negative. In general, these tumors respond well to treatment with hormone therapy (with or without ovarian function suppression if the person is premenopausal). We do see higher “recurrence” scores in people whose tumors are PR-negative, suggesting that chemotherapy may be considered more frequently in tumors that are PR-negative. Because the prognosis is excellent, however, we generally do not consider PR-negative tumors to be aggressive.
@@yerbba thank you. It was so hard to find any information on this.
Yes, I can not find any information about this as well. I am Er+ PR- Her 2 -
Can you make a video on mammaprint and blue print? I scored high risk luminal B
@@ms.kathleencurry7220hi I am from Ireland I am the same. I am 35 breastfeed all my kids. Do not drink alcohol and still got breast cancer with no family history of it. I feel so alone because I don’t know anyone with the same type as me. I am due for left breast removal next week. I am a 2cm and 7mm tumour, so far from what they can see its not in my nodes
@@siofra3819Hope you had a successful surgery and recovery.
Hi! my mom is diagnosed with stage 1 breast CA.
She had already undergone mastectomy.
ER positive/ PR negative/ Her2 negative.
she is 67 years old.
What will be the best treatment option?
There are quite a few factors that help us make treatment recommendations. Without knowing your mother or other details of the tumor, it is not possible for us to make recommendations. If your mother lives in the US, she can use a Yerbba report from www.yerbba.com to get more information on specific diagnoses and treatment options.