Glioblastoma histopathologic diagnosis - Adventures in Neuropathology

A review of the histopathologic diagnosis of the most common primary malignant brain tumor: glioblastoma.
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[@anubratadas1]

Thank you so much

[@Kat_EVV]

8:55 How come on the video, high-grade (3) of astrocytomas, there is less presence of necrosis? Is it not the opposite? Less blood supply, therefore more necrosis.

[@caiyu538]

I am reviewing your series. It helps me a lot. Great series. Look forward to more your excellent tutorials.

[@1992deval]

Please make more excellent videos like this related to CNS neoplasms... please!!

[@spartonsfan911]

Thank you so much, I am finding this very helpful.

[@zaramullally9541]

What are the very bright pink staining regions?

[@AdventuresinNeuropathology]

The background brain tissue through which the tumor is infiltrating is pink. Is that what you are referring to?

[@AlexanderXVIIII]

I have a question if someone can answer, if you take a biopsy from the center of a glioblastoma will the result of the histopathology be affected by this?
Do you need to take a biopsy from the edge of the tumor to make the difference between an astrocytoma grade II/III and glioblastoma grade IV?

[@AdventuresinNeuropathology]

Gliomas are undoubtedly heterogeneous. Biopsy of the enhancing areas is more important than central vs peripheral location of the biopsy. Areas of enhancing on MRI is usually where the highest grade tumor is located (enhancement is an indicator of necrosis or abnormal tumor-induced vascular proliferation). Be cautious of a biopsy that shows lower grade (2-3) if imaging shows an areas of contrast enhancement as it is likely non representative

[@caiyu538]

Great