Dr. David Sinclair with Dr. Lee Hood: Why We Age--And Why We Don't Have To
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- Опубликовано: 22 июл 2024
- Is aging a disease? How old does your body say it is? How can we live longer, healthier lives? Dr. David Sinclair, Harvard professor of genetics and bestselling author, joins ISB co-founder and genomics pioneer Dr. Lee Hood for a conversation about the very latest in aging research.
David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics, Blavatnik Insitute, and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He has published over 200 scientific papers, is a co-inventor on over 50 patents, and is the New York Times bestselling author of Lifespan. He serves as co-chief editor of the scientific journal Aging. In 2018, he became an Officer of the Order of Australia (AO).
Lee Hood, MD, PhD is a world-renowned scientist. Dr. Lee Hood co-founded Seattle’s Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000-2017. In 2016, ISB affiliated with Providence, and Dr. Hood became Providence’s Senior Vice President and Chief Science Officer. He is also Chief Strategy Officer and Professor at ISB. He is a member of the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine.
This is what the internet was made for. Thank you for hosting and uploading.
Internet was made so that Russian hackers can mess up the US economy and Trump can become a Demi God and promote his cult. Any questions?
Wow,🕺🕺 Thanks to these two wonderful men, happy to be part of their conversation.
Most appreciated💖
So excited💖
I had tears in my eyes at the end of the interview...
Looking forward to hearing more about the molecule results, new book and a big Thank you to Dr Sinclair.
So proud of him for humanity🙏🙏🙏💙💙💙🦋🦋🦋
I like David Sinclair for sure. I'm totally interested in staying alive much longer and have tons of new hope about longevity. It cracks me up when he talks like a mad scientist though hehe.
How much longer?
David Sinclair IS a mad scientist
@@sleepsmartsmashstress8705 In a gud way...lol
Lee (Leroy) Hood revolutionized methods and instruments to analyze proteins and nuclei acids,, He, if anyone, could come up with ways to quickly measure the methylome., NAD etc I would highly recommend following his ISB ( Science transformation health ) program . Lee is a legend in molecular biology, and most of all a doer who makes his ideas become real applications !!
Great interview, Dr Lee Wood directed this very well with great questions and didn't interrupt and Dr Sinclair is doing a great job on improving humanity in the field of longevity, we have a bright future ahead!
It is always nice to listen Davi Sinclair, him with some other great scientist are bringing more awareness for a healthy lifestyle by bringing the high technical scientific knowledge to the general public. Thank you!
I agree .. he is amazing person, speaks clear and its easy to comprehend!!!
I am waiting for David's new book. I am taking NMN, fisetin, jiaogulan, and resveratrol., exercising, eating high quality food but not too much and doing periodic fasting.
what is NMN and fisetinm jiao gulan?
Dr. Sinclair he explain simple . Fan #1.
Thank you most interesting and knowledgeable.
Really interesting. If you just look at David and see how young he looks, it really makes you want to change.
Are you now deciding to become so superficial and start to go after looks, Remember beauty is only skin deep. But in your defence good skin also goes with good brain. Both are ectodermal in origin. So if you can keep your skin glistening smooth without use of creams it means your brain is in good shape too. You might notice vegans having great looking skin. I can actually tell if someone is a vegan by their skin suppleness. So do the work to get "the looks?
@@sleepsmartsmashstress740 Maybe I didn't explain myself well. But when I had heard what he eats lots of vegetables, he stopped eating desserts, sometimes bit of fish etc and recently more interested in olive oil in other interviews, I tried it myself. And he looks better than he used to. I stopped taking diary, eat veg daily although I am no vegan. Still eat bit of chicken and fish but since the change, I feel much better and my skin is looking better although I need to keep it hydrated with creams. So, I can say when I saw how much better he was looking by time, it does make you want to change. I did.
He doesn't look young he looks like a wimpy looking man in his late 50's
@@jackcambric8480 you desperately need GLASSES 🤓👓🤓
He looks like a fragile man with stain hair.
Please Dr. David Sinclair.. Please do something quick.. I really love my parents alot..☹️🙏Love from India..
Actually Dr. Hood right here is a good example of successful aging as exemplified by his sharp mind and concise language.
Dr. Sinclair is surprisingly humble when talking about how long hoping to live, at least verbally, a stark contrast to his huge efforts and achievement in the area of aging research. This contrast made me wonder.
Great work... Great having people popularising cutting edge science in such a popular way. Bioinfomatics sounds like a great tool for medical studies massively opening up avenues for research. Dr Sinclair reminds me of the scientists and doctors that Bill Bryson talks about in The Body. Not quite as extreme. All very interesting. Cold showers and missing out breakfast occasionally for me :) Look forward to human studies. Controversial topic so it will be interesting how it develops.
Absorbed every word, David Sinclair thank you for existing!
We are eternal. I am 86 and I like you to read a little poem that I composed some fifty years ago. The title is ETERNITY and goes like this: I was the sky and I was the sea, I was the wind and I was the tree. For this reason I know, that I was, that I am, and after I die, through the atoms of my body, in a million forms and in millions of millennia, I will always be. Life is like a vacation, short or long, that we should enjoy in full. Italians have an expression: to pay and to die, as late as possible. I am sure that your acquired knowledge about growing young , helps the people of the world.
So happy I discovered David Sinclair's work at my age. I started taking NAD+ and resveratrol since I've been 25, and was fasting since 18. Love that fasting is actually being studied scientifically now. Fun Fact:
Kombucha can also help promote the production of NAD+ in the body, that's probably why it's called "the tea of eternal life"
Y muchos, de nuestros mayores se puedan beneficiar de medicamentos, etc. Lo que encuentren, para retardar el envejecimiento, o incluso; curarlo.
I can't seem to find the longevity's biological age test. Can anyone send a link? Thank you. PS: Great conversation, thank you both.
Dr.sinclesr the best🤗
The title photo of Dr Sinclair made me want to check out what the mad scientist pouring blue juice on his feet was up to. Looks like he makes super villains in a lab..that said, I take dhea on his (evil) suggestion and love it.
Excellente cientifico, ojalá se cumolan muchas averiguaciones, de las que va ejerciendo; para lograr un futuro mejor, mas longevo, y menos enfermedades, que nos afectan mundislmente. Saludos desde Las Islas Canarias, España.
David,
Try a 10 day fast. Only distilled water.
It will do a lot. I like doing it. Fasting is just part of my life.
Sounds like David Sinclairs new book about "the treadmill" is the same as Eric Edmeads hypothesis "the evolution gab". It will be very interesting to read about it from a scientists perspective!
What do you think of (Max) Gerson therapy/lifestyle?
I am interested in the Horvath Clock measurement. What will it be called?
Poner su títulos en español, gracias
There are two broad types of people namely those who move a lot and those who move very little. First, two types of young people emerge namely one that plays a lot and the rest who do not, told not to, or prevented from play. Then two types of adults are made namely one that exercises and one that just pass day by day. The elderly follow the human instinct or advice of doctors to start slow movements. In all cases, gradual degradation of muscular buildup can be slowed, maintained or reversed by incremental intensity of physical exercises in order to avoid injuries and discomforting muscle sores afterwards.
Has there been any new information about NMN's effect on cancer cells that are already in the body?
Yes, you may find this useful ruclips.net/video/-04-1OX4RVM/видео.html
David Sinclair in one of few who is a testament to his finding……he looks 22 lol
He looks younger by the day!’
Your are delusional.
If it biology retains a blueprint for resetting or health then there is an access point to enable it without external medical intervention. It understanding is that of infants on how the miracle of the human body exists and thrives. Indigenous cultures understand it differently, non scientifically, we Need to collaborate if their approach and enable self healing.
Eating less often
Muscle mass maintaining
Resveratrol
MNM
Did i forget anythig?
Honestly, I just don't want to be a wrinkly grey-haired useless woman who can’t remember stuff in my ripe age. If I can get older and be able to sustain my body slowing down aging or even biologically reverse aging to my prime, that is ideal. Obviously, nobody can live forever, but I feel like we can live a lot longer, so why not slow our age rather than age slowing us down? This is why I am constantly taking Dr. Sinclair’s NMN, a NAD booster and indeed a health provider. With NMN Vitruvin Nutrition (500mg) a day every morning with protein drink and Greek yogurt, it has radically changed everything. All sorts of problems have disappeared. Now, age is just a number.
As we age, joint movement becomes stiffer and less flexible because the amount of lubricating fluid inside our joints decreases and the cartilage becomes thinner. This is very common to elderly as they age 45 and above. In order to keep your bones and joints strong as you age, regular walking will help tone the leg muscles, build strength and improve circulation. Experts recommend walking for a minimum of 30 minutes, at least 5 times a week. Running, swimming, jogging, biking, trekking, leg strengthening exercises a few times a week may also help. Accompany your exercise with NMN by Vitruvin Nutrition. NMN supplementation increases the endurance performance of middle-aged people improving aerobic capacity. I will be 75 on my next birthday and I am still fit as a fiddle.
I have a small spot on my lung. Can taking NMN and/or Resveratrol cause that cancer to grow?
Hi @JoeCampbell first sorry to hear for your small spot on your lung.
Were you on these molecules or planning to begin to those molecules , with the spot on your lung..
Generally they reply specially if you e mail them.
Pls let me know the result ,if you hear anything .
Wish you a speedy recovery , will be praying for you🙏💙
@@semaaral2498 thanks for your concern. I have been taking NMN and Resveratrol since reading Dr. Sinclair's book over a year ago. I stopped a month ago when I first heard about a potential problem. I just got back my catscan with a no change diagnosis from my Doctor. I think I will wait for more research before beginning again. I exercise daily, intermittent fasting, and continue to eat healthy.
@@lovely7983 What is the difference between daily Intermittent Fasting (time restricted feeding window) and/or KETO (or low carb) with Dr. Longo’s Fasting Mimicking Diet?
I’ve been doing daily intermittent fasting, sometimes OMAD and a healthy version of KETO/ Low Carb (including most non starchy veggies and occasionally berries). I now know that for most people longer fasts than just 16 to 23 hours are necessary for AUTOPHAGY (self cleansing of toxic/ pre or cancerous cells) to kick in... Does anyone have links to direct information about how Longo’s Fasting Mimicking diet relates to this?
@@lovely7983 👏👏 Thank you for your great synopsis. You have a wealth of information on this topic and explain things very well! 🤩
I love M&M TOO!
does clone animals have the same aging process compared to its host? is there a way for a mature brain transplanted to a clone? thanks.
The cloned animals age faster than natural bread counterparts.Mature brain is very stubborn You cant mess with it . But then brain actually never matures and if it does you get dementia Brain transplant is a biological impossibility. Never going to be even attempted.
@@sleepsmartsmashstress740 thank you very much.....
Stop watching sci Fi your born to die.
👍
Thank you for this video . I love science and I believe Nicola Tesla and his innovations will solve the energy problem . Life extension should be one of the many innovations that will change this 🌎 make it a better place … including climate change , nanotechnology, epigenetic, physics…. innovation … innovation, innovation. 👏👏
Where is the evidence if these longevity genes?
Change the world? Why? I just want to win a Nobel Prize without given up all my secrets.
He wants to be Benjamin Button...
Exactly !
Fund raise the way governments do , one dollar times 350 million people brings in a lot of money. Efforts to reach a average Joe could be enormous.
David looks even younger then he did in 2019, is he taking something?
Lol. I reckon a heady cocktail of metformin, berberine,resveratrol, rapamycin and fasting.
At 6:34 David says "It's now 1995" so was this video streamed recently but actually filmed in 1995?
Nevermind I looked up a transcript of this interview and this is what he said "That's right. Yeah. So, I've been studying aging since I was at MIT, this is now in 1995.". So he was referring to when he started at MIT.
He takes NMN, resveratrol, quercetin and metformin.
@@katarzynahansen6970 I was close. Three out of four
54:54 boosters
Why do we age? It's simple! It's called oxidative stress and just living and breathing causes it.
True! Taking an NAD booster to increase your NAD levels as David Sinclair is talking about will address this. Increasing your NAD levels increases cellular repair and deceases oxidative stress. Did you watch the whole video? He's been researching various ways to slow down and even partly "reset" age.
@@joannaelizabeth4749 I'm very familiar with David Sinclair and his works. I'm an exercise physiologist with specialized training in functional and holistic medicine for the last 27 years. I also specialize in disease prevention and the reversal of disease. You know what my best go to supplement is when it comes to boosting NAD levels? Niacin! Work your way up to 1000mg per day and then incorporate using an infrared sauna and infrared light therapy and watch what happens! If you have blood sugar issues then take the Niacin with 500mg of Niacinamide. Also throw in some LDN (low dose naltrexone) and hold on. Oh, and throw Resveratrol in the trash. It has some horrible properties that would take too long to explain here! Take care!
Did you read or watch lectures on the roles of sirtuins and the epigenetic effects related to aging? Oxidative stress might play some role but it is definitely not the whole story. You should check out Sinclair. Guarente, and Kenyon's work.
@@angelogarcia1918 I know Sinclair. I've been in the health industry for over 27 years! As a health professional, I will say this. It's ALL about oxidative stress which then leads to ROS which then leads to inflammation. Yes, it's much more than that - but this is how it all starts and you will NEVER stop it! Why? Just because Sinclair has a theory doesn't mean he is absolutely correct. Can you slow down the aging process? Of course, but your genome will determine a lot of this. Can you manipulate or turn off or turn on certain genes? Of course, BUT science is not quite there yet and even if it were, you'd still age! There is a lot to this and I have had many debates with Sinclair regarding this topic. He promotes a lot of supplements. One is resveratrol and in my opinion it's one of the worst supplements you can take. Number one supplements on my list are Niacin and NT-Factor. In the end do what works for YOU! We are ALL different and what I have learned the most from 27 years of learning and teaching about the human body is that we are all different. You should get a DNA analysis done and then start by taking astaxanthin, R-Lipoic Acid, high dose liposomal C, working up to high dose 1g niacin, add in the NT-Factor and use infrared sauna and infrared light therapy on a daily basis. This basic protocol alone will reduce oxidative stress, decrease toxic load, and increase mitochondria and it's function along with repairing cell membranes. Oh, if you take the high dose Niacin, add in B6 and TMG. If you already have an autoimmune disorder or inflammation, then add in LDN - low dose naltrexone. Also, this is just the basics. As I stated, every person is different and I design custom protocols for an individual based on their DNA and countless blood tests. Take care!
@@Total_Body_Fitness_USACan a person get rid of lymphodema of one arm?
He looks like Mephistopheles...
香港台灣新加坡馬來西亞
NMN優世德代理商有興趣聯絡我~
Revelation 13:15
“And he had power to give life unto the image of the beast, that the image of the beast should both speak, and cause that as many as would not worship the image of the beast should be killed.”
Transhumanists do not write The Future
Dr David’s forehead doesn’t move
botox
@@deannkennedy1795 Which pixel are you referring to?
Pushing statins, Metformin, and blood-pressure meds. I smell BS…
If you can smell BS your brain is intact
The lively novel bacteriologically stay because apparatus impressively chase qua a immense blanket. savory, horrible angle
I don’t want to look like an “iguana !”
Dr. David Sinclair was actually born in East Africa and moved to Australia as a kid. He is a cousin of that fossil called Lucy by the paleontologists. So that is his true age. ha ha
I am from where Lusi came from
@@davidharcot220 Lusi came? They take forever!
@@sleepsmartsmashstress740 what do you mean make it clear please? By the way lusi is from Ethiopia
@@davidharcot220 YES Lucy fossil was dug up in now Ethiopia
Dr Lee
Look in the mirror. Then you will know , why we age .
He needs glasses at his age and his glasses and mirrors are incompatible so he cant look inn the mirror at himself. Spare the old man please
Why We Age? Coz Earth spins make that stop to STOP AGING I am not certain about certuin jeans